Mathilde Arrivé, Le Primitivisme mélancolique d’Edward S. Curtis

La photographie comme réparation : les images d’Edward S. Curtis En 1898, le photographe Edward S. Curtis (1868-1952) s’était lancé dans la réalisation d’une encyclopédie consacrée aux Amérindiens d’Amérique du Nord. Publiée en vingt volumes entre 1907 et 1930 sous le titre The North American Indian, cette œuvre sans équivalent comporte 2228 photogravures des quelque 80 peuples autochtones photographiés tout au long de ces années. Curtis commençait sa quête au lendemain de la fin de la conquê..

Sarah Hatchuel, Lost, fiction vitale, Paris, PUF, 2012, 145 pages

L’industrie télévisuelle américaine produit depuis quelques années des séries qui rencontrent un succès public et critique grandissant et qui constituent souvent la culture commune des étudiants d’aujourd’hui. Il est donc tout à fait normal que l’université se penche à son tour sur ce phénomène culturel. En France, un certain nombre de pionniers, à l’Université du Havre, à Rouen, à Paris 7 et dans d’autres centres de recherche ont ouvert ce nouveau champ d’exploration. Sarah Hatchuel, spécial..

The Unendorsable Frank Zappa

The title seems cryptic at first, and the thanks extended to “Jesus Christ—the author of all things good” in the acknowledgments section somewhat puzzling. This collection of essays gathered by Paul Carr offers a comprehensive view of Frank Zappa the artist, the public figure and the man. A prolific performer, composer, producer, recording engineer, social commentator and occasional film director, Frank Zappa never achieved the level of popularity of the major American bands that emerged in t..

“Lemme tell you a couple of three things” : la littérature selon Les Sopranos (1999-2007)

La série Les Sopranos baigne dans une atmosphère littéraire créée et entretenue par une succession de références au corpus traditionnel des œuvres enseignées dans les lycées et les premières années des universités. Il est donc intéressant d’explorer plus avant un thème qui n’a pas semblé retenir l’attention des commentateurs, à savoir celui des rapports qu’entretient et que manifeste cette série « de qualité » avec la littérature et le livre, envisagés ici comme objets culturels extérieurs au..

“Lemme tell you a couple of three things” : la littérature selon Les Sopranos (1999-2007)

La série Les Sopranos baigne dans une atmosphère littéraire créée et entretenue par une succession de références au corpus traditionnel des œuvres enseignées dans les lycées et les premières années des universités. Il est donc intéressant d’explorer plus avant un thème qui n’a pas semblé retenir l’attention des commentateurs, à savoir celui des rapports qu’entretient et que manifeste cette série « de qualité » avec la littérature et le livre, envisagés ici comme objets culturels extérieurs au..

Dominant Role of CD80–CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LATY136F CD4+ T Cells

Coordinated interactions between T and B cells are crucial for inducing physiological B cell responses. Mutant mice in which tyrosine 136 of linker for activation of T cell (LAT) is replaced by a phenylalanine (LatY136F) exhibit a strong CD4+ T cell proliferation in the absence of intended immunization. The resulting effector T cells produce high amounts of TH2 cytokines and are extremely efficient at inducing polyclonal B cell activation. As a consequence, these LatY136F mutant mice showed massive germinal center formations and hypergammaglobulinemia. Here, we analyzed the involvement of different costimulators and their ligands in such T–B interactions both in vitro and in vivo, using blocking antibodies, knockout mice, and adoptive transfer experiments. Surprisingly, we showed in vitro that although B cell activation required contact with T cells, CD40, and inducible T cell costimulator molecule-ligand (ICOSL) signaling were not necessary for this process. These observations were further confirmed in vivo, where none of these molecules were required for the unfolding of the LAT CD4+ T cell expansion and the subsequent polyclonal B cell activation, although, the absence of CD40 led to a reduction of the follicular B cell response. These results indicate that the crucial functions played by CD40 and ICOSL in germinal center formation and isotype switching in physiological humoral responses are partly overcome in LatY136F mice. By comparison, the absence of CD80–CD86 was found to almost completely block the in vitro B cell activation mediated by LatY136F CD4+ T cells. The role of CD80–CD86 in T–B cooperation in vivo remained elusive due to the upstream implication of these costimulatory molecules in the expansion of LatY136F CD4+ T cells. Together, our data suggest that CD80 and CD86 costimulators play a key role in the polyclonal B cell activation mediated by LatY136F CD4+ T cells even though additional costimulatory molecules or cytokines are likely to be required in this process

