15 research outputs found
EEOC and Angel Butterbaugh, Cindy Douglas, Kristina Starr v. U.S. Investigations Services, Inc.
- Author
- Publication venue
- DigitalCommons@ILR
- Publication date
- 28/11/2007
- Field of study
Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility
- Author
- Adu Aderonke
- Ahmad Yasmeen
- Ahmad Yasmeen
- Akil Mohammed
- Alavi A.
- Alten Rieke
- Alten Rieke
- Alten Rieke
- Ang Andrea
- Arendt C.
- Arthanari S.
- Arthanari S.
- Askari Ayman
- Atchia Ismael
- Axford J.
- Aynsley Sarah
- Aynsley Sarah
- Baker Daniel
- Bakshi Jyoti
- Bakshi Jyoti
- Balint Peter
- Baskar Sangeetha
- Batra Rajbir
- Becerra Elena
- Bell Aubrey
- Bennett B.
- Bensen William
- Benson Claire
- Berenbaum F.
- Bernasconi Corrado
- Berner Hammer Hilde
- Bharadwaj Anurag
- Bingham Clifton O.
- Bombardieri Michele
- Bombardieri Michele
- Borukhson Liubov
- Bosworth Ailsa
- Boumpas Dimitrios
- Bowman S.
- Bruce Ellen
- Bruce Ellen
- Bruce Ian
- Buckley Christopher
- Buckley Christopher
- Buckley Christopher
- Buckley Felicity
- Bukhari Marwan
- Burkhardt H.
- Burmester Gerd R.
- Burmester Gerd R.
- Bykerk V.
- Cairns Andrew
- Cambridge Geraldine
- Carpenter Lewis
- Carpenter Lewis
- Carruthers David
- Carruthers David
- Cartwright Alison
- Cavet Guy
- Chalam Venkat C.
- Chan Angela Marie L.
- Chan Antoni
- Chan Esther
- Chan Esther
- Chana Jasroop
- Chandratre Priyanka N.
- Chartier Melanie
- Chhabara Monica
- Chipping Jacqueline
- Christie Jennifer D.
- Churchill Duncan
- Clarke Shane
- Clarson Lorna
- Clowse M.
- Collins David
- Congreve Carron
- Conway Katie
- Cooper Cyrus
- Cope Andrew
- Cope Andrew
- Cope Andrew
- Cornell Patricia
- Cox Maureen
- Croft Adam P.
- Croot Lorraine
- Cumming Jo
- Cush J.
- D'Agostino Maria A.
- D'Cruz David
- Dadoun Sabrina
- Dahanayake Chanaka
- Dahanayake Chanaka
- Das Sudipto
- Davari Ejtehadi Hora
- Davies Emma J.
- Davies O.
- Davies O.
- Davies Rebecca
- Dawes Peter
- Dawson Julie
- Dawson Julie
- De La Torre Inmaculada
- de Longueville M.
- De Pablo Paola
- de Pablo Paola
- de-Soyza Anthony
- Dean Gillian
- Deeming Alison
- Dejonckheere Fred
- Dejonckheere Fred
- Delaet Ingrid
- Desanti Guillaume
- Devenport Jenny
- Dharmapalaiah Chethana
- Di Cicco Maria
- Diamantopoulos Alex
- Disney Benjamin
- Dixey Josh
- Dixey Josh
- Dixon Will
- Dixon Will
- Dixon William G.
- Dixon William G.
- Dobson Joanne
- Douglas Barbara
- Doyle Mittie
- Dubash Sayam
- Durez Patrick
- Eggleton Paul
- Ehrenstein Michael
- El Haj Alicia
- Ellerby Nicholas
- Emerling Daniel
- Emery Paul
- Emery Paul
- Emery Paul
- Faizal Abdul
- Farrar Wendy
- Fearon Ursula
- Ferraccioli G.
- Ffolkes Lorrette
- Filer Andrew
- Filippucci Emilio
- Filter Andrew
- Finckh Axel
- Fisher Benjamin
- Fleischmann Roy
- Fleischmann Roy
- Fleischmann Roy
- Fleischmann Roy
- Ford Kerri
- Fossati G.
- Freimanis G.
- Furst Daniel E.
- Gabriel Carolyn
- Gaillez Corine
- Galeazzi Mauro
- Galeazzi Mauro
- Galloway James
- Galloway James
- Garg Nidhi
- Gayed Mary
- Gee Andrew H.
