Unagreement is an illusion

This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s11049-015-9311-yThis paper proposes an analysis of unagreement, a phenomenon involving an apparent mismatch between a definite third person plural subject and first or second person plural subject agreement observed in various null subject languages (e.g. Spanish, Modern Greek and Bulgarian), but notoriously absent in others (e.g. Italian, European Portuguese). A cross-linguistic correlation between unagreement and the structure of adnominal pronoun constructions suggests that the availability of unagreement depends on whether person and definiteness are hosted by separate heads (in languages like Greek) or bundled on a single head (i.e. pronominal determiners in languages like Italian). Null spell-out of the head hosting person features high in the extended nominal projection of the subject leads to unagreement. The lack of unagreement in languages with pronominal determiners results from the interaction of their syntactic structure with the properties of the vocabulary items realising the head encoding both person and definiteness. The analysis provides a principled explanation for the cross-linguistic distribution of unagreement and suggests a unified framework for deriving unagreement, adnominal pronoun constructions, personal pronouns and pro

The third person gap in adnominal pronoun constructions

The lack of third person adnominal pronouns in English-type languages (*they linguists) is argued to be an effect of contextually conditioned allomorphy between the exponents of the definite article and third person pronouns within a pronominal determiner structure. A crosslinguistic survey of 82 languages finds that the third person gap is crosslinguistically relatively rare and may be restricted to Europe and surrounding areas. The survey also suggests a potential interaction between the third person gap and the availability of distinct articles, as expected on the proposed analysis. The paper also discusses issues raised by the third person gap for alternative analyses, including those advocating an NP-analysis.</jats:p

Preposition Allomorphy in Calabrian Greek (Greko) and Standard Modern Greek and Its Theoretical Implications

The article argues that the alternation between the prepositions asce ‘from’ and an ‘from’ in the south Italian Greek variety Greko and a similar alternation between the preposition se ‘in, to, into’ and the allomorph s- found in both Greko and Standard Modern Greek represent instances of contextually conditioned allomorphy sensitive to a linearly adjacent definite article. Alternative approaches in terms of portmanteaux or making use of hyper-contextual rules for vocabulary insertion are shown to be unable to account for the data, supporting the need for allowing reference to linear adjacency relations in morphosyntactic theories of allomorphy

Preposition Allomorphy in Calabrian Greek (Greko) and Standard Modern Greek and Its Theoretical Implications

The article argues that the alternation between the prepositions asce ‘from’ and an ‘from’ in the south Italian Greek variety Greko and a similar alternation between the preposition se ‘in, to, into’ and the allomorph s- found in both Greko and Standard Modern Greek represent instances of contextually conditioned allomorphy sensitive to a linearly adjacent definite article. Alternative approaches in terms of portmanteaux or making use of hyper-contextual rules for vocabulary insertion are shown to be unable to account for the data, supporting the need for allowing reference to linear adjacency relations in morphosyntactic theories of allomorphy.</jats:p

The third person gap in adnominal pronoun constructions

The lack of third person adnominal pronouns in English-type languages (*they linguists) is argued to be an effect of contextually conditioned allomorphy between the exponents of the definite article and third person pronouns within a pronominal determiner structure. A crosslinguistic survey of 82 languages finds that the third person gap is crosslinguistically relatively rare and may be restricted to Europe and surrounding areas. The survey also suggests a potential interaction between the third person gap and the availability of distinct articles, as expected on the proposed analysis. The paper also discusses issues raised by the third person gap for alternative analyses, including those advocating an NP-analysis.Open-Access-Publikationsfonds 2020peerReviewe

Assessment of retinopathy of prematurity regression and reactivation using an artificial intelligence–based vascular severity score

