Ishu bunsan shisutemu ni okeru kabun tasuku no sukejulingu

制度:新 ; 報告番号:甲2691号 ; 学位の種類:博士(国際情報通信学) ; 授与年月日:2008/7/30 ; 早大学位記番号:新486

Harmonic compensation in a grid using doubly fed induction generators

Ideally, electric utilities are expected to deliver a sinusoidal voltage with a constant rated frequency, while customers are expected to draw a sinusoidal current with unity power factor. The recent widespread use of harmonic producing equipment in industrial applications, especially non-linear loads, has increased the distortion of electric currents and voltages in transmission and distribution systems. This thesis proposes a method of using multiple reference frame theory for measuring and mitigating harmonic currents of nonlinear loads using a doubly fed induction generator. The most significant low-order harmonics to be compensated are calculated using a multiple reference frame harmonic observer. This observer is simulated using Matlab® Simulink® and then implemented using the Texas Instruments TMS320F28335 digital signal processor. Experimental and simulation results are provided to verify the analysis of the observer by comparing the results with calculations from the Fourier spectrum. Along with active and reactive power generation, an algorithm is proposed to inject currents in the rotor for the mitigation of harmonics in the system. Simulation results are presented to demonstrate the performance of this proposed method. These results validate the effectiveness of the method in compensating the targeted harmonics in the system. This method of measuring and compensating harmonics discussed in this thesis is accurate, straightforward, easily implemented and effective in the mitigation of any harmonic in the system. The currents obtained in the fundamental reference frame can be further employed for the control of active and reactive power flow --Abstract, page iii

First light for avian embryos: eggshell thickness and pigmentation mediate variation in development and UV exposure in wild bird eggs

Article first published online: 29 JUL 20141. The avian embryo's development is influenced by both the amount and the wavelength of the light that passes through the eggshell. Commercial poultry breeders use light of specific wavelengths to accelerate embryonic growth, yet the effects of the variably patterned eggshells of wild bird species on light transmission and embryonic development remain largely unexplored. 2. Here, we provide the first comparative phylogenetic analysis of light transmission, through a diverse range of bird eggshells (74 British breeding species), in relation to the eggshell's thickness, permeability, pigment concentration and surface reflectance spectrum (colour). 3. The percentage of light transmitted through the eggshell was measured in the spectral range 250–700 nm. Our quantitative analyses confirm anecdotal reports that eggshells filter the light of the externally coloured shell. Specifically, we detected a positive relationship between surface eggshell reflectance (‘brightness’) and the percentage of light transmitted through the eggshell, and this relationship was strongest at wavelengths in the human-visible blue-green region of the spectra (c. 435 nm). 4. We show that less light passes through thicker eggshells with greater total pigment concentrations. By contrast, permeability (measured as water vapour conductance) did not covary significantly with light transmission. Eggs of closed-nesting species let more light pass through, compared with open nesters. 5. We postulate that greater light transmission is required to assist embryonic development under low light exposure. Importantly, this result provides an ecological explanation for the repeated evolution of immaculate, white- or pale-coloured eggshells in species nesting in enclosed spaces. 6. Finally, we detected correlative support for the solar radiation hypothesis, in that eggshells of bird species with a longer incubation period let significantly less of the potentially harmful, ultraviolet (UV) light pass through the eggshell. In summary, we demonstrate suites of avian eggshell properties, including eggshell structure and pigmentation, which are consistent with an evolutionary pressure to both enhance and protect embryonic development.Golo Maurer, Steven J. Portugal, Mark E. Hauber, Ivan Mikšík, Douglas G. D. Russell and Phillip Casse

Identification of the heart as the critical site of adenosine mediated embryo protection

