2 research outputs found
Drug Delivery with a Calixpyrrole–<i>trans</i>-Pt(II) Complex
A <i>meso</i>-<i>p</i>-nitroaniline-calixÂ[4]Âpyrrole
derivative <i>trans</i>-coordinated to a PtÂ(II) center was
synthesized and its structure solved by X-ray analysis. Adenosine
monophosphate (AMP) was used as a model compound to evaluate the potential
for the assisted delivery of the metal to the DNA nucleobases via
the phosphate anion-binding properties of the calix[4]Âpyrrole unit.
An NMR investigation of the kinetics of AMP complexation in the absence
of an H-bonding competing solvent (dry CD<sub>3</sub>CN) was consistent
with this hypothesis, but we could not detect the interaction of the
calix[4]Âpyrrole with phosphate in the presence of water. However,
in vitro tests of the new <i>trans</i>-calixpyrrole–PtÂ(II)
complex on different cancer cell lines indicate a cytotoxic activity
that is unquestionably derived from the coexistence of both the <i>trans</i>-PtÂ(II) fragment and the calix[4]Âpyrrole unit
Drug Delivery with a Calixpyrrole–<i>trans</i>-Pt(II) Complex
A <i>meso</i>-<i>p</i>-nitroaniline-calixÂ[4]Âpyrrole
derivative <i>trans</i>-coordinated to a PtÂ(II) center was
synthesized and its structure solved by X-ray analysis. Adenosine
monophosphate (AMP) was used as a model compound to evaluate the potential
for the assisted delivery of the metal to the DNA nucleobases via
the phosphate anion-binding properties of the calix[4]Âpyrrole unit.
An NMR investigation of the kinetics of AMP complexation in the absence
of an H-bonding competing solvent (dry CD<sub>3</sub>CN) was consistent
with this hypothesis, but we could not detect the interaction of the
calix[4]Âpyrrole with phosphate in the presence of water. However,
in vitro tests of the new <i>trans</i>-calixpyrrole–PtÂ(II)
complex on different cancer cell lines indicate a cytotoxic activity
that is unquestionably derived from the coexistence of both the <i>trans</i>-PtÂ(II) fragment and the calix[4]Âpyrrole unit