IMPORTANCE One of the biggest challenges when using anti-vascular endothelial growth factor (VEGF) agents to treat retinopathy of prematurity (ROP) is the need to perform long-term follow-up examinations to identify eyes at risk of ROP reactivation requiring retreatment. OBJECTIVE To evaluate whether an artificial intelligence (AI)-based vascular severity score (VSS) can be used to analyze ROP regression and reactivation after anti-VEGF treatment and potentially identify eyes at risk of ROP reactivation requiring retreatment. DESIGN, SETTING, AND PARTICIPANTS This prognostic study was a secondary analysis of posterior pole fundus images collected during the multicenter, double-blind, investigator-initiated Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity (CARE-ROP) randomized clinical trial, which compared 2 different doses of ranibizumab (0.12 mg vs 0.20 mg) for the treatment of ROP. The CARE-ROP trial screened and enrolled infants between September 5, 2014, and July 14, 2016. A total of 1046 wide-angle fundus images obtained from 19 infants at predefined study time points were analyzed. The analyses of VSS were performed between January 20, 2021, and November 18, 2022. INTERVENTIONS An AI-based algorithm assigned a VSS between 1 (normal) and 9 (most severe) to fundus images. MAIN OUTCOMES AND MEASURES Analysis of VSS in infants with ROP over time and VSS comparisons between the 2 treatment groups (0.12 mg vs 0.20mg of ranibizumab) and between infants who did and did not receive retreatment for ROP reactivation. RESULTS Among 19 infants with ROP in the CARE-ROP randomized clinical trial, the median (range) postmenstrual age at first treatment was 36.4 (34.7-39.7) weeks; 10 infants (52.6%) were male, and 18 (94.7%) were White. The mean (SD) VSS was 6.7 (1.9) at baseline and significantly decreased to 2.7 (1.9) at week 1 (P < .001) and 2.9 (1.3) at week 4 (P < .001). The mean (SD) VSS of infants with ROP reactivation requiring retreatment was 6.5 (1.9) at the time of retreatment, which was significantly higher than the VSS at week 4 (P < .001). No significant difference was found in VSS between the 2 treatment groups, but the change in VSS between baseline and week 1 was higher for infants who later required retreatment (mean [SD], 7.8 [1.3] at baseline vs 1.7 [0.7] at week 1) vs infants who did not (mean [SD], 6.4 [1.9] at baseline vs 3.0 [2.0] at week 1). In eyes requiring retreatment, higher baseline VSS was correlated with earlier time of retreatment (Pearson r = -0.9997; P < .001). CONCLUSIONS AND RELEVANCE In this study, VSS decreased after ranibizumab treatment, consistent with clinical disease regression. In cases of ROP reactivation requiring retreatment, VSS increased again to values comparable with baseline values. In addition, a greater change in VSS during the first week after initial treatment was found to be associated with a higher risk of later ROP reactivation, and high baseline VSS was correlated with earlier retreatment. These findings may have implications for monitoring ROP regression and reactivation after anti-VEGF treatment

Assessment of Retinopathy of Prematurity Regression and Reactivation Using an Artificial Intelligence–Based Vascular Severity Score

ImportanceOne of the biggest challenges when using anti–vascular endothelial growth factor (VEGF) agents to treat retinopathy of prematurity (ROP) is the need to perform long-term follow-up examinations to identify eyes at risk of ROP reactivation requiring retreatment.ObjectiveTo evaluate whether an artificial intelligence (AI)–based vascular severity score (VSS) can be used to analyze ROP regression and reactivation after anti-VEGF treatment and potentially identify eyes at risk of ROP reactivation requiring retreatment.Design, Setting, and ParticipantsThis prognostic study was a secondary analysis of posterior pole fundus images collected during the multicenter, double-blind, investigator-initiated Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity (CARE-ROP) randomized clinical trial, which compared 2 different doses of ranibizumab (0.12 mg vs 0.20 mg) for the treatment of ROP. The CARE-ROP trial screened and enrolled infants between September 5, 2014, and July 14, 2016. A total of 1046 wide-angle fundus images obtained from 19 infants at predefined study time points were analyzed. The analyses of VSS were performed between January 20, 2021, and November 18, 2022.InterventionsAn AI-based algorithm assigned a VSS between 1 (normal) and 9 (most severe) to fundus images.Main Outcomes and MeasuresAnalysis of VSS in infants with ROP over time and VSS comparisons between the 2 treatment groups (0.12 mg vs 0.20 mg of ranibizumab) and between infants who did and did not receive retreatment for ROP reactivation.ResultsAmong 19 infants with ROP in the CARE-ROP randomized clinical trial, the median (range) postmenstrual age at first treatment was 36.4 (34.7-39.7) weeks; 10 infants (52.6%) were male, and 18 (94.7%) were White. The mean (SD) VSS was 6.7 (1.9) at baseline and significantly decreased to 2.7 (1.9) at week 1 (P &amp;amp;lt; .001) and 2.9 (1.3) at week 4 (P &amp;amp;lt; .001). The mean (SD) VSS of infants with ROP reactivation requiring retreatment was 6.5 (1.9) at the time of retreatment, which was significantly higher than the VSS at week 4 (P &amp;amp;lt; .001). No significant difference was found in VSS between the 2 treatment groups, but the change in VSS between baseline and week 1 was higher for infants who later required retreatment (mean [SD], 7.8 [1.3] at baseline vs 1.7 [0.7] at week 1) vs infants who did not (mean [SD], 6.4 [1.9] at baseline vs 3.0 [2.0] at week 1). In eyes requiring retreatment, higher baseline VSS was correlated with earlier time of retreatment (Pearson r = −0.9997; P &amp;amp;lt; .001).Conclusions and RelevanceIn this study, VSS decreased after ranibizumab treatment, consistent with clinical disease regression. In cases of ROP reactivation requiring retreatment, VSS increased again to values comparable with baseline values. In addition, a greater change in VSS during the first week after initial treatment was found to be associated with a higher risk of later ROP reactivation, and high baseline VSS was correlated with earlier retreatment. These findings may have implications for monitoring ROP regression and reactivation after anti-VEGF treatment.</jats:sec