Medical care of asylum seekers: a descriptive study of the appropriateness of nurse practitioners' care compared to traditional physician-based care in a gatekeeping system

<p>Abstract</p> <p>Background</p> <p>Medical care for asylum seekers is a complex and critical issue worldwide. It is influenced by social, political, and economic pressures, as well as premigration conditions, the process of migration, and postmigration conditions in the host country. Increasing needs and healthcare costs have led public health authorities to put nurse practitioners in charge of the management of a gatekeeping system for asylum seekers. The quality of this system has never been evaluated. We assessed the competencies of nurses and physicians in identifying the medical needs of asylum seekers and providing them with appropriate treatment that reflects good clinical practice.</p> <p>Methods</p> <p>This cross-sectional descriptive study evaluated the appropriateness of care provided to asylum seekers by trained nurse practitioners in nursing healthcare centers and by physicians in private practices, an academic medical outpatient clinic, and the emergency unit of the university hospital in Lausanne, Switzerland. From 1687 asylum seeking patients who had consulted each setting between June and December 2003, 450 were randomly selected to participate. A panel of experts reviewed their medical records and assessed the appropriateness of medical care received according to three parameters: 1) use of appropriate procedures to identify medical needs (medical history, clinical examination, complementary investigations, and referral), 2) provision of access to treatment meeting medical needs, and 3) absence of unnecessary medical procedures.</p> <p>Results</p> <p>In the nurse practitioner group, the procedures used to identify medical needs were less often appropriate (79% of reports vs. 92.4% of reports; p < 0.001). Nevertheless, access to treatment was judged satisfactory and was similar (p = 0.264) between nurse practitioners and physicians (99% and 97.6% of patients, respectively, received adequate care). Excessive care was observed in only 2 physician reports (0.8%) and 3 nurse reports (1.5%) (p = 0.481).</p> <p>Conclusion</p> <p>Although the nursing gatekeeping system provides appropriate treatment to asylum seekers, it might be improved with further training in recording medical history and performing targeted clinical examination.</p

www.fevertravel.ch: an online study prototype to evaluate the safety and feasibility of computerized guidelines for fever in returning travellers and migrants

