25 research outputs found
Asymmetric synthesis of 3,5-disubstituted indolizidines by intermolecular addition of an allylsilane on an N-acyliminium ion.
A diastereoselective synthesis of 3,5-disubstituted indolizidines based on an intermolecular addition of an allylsilane on an acyliminium ion derived from (S)-pyroglutamic acid is described. The synthetic potential of this methodology is demonstrated by the enantioselective synthesis of (−)-indolizidine 195B, (−)-indolizidine 223AB, (+)-monomorine and (−)-3-butyl-5-propyl indolizidin
A new asymmetric synthesis of 2,6-cis-disubstituted-4-methylenpiperidines. Total synthesis of (+)-alkaloid 241D and (+)-isosolenopsin A
A highly diastereoselective synthesis of 2,6-cis-disubstituted-4-methylenepiperidines based on a Mannich type intramolecular cyclization of an allylsilane on an iminium ion is described. The synthetic potential of this methodology is demonstrated by the enantioselective synthesis of two natural piperidine alkaloids: (+)-alkaloid 241D and (+)-isosolenopsin
Catalytic asymmetric synthesis of the alkaloid (+)-myrtine
A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient synthesis of (+)-myrtine has been achieved via this route.
ChemInform Abstract: REACTION OF S,S-DIPHENYLSULFILIMINE WITH ALDEHYDES; A NEW SYNTHESIS OF NITRILES
A convenient access to the piperidine ring by cyclization of allylsilyl substituted N-acyliminium and iminium ions : application to the synthesis of piperidine alkaloids
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