36 research outputs found
Short Physical Performance Battery and Study of Osteoporotic Fractures Index in the Exploration of Frailty Among Older People in Cameroon
Objectives: To investigate the relationship between the Short Physical Performance Battery (SPPB) and the Study of Osteoporotic Fractures (SOF) index.Methods: We present data from a cross-sectional survey conducted in Cameroon. Frailty was defined as an SOF index > 0. The sensitivity and specificity of the SPPB were investigated. Principal component analysis (PCA) was performed to assess the contribution of each subtest of the SPPB to the relationship with the SOF.Results: Among 403 people included (49.6% women), average age of 67.1 (±6.2) years, 35.7% were frail according to the SOF. After determining the best SPPB threshold for diagnosing frailty (threshold = 9, Se = 88.9%, Sp = 74.9%), 47.9% were frail according to the SPPB. The first dimension of PCA explained 55.8% of the variability in the data. Among the subtests of the SPPB, the chair stand test item was the component most associated with the SOF index.Conclusion: Despite the overlap between the SOF and the SPPB, our results suggest that a negative result on the five chair-stands test alone would be sufficient to suspect physical frailty
Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing
INTRODUCTION: Previous meta-analyses have linked social connections and mild cognitive impairment, dementia, and mortality. However, these used aggregate data from North America and Europe and examined a limited number of social connection markers. METHODS: We used individual participant data (N = 39271, Mage  = 70.67 (40-102), 58.86% female, Meducation  = 8.43 years, Mfollow-up  = 3.22 years) from 13 longitudinal ageing studies. A two-stage meta-analysis of Cox regression models examined the association between social connection markers with our primary outcomes. RESULTS: We found associations between good social connections structure and quality and lower risk of incident mild cognitive impairment (MCI); between social structure and function and lower risk of incident dementia and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality. DISCUSSION: Different aspects of social connections - structure, function, and quality - are associated with benefits for healthy aging internationally. HIGHLIGHTS: Social connection structure (being married/in a relationship, weekly community group engagement, weekly family/friend interactions) and quality (never lonely) were associated with lower risk of incident MCI. Social connection structure (monthly/weekly friend/family interactions) and function (having a confidante) were associated with lower risk of incident dementia. Social connection structure (living with others, yearly/monthly/weekly community group engagement) and function (having a confidante) were associated with lower risk of mortality. Evidence from 13 longitudinal cohort studies of ageing indicates that social connections are important targets for reducing risk of incident MCI, incident dementia, and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality
Sex differences in dementia risk and risk factors: Individualâparticipant data analysis using 21 cohorts across six continents from the COSMIC consortium
Introduction: Sex differences in dementia risk, and risk factor (RF) associations with dementia, remain uncertain across diverse ethnoâregional groups. Methods: A total of 29,850 participants (58% women) from 21 cohorts across six continents were included in an individual participant data metaâanalysis. Sexâspecific hazard ratios (HRs), and womenâtoâmen ratio of hazard ratios (RHRs) for associations between RFs and allâcause dementia were derived from mixedâeffect Cox models. Results: Incident dementia occurred in 2089 (66% women) participants over 4.6 years (median). Women had higher dementia risk (HR, 1.12 [1.02, 1.23]) than men, particularly in lowâ and lowerâmiddleâincome economies. Associations between longer education and former alcohol use with dementia risk (RHR, 1.01 [1.00, 1.03] per year, and 0.55 [0.38, 0.79], respectively) were stronger for men than women; otherwise, there were no discernible sex differences in other RFs. Discussion: Dementia risk was higher in women than men, with possible variations by countryâlevel income settings, but most RFs appear to work similarly in women and men