<p>Abstract</p> <p>Background</p> <p>Our understanding of the mechanisms that protect the developing embryo from intrauterine stress is limited. Recently, adenosine has been demonstrated to play a critical role in protecting the embryo against hypoxia via adenosine A1 receptors (A1ARs), which are expressed in the heart, nervous system, and other sites during development. However, the sites of A1AR action that mediate embryo protection are not known. To determine if the heart is a key site of adenosine-mediated embryo protection, A1ARs were selectively deleted in the embryonic heart using a Cre-LoxP system in which the alpha-myosin heavy chain promoter drives Cre-recombinase expression and excision of the A1AR gene from cardiomyocytes.</p> <p>Results</p> <p>With increasing exposure of maternal hypoxia (10% O₂) from 48-96 hours beginning at embryonic day (E) 8.5, embryo viability decreased in the cardiac-A1AR deleted embryos. 48 hours of hypoxia reduced embryonic viability by 49% in embryos exposed from E10.5-12.5 but no effect on viability was observed in younger embryos exposed to hypoxia from E8.5-10.5. After 72 hours of hypoxia, 57.8% of the cardiac-A1AR deleted embryos were either dead or re-absorbed compared to 13.7% of control littermates and after 96 hours 81.6% of cardiac-A1AR deleted embryos were dead or re-absorbed. After 72 hours of hypoxia, cardiac size was reduced significantly more in the cardiac-A1AR deleted hearts compared to controls. Gene expression analysis revealed clusters of genes that are regulated by both hypoxia and A1AR expression.</p> <p>Conclusions</p> <p>These data identify the embryonic heart as the critical site where adenosine acts to protect the embryo against hypoxia. As such these studies identify a previously unrecognized mechanism of embryo protection.</p

Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.

The integrity of blood vessels is fundamental to vascular homeostasis. Inactivating mutations in the bone morphogenetic protein (BMP) receptor type II (BMPR2) gene cause hereditary vascular disorders, including pulmonary arterial hypertension and hereditary hemorrhagic telangiectasia, suggesting that BMPR2 and its downstream signaling pathway are pivotal to the maintenance of vascular integrity through an unknown molecular mechanism. Here we report that inactivation of BMPR2 in pulmonary vascular endothelial cells results in a deficit of RAD51, an enzyme essential for DNA repair and replication. Loss of RAD51, which causes DNA damage and cell death, is also detected in animal models and human patients with pulmonary arterial hypertension. Restoration of BMPR2 or activation of the BMP signaling pathway rescues RAD51 and prevents DNA damage. This is an unexpected role of BMP signaling in preventing the accumulation of DNA damage and the concomitant loss of endothelial integrity and vascular remodeling associated with vascular disorders

Decision support system for blockchain (DLT) platform selection based on ITU recommendations: A systematic literature review approach

Blockchain technologies, also known as Distributed Ledger Technologies (DLT), are increasingly being explored in many applications, especially in the presence of (potential) dis-/mis-/un-trust among organizations and individuals. Today, there exists a plethora of DLT platforms on the market, which makes it challenging for system designers to decide what platform they should adopt and implement. Although a few DLT comparison frameworks have been proposed in the literature, they often fail in covering all performance and functional aspects, adding that they too rarely build upon standardized criteria and recommendations. Given this state of affairs, the present paper considers a recent and exhaustive set of assessment criteria recommended by the ITU (International Telecommunication Union). Those criteria (about fifty) are nonetheless mostly defined in a textual form, which may pose interpretation problems during the implementation process. To avoid this, a systematic literature review regarding each ITU criterion is conducted with a twofold objective: (i) to understand to what extent a given criterion is considered/evaluated by the literature; (ii) to come up with ‘formal’ metric definition (i.e., on a mathematical or experimental ground) based, whenever possible, on the current literature. Following this formalization stage, a decision support tool called CREDO-DLT, which stands for “multiCRiteria-basEd ranking Of Distributed Ledger Technology platforms”, is developed using AHP and TOPSIS, which is publicly made available to help decision-maker to select the most suitable DLT platform alternative (i.e., that best suits their needs and requirements). A use case scenario in the context of energy communities is proposed to show the practicality of CREDO-DLT. •Blockchain (DLT) standardization initiatives are reviewed.•To what extent ITU’s DLT assessment criteria are covered in literature is studied.•A mathematical formalizations of the ITU recommendations are proposed.•A decision support tool (CREDO-DLT) is designed for DLT platform selection.•An energy community use case is developed to show the practicality of CREDO-DLT

