Diagram of model 1.

<p>The first five hospitalizations are considered. “In” stands for admission in hospital, “Out” for discharge from hospital and “D” for death. Patients with first admission for HF are considered. No distinction has been done between rehospitalization for heart failure or for any cause.</p

Descriptive analysis of ICU/IHC events.

<p>Descriptive analysis of ICU/IHC events.</p

Diagram of model 2.

<p>The state space is made by all the possible events described in the dataset: admission to hospital (H), to ICU or IHC, discharge from any state (OUT) and death.</p

Hazard rates (and corresponding 95% CIs) for transitions of model 2.

<p>Hazard rates (and corresponding 95% CIs) for transitions of model 2.</p

Descriptive analysis of the whole cohort.

<p>Descriptive analysis of the whole cohort.</p

sj-docx-1-tej-10.1177_20417314231190147 – Supplemental material for Engineered heart tissue maturation inhibits cardiomyocyte proliferative response to cryoinjury

Supplemental material, sj-docx-1-tej-10.1177_20417314231190147 for Engineered heart tissue maturation inhibits cardiomyocyte proliferative response to cryoinjury by Giulio Ciucci, Karim Rahhali, Giovanni Cimmino, Francesco Natale, Paolo Golino, Gianfranco Sinagra, Chiara Collesi and Francesco S Loffredo in Journal of Tissue Engineering</p

Bioinformatics filtering algorithm.

<p>Shown are bioinformatics analysis tools used and individual and mean variant numbers at each step of filtering with resulting decrease in variant numbers at each decision step.</p

IL-1Ra protects cardiomyocytes from ischemia-induced apoptosis.

<p>(a) Hystochemistry of IL-1Ra expression (purple) in the heart following coronary artery ligation in mice: ventricle cross section, and (b) specific, diffuse IL-1Ra staining of cardiomyocytes in the ischemic heart area. (c) Time course of secreted (s) and intracellular (ic) IL-1Ra mRNA expression in the hypoxic heart of WT (Il-1ra+/+) mice. The graphs represent the fold change after normalization with the expression of β-actin. (d) Histology of TUNEL staining (red stain) of Il-1ra+/+ and (e) Il-1ra−/− mouse hearts after 6 hr hypoxia, and of (f) Il-1ra+/+ and (g) Il-1ra−/− mouse hearts not exposed to hypoxia. (h) Rate of TUNEL staining in d-g conditions. Results are means ± SE, n = 3, **p<0.001 for Il-1ra−/− vs control Il-1ra+/+ mouse hearts after 6 hr hypoxia, *p<0.001 for Il-1ra+/+ mouse hearts after 6 hr hypoxia vs hearts not exposed to hypoxia. Bars, a 2 mm, b 20 um; d, e, g, h 40 um.</p

Visualization of NGS alignment and chromatogram from Sanger sequencing confirming the <i>TNNT2 Arg173Trp</i> variant.

<p>The alignment and Sanger sequencing profiles of the TNNT2 R173W variant are shown. A) C>T variant alignment reads of Arg173Trp variant B) (inset) Chromatogram of C>T variant of Arg173Trp variant from Sanger sequencing; arrow depicts the c.517T C>T (chr1∶201,332,477) position.</p

Clinical features of key member of family AD-FDC1 and AD-FDC27.

<p>NYHA - New York Heart Association class; ECG - Electrocardiogram; LVEDD - left ventricular end-diastolic diameter; LVEF - left ventricular ejection fraction; FS - fractional shortening; DOE - Dyspnea on exertion, PND - Paroxysmal nocturnal dyspnea, DCM - Dilated cardiomyopathy, PVC - Premature ventricular contractions, LBBB - Left bundle branch block, CHF - Congestive heart failure, SD - Sudden death, NSVT - Non-sustained ventricular tachycardia, PM - Pace maker, RBBB - Right bundle branch block, AF - Atrial fibrillation, AVB - 1st degree atrio-ventricular block, LAFB - Left anterior fascicular block, SSS - sick sinus syndrome.</p