The 2022 symposium on dementia and brain aging in lowâ and middleâincome countries: Highlights on research, diagnosis, care, and impact
Two of every three persons living with dementia reside in lowâ and middleâincome countries (LMICs). The projected increase in global dementia rates is expected to affect LMICs disproportionately. However, the majority of global dementia care costs occur in highâincome countries (HICs), with dementia research predominantly focusing on HICs. This imbalance necessitates LMICâfocused research to ensure that characterization of dementia accurately reflects the involvement and specificities of diverse populations. Development of effective preventive, diagnostic, and therapeutic approaches for dementia in LMICs requires targeted, personalized, and harmonized efforts. Our article represents timely discussions at the 2022 Symposium on Dementia and Brain Aging in LMICs that identified the foremost opportunities to advance dementia research, differential diagnosis, use of neuropsychometric tools, awareness, and treatment options. We highlight key topics discussed at the meeting and provide future recommendations to foster a more equitable landscape for dementia prevention, diagnosis, care, policy, and management in LMICs. Highlights: Twoâthirds of persons with dementia live in LMICs, yet research and costs are skewed toward HICs. LMICs expect dementia prevalence to more than double, accompanied by socioeconomic disparities. The 2022 Symposium on Dementia in LMICs addressed advances in research, diagnosis, prevention, and policy. The Nairobi Declaration urges global action to enhance dementia outcomes in LMICs
Déficience visuelle et ses conséquences (troubles cognitifs, dépendance, mauvaise qualité de vie, fragilité) chez les personnes ùgées en Afrique Sub-Saharienne
Sub-Saharan Africa (SSA) is the second world region that will experience a steep increase in the number of older people within its population (+218% between 2019 and 2050). However, little attention is devoted to health issues related to aging. The main aim of this PhD thesis was to investigate the relationships between Visual Impairment (VI) and other adverse health conditions such as cognitive disorders, dependence, poor Vision-Related Quality of Life (VRQoL), and frailty among older people in SSA. To achieve this goal, several studies were conducted using data from the EPIDEMCA/FU programs. These showed that VI was very common among older people in Congo (68.8%) and that it affected daily functioning and VRQoL in this population. We also found that the residence area explained the relationship between VI and cognitive disorders in our study population without any clinical mechanism being involved (adjusted OR =1.7; 95% confidence interval: 0.6 - 4.7). Finally, focusing on older people with cognitive dysfunction, we observed that those who self-reported visual impairment were highly likely to present frailty (adjusted OR =2.2; 95% CI: 1.1 - 4.3). All these results suggest that public health actions towards prevention and promotion of management of vision issues in older people are needed to reduce the consequences of this impairment and to contribute to healthy aging of the population. Through the donation of corrective eyeglasses to older people living in Benin, we hope to bring additional evidence that will strengthen our above conclusions. Indeed, we have already prepared in this thesis a protocol for an interventional study that aims to assess the extent to which correction of VI could reduce dependence and improve VRQoL among the older people in an SSA setting.LâAfrique subsaharienne (ASS) est la deuxiĂšme rĂ©gion du monde qui va connaĂźtre une hausse spectaculaire du nombre de personnes ĂągĂ©es au sein de sa population (+218% entre 2019 et 2050). Cependant, les problĂ©matiques sanitaires liĂ©es au vieillissement font encore objet de peu dâattention. Lâobjectif