Following the paper publication of practice guidelines for the management of febrile patients returning from the tropics, we constructed a consultation website that comprises a decision chart and specific diagnostic features providing medical diagnostic assistance to primary care physicians. We then integrated a research component to evaluate the implementation of these computerized guidelines. This study website has the same interface as the consultation website. In addition, one is able to record: (i) the pathway followed by the physician through the decision chart, (ii) the diagnostic tests performed, (iii) the initial and final diagnoses as well as outcome and (iv) reasons for non-adherence when the physician diverges from the proposed attitude. We believe that Internet technology is a powerful medium to reach physicians of different horizons in their own environment, and could prove to be an effective research tool to disseminate practice guidelines and evaluate their appropriateness. Here we describe the design, content, architecture and system implementation of this interactive study prototype aimed at integrating operational research in primary care practice. [Authors]]]> Emigration and Immigration; Fever; Guidelines as Topic; Internet; Travel eng oai:serval.unil.ch:BIB_4BBC99034368 2022-05-07T01:17:24Z ehelvetica openaire documents phdthesis urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_4BBC99034368 Usage conditionnel et inconditionnel des droits humains dans la vie quotidienne Anex, Emmanuelle Université de Lausanne, Faculté des sciences sociales et politiques info:eu-repo/semantics/doctoralThesis phdthesis 2018 fre https://serval.unil.ch/resource/serval:BIB_4BBC99034368.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_4BBC990343683 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4BBC990343683 info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_4BA5F44A285D 2022-05-07T01:17:24Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_4BA5F44A285D A double-blind, placebo-controlled study of citalopram with and without lithium in the treatment of therapy-resistant depressive patients: a clinical, pharmacokinetic, and pharmacogenetic investigation Baumann, Pierre Nil, Rico Souche, Alain Montaldi, Stefano Baettig, Dominique Lambert, Susanne Uehlinger, Claude Kasas, Anton Amey, Marlyse Jonzier-Perey, Michèle info:eu-repo/semantics/article article 1996 Journal of Clinical Psychopharmacology, vol. 16, pp. 307-314 one$; TBOK eng oai:serval.unil.ch:BIB_4BA60F08CDFC 2022-05-07T01:17:24Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_4BA60F08CDFC Busulfan Pharmacokinetics in Adenosine Deaminase-Deficient Severe Combined Immunodeficiency Gene Therapy. info:doi:10.1016/j.bbmt.2020.07.004 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbmt.2020.07.004 info:eu-repo/semantics/altIdentifier/pmid/32653625 Bradford, K.L. Liu, S. Krajinovic, M. Ansari, M. Garabedian, E. Tse, J. Wang, X. Shaw, K.L. Gaspar, H.B. Candotti, F. Kohn, D.B. info:eu-repo/semantics/article article 2020-10 Biology of blood and marrow transplantation, vol. 26, no. 10, pp. 1819-1827 info:eu-repo/semantics/altIdentifier/eissn/1523-6536 urn:issn:1083-8791 <![CDATA[The pharmacokinetics of low-dose busulfan (BU) were investigated as a nonmyeloablative conditioning regimen for autologous gene therapy (GT) in pediatric subjects with adenosine deaminase-deficient severe combined immunodeficiency disease (ADA SCID). In 3 successive clinical trials, which included either γ-retroviral (γ-RV) or lentiviral (LV) vectors, subjects were conditioned with BU using different dosing nomograms. The first cohort received BU doses based on body surface area (BSA), the second cohort received doses based on actual body weight (ABW), and in the third cohort, therapeutic drug monitoring (TDM) was used to target a specific area under the concentration-time curve (AUC). Neither BSA-based nor ABW-based dosing achieved a consistent cumulative BU AUC; in contrast, TDM-based dosing led to more consistent AUC. BU clearance increased as subject age increased from birth to 18 months. However, weight and age alone were insufficient to accurately predict the dose that would consistently achieve a target AUC. Furthermore, various clinical, laboratory, and genetic factors (eg, genotypes for glutathione-S-transferase isozymes known to participate in BU metabolism) were analyzed, but no single finding predicted subjects with rapid versus slow clearance. Analysis of BU AUC and the postengraftment vector copy number (VCN) in granulocytes, a surrogate marker of the level of engrafted gene-modified hematopoietic stem and progenitor cells (HSPCs), demonstrated gene marking at levels sufficient for therapeutic benefit in the subjects who had achieved the target BU AUC. Although many factors determine the ultimate engraftment following GT, this work demonstrates that the BU AUC correlated with the eventual level of engrafted gene-modified HSPCs within a vector group (γ-RV versus LV), with significantly higher levels of granulocyte VCN in the recipients of LV-modified grafts compared to recipients of γ-RV-transduced grafts. Taken together, these findings provide insight into low-dose BU pharmacokinetics in the unique setting of autologous GT for ADA SCID, and these dosing principles may be applied to future GT trials using low-dose BU to open the bone marrow niche