- Gendi Nagui
- Genovese Mark
- Genovese Mark
- Genovese Mark
- Gibbons Carl
- Gibson Kellie
- Goff Iain
- Golla Janardhana
- Gomez-Reino Juan J.
- Gray Leanne
- Grindulis Karl
- Grove Matthew
- Hall Frances C.
- Hamilton Jennifer
- Han Chenglong
- Hands Rebecca
- Hardie Debbie
- Hardy Jacob
- Harland Dave
- Harris Helen E.
- Hart Jennifer C.
- Hassan Nada
- Hassan Sadon
- Hawtree Sarah
- Healy L.
- Helliwell Philip
- Heritage Caroline
- Hewitt Jamie
- Heycock Carol
- Hider Samantha
- Hider Samantha L.
- Hofmann Darija
- Holder Susan
- Hooley P.
- Hotopf Matthew
- Hsia Elizabeth C.
- Huertas Catherine
- Huizinga Tom W.
- Hull Richard
- Humby Frances
- Humphreys Jennifer
- Humphreys Jennifer
- Hunter John
- Hutchinson David
- Hutchinson David
- Hyrich Kimme
- Hyrich Kimme
- Hyrich Kimme
- Hyrich Kimme L.
- Iagnocco Annamaria
- Ibrahim Fowzia
- Isenberg David
- Jansen Jeroen P.
- Jaurez Maria
- Javaid Muhammad K.
- Jayakumar Keeranur
- Jobanputra Paresh
- Johnson Simon
- Johnston Graeme
- Jones Graeme
- Jones Peter
- Judge Andrew
- Jury Elizabeth
- Kaine Jeffrey
- Karjigi Uma
- Karppinen Jaro
- Kary Sonja
- Kaur Jaspreet
- Kaur Ladbans
- Keay Fiona
- Kehoe Oksana
- Kelly Clive
- Kelly Clive
- Kelly Clive
- Kelly Clive
- Kelly Sheila
- Kelly Stephen
- Kerselaers Wendy
- Keystone Edward C.
- Khan Afsha
- Khanna Dinesh
- Kidd Bruce
- Kiely Patrick
- Kiely Patrick
- Kilding Rachael
- Kim Lilianne
- Kinderlerer Anne R.
- Kinderlerer Anne R.
- Kingsley Gabrielle
- Kingsley Gabrielle H.
- Kingsley Gabrielle H.
- Kinnear William
- Kirwan John R.
- Kitas George D.
- Kitas George D.
- Koduri Gouri
- Koduri Gouri
- Koetse W.
- Kosutic G.
- Koutedakis Yiannis
- Kremer Joel M.
- Krishan Pawan
- Krutikov Maria
- Kupper Hartmut
- Lanyon Peter
- Lazarus Mark N.
- Lazarus Mark N.
- Le Bars Manuela
- Le Bars Manuela
- Leandro Maria J.
- Lempp Heidi
- Lepley Denise
- Li Wanying
- Lieberman Abigail
- Litwic Anna E.
- Lorenz Hannes M.
- Lorenzi Alice
- Low Audrey
- Low Audrey
- Low Audrey
- Lu Jiandong
- Luijtens K.
- Luijtens K.
- Lunt Mark
- Lunt Mark
- Lunt Mark
- Lunt Mark
- Lunt Mark
- Ma Margaret H.
- Ma Margaret H.
- Ma Margaret H.
- Maatta Juhani
- Maciver Helen
- Maciver Helen
- Mack Michael
- Mackenzie-Green Bronwen
- Maclaren Zoe
- Maggs Fiona
- Mahadevan U.
- Mahendran Prini
- Maldonado Michael
- Maldonado Michael A.
- Malik Saadia P.
- Mallen Christian
- Marguerie Christopher
- Mariette X.
- Mark Wilkinson J.
- Marshall Robert W.
- Marshall Tarnya
- Marshall Tarnya
- Matcham Faith
- Mattey Derek L.