gĂ©nĂ©ral de cette thĂšse Ă©tait dâĂ©tudier les relations entre la dĂ©ficience visuelle (DV) et les conditions morbides telles que les troubles cognitifs, la dĂ©pendance, la mauvaise qualitĂ© de vie liĂ©e Ă la vision (QVLV) et la fragilitĂ© chez les personnes ĂągĂ©es en ASS. Pour atteindre cet objectif, plusieurs travaux ont Ă©tĂ© menĂ©s sur la base des donnĂ©es issues des programmes EPIDEMCA/FU. Ces travaux ont permis de montrer que la DV Ă©tait trĂšs frĂ©quente chez les personnes ĂągĂ©es au Congo (68,8%) et quâelle altĂ©rait le fonctionnement quotidien et la qualitĂ© de vie liĂ©e Ă la vision dans cette population. Nous avons retrouvĂ© que le milieu de rĂ©sidence expliquait la relation entre la DV et les troubles cognitifs dans notre population dâĂ©tude sans quâaucun mĂ©canisme clinique ne soit mis en cause (OR ajustĂ© = 1,7 ; Intervalle de confiance Ă 95%: 0,6 - 4,7). Enfin, chez les personnes ayant des dysfonctionnements cognitifs, celles qui auto-dĂ©claraient une DV Ă©taient fortement susceptibles de prĂ©senter une fragilitĂ© (OR ajustĂ© = 2,2 ; IC95%: 1,1 â 4,3). Tous ces rĂ©sultats suggĂšrent que des actions de santĂ© publique allant dans le sens de la prĂ©vention et de la promotion de la prise en charge des problĂšmes visuels chez les personnes ĂągĂ©es sont nĂ©cessaires pour rĂ©duire les consĂ©quences de cette dĂ©ficience et pour contribuer au vieillissement en bonne santĂ© de la population. GrĂące Ă un don de lunettes de correction aux personnes ĂągĂ©es au BĂ©nin nous espĂ©rons apporter des Ă©lĂ©ments supplĂ©mentaires qui renforceront nos conclusions. En effet, nous avons rĂ©digĂ© le protocole dâune Ă©tude interventionnelle qui a pour objectif dâĂ©valuer Ă quel point la correction de la DV pourrait rĂ©duire la dĂ©pendance et amĂ©liorer la QVLV chez personnes ĂągĂ©es dans cette population dâASS
Déficience visuelle et ses conséquences (troubles cognitifs, dépendance, mauvaise qualité de vie, fragilité) chez les personnes ùgées en Afrique Sub-Saharienne
Sub-Saharan Africa (SSA) is the second world region that will experience a steep increase in the number of older people within its population (+218% between 2019 and 2050). However, little attention is devoted to health issues related to aging. The main aim of this PhD thesis was to investigate the relationships between Visual Impairment (VI) and other adverse health conditions such as cognitive disorders, dependence, poor Vision-Related Quality of Life (VRQoL), and frailty among older people in SSA. To achieve this goal, several studies were conducted using data from the EPIDEMCA/FU programs. These showed that VI was very common among older people in Congo (68.8%) and that it affected daily functioning and VRQoL in this population. We also found that the residence area explained the relationship between VI and cognitive disorders in our study population without any clinical mechanism being involved (adjusted OR =1.7; 95% confidence interval: 0.6 - 4.7). Finally, focusing on older people with cognitive dysfunction, we observed that those who self-reported visual impairment were highly likely to present frailty (adjusted OR =2.2; 95% CI: 1.1 - 4.3). All these results suggest that public health actions towards prevention and promotion of management of vision issues in older people are needed to reduce the consequences of this impairment and to contribute to healthy aging of the population. Through the donation of corrective eyeglasses to older people living in Benin, we hope to bring additional evidence that will strengthen our above conclusions. Indeed, we have already prepared in this thesis a protocol for an interventional study that aims to assess the extent to which correction of VI could reduce dependence and improve VRQoL among the older people in an SSA setting.LâAfrique subsaharienne (ASS) est la deuxiĂšme rĂ©gion du monde qui va connaĂźtre une hausse spectaculaire du nombre de personnes ĂągĂ©es au sein de sa population (+218% entre 2019 et 2050). Cependant, les problĂ©matiques sanitaires liĂ©es au vieillissement font encore objet de peu dâattention. Lâobjectif gĂ©nĂ©ral de cette thĂšse Ă©tait dâĂ©tudier les relations