Shear critical R/C columns under increasing axial load

Structural elements in old reinforced concrete (R/C) frame buildings are often prone to shear or flexure-shear failure, which can eventually lead to loss of axial load capacity of vertical elements and initiate vertical progressive collapse of a building. An experimental investigation of shear and flexure-shear critical R/C elements subjected to increasing axial load is reported herein. The focus is on the effect of vertical load redistribution from axially failing columns on the non-linear (pre- and post-peak) response of neighboring shear-dominated members. The test results along with an analysis of the recorded deformation, strength, stiffness and energy dissipation characteristics shed light on the performance of sub-standard columns under constant and increasing axial load subsequent, or just prior, to failing in shear, thus providing useful insights into the assessment of existing R/C structures

Investigating the Place of Children’s Home Literacy in the Ontario Kindergarten Curriculum: A Document Analysis

The Ontario Kindergarten programmatic curriculum was examined to determine and articulate how it represents children’s and families’ funds of knowledge and how it relates to home literacy and literacy learning at school. The Kindergarten Program (2016) was the primary source within the document analysis methodology. Funds of knowledge underpins this study as the theoretical framework. This study was driven by three questions: In what ways does programmatic curriculum, The Kindergarten Program (2016), connect (or not) literacy learning with children’s home language and literacy experiences from home? How are families depicted within (if at all) the programmatic curriculum in relation to their children’s literacy? What are some recommendations for programmatic curricula based on the analysis? The findings indicated that The Kindergarten Program had little emphasis on family involvement, home language, and deep understandings of children’s home, culture, and community perspectives. However, the programmatic curriculum document highlighted children’s sense of belonging, and the freedom to express their opinion and ideas. The study recommends that the programmatic curriculum needs to look closely at children’s funds of knowledge and funds of identity to allow educators to include the child as a whole and value the experiences they bring to school from home. Funds of knowledge also give teachers the chance to communicate and create relationships with families that are built on a mutual trust. These relationships between teachers, children, and families contribute to the construction of a concrete bridge between school and home allowing children to value who they are and create a solid basis for being lifelong learners

Classification of grouplike categories

In this paper we study grouplike monoids, these are monoids that contain a group to which we add an ordered set of idempotents. We classify finite categories with two objects having grouplike endomorphism monoids, and we give a count of certain categories with grouplike monoids.Comment: Minor changes in Lemma 3.18. Added Definition 4.3, Lemma 4.4 and Remark 4.5. And the proof of Proposition 4.6 is improve

The effect of selected steroids on the growth, morphology, and sterol contents of Candida albicans

The effect of three selected steroids—decadron, alphadolone acetate and cholic acid salt—on the growth, morphology and sterol content of the yeast and mycelial form of Candida albicans was studied. The effect on growth was measured by dry weight, turbidity and viable count. It was observed that the three steroids promoted the growth of C. albicans. The morphology studies showed two different types of cells: (1) cells which were able to adapt to growth in the presence of exogenous steroids; and (2) cells which were unable to so adapt. Adapted yeast cells were longer and more elongated with a smooth surface. These cells were observed to grow very well and to be involved in cell division especially at high steroid concentrations. The internal structures of these adapted cells were well preserved with distinct intracytoplasmatic structures. [Continues.

Micellar high performance liquid chromatographic determination of Itraconazole in bulk, pharmaceutical dosage forms and human plasma

A micellar liquid chromatographic method was developed for determination of Itraconazole in bulk, dosage form and human plasma using µBondapack cyano column and a mobile phase consisting of 0.1 M sodium dodecyl sulphate, 20% 1-propanol, 0.3% triethylamine in 0.02 M orthophosphoric acid (pH = 3.5). The UV detection was achieved at 258 nm. Various chromatographic parameters were studied, e.g. types of columns, pH of mobile phase, concentration of sodium dodecyl sulphate, 1-propanol, triethylamine, etc .The method was linear over the concentration range 16.4-320.0 µg/mL with regression coefficient 0.999 and limit of detection 5.4 µg/mL in bulk. Inter and intra-day results showed %RSD < 1.49%. The result obtained by the proposed method was compared with that obtained by the reference HPLC technique. Furthermore, the proposed method was successfully applied as stability-indicating method for determination of Itraconazole under different stressed conditions. The method showed good selectivity, repeatability, linearity and sensitivity according to the evaluation of the validation parameters