- Matucci-Cerinic Marco
- McCrae Fiona
- McCrae Fiona
- McFadyen Charles
- McHenry Michelle
- Mehta Puja
- Mendelsohn Alan
- Mercer Louise
- Mercer Louise
- Mercer Louise
- Mercieca Cecilia
- Metsios George
- Metsios George
- Middleton Jim
- Moller Ingrid
- Molloy Cauline
- Moore Samantha
- Morrison Elaine
- Moullaali Thomas
- Movahedi Mohammad
- Mpofu Chiedzo
- Mukherjee Sandeep
- Mulherin Diarmuid
- Muller-Ladner Ulf
- Muthana Munitta
- Muthana Munitta
- Nadesalingam Kavitha
- Nandagudi Anupama
- Nandagudi Anupama
- Narayan Nehal
- Naredo Esperanza
- Nash Peter
- Navarro-Blasco Francisco
- Naylor Amy
- Nelson P. N.
- Nesbitt A.
- Neumann Elena
- Nevill A.
- Ng Nora
- Nightingale Peter
- Nikiphorou Elena
- Nikiphorou Elena
- Nikiphorou Elena
- Nisar Mohamed
- Nisar Mohamed
- Nuki George
- Nurmohamed Michael T.
- Nusslein Hubert
- O'Brien Anne
- O'Dowd Emma
- Ostergaard Mikkel
- Ostlere Lucy
- Ottery Faith D.
- Packham Jonathan
- Pang Hok
- Patel Priya
- Patel Salil
- Patel Sanjeev
- Paul Anupam
- Pavelka Karel
- Pendleton Adrian
- Penn Henry
- Perry Elizabeth
- Peter Hans-Hartmut
- Pitts Laura
- Pitzalis Costantino
- Pitzalis Costantino
- Platt Phil
- Platt Philip N.
- Poncet Coralie
- Poole Kenneth E.
- Poore Sophie
- Pratt Arthur
- Price Elizabeth
- Price Tom
- Prouse Peter J.
- Pugh Mark
- Pyne Dev
- Quin John
- Raftery Graham
- Rahmeh Fouz
- Rainer Franz
- Rajagopal Vivek
- Ramachandran Nair Jagdish
- Rauch Christiane
- Ravindran Vinod
- Ray David W.
- Rayner Lauren
- Raza Karim
- Reddy Venkat
- Rees Frances
- Reynolds Gary
- Reynolds Timothy D.
- Richards Selwyn
- Richardson Jane
- Riches Philip
- Robinson Helena
- Rocher Vidalba
- Roddy Edward
- Roden D.
- Roncaroli Frederico
- Rose Diana
- Round Gemma
- Roy Matthew
- Rubbert-Roth Andrea
- Rylance P. B.
- Rynne Martin
- Samarawickrama Amanda
- Samborski W.
- Samson Kay
- Sandoo Aamer
- Saravanan Vadivelu
- Sargeant Ify
- Sasso Eric H.
- Sathi Nav
- Sathi Nav
- Scali Juan J.
- Schiff Michael
- Schiff Michael H.
- Scott David L.
- Scott David L.
- Scott David L.
- Scott David L.
- Scott David L.
- Scott Ian C.
- Scott Ian C.
- Scott Ian C.
- Scott Nicola
- Sebba Anthony
- Sebba Anthony
- Seth Rakhi
- Shah Preeti
- Sharif Mohammed I.
- Shaw M.
- Sheeran Tom
- Shingler Wendy
- Shingler Wendy
- Simpson Carol
- Singh Animesh
- Singh Deepwant
- Singhal Saket
- Skaparis Yiannis
- Skibinska Malgorzata
- Smart Devi
- Smolen Josef
- Smolen Josef
- Sokoll Katharina
- Solymossy Csilla
- Stach C.
- Stannett Peter
- Stavropoulos Kalinoglou Antonios
- Stavropoulos-Kalinoglou Antonios
- Steer Sophia
- Stevens Richard
- Stone Millicent A.
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah P.
- Syngle Ashit
- Taggart Allister
- Taylor Peter
- Telfer Scott
- Terpstra I.
- Thompson Ben
- Thompson Paul W.
- Thompson Robert N.
- Thomson Janet
- Tierney Ann
- Treece Graham M.
- Tugnet N.
- Turmezei Thomas D.
- Tweedie Fiona
- Unnebrink Kristina
- Vagadia Vipul
- van der Heijde Desiree
- Van Holder Karina
- van Vollenhoven Ronald F.
- van Vollenhoven Ronald F.
