White Organic Light-Emitting Diodes with fine chromaticity tuning via ultrathin layer position shifting

Non-doped white organic light-emitting diodes using an ultrathin yellow-emitting layer of rubrene (5,6,11,12-tetraphenylnaphtacene) inserted on either side of the interface between a hole-transporting NPB (4,4'-bis[N-(1-naphtyl)-N-phenylamino]biphenyl) layer and a blue-emitting DPVBi (4,4'-bis(2,2'-diphenylvinyl)-1,1'-biphenyl) layer are described. Both the thickness and the position of the rubrene layer allow fine chromaticity tuning from deep-blue to pure-yellow via bright-white with CIE coordinates (x= 0.33, y= 0.32), a external quantum efficiency of 1.9%, and a color rendering index of 70. Such a structure also provides an accurate sensing tool to measure the exciton diffusion length in both DPVBi and NPB (8.7 and 4.9 nm respectively)

Clinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. A study by the French ALFA group

Assessment of minimal residual disease has emerged as a powerful prognostic factor in acute myeloid leukemia. In this study, we investigated the potential of IDH1/2 mutations as targets for minimal residual disease assessment in acute myeloid leukemia, since these mutations collectively occur in 15–20% of cases of acute myeloid leukemia and now represent druggable targets. We employed droplet digital polymerase chain reaction assays to quantify IDH1R132, IDH2R140, and IDH2R172 mutations on genomic DNA in 322 samples from 103 adult patients with primary IDH1/2 mutant acute myeloid leukemia and enrolled on Acute Leukemia French Association (ALFA) - 0701 or -0702 clinical trials. The median IDH1/2 mutant allele fraction in bone marrow samples was 42.3% (range, 8.2 – 49.9%) at diagnosis of acute myeloid leukemia, and below the detection limit of 0.2% (range

Etude de l'arthropathie fémoro-tibiale médicale sur 133 trotteurs (intérêts d'un examen échographique standardisé)

L affection dégénérative articulaire est courante mais son expression dans l articulation fémoro-tibiale médiale chez le trotteur français n est pas décrite dans la littérature. L objectif de cette étude est de proposer des critères d évaluation échographique répétables et reproductibles d une part (synovite, atteinte cartilagineuse, ostéophytes tibial et fémoral) et de tenter de distinguer ceux qui ont une incidence sur la performance d autre part.TOULOUSE-EN Vétérinaire (315552301) / SudocNANTES-Ecole Nat.Vétérinaire (441092302) / SudocSudocFranceF

Searching for organic compounds in the Universe

International audienceSearching for signs of past or present life in our Solar System is a major challenge for the space-research community. One approach involves searching for organics. However, it encompasses major challenges, such as their very low concentration levels, their ambiguous origins (biotic or abiotic) and their supposed diversity and complexity. Even if, during the past 40 years, tremendous improvements in sample treatment, stationary phase and mass spectrometry detection have been achieved, there is still a need for new in-situ scientific instrumentation. The objective of this article is to give a broad canvas of instrumentation and technology available to space-survey missions and those further out. It is also a critical review where we discuss analytical science questions, and the technology needed to address the

Simple Derivatization–Gas Chromatography–Mass Spectrometry for Fatty Acids Profiling in Soil Dissolved Organic Matter

Dissolved organic matter is an important component of the global carbon cycle that allows the distribution of carbon and nutrients. Therefore, analysis of soil dissolved organic matter helps us to better understand climate change impacts as it is the most dynamic and reactive fraction in terrestrial ecosystems. Its characterization at the molecular level is still challenging due to complex mixtures of hundreds of compounds at low concentration levels in percolating water. This work presents simple methods, such as thermochemolysis– or derivatization–gas chromatography, as an alternative for the analysis of fatty acids in dissolved organic matter without any purification step. The variables of the protocols were examined to optimize the processing conditions for the C9–C18 range. As a proof of concept, fatty acid distributions of soil percolating water samples from a long-term field experiment were successfully assessed. The variability of dissolved organic acid distributions was pronounced through depth profile and soil treatment but no major change in composition was observed. However, although the optimization was done from C9 to C18, detection within the C6-C32 fatty acids range was performed for all samples

Assessment and diffusion of medical innovations in France: an overview

Background: In France, a significant part of health expenditure is publicly funding. This put a heavy burden on society. In an economic context requiring tight control of public spending, it seems relevant to control the diffusion of medical innovations. That is why health technology assessment is subject to an increasing interest at national level for management and approval decisions. This article provides an overview of the assessment and diffusion of medical innovation in France. Method: The data are extracted from French authorities or organisations websites and documents and from French legislative texts. In addition, regarding discussion, a search in MEDLINE database was carried out. Results: An overview of the assessment and diffusion of medical innovation in France is given by presenting the different types of medical innovations according to French health system definition (I); introducing French authorities participating to health technology assessment and describe assessment procedures of medical innovations (II); and giving details about market access process of innovative health product in France (III). Key opportunities and challenges of medical innovation assessment and diffusion in France are discussed at the end of this article. Conclusion: In France, medical innovation is considered as a crucial component for quality of care and performance of healthcare system. The aim of health technology assessment is to promote a secure and timely access to innovation for patients. Nevertheless, it appears necessary to improve regulatory mechanisms