1,352 research outputs found
On the crack path of rolling contact fatigue cracks in a railway wheel steel
The objective of the present paper is to give some preliminary results obtained in the frame of a more wide investigation on the rolling contact fatigue (RCF) behavior of a railway wheel steel.
The effect of different test parameters on the RCF fatigue strength of the railway wheel steel was evaluated. RCF tests were conducted using two cylindrical contact specimens under different Po/k ratio (where Po is the maximum Hertzian pressure, k is the yield stress in shear of the material), under dry contact conditions or with water lubrication, and at varying slip ratio.
In the present study crack initiation location and crack growth direction were carefully investigated; microscopic examination showed that the cracks were initiated at the surface, propagated obliquely in the depth direction and then occasionally branched into two directions.
Usually multiple cracks are initiated, at the rolling contact surface, caused by the accumulation of shear deformation due to repeated rollingâsliding contact loading.
Subsequent crack growth has been found to occur along specific sloped directions. The influence of Po/k ratio, dry or wet contact, and slip ratio on crack slope angle to the radial direction and the depths at which slope changes occur has been investigated.
Observed crack slopes and slope change position have been discussed according to crack path prediction criteria in the literature
The activated torsion oscillation magnetometer
The activated torsion oscillation magnetometer exploits the mechanical
resonance of a cantilever beam, driven by the torque exerted on the sample by
an ac field applied perpendicularly to the film plane. We describe a model for
the cantilever dynamics which leads to the calculation of the cantilever
dynamic profile and allows the mechanical sensitivity of the instrument to be
expressed in terms of the minimum electronically detectable displacement. We
have developed a capacitance detector of small oscillations which is able to
detect displacements of the order of 0.1 nm. We show that sensitivities of the
order of 0.5(10-11 Am2 can be in principle achieved. We will subsequently
describe the main features of the ATOM prototype which we have built and
tested, with particular attention to the design solutions which have been
adopted in order to reduce the effects of parasitic vibrations due either to
acoustic noise, originating from the ac field coil, or to eddy currents in the
capacitor electrodes. The instrument is mounted in a continuous flow cryostat
and can work in the 4.2-300 K temperature range. Finally, we will show that our
experimental set-up has a second mode of operation, named Torsion Induction
Magnetometer (TIM).Comment: Invited Talk at the Moscow International Symposium on Magnetism, 2002
to appear in the J. Mag. Mag. Mat Revised versio
Magnetoelectric CoFe2O4/polyvinylidene fluoride electrospun nanofibres.
Magnetoelectric 0-1 composites comprising CoFe2O4 (CFO) nanoparticles in a polyvinylidene fluoride (PVDF) polymer-fibre matrix have been prepared by electrospinning. The average diameter of the electrospun composite fibres is âŒ325 nm, independent of the nanoparticle content, and the amount of the crystalline polar ÎČ phase is strongly enhanced when compared to pure PVDF polymer fibres. The piezoelectric response of these electroactive nanofibres is modified by an applied magnetic field, thus evidencing the magnetoelectric character of the CFO/PVDF 0-1 composites.This work was supported by FEDER through the COMPETE Program and
by the Portuguese Foundation for Science and Technology (FCT) in the
framework of the Strategic Project PEST C/FIS/UI607/2014 and
PTDC/CTM NAN/112574/2009. R. G., P. M., V. S., G. B. and S. L. M.
acknowledge support from âMatepro â Optimizing Materials and
Processesâ (ref. NORTE-07-0124-FEDER-000037), co funded by
âPrograma Operacional Regional do Norteâ (ON.2 â O Novo Norte,
QREN, FEDER). P. M. and R. Gonçalves acknowledges also support from
FCT (SFRH/BPD/96227/2013 and SFRH/BD/88397/2012 grants
respectively). X. M. acknowledges support from the RamĂłn y Cajal (RYC)
Programme (Spanish MEC) and the Royal Society.This is the accepted manuscript. The final version is available at http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/c5nr00453e#!divAbstract
Humoral and cellular response to BoHV-1 in buffalo and cattle treated with an inactivated marker vaccine
The study is aimed at assessing and comparing the immune response to BoHV-1 elicited by an inactivated marker vaccine in buffaloes and cattle. Vaccination did not produced any local or general reactions in buffaloes. Seroneutralizing antibodies and cellular response by IFN-Îł- test have been detected in buffaloes and cattle after a prime/ booster vaccination strategy. Humoral and cellular responses were significantly higher in cattle than in buffaloes. Data pointed out the possibility to use the marker vaccine in buffaloes. However, further studies must be planned to assess the immune pressure of marker vaccines in terms of IBR eradicative attitude in infected buffalo herds
Targeting immune-related biological processes in solid tumors : we do need biomarkers
Immunotherapy has become the standard-of-care in many solid tumors. Despite the significant recent achievements in the diagnosis and treatment of cancer, several issues related to patients' selection for immunotherapy remain unsolved. Multiple lines of evidence suggest that, in this setting, the vision of a single biomarker is somewhat na\uefve and imprecise, given that immunotherapy does not follow the rules that we have experienced in the past for targeted therapies. On the other hand, additional immune-related biomarkers that are reliable in real-life clinical practice remain to be identified. Recently, the immune-checkpoint blockade has been approved in the US irrespective of the tumor site of origin. Further histology-agnostic approvals, coupled with with tumor-specific companion diagnostics and guidelines, are expected in this field. In addition, immune-related biomarkers can also have a significant prognostic value. In this review, we provide an overview of the role of these biomarkers and their characterization in the management of lung cancer, melanoma, colorectal cancer, gastric cancer, head and neck cancer, renal cell carcinoma, urothelial cancers, and breast cancer
Development and Multicenter Validation of a Novel Immune-Inflammation-Based Nomogram to Predict Survival in Western Resectable Gastric and Gastroesophageal Junction Adenocarcinoma (GEA): The NOMOGAST
Background. More than 50% of operable GEA relapse after curative-intent resection. We aimed at externally validating a nomogram to enable a more accurate estimate of individualized risk in resected GEA. Methods. Medical records of a training cohort (TC) and a validation cohort (VC) of patients undergoing radical surgery for c/uT2-T4 and/or node-positive GEA were retrieved, and potentially interesting variables were collected. Cox proportional hazards in univariate and multivariate regressions were used to assess the effects of the prognostic factors on OS. A graphical nomogram was constructed using R softwareâs package Regression Modeling Strategies (ver. 5.0-1). The performance of the prognostic model was evaluated and validated. Results. The TC and VC consisted of 185 and 151 patients. ECOG:PS > 0 (p < 0.001), angioinvasion (p < 0.001), log (Neutrophil/Lymphocyte ratio) (p < 0.001), and nodal status (p = 0.016) were independent prognostic values in the TC. They were used for the construction of a nomogram estimating 3- and 5-year OS. The discriminatory ability of the model was evaluated with the c-Harrell index. A 3-tier scoring system was developed through a linear predictor grouped by 25 and 75 percentiles, strengthening the modelâs good discrimination (p < 0.001). A calibration plot demonstrated a concordance between the predicted and actual survival in the TC and VC. A decision curve analysis was plotted that depicted the nomogramâs clinical utility. Conclusions. We externally validated a prognostic nomogram to predict OS in a joint independent cohort of resectable GEA; the NOMOGAST could represent a valuable tool in assisting decision-making. This tool incorporates readily available and inexpensive patient and disease characteristics as well as immune-inflammatory determinants. It is accurate, generalizable, and clinically effectivex
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