- Veale Douglas
- Veitch A. M.
- Veldhuijzen van Zanten Jet J.
- Veldhuijzen van Zanten Jet J.
- Verma Inderjeet
- Vernon Emma
- Verstappen Suzanne
- Verstappen Suzanne M.
- Vincent Tonia
- Vital Edward M.
- Vittecoq Olivier
- Vohra Kanchan
- Wakefield Richard
- Walker-Bone Karen E.
- Walsh David
- Walsh Maeve
- Ward Lorna
- Warner Alexander J.
- Watson Kath
- Watson Kath D.
- Wearn Koh Li
- Weinblatt Michael E.
- Weinblatt Michael E.
- Weinblatt Michael E.
- Weinblatt Michael E.
- Wernham Aaron
- Westhovens Rene
- Westlake Sarah L.
- White Marie
- Wig Surabhi
- Williams Debbie
- Williams Francis
- Williams Peter
- Williams S.
- Williamson Lyn
- Wilson Anthony G.
- Wilson Gerry
- Wilson Hilary
- Wolber Lisa
- Wolf D.
- Wolfson Marsha
- Woodburn James
- Woodhead Felix A.
- Woodhead Felix A.
- Woon Kam Ngar
- Worsnop Fiona
- Wray Maria
- Wright Gary
- Wykes Til
- Yood Robert
- Young Adam
- Young Adam
- Young Adam
- Young Adam
- Zimmermann Birgit
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Addo A.
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- Agbeko R.
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- Al Aaraj A.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
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- Data Monitoring Committee of the RECOVERY Collaborative Group
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- Health records (for the RECOVERY Collaborative Group)
- Hector G.
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- Jaime F.
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- Jeebun V.
- Jeffery Katie
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- Jenkins P.
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- Jerry D.
- Jimenez Gil A.
- Johal S.
- John A.
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- Jones A.
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- Jordache R.
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- Josiah B.
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- Judge P.
- Juszczak Edmund
- Kailey A.
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- Liu P.
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- Local Clinical Centre staff (for the RECOVERY Collaborative Group)
- Lock S.
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- Lockett T.
- Lodhia K.
- Lofthouse M.
- Logan M.
- Logue C. A.
- Lokanathan S.
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- Mackey A.
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- Mahaveer A.
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- Maheswaran A.
- Mahmood W.
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- Malein Flora
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- Manso K.
- Mansour M.
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- Maria del Rocio F.
- Mariano V.
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- May P.
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- Mediana A.
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- Metryka A.
- Mew L.
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- Michalak N.
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- Montasser M.
- Montgomery Alan
- Moon A.
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- Morrow A.
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- Mounce G.
- Mtuwa S.
- Muazzam A.
- Mudawi D.
- Mulcahy M.
- Mulligan S.
- Mumford Andrew
- Munavvar Mohammed
- Munt S.
- Murphy S.
- Murray C.
- Murray D.
- Murray I.
- Murray K.
- Murray L.
- Murthy M.
- Mutch C.
- Muzengi N.
- Mwaura E.
- Nafei M.
- Nagarajan T.
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- Nandani A.
- Nandwani T.
- Nasa S.
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- Neal A.
- Nelson B.
- Nelson S.
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- Newby D.
- Newman T.
- Newport R.
- Ng S.
- Ngumo A.
- Nicholas N.
- Nicholas P.
- Nickson I.
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- Nightingale T.
- Nilsson A.
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- Nirmalan M.
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- Oliver A.
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- Oomatia A.
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- Osei-Bobie J.
- Oxlade R.
- O’Brien R.
- O’Callaghan C.
- O’Connor G.
- O’Donovan C.
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- O’Riordan D.
- O’Sullivan E.
- Padden G.
- Page I.
- Page S.
- Pagett K.
- Pajak S.
- Pakou G.
- Palacios A.
- Palfrey H.
- Pandya T.
- Panes A.
- Pantin C.
- Parambil V.
- Parashar S.
- Parekh A.
- Parekh D.
- Parker B.
- Parker J.
- Parker S.
- Parkinson A.
- Passby L.
- Passey S.
- Patachako J.
- Patel M.
- Patel P.
- Patel S.
- Patience A.
- Patten S.
- Patterson C.
- Patterson L.
- Pauls L.
- Paulus S.
- Payne B.
- Payne E.
