Bioclipse-R: integrating management and visualization of life science data with statistical analysis

SUMMARY: Bioclipse, a graphical workbench for the life sciences, provides functionality for managing and visualizing life science data. We introduce Bioclipse-R, which integrates Bioclipse and the statistical programming language R. The synergy between Bioclipse and R is demonstrated by the construction of a decision support system for anticancer drug screening and mutagenicity prediction, which shows how Bioclipse-R can be used to perform complex tasks from within a single software system. Availability and implementation: Bioclipse-R is implemented as a set of Java plug-ins for Bioclipse based on the R-package rj. Source code and binary packages are available from https://github.com/bioclipse and http://www.bioclipse.net/bioclipse-r, respectively. CONTACT: [email protected] SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online

Performance of the PADME calorimeter prototype at the DAΦ\PhiNE BTF

The PADME experiment at the DA$\Phi$NE Beam-Test Facility (BTF) aims at searching for invisible decays of the dark photon by measuring the final state missing mass in the process $e^+e^- \to \gamma+ A'$, with $A'$ undetected. The measurement requires the determination of the 4-momentum of the recoil photon, performed using a homogeneous, highly segmented BGO crystals calorimeter. We report the results of the test of a 5$\times$5 crystals prototype performed with an electron beam at the BTF in July 2016

Constitutional and Legal Regulation of State Authority Interaction on Citizen Appeals: Foreign Experience

The purpose of this article is to identify the foreign experience of constitutional legalization of the basic foundations of interaction between government bodies regarding citizens' appeals. The study was built based on a dialectical approach to the disclosure of legal phenomena and processes using general scientific (systemic, logical, analysis and synthesis) and private scientific methods. The claimed interaction becomes relevant in modern conditions because that there is the coordination of the interests between an individual and the state in this process that is demanded to strengthen democratic values. Systematization of foreign constitutional experience, which appears in the comparative legal aspect as part of the general human rights theory

Application of avalanche photodiodes as a readout for scintillator tile-fiber systems

The application of reach-through avalanche photodiodes (R'APD) as a photodetector for scintillator tiles has been investigated. The light collected by WLS fibers (0.84mm and 1mm diameter) embedded in the scintillator has been transmited to the 0.5mm2 active surface of APD by clear optical fibers and optical connectors. A low noise charge sensitive preamplifier (approximately 400 electrons equivalent noise charge) has been used to gain the photodiode signal. Various configurations of tile-fibre systems, suitable for CMS and LHCb experiments at LHC have been studied using cosmic muons and muon beam at SPS at CERN. In order to optimize the performance of APD, measurments in the temperature range from -10C to +25C have been done. The MIP detection efficiency and electron/MIP separation have been estimated in order to determine applicability of the readout for LHCb preshower.Comment: 20 pages,13 figure

Timing performance of a double layer diamond detector

In order to improve the time precision of detectors based on diamonds sensors we have built a detector with two scCVD layers connected in parallel to the same amplifier. This work describes the design and the first measurements of such a prototype performed on a particle beam at CERN. With this different configuration we have obtained an improvement larger than a factor of 1.6-1.7 for the timing precision of the measurement when compared to a one layer scCVD diamond detector.Peer reviewe

Local height probabilities in a composite Andrews-Baxter-Forrester model

We study the local height probabilities in a composite height model, derived from the restricted solid-on-solid model introduced by Andrews, Baxter and Forrester, and their connection with conformal field theory characters. The obtained conformal field theories also describe the critical behavior of the model at two different critical points. In addition, at criticality, the model is equivalent to a one-dimensional chain of anyons, subject to competing two- and three-body interactions. The anyonic-chain interpretation provided the original motivation to introduce the composite height model, and by obtaining the critical behaviour of the composite height model, the critical behaviour of the anyonic chains is established as well. Depending on the overall sign of the hamiltonian, this critical behaviour is described by a diagonal coset-model, generalizing the minimal models for one sign, and by Fateev-Zamolodchikov parafermions for the other.Comment: 34 pages, 5 figures; v2: expanded introduction, references added and other minor change

Characterization and Performance of PADME's Cherenkov-Based Small-Angle Calorimeter

The PADME experiment, at the Laboratori Nazionali di Frascati (LNF), in Italy, will search for invisible decays of the hypothetical dark photon via the process $e^+e^-\rightarrow \gamma A'$, where the $A'$ escapes detection. The dark photon mass range sensitivity in a first phase will be 1 to 24 MeV. We report here on measurement and simulation studies of the performance of the Small-Angle Calorimeter, a component of PADME's detector dedicated to rejecting 2- and 3-gamma backgrounds. The crucial requirement is a timing resolution of less than 200 ps, which is satisfied by the choice of PbF$_2$ crystals and the newly released Hamamatsu R13478UV photomultiplier tubes (PMTs). We find a timing resolution of 81 ps (with double-peak separation resolution of 1.8 ns) and a single-crystal energy resolution of 5.7%/$\sqrt{E}$ with light yield of 2.07 photo-electrons per MeV, using 100 to 400 MeV electrons at the Beam Test Facility of LNF. We also propose the investigation of a two-PMT solution coupled to a single PbF$_2$ crystal for higher-energy applications, which has potentially attractive features.Comment: 12 pages, 19 figures. v2: added section on radiation damage studie

Optical monitoring of the z=4.40 quasar Q 2203+292

We report Cousins R-band monitoring of the high-redshift (z=4.40) radio quiet quasar Q 2203+292 from May 1999 to October 2007. The quasar shows maximum peak-to-peak light curve amplitude of ~0.3 mag during the time of our monitoring, and ~0.9 mag when combined with older literature data. The rms of a fit to the light curve with a constant is 0.08 mag and 0.2 mag, respectively. The detected changes are at ~3-sigma level. The quasar was in a stable state during the recent years and it might have undergone a brightening event in the past. The structure function analysis concluded that the object shows variability properties similar to those of the lower redshift quasars. We set a lower limit to the Q 2203+292 broad line region mass of 0.3-0.4 M_odot. Narrow-band imaging search for redshifted Ly_alpha from other emission line objects at the same redshift shows no emission line objects in the quasar vicinity.Comment: 9 pages, 8 figures, accepted for publication in MNRA