PI-controlled bioreactor as a generalized Lienard system

It is shown that periodic orbits can occur in Cholette's bioreactor model working under the influence of a PI-controller. We find a diffeomorphic coordinate transformation that turns this controlled enzymatic reaction system into a generalized Lienard form. Furthermore, we give sufficient conditions for the existence and uniqueness of limit cycles in the new coordinates. We also perform numerical simulations illustrating the possibility of the existence of a local center (period annulus). A result with possible practical applications is that the oscillation frequency is a function of the integral control gain parameterComment: 15 pages, 5 figures, accepted version at Computers & Chem. En

Experimental Realization of Optimal Noise Estimation for a General Pauli Channel

We present the experimental realization of the optimal estimation protocol for a Pauli noisy channel. The method is based on the generation of 2-qubit Bell states and the introduction of quantum noise in a controlled way on one of the state subsystems. The efficiency of the optimal estimation, achieved by a Bell measurement, is shown to outperform quantum process tomography

Laccase-Carrying Polylactic Acid Electrospun Fibers, Advantages and Limitations in Bio-Oxidation of Amines and Alcohols

Laccases are oxidative enzymes that could be good candidates for the functionalization of biopolymers with several applications as biosensors for the determination of bioactive amine and alcohols, for bioremediation of industrial wastewater, and for greener catalysts in oxidation reactions in organic synthesis, especially used for non-phenolic compounds in combination with redox mediators in the so-called Laccase Mediator System (LMS). In this work, we describe the immobilization of Laccase from Trametes versicolor (LTv) in poly-L-lactic acid (PLLA) nanofibers and its application in LMS oxidation reactions. The PLLA-LTv catalysts were successfully produced by electrospinning of a water-in-oil emulsion with an optimized method. Different enzyme loadings (1.6, 3.2, and 5.1% (w)/(w)) were explored, and the obtained mats were thoroughly characterized. The actual amount of the enzyme in the fibers and the eventual enzyme leaching in different solvents were evaluated. Finally, the PLLA-LTv mats were successfully applied as such in the oxidation reaction of catechol, and in the LMS method with TEMPO as mediator in the oxidation of amines with the advantage of easier work-up procedures by the immobilized enzyme. However, the PLLA-LTv failed the oxidation of alcohols with respect to the free enzyme. A tentative explanation was provided

Incentive-driven inattention

“Rational inattention” is becoming increasingly prominent in economic modeling, but there is little empirical evidence for its central premise-that the choice of attention results from a cost-benefit optimization. Observational data typically do not allow researchers to infer attention choices from observables. We fill this gap in the literature by exploiting a unique dataset of professional forecasters who update their inflation forecasts at days of their choice. In the data we observe how many forecasters update (extensive margin of updating), the magnitude of the update (intensive margin), and the objective of optimization (forecast accuracy). There are also “shifters” in incentives: A contest that increases the benefit of accurate forecasting, and the release of official data that reduces the cost of processing information. These features allow us to link observables to attention and incentive parameters. We structurally estimate a model where the decision to update and the magnitude of the update are endogenous and the latter is the outcome of a rational inattention optimization. The empirical findings provide support for the key implication of rational inattention that information-processing efforts react to changing incentives. Counterfactuals reveal that accuracy is maximized if the contest date coincides with the release of information, aligning higher benefits with lower costs of attention

Is executive function associatedwith symptom severity in schizophrenia?

Abstract.: This paper reports on a study that was designed to investigate the relationship between psychopathology and executive functions in schizophrenia. Correlations were sparse and mostly weak. The most robust finding was the association between letter fluency and negative symptoms; however, most other applied tasks were not associated with symptom level. Our results support previous findings of differential relationships between impaired executive functions and symptom leve

Dating long thrust systems on Mercury: new clues on the thermal evolution of the planet