- Payne R.
- Peacock L.
- Pearce J.
- Pearson K.
- Peasley A.
- Peggie H.
- Pelham C.
- Penman C.
- Penman J.
- Penman R.
- Percival R.
- Perez E.
- Periyasamy L.
- Perry A.
- Perry M.
- Pessoa-Amorim Guilherme
- Peters C.
- Peterson A.
- Peto Leon
- Petrova B.
- Pezard-Snell M.
- Phelan P.
- Philbin J.
- Phillips N.
- PI M.
- Pick S.
- Pickard J.
- Pickering G.
- Piercy C.
- Pinches H.
- Pine K.
- Pinjala M.
- Pitchford M.
- Pleass R.
- Plowright M.
- Plumptre C.
- Pomery F.
- Poole L.
- Porter D.
- Porter L.
- Potter A.
- Potts J.
- Poustie V.
- Power N.
- Poyner E.
- Pradhan V.
- Prady H.
- Prasath S.
- Pratt A.
- Pratt S.
- Preiss D.
- Prest C.
- Price A.
- Price C.
- Price D.
- Price K.
- Price L.
- Price V.
- Price-Eland R.
- Priest A.
- Prince C.
- Pringle S.
- Pristopan V.
- Priyash V.
- Prudon Benjamin
- Pugh L.
- Purdue C.
- Purdy R.
- Pursell M.
- Purvis S.
- Putensen D.
- Pyart E.
- Quek E.
- Quigley J.
- Quindoyos J.
- Quinn T.
- Rabinowicz S.
- Rafique J.
- Rahman M.
- Rai S.
- Raithatha A.
- Rajasri A.
- Ramanan A.
- Ramasamy M.
- Ramchandani A.
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- Ramsay J.
- Ramshaw A.
- Rana G.
- Rand J.
- Rank H.
- Rankhelawon R.
- Rasheed A.
- Ratcliffe S.
- Raw J.
- Razvi Z.
- RECOVERY Collaborative Group
- Redknap I.
- Redman N.
- Rees A.
- Rees M.
- Rees S.
- Rehman Z.
- Reilly M.
- Reith C.
- Renshaw S.
- Rey S.
- Reynard C.
- Reynolds H.
- Rhodes J.
- Rice E.
- Rice M.
- Rice N.
- Richardson E.
- Richardson N.
- Rigby L.
- Riley M.
- Riley P.
- Ripley D.
- Rishton C.
- Riste M.
- Ritchings A.
- Rivera Ortega P.
- Robbins E.
- Roberts V.
- Robertson C.
- Robertson J.
- Robertson N.
- Robinson J.
- Robinson L.
- Robinson S.
- Robson S.
- Roderick M.
- Rodger A.
- Rodgers A.
- Rodgers N.
- Rodgers P.
- Roehr C.
- Rogers J.
- Rogers S.
- Rogers T.
- Rook C.
- Rooney L.
- Rosby E.
- Rose A.
- Rose Z.
- Ross I.
- Rothman A.
- Rothwell J.
- Roughley L.
- Rowan Kathryn
- Rowan N.
- Rowe A.
- Rowe N.
- Rowley M.
- Rudenko A.
- Rule R.
- Rushmer J.
- Ryan A.
- Ryan L.
- Ryan P.
- Rybka E.
- Ryder S.
- Salberg A.
- Saleh M.
- Salih H.
- Salman R.
- Salmon R.
- Sam M.
- Sam S.
- Saminathan S.
- Sammons E.
- Sammut D.
- Sampson J.
- Samuel M.
- Samuel Y.
- Sanchez Gonzalez A.
- Sanchez V.
- Sandercock Peter
- Sangombe M.
- Sanju M.
- Santosh R.
- Sarfatti A.
- Sarkar R.
- Sarwar Z.
- Sathyanarayanan L.
- Saunderson A.
- Scaletta D.
- Scanlon D.
- Scarratt L.
- Scattergood S.
- Schadenberg A.
- Schafers J.
- Schneblen W.
- Schofield E.
- Schumacher N.
- Schunke N.
- Scobie A.
- Scoones T.
- Scott A.
- Scott C.
- Scullion A.
- Seaton I.
- Sedano J.
- Segovia M.
- Selby F.
- Sellers K.
- Sen N.
- Sengupta A.
- Sewdin T.
