54 research outputs found

    Fermat-linked relations for the Boubaker polynomial sequences via Riordan matrices analysis

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    The Boubaker polynomials are investigated in this paper. Using Riordan matrices analysis, a sequence of relations outlining the relations with Chebyshev and Fermat polynomials have been obtained. The obtained expressions are a meaningful supply to recent applied physics studies using the Boubaker polynomials expansion scheme (BPES).Comment: 12 pages, LaTe

    Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial Fibrillation

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    Sinus node dysfunction (SND) and atrial fibrillation (AF) often coexist; however, the molecular mechanisms linking both conditions remain elusive. Mutations in the homeobox-containing SHOX2 gene have been recently associated with early-onset and familial AF. Shox2 is a key regulator of sinus node development, and its deficiency leads to bradycardia, as demonstrated in animal models. To provide an extended SHOX2 gene analysis in patients with distinct arrhythmias, we investigated SHOX2 as a susceptibility gene for SND and AF by screening 98 SND patients and 450 individuals with AF. The functional relevance of the novel mutations was investigated in vivo and in vitro, together with the previously reported p.H283Q variant. A heterozygous missense mutation (p.P33R) was identified in the SND cohort and four heterozygous variants (p.G77D, p.L129=, p.L130F, p.A293=) in the AF cohort. Overexpression of the pathogenic predicted mutations in zebrafish revealed pericardial edema for p.G77D and the positive control p.H283Q, whereas the p.P33R and p.A293= variants showed no effect. In addition, a dominant-negative effect with reduced heart rates was detected for p.G77D and p.H283Q. In vitro reporter assays demonstrated for both missense variants p.P33R and p.G77D significantly impaired transactivation activity, similar to the described p.H283Q variant. Also, a reduced Bmp4 target gene expression was revealed in zebrafish hearts upon overexpression of the p.P33R mutant. This study associates additional rare variants in the SHOX2 gene implicated in the susceptibility to distinct arrhythmias and allows frequency estimations in the AF cohort (3/990). We also demonstrate for the first time a genetic link between SND and AF involving SHOX2. Moreover, our data highlight the importance of functional investigations of rare variants

    Dynamic response of Dam-Reservoir systems : review and a semi-analytical proposal

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    This paper presents a review of current techniques employed for dynamic analysis of concrete gravity dams under seismic action. Traditional procedures applied in design bureaus, such as the Pseudo-Static method, often neglect structural dynamic properties, as well as ground amplification effects. A practical alternative arises with the Pseudo-Dynamic method, which considers a simplified spectrum response in the fundamental mode. The authors propose a self-contained development and detailed examples of this latter method, including a comparison with finite element models using transient response of fluid-structure systems. It is verified that application of the traditional procedure should be done carefully and limited to extremely rigid dams. On the other hand, the proposed development is straightforward and in agreement with finite element results for general cases where dam flexibility plays an important role

    Investigation of vanadium and nitride alloys thin layers deposited by PVD

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    Lien vers la version Ă©diteur: http://dx.doi.org/10.1051/epjconf/20122900042In this work we present the technique of magnetron vapor deposition and the effect of several deposition parameters on the structural and morphological properties of prepared thin films. It was noted that the deposition time has an effect on the crystallinity, mechanical properties such as residual stress, roughness surface and the layer composition from target products. Studies were carried out on layers of vanadium (V) and the nitride vanadium (VN)

    Thermal resistance investigation of the giant magnetoresistance thin layers by the PTD technique

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    In this paper, we present a thermal properties investigation of giant magnetoresistance Mn/Fe layers as a function of Mn thickness using the Photothermal Deflexion Technique (PTD). We observe that the thermal resistance reaches its maximum for a Mn critical thickness corresponding to the antiparallel ferromagnetic coupling

    Thermal resistance investigation of the giant magnetoresistance thin layers by the PTD technique

    No full text
    In this paper, we present a thermal properties investigation of giant magnetoresistance Mn/Fe layers as a function of Mn thickness using the Photothermal Deflexion Technique (PTD). We observe that the thermal resistance reaches its maximum for a Mn critical thickness corresponding to the antiparallel ferromagnetic coupling

    Avulsion post-traumatique de la tubérosité ischiatique chez le sportif

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    Fracture-avulsion de l'ischion chez un jeune pratiquant le karaté. Traitement chirurgical par réduction puis ostéosynthèse du fragment détach

    Systematic study of optoelectronic and thermoelectric properties of AHfO

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    The physical properties of AHfO3 (A = Ca, Ba) are revealed using the density functional theory (DFT) based FP-LAPW+lo approach. The existing work investigates the pressure dependence of mechanical, electronic characteristics for specifying the optical and thermoelectric device applications of alkaline rare-earth hafnate perovskites. The PBEsol-GGA functional has been applied for the dealing of the exchange-correlation energy. The lattice constants of the stable cubic phases are extracted by structural optimization, which is similar to the existing experimental and theoretical literature. The bulk moduli (B) and cubic elastic constants are computed for evaluating the mechanical strength against external pressure up to 15 GPa. The electronic properties reveal that Hf-3d states primarily construct conduction band minima, while O–2p states construct valence band maxima at 0 GPa, exhibiting an indirect bandgap (Γ–M), which has been transformed to direct bandgap (Γ–Γ) at 15 GPa. Investigations of the optical properties illustrate that change in pressure can tune the optical parameters of these materials within ultraviolet (UV) energies suggesting commercial optoelectronic utilities. Our analysis shows that BAHfO3 exhibits better thermoelectric properties than CAHfO3 at room temperature whereas, thermoelectric performance both the compounds become comparable at a higher temperature
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