Unravelling the variations of the society of England and Wales through diffusion mapping analysis of census 2011

We propose a new approach to identify geographical clustering and inequality hotspots from decadal census data, with a particular emphasis on the method itself. Our method uses diffusion mapping to study the 181 408 output areas in England and Wales (EW), which enables us to decompose the census data's EW-specific feature structures. We further introduce a localization metric, inspired by statistical physics, to reveal the significance of minority groups in London. Our findings can be adapted to analogous datasets, illuminating spatial patterns and differentiating within datasets, especially when meaning factors for determining the datasets' structure are scarce and spatially heterogeneous. This approach enhances our ability to describe and explore patterns of social deprivation and segregation across the country, thereby contributing to the development of targeted policies. We also underscore the method's intrinsic objectivity, guaranteeing its ability to offer comprehensive and unbiased analysis, unswayed by preconceived hypotheses or subjective interpretations of data patterns

Spatialising ‘carceral mobilities’: extracting census data for analysis of prisoner inflow, transfer and release

Responding to the dearth of fully-comprehensive or summary data on prisoner or ‘carceral mobilities’, this paper provides the first comprehensive case study analysis of the flow into, between and out from prisons. By uniquely extracting data from the 2011 UK Census to identify and visualise trends in movement, highlight centrality of institutions and observe the self-containedness of regions of operation, findings reveal specific volumes and geographies of prisoner flow as well as discrepancies with the expected practices of prison category transfers and disparities between the distances travelled by prisoners in establishments with different functions. Such analysis is a critical tool in appraising (in)efficiencies with the governance of prisons at the regional and national level. In conclusion, Census Data is revealed as a viable source of data for analysis in situations where institutional data is not forthcoming/available, which provides significant potential for the advancement of the range and scope of studies in carceral mobilities and criminological research more broadly

Novel compound heterozygous mutations in CNGA1in a Chinese family affected with autosomal recessive retinitis pigmentosa by targeted sequencing

Gene symbol list that include in the Hereditary Ophthalmological Disease GenePanel. (XLSX 12 kb

Analyses of Japanese Manufacturing Management and its Application to Tibet

修士論文要

Mobility Census for the analysis of rapid urban development

Traditionally urban structure and development are monitored using infrequent high-quality datasets such as censuses. However, human culture is accelerating and aggregating, leading to ever-larger cities and an increased pace of urban development. Our modern interconnected world also provides us with new data sources that can be leveraged in the study of cities. However, these often noisy and unstructured sources of big data pose new challenges. Here we propose a method to extract meaningful explanatory variables and classifications from such data. Using movement data from Beijing, which is produced as a byproduct of mobile communication, we show that meaningful features can be extracted, revealing for example the emergence and absorption of subcenters. In the future this method will allow the analysis of urban dynamics at a high spatial resolution (here, 500m) and near real-time frequency

Cell-Free DNA Sequencing of Intraocular Fluid as Liquid Biopsy in the Diagnosis of Vitreoretinal Lymphoma

PurposeTo seek novel diagnostic approaches, we improved the workflow of cell-free DNA (cfDNA) sequencing and evaluated its feasibility in vitreoretinal lymphoma (VRL) specimens; the profile of mutations was preliminarily analyzed for potential diagnostic value.MethodsThe study was a diagnostic trial. 23 eyes of 23 patients with VRL and 25 eyes of 25 patients with inflammatory eye diseases were enrolled. Approximate 500μl undiluted vitreous humor and 10ml diluted vitreous fluid was obtained through diagnostic vitrectomy and sent for cytopathological examinations. 500μl of the diluted vitreous fluid was spared for cfDNA sequencing. For cfDNA sequencing, DNA fragmentation procedure was added to the workflow to improve the extraction efficiency; mutations detected were analyzed for potential diagnostic model. The sensitivity and specificity of the cytopathology and cfDNA sequencing were compared. The clinical manifestations were preliminarily analyzed for potential correlations with the genotypes.ResultsCfDNA sequencing was accomplished in 23 eyes with VRL and 20 eyes with inflammatory eye diseases. VRL-related mutated genes included MYD88 (18 eyes, 78%), ETV6 (11 eyes, 48%), PIM1 (11 eyes,48%), BTG2 (7 eyes, 30%), IRF4 (7 eyes, 30%), CD79B (6 eyes, 26%), LRP1B (6 eyes, 26%), etc. Logistic regression based on the mutations of MYD88 and ETV6 was of the potential for the diagnosis of VRL (P<0.001, adjusted R2 = 0.789, sensitivity 0.913, specificity 0.950); by comparison, the sensitivity and specificity of the vitreous cytopathology were 0.826 and 1.000, respectively. Further analysis of the mutation profile showed that patients carrying CD79B mutation tended to have higher intraocular interleukin-10 level (P=0.030), that CARD11 mutation was correlated with younger age at ocular onset (P=0.039), and that patients with intracranial involvement carried more multiple-site mutations in the BTG2 gene (P=0.013).ConclusionsThe improved workflow of CfDNA sequencing is of sound feasibility in a limited amount of vitreous humor. The logistic model based on the mutations could help to provide reliable clues for the diagnosis of VRL

Case report and literature review: fatal cerebral fat embolism following facial autologous fat graft

BackgroundSevere cerebral artery embolism is a rare complication of facial autologous fat injection. However, its incidence has markedly increased with the recent rise in facial cosmetic procedures.Case presentationWe report a 31-year-old Chinese woman who presented with unconsciousness 6 h after having undergone a facial autologous fat injection. A neurological examination revealed stupor, bilaterally diminished pupillary light reflexes, right-sided central facial palsy, and no reaction to pain stimulation of right limbs. Diffusion-weighted imaging displayed patchy hyperintense lesions in the left frontal, parietal, and temporal lobes. Magnetic resonance angiography demonstrated fat embolism in the left internal carotid artery, anterior cerebral artery, and middle cerebral artery. We immediately performed mechanical thrombectomy under sufficient preoperative preparations but failed to achieve complete recanalization. Pathological examination of the embolus confirmed the presence of adipocytes. Although we actively administered symptomatic and supportive treatments, the patient eventually died due to the progression of cerebral herniation and systemic infection.ConclusionDue to the ineffectiveness of current treatment and the inferior prognosis, fat embolism, a severe complication of autologous fat graft, should draw the attention of both plastic surgeons and neurologists so that actions may be taken for both its prevention and treatment

Development of Research and Innovation Capacity Index of HEIs on Disaster Resilience Related Studies

Research capacity development is one of the most critical challenges facing HEIs in the Asian countries. Growing the number and quality of researchers is a strategic issue. For academia, developing research capacity can help enhance academic fulfilment as well as provide career advancement. The notion that excellent people are a resource to be treasured has led to increased attention being paid to how to attract, support and retain them, thereby building research capacity. This paper is part of an Erasmus plus co-funded project called ASCENT, which focuses on building the research and innovation capacity (R&I) of Higher Education Institutions (HEI) on disaster resilience related studies. This paper particularly aims at reviewing the current context and gaps in the literature with regards to the indices used to assess the research capacity of the higher education institutions. Qualitative systematic review approach was adopted at the initial stage, followed by three-round Focus Group Discussion with high -level academics from 14 countries in Asia and Europe. Twenty-one Key Performance Indicators (KPIs) of HEIs Research and Innovation Capacity were identified, which were grouped into three themes: Structure, System, and Policy; Skills and Training; and Staff