Recruitment process.

<p>Recruitment process.</p

Nutrition impact symptoms as reported on the PG-SGA compared between SGA groups using Chi-square analysis.

*<p>Statistically significant difference between SGA classifications (p<0.05). Abbreviations: PG-SGA = Patient-Generated Subjective Global Assessment, SGA = Subjective Global Assessment.</p

Characteristics of the participants compared between nutritional status categories using Mann-Whitney analysis for continuous variables and Chi square analysis for categorical variables and reported as median (range).

*<p>Statistically significant difference between SGA classifications (p<0.05).</p>†<p>Reported as frequencies (percentages). Abbreviations: BMI = body mass index, MAC = mid-arm circumference, PD = Parkinson’s disease, PG-SGA = Patient-Generated Subjective Global Assessment, SGA = Subjective Global Assessment.</p

Characteristics of the total sample and of the malnourished participants compared between genders using Mann-Whitney analysis and reported as median (range).

*<p>Statistically significant difference between genders (p<0.05).</p>†<p>Reported as frequencies (percentages). Abbreviations: BMI = body mass index, H&Y = Hoehn & Yahr, MAC = mid-arm circumference, PD = Parkinson’s disease, PG-SGA = Patient-Generated Subjective Global Assessment.</p

Demographic and motor symptom characteristics of the participants compared between nutritional states.

†<p>Reported as frequencies (percentages).</p>*<p>Statistically significant difference between SGA classifications (p<0.05).</p><p>Abbreviations: H&Y = Hoehn & Yahr; FOG-Q = Freezing of Gait Questionnaire; LEDD = levodopa equivalent daily doses; PD = Parkinson's disease; PG-SGA = Patient Generated Subjective Global Assessment; SGA = Subjective Global Assessment; UPDRS = Unified Parkinson's Disease Rating Scale.</p

Significant predictors of log-adjusted PG-SGA score.

<p>Abbreviations: BDI = Beck's Depression Inventory; PG-SGA = Patient Generated Subjective Global Assessment; UPDRS = Unified Parkinson's Disease Rating Scale.</p

Significant predictors of malnutrition (SGA-B) and corresponding odds ratios.

*<p>Significant independent predictors of nutritional status (<i>p</i><.05) in the unadjusted univariable analysis.</p>†<p>Significant predictors of nutritional status (<i>p</i><.05) in the multivariable analysis.</p><p>Abbreviations: ACE-R = Addenbrooke's Cognitive Examination-Revised; BDI = Beck's Depression Inventory; FOG-Q = Freezing of Gait Questionnaire; H&Y = Hoehn & Yahr; LEDD = levodopa equivalent daily doses; MCAS = Modified Constipation Assessment Scale; MMSE = Mini-Mental State Examination; PD = Parkinson's disease; SCOPA-AUT = Scales for Outcomes in Parkinson's disease – Autonomic; SGA = Subjective Global Assessment; STAI = Spielberger Trait Anxiety Inventory; UPDRS = Unified Parkinson's Disease Rating Scale.</p

Gene-environment interactions.

<p>^a major/minor allele</p><p>^b odds ratio</p><p>^c adjusted for age and gender</p><p>^d ≥ 17 pack years (median)</p><p>^e lifetime exposure to pesticide >26 days.</p><p>Gene-environment interactions.</p

Study demographics.

<p>^a Odds ratio (95% CI) calculated using binary logistic regression</p><p>^b Wilcoxon rank sum test</p><p>^c pack years equivalent to packs per day multiplied by years smoked</p><p>^d pack years dichotomised according to median <17 & ≥ 17 pack years (zero pack years removed)</p><p>^e Pesticide exposure is equivalent to exposure of herbicides, pesticides, or fungicides at least once weekly for a period of six months.</p><p>Study demographics.</p

Haplotype construction map (VO1-VO7 & T1–T7) and associated AAO effects.

<p>NS = not significant (>0.05).</p