- Seymour J.
- Shah H.
- Shah R.
- Shah S.
- Shaibu A.
- Shanahan T.
- Sharaf H.
- Sharma B.
- Sharma O.
- Sharma S.
- Sharp L.
- Sharratt P.
- Shaw D.
- Shaw J.
- Shawcross A.
- Shea D. O.
- Sheffield J.
- Shehata Z.
- Shenton J.
- Shepherd A.
- Shepherd K.
- Shepherd L.
- Sheppeard R.
- Sheridan H.
- Sheridan R.
- Sherwin S.
- Shibly S.
- Shiham F.
- Shilladay C.
- Shillitoe B.
- Shioi C.
- Shirley K.
- Shurlock J.
- Shurmer Jack
- Siamia L.
- Siddle E.
- Sime R.
- Simpson A.
- Simpson D.
- Simpson J.
- Simpson M.
- Simpson P.
- Sinclair S.
- Singh C.
- Singh S.
- Singhal P.
- Sithiravel S.
- Sivanadarajah S.
- Skaria A.
- Skehan N.
- Skinner T.
- Skinner V.
- Skorko A.
- Slack A.
- Slade H.
- Small E.
- Smallridge A.
- Smart B.
- Smith C.
- Smith E.
- Smith H.
- Smith J.
- Smith L.
- Smith M.
- Smith N.
- Smith P.
- Smith R.
- Smith S.
- Smith T.
- Smith V.
- Snell D.
- Sobande T.
- Sobrino Diaz A.
- Solly R.
- Soni G.
- Soor P.
- Soothill G.
- Soren J.
- Spiller W.
- Spring O.
- Squires G.
- Squires J.
- Squires R.
- Srinivasan R.
- Stagg W.
- Stanton A.
- Staplin Natalie
- Starnes D.
- Steer J.
- Stefania V.
- Stefanowska P.
- Stephens A.
- Stephensen D.
- Stephenson E.
- Sterrenburg M.
- Stevens W.
- Stevenson A.
- Stevenson S.
- Steward M.
- Stewart C.
- Stewart K.
- Stewart Richard
- Stickley J.
- Stirrup S.
- Stock S.
- Stockdale A.
- Stone B.
- Stone S.
- Storey I.
- Stratton E.
- Stratton J.
- Stubbs A.
- Stuttard M.
- Subudhi C.
- Sugden P.
- Sukumaran A.
- Sundar S.
- Surtees M.
- Sutherland R.
- Sutherland S.
- Sutu M.
- Swanson-Low C.
- Swart T.
- Swift E.
- Swist-Szulik K.
- Sykes D.
- Sykes E.
- Symon D.
- Syndercombe A.
- T-Michael H.
- Tadros M.
- Tague L.
- Tahir H.
- Tait J.
- Talbot P.
- Tallent R.
- Tallon B.
- Tanney C.
- Tanton E.
- Taribagil P.
- Tarr E.
- Tasiou A.
- Tate A.
- Taylor C.
- Taylor J.
- Taylor K.
- Taylor L.
- Taylor R.
- Taylor-Siddons M.
- Teasdale F.
- Teasdale J.
- Teasdale K.
- Tebbutt J.
- Telfer A.
- Tempany J.
- Tereszkowski-Kaminski R.
- Tewkesbury D.
- Thake M.
- Thakker M.
- Thamu B.
- Thet P.
- Thomas A.
- Thomas E.
- Thomas K.
- Thomas R.
- Thomas S.
- Thompson E.
- Thompson J.
- Thompson K.
- Thompson R.
- Thornton D.
- Thornton J.
- Thornton S.
- Thorpe S.
- Thrasyvoulou L.
- Thraves H.
- Thu-Ta P.
- Thwaites Guy
- Tilbey S.
- Timerick J.
- Timmins A.
- Tinkler H.
- Tipper J.
- Tivenan H.
- Todd S.
- Tohfa M.
- Toohey C.
- Topham K.
- Topping M.
- Tousis R.
- Trevelyan M.
- Trewick N.
- Truell R.
- Tsakiridou K.
- Tsang C.
- Tucker S.
- Tufail A.
- Tuff J.
- Tully R.
- Turbitt K.
- Turgut T.
- Turner G.
- Turner K.
- Turner S.
- Turner-Bone I.
- Turney S.