The global tectonics of Mercury is dominated by contractional features mainly represented by lobate scarps, high relief ridges, and wrinkle ridges. These structures are the expression of thrust faults and are linear or arcuate features widely distributed on Mercury. Locally, these structures are arranged in long systems characterized by a preferential orientation and non-random spatial distribution. In this work we identified five thrust systems, generally longer than 1000 km. They were named after the main structure or crater encompassed by the system as: Thakur, Victoria, Villa Lobos, Al-Hamadhani, and Enterprise. In order to gain clues about their formation, we dated them using the buffered crater counting technique, which can be applied to derive the ages of linear landforms such as faults, ridges and channels. To estimate the absolute age for the end of the thrust system's activity, we applied both Le Feuvre and Wieczorek Production Function and Neukum Production Functions. Moreover, to further confirm the results obtained with the buffered crater counting method, the classic stratigraphic approach has been adopted, in which a faulted and an unfaulted craters were dated for each system. The results gave consistent ages and suggested that the most movements along major structures all over Mercury most likely ended at about 3.6–3.8 Ga. This gives new clues to better understand the tectonics of the planet and, therefore, its thermal evolution. Indeed, the early occurrence of tectonic activity in the planet's history, well before than predicted by the thermophysical models, coupled with the orientation and spatial distribution of the thrust systems, suggests that other processes beside global contraction, like mantle downwelling or tidal despinning, could have contributed to the first stage of the planet's history. Keywords: Mercury, Thrust systems, Crater counting, Thermal evolution, Planetary geology, Structural geolog

An analytical approximation scheme to two point boundary value problems of ordinary differential equations

A new (algebraic) approximation scheme to find {\sl global} solutions of two point boundary value problems of ordinary differential equations (ODE's) is presented. The method is applicable for both linear and nonlinear (coupled) ODE's whose solutions are analytic near one of the boundary points. It is based on replacing the original ODE's by a sequence of auxiliary first order polynomial ODE's with constant coefficients. The coefficients in the auxiliary ODE's are uniquely determined from the local behaviour of the solution in the neighbourhood of one of the boundary points. To obtain the parameters of the global (connecting) solutions analytic at one of the boundary points, reduces to find the appropriate zeros of algebraic equations. The power of the method is illustrated by computing the approximate values of the ``connecting parameters'' for a number of nonlinear ODE's arising in various problems in field theory. We treat in particular the static and rotationally symmetric global vortex, the skyrmion, the Nielsen-Olesen vortex, as well as the 't Hooft-Polyakov magnetic monopole. The total energy of the skyrmion and of the monopole is also computed by the new method. We also consider some ODE's coming from the exact renormalization group. The ground state energy level of the anharmonic oscillator is also computed for arbitrary coupling strengths with good precision.Comment: 5 pages, 3 tables, Late

Dynamics of Saccharomyces cerevisiae strains isolated from vine bark in vineyard: Influence of plant age and strain presence during grape must spontaneous fermentations

In this study, two vineyards of different age were chosen. During three years, a sampling campaign was performed for isolating vineyard-associated Saccharomyces cerevisiae (S. cerevisiae) strains. Bark portions and, when present, grape bunches were regularly collected from the same vine plants during the overall sampling period. Each bark portion was added to a synthetic must, while each grape bunch was manually crushed, and fermentations were run to isolate S. cerevisiae strains. All collected yeasts were identified at different species and strain levels to evaluate the genetic variability of S. cerevisiae strains in the two vineyards and strains dynamics. Moreover, bark-associated strains were compared with those isolated from spontaneous fermentations of grapes collected during the two harvests. Regarding the youngest vineyard, no S. cerevisiae was identified on bark and grape surface, highlighting the importance of vine age on yeast colonization. Results reported the isolation of S. cerevisiae from vine bark of the old vineyard at all sampling times, regardless of the presence of the grape bunch. Therefore, this environment can be considered an alternative ecological niche that permanently hosts S. cerevisiae. Bark-associated strains were not found on grape bunches and during pilot-scale vinifications, indicating no significative strain transfer from vine bark to the grape must. Commercial starters were identified as well both in vineyards and during vinifications

EU-Funded Telemedicine Projects – Assessment of, and Lessons Learned From, in the Light of the SARS-CoV-2 Pandemic

The SARS-CoV-2 health emergency has demonstrated the need for developing structured telemedicine systems to protect citizens from the spread of the virus. Thereby, their importance and the necessity to tailor their diffusion at large scale for providing services both at a distance and in time has been shown. For these reasons, the European Union advocates the digital transition of health systems for the next 5 years. The main aim of this work is to revisit the telemedicine research projects financed by European Community during the period 2000-2020 with particular respect to the results derived from their application. The analysis showed that some integration of tele-care and tele-health could be obtained with tele-monitoring systems and the implementation of Electronic Personal Record (EPR). Furthermore, telemedicine allows enhancing health care in critical environments, to protect health and life of the most vulnerable patients, and to encourage cross-border dialogue. The criteria of “from distance” and “timely delivered” are granted, but the effectiveness of the overall offered services highly depends on the availability and the quality of the input data. Unfortunately, this remains a relevant problem in the SARS-CoV-2 pandemic