TECHNOLOGY OF CINEMATIC ARCHITECTURE IN SCIENCE FICTION MOVIES

Cinematic architecture in the broadest terms, portrayed spaces as a scene, where it conceives and reads the built environment in terms of sequences. It explores the effect of futuristic architecture and highlight the significant role of cinematic architecture in the society. Both movies and architecture function as languages, with two components: the signifiers, which are the tangible forms of signs, and the signified, which are the concepts, thoughts, and ideals that the signifiers contain. Unfortunately, the world is experiencing fast changes as a result of the massive rise of technology and capitalism, and the cinema industry plays an important role in displaying these improvements, showing the up - coming future through various science fiction movies, that either operate as an alert system for transformation, with the majority of these depictions viewing futuristic architecture and urban design as a dystopian realm, a lack of how to manage the upcoming issues, and these visions may come to pass. This paper aims to recognize different technological approaches to create the cinematic architecture, presented in the science fiction movies. To achieve this aim, the paper will start with literature review, based on desk research, reviewing previous readings, then the paper will analyze two case studies, which are the Movie of Tron Legacy, 2010, and the Avatar movie, James Cameron, 2009. As a conclusion, a better understanding the link between movie and architecture, it may be a better convey the complex concepts and ambitions for cities through architectural elements and signifiers

Evaluation of the ability of a novel miconazole formulation to penetrate nail by using three in vitro nail models

This document is the Accepted Manuscript of the following article: Luisa Christensen, Rob Turner, Sean Weaver, Francesco Caserta, Lisa Long, Mahmoud Ghannoum, and Marc Brown, ‘Evaluation of the Ability of a Novel Miconazole Formulation To Penetrate Nail by Using Three In Vitro Nail Models’, Antimicrobial Agents and Chemotherapy, Vol. 61 (7): e02554-16, July 2017. The final, published version is available online at DOI: https://doi.org/10.1128/AAC.02554-16.In an effort to increase the efficacy of topical medications for treating onychomycosis, several new nail penetration enhancers were recently developed. In this study, the ability of 10% (wt/wt) miconazole nitrate combined with a penetration enhancer formulation to permeate the nail is demonstrated by the use of a selection of in vitro nail penetration assays. These assays included the bovine hoof, TurChub zone of inhibition, and infected-nail models.Peer reviewedFinal Accepted Versio

Characterization and partial purification of Candida albicans Secretory IL-12 Inhibitory Factor

© 2008 Wang et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Licens

Shade compromises the photosynthetic efficiency of NADP-ME less than that of PEP-CK and NAD-ME C4 grasses

The high energy cost and apparently low plasticity of C4 photosynthesis compared with C3 photosynthesis may limit the productivity and distribution of C4 plants in low light (LL) environments. C4 photosynthesis evolved numerous times, but it remains unclear how different biochemical subtypes perform under LL. We grew eight C4 grasses belonging to three biochemical subtypes [NADP-malic enzyme (NADP-ME), NAD-malic enzyme (NAD-ME), and phosphoenolpyruvate carboxykinase (PEP-CK)] under shade (16% sunlight) or control (full sunlight) conditions and measured their photosynthetic characteristics at both low and high light. We show for the first time that LL (during measurement or growth) compromised the CO2-concentrating mechanism (CCM) to a greater extent in NAD-ME than in PEP-CK or NADP-ME C4 grasses by virtue of a greater increase in carbon isotope discrimination (∆P) and bundle sheath CO2 leakiness (ϕ), and a greater reduction in photosynthetic quantum yield (Φmax). These responses were partly explained by changes in the ratios of phosphoenolpyruvate carboxylase (PEPC)/initial Rubisco activity and dark respiration/photosynthesis (Rd/A). Shade induced a greater photosynthetic acclimation in NAD-ME than in NADP-ME and PEP-CK species due to a greater Rubisco deactivation. Shade also reduced plant dry mass to a greater extent in NAD-ME and PEP-CK relative to NADP-ME grasses. In conclusion, LL compromised the co-ordination of the C4 and C3 cycles and, hence, the efficiency of the CCM to a greater extent in NAD-ME than in PEP-CK species, while CCM efficiency was less impacted by LL in NADP-ME species. Consequently, NADP-ME species are more efficient at LL, which could explain their agronomic and ecological dominance relative to other C4 grasses.This research was funded by the Australian Research Council: DP120101603 (OG and SMW), DE130101760 (RES), and CE140100015 (OG and SMW)