DigBug—Pre/post-processing operator selection for accurate bug localization

Bug localization is a recurrent maintenance task in software development. It aims at identifying relevant code locations (e.g., code files) that must be inspected to fix bugs. When such bugs are reported by users, the localization process become often overwhelming as it is mostly a manual task due to incomplete and informal information (written in natural languages) available in bug reports. The research community has then invested in automated approaches, notably using Information Retrieval techniques. Unfortunately, reported performance in the literature is still limited for practical usage. Our key observation, after empirically investigating a large dataset of bug reports as well as workflow and results of state-of-the-art approaches, is that most approaches attempt localization for every bug report without considering the different characteristics of the bug reports. We propose DigBug as a straightforward approach to specialized bug localization. This approach selects pre/post-processing operators based on the attributes of bug reports; and the bug localization model is parameterized in accordance as well. Our experiments confirm that departing from “one-size-fits-all” approaches, DigBug outperforms the state-of-the-art techniques by 6 and 14 percentage points, respectively in terms of MAP and MRR on average

Big Code Search: A Bibliography

peer reviewedCode search is an essential task in software development. Developers often search the internet and other code databases for necessary source code snippets to ease the development efforts. Code search techniques also help learn programming as novice programmers or students can quickly retrieve (hopefully good) examples already used in actual software projects. Given the recurrence of the code search activity in software development, there is an increasing interest in the research community. To improve the code search experience, the research community suggests many code search tools and techniques. These tools and techniques leverage several different ideas and claim a better code search performance. However, it is still challenging to illustrate a comprehensive view of the field considering that existing studies generally explore narrow and limited subsets of used components. This study aims to devise a grounded approach to understanding the procedure for code search and build an operational taxonomy capturing the critical facets of code search techniques. Additionally, we investigate evaluation methods, benchmarks, and datasets used in the field of code search

The Ca2+-activated Cl- channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons

The Ca(2+)-activated Cl(-) channel TMEM16B is highly expressed in the cilia of olfactory sensory neurons (OSNs). Although a large portion of the odor-evoked transduction current is carried by Ca(2+)-activated Cl(-) channels, their role in olfaction is still controversial. A previous report (Billig et al. 2011. Nat. Neurosci. http://dx.doi.org/10.1038/nn.2821) showed that disruption of the TMEM16b/Ano2 gene in mice abolished Ca(2+)-activated Cl(-) currents in OSNs but did not produce any major change in olfactory behavior. Here we readdress the role of TMEM16B in olfaction and show that TMEM16B knockout (KO) mice have behavioral deficits in odor-guided food-finding ability. Moreover, as the role of TMEM16B in action potential (AP) firing has not yet been studied, we use electrophysiological recording methods to measure the firing activity of OSNs. Suction electrode recordings from isolated olfactory neurons and on-cell loose-patch recordings from dendritic knobs of neurons in the olfactory epithelium show that randomly selected neurons from TMEM16B KO mice respond to stimulation with increased firing activity than those from wild-type (WT) mice. Because OSNs express different odorant receptors (ORs), we restrict variability by using a mouse line that expresses a GFP-tagged I7 OR, which is known to be activated by heptanal. In response to heptanal, we measure dramatic changes in the firing pattern of I7-expressing neurons from TMEM16B KO mice compared with WT: responses are prolonged and display a higher number of APs. Moreover, lack of TMEM16B causes a markedly reduced basal spiking activity in I7-expressing neurons, together with an alteration of axonal targeting to the olfactory bulb, leading to the appearance of supernumerary I7 glomeruli. Thus, TMEM16B controls AP firing and ensures correct glomerular targeting of OSNs expressing I7. Altogether, these results show that TMEM16B does have a relevant role in normal olfaction