- Tyer A.
- UK National Institute for Health Research Clinical Research Network (for the RECOVERY Collaborative Group)
- Ul Haq M.
- Ul Hassan W.
- Underwood C.
- Unsworth A.
- Uriel Alison
- Usher R.
- Ustianowski A.
- Vankayalapati P.
- Van’t Hoff W.
- Varghese M.
- Varnier G.
- Vasu V.
- Vatish M.
- Veerasamy S.
- Velankar S.
- Vella N.
- Velugupati A.
- Venables I.
- Venditti M.
- Veres M.
- Vergnano S.
- Vernall R.
- Verula J.
- Vethanayagam N.
- Vettikumaran S.
- Victoria S.
- Vinay S.
- Vincent O.
- Vincent R.
- Vyras E.
- Wade P.
- Waite A.
- Walden A.
- Walker I.
- Walker K.
- Walker S.
- Wallace G.
- Wallendszus K.
- Wallis G.
- Walsh D.
- Walters J.
- Walton E.
- Walton O.
- Wang N.
- Wang R.
- Wang S.
- Warburton S.
- Ward J.
- Ward L.
- Ward R.
- Wardle S.
- Warmington J.
- Warner C.
- Warran S.
- Warren R.
- Warren Y.
- Warris Adilia
- Wasson E.
- Waterfall H.
- Waters D.
- Watson A.
- Watson E.
- Watson J. G. R.
- Watson L.
- Watson R.
- Watterson D.
- Watts M.
- Waugh V.
- Wayman E.
- Weatherhead M.
- Webb C.
- Webster I.
- Weerakoon R.
- Weetman M.
- Wei S.
- Welch J.
- Welch S.
- Wels R.
- Welters I.
- Welton R.
- Wentworth L.
- West R.
- West S.
- Western L.
- Westhead R.
- Weston H.
- Wetherill B.
- White A.
- Whitehead C.
- Whitehouse A.
- Whitehouse T.
- Whiteley J.
- Whiteley S.
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- Nature Publishing Group
- Publication date
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
The role of assisted manipulation in cognitive development
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- International Organization for Standardization
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- Wright M
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- 'Informa UK Limited'
- Publication date
- Field of study
In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm
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- A Haouzi
- A Kiotsekoglou
- AK Prall
- AS Rios
- AT Yetman
- AW Chung
- AW Chung
- AW Chung
- AW Chung
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- C Gibson
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- D Petrinec
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- 'Springer Science and Business Media LLC'
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- Field of study
An Empirical Study on the Effects of Career Ambition and Self-Compassion on Innovation Work Behavior of CEOs and Executives of SMEs
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- 김경재
- 김계수
- 김병원
- 김장기
- 김종관
- 김학수
- 김형진
- 박경환
- 서성무
- 신주훈
- 안류연
- 안영갑
- 용홍출
- 이동섭
- 이보라
- 이지우
- 임선아
- 장광순
- 전인
- 정기영
- 정재금
- 조영복
- 최석봉
- 최석봉
- 최용호
- 홍세희
- 홍완기
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- 'The Korean Society of Business Venturing'
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- Field of study
Leadership Substitutes and Personality Impact on Time and Quality in Virtual New Product Development Projects
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- Amabile T. M.
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- 'Wiley'
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- Field of study
Field topologies in ideal and near-ideal magnetohydrodynamics and vortex dynamics
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- A A Pevtsov
- A Bhattacharjee
- A Boozer
- A Boozer
- A F Rappazzo
- A H Boozer
- A H Boozer
- A L Ariste
- A M Dixon
- A M Janse
- A M Janse
- A Malanushenko
- A Malanushenko
- B C Low
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- DM Rust
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- E N Parker
- E N Parker
- E N Parker
- E N Parker
- E N Parker
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- E N Parker
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- G Yu
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- M A Berger
- M A Berger
- M A Berger
- M A Berger
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- M Tabor
- M Yamada
- M Zhang
- M Zhang
- M Zhang
- M Zhang
- M Zhang
- M Zhang
- N Flyer
- N Gopalswamy
- N Labrosse
- P Antolin
- P F Chen
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- P F Chen
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- S Chandrasekhar
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- S E Gibson
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- S Kumar
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- X Cheng
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- 'Springer Science and Business Media LLC'
- Publication date
- Field of study