73 research outputs found
Potential impact of invasive alien species on ecosystem services provided by a tropical forested ecosystem: a case study from Montserrat
Local stakeholders at the important but
vulnerable Centre Hills on Montserrat consider that
the continued presence of feral livestock (particularly
goats and pigs) may lead to widespread replacement of
the reserve’s native vegetation by invasive alien trees
(Java plum and guava), and consequent negative
impacts on native animal species. Since 2009, a
hunting programme to control the feral livestock has
been in operation. However long-term funding is not
assured. Here, we estimate the effect of feral livestock
control on ecosystem services provided by the forest to
evaluate whether the biodiversity conservation rationale
for continuation of the control programme is
supported by an economic case. A new practical tool
(Toolkit for Ecosystem Service Site-based Assessment)
was employed to measure and compare ecosystem
service provision between two states of the
reserve (i.e. presence and absence of feral livestock
control) to estimate the net consequences of the
hunting programme on ecosystem services provided
by the forest. Based on this we estimate that cessation
of feral livestock management would substantially
reduce the net benefits provided by the site, including a
46 % reduction in nature-based tourism (from
228,000) and 36 % reduction in harvested
wild meat (from 132,000). The
overall net benefit generated from annual ecosystem
service flows associated with livestock control in thereserve, minus the management cost, was $214,000
per year. We conclude that continued feral livestock
control is important for maintaining the current level
of ecosystem services provided by the reserve
Shorter courses of parenteral antibiotic therapy do not appear to influence response rates for children with acute hematogenous osteomyelitis: a systematic review
BACKGROUND: Acute hematogenous osteomyelitis (AHO) occurs primarily in children and is believed to evolve from bacteremia followed by localization of infection to the metaphysis of bones. Currently, there is no consensus on the route and duration of antimicrobial therapy to treat AHO. METHODS: We conducted a systematic review of a short versus long course of treatment for AHO due primarily to Staphylococcus aureus in children aged 3 months to 16 years. We searched Medline, Embase and the Cochrane trials registry for controlled trials. Clinical cure rate at 6 months was the primary outcome variable, and groups receiving less than 7 days of intravenous therapy were compared with groups receiving one week or longer of intravenous antimicrobials. RESULTS: 12 eligible prospective studies, one of which was randomized, were identified. The overall cure rate at 6 months for the short course of intravenous therapy was 95.2% (95% CI = 90.4, 97.7) compared to 98.8% (95% CI = 93.6, 99.8) for the longer course of therapy. There was no significant difference in the duration of oral therapy between the two groups. CONCLUSIONS: Given the potential increased morbidity and cost associated with longer courses of intravenous therapy, this finding should be confirmed through a randomized controlled equivalence trial
Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation
Advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs) have a pathogenetic role in the development and progression of different oxidative-based diseases including diabetes, atherosclerosis, and neurological disorders. AGEs and ALEs represent a quite complex class of compounds that are formed by different mechanisms, by heterogeneous precursors and that can be formed either exogenously or endogenously. There is a wide interest in AGEs and ALEs involving different aspects of research which are essentially focused on set-up and application of analytical strategies (1) to identify, characterize, and quantify AGEs and ALEs in different pathophysiological conditions ; (2) to elucidate the molecular basis of their biological effects ; and (3) to discover compounds able to inhibit AGEs/ALEs damaging effects not only as biological tools aimed at validating AGEs/ALEs as drug target, but also as promising drugs. All the above-mentioned research stages require a clear picture of the chemical formation of AGEs/ALEs but this is not simple, due to the complex and heterogeneous pathways, involving different precursors and mechanisms. In view of this intricate scenario, the aim of the present review is to group the main AGEs and ALEs and to describe, for each of them, the precursors and mechanisms of formation
A comprehensive overview of radioguided surgery using gamma detection probe technology
The concept of radioguided surgery, which was first developed some 60 years ago, involves the use of a radiation detection probe system for the intraoperative detection of radionuclides. The use of gamma detection probe technology in radioguided surgery has tremendously expanded and has evolved into what is now considered an established discipline within the practice of surgery, revolutionizing the surgical management of many malignancies, including breast cancer, melanoma, and colorectal cancer, as well as the surgical management of parathyroid disease. The impact of radioguided surgery on the surgical management of cancer patients includes providing vital and real-time information to the surgeon regarding the location and extent of disease, as well as regarding the assessment of surgical resection margins. Additionally, it has allowed the surgeon to minimize the surgical invasiveness of many diagnostic and therapeutic procedures, while still maintaining maximum benefit to the cancer patient. In the current review, we have attempted to comprehensively evaluate the history, technical aspects, and clinical applications of radioguided surgery using gamma detection probe technology
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