entre la dĂ©ficience visuelle (DV) et les conditions morbides telles que les troubles cognitifs, la dĂ©pendance, la mauvaise qualitĂ© de vie liĂ©e Ă la vision (QVLV) et la fragilitĂ© chez les personnes ĂągĂ©es en ASS. Pour atteindre cet objectif, plusieurs travaux ont Ă©tĂ© menĂ©s sur la base des donnĂ©es issues des programmes EPIDEMCA/FU. Ces travaux ont permis de montrer que la DV Ă©tait trĂšs frĂ©quente chez les personnes ĂągĂ©es au Congo (68,8%) et quâelle altĂ©rait le fonctionnement quotidien et la qualitĂ© de vie liĂ©e Ă la vision dans cette population. Nous avons retrouvĂ© que le milieu de rĂ©sidence expliquait la relation entre la DV et les troubles cognitifs dans notre population dâĂ©tude sans quâaucun mĂ©canisme clinique ne soit mis en cause (OR ajustĂ© = 1,7 ; Intervalle de confiance Ă 95%: 0,6 - 4,7). Enfin, chez les personnes ayant des dysfonctionnements cognitifs, celles qui auto-dĂ©claraient une DV Ă©taient fortement susceptibles de prĂ©senter une fragilitĂ© (OR ajustĂ© = 2,2 ; IC95%: 1,1 â 4,3). Tous ces rĂ©sultats suggĂšrent que des actions de santĂ© publique allant dans le sens de la prĂ©vention et de la promotion de la prise en charge des problĂšmes visuels chez les personnes ĂągĂ©es sont nĂ©cessaires pour rĂ©duire les consĂ©quences de cette dĂ©ficience et pour contribuer au vieillissement en bonne santĂ© de la population. GrĂące Ă un don de lunettes de correction aux personnes ĂągĂ©es au BĂ©nin nous espĂ©rons apporter des Ă©lĂ©ments supplĂ©mentaires qui renforceront nos conclusions. En effet, nous avons rĂ©digĂ© le protocole dâune Ă©tude interventionnelle qui a pour objectif dâĂ©valuer Ă quel point la correction de la DV pourrait rĂ©duire la dĂ©pendance et amĂ©liorer la QVLV chez personnes ĂągĂ©es dans cette population dâASS
Déficience visuelle et ses conséquences (troubles cognitifs, dépendance, mauvaise qualité de vie, fragilité) chez les personnes ùgées en Afrique Sub-Saharienne
Sub-Saharan Africa (SSA) is the second world region that will experience a steep increase in the number of older people within its population (+218% between 2019 and 2050). However, little attention is devoted to health issues related to aging. The main aim of this PhD thesis was to investigate the relationships between Visual Impairment (VI) and other adverse health conditions such as cognitive disorders, dependence, poor Vision-Related Quality of Life (VRQoL), and frailty among older people in SSA. To achieve this goal, several studies were conducted using data from the EPIDEMCA/FU programs. These showed that VI was very common among older people in Congo (68.8%) and that it affected daily functioning and VRQoL in this population. We also found that the residence area explained the relationship between VI and cognitive disorders in our study population without any clinical mechanism being involved (adjusted OR =1.7; 95% confidence interval: 0.6 - 4.7). Finally, focusing on older people with cognitive dysfunction, we observed that those who self-reported visual impairment were highly likely to present frailty (adjusted OR =2.2; 95% CI: 1.1 - 4.3). All these results suggest that public health actions towards prevention and promotion of management of vision issues in older people are needed to reduce the consequences of this impairment and to contribute to healthy aging of the population. Through the donation of corrective eyeglasses to older people living in Benin, we hope to bring additional evidence that will strengthen our above conclusions. Indeed, we have already prepared in this thesis a protocol for an interventional study that aims to assess the extent to which correction of VI could reduce dependence and improve VRQoL among the older people in an SSA setting.LâAfrique subsaharienne (ASS) est la deuxiĂšme rĂ©gion du monde qui va connaĂźtre une hausse spectaculaire du nombre de personnes ĂągĂ©es au sein de sa population (+218% entre 2019 et 2050). Cependant, les problĂ©matiques sanitaires liĂ©es au vieillissement font encore objet de peu dâattention. Lâobjectif gĂ©nĂ©ral de cette thĂšse Ă©tait dâĂ©tudier les relations entre la dĂ©ficience visuelle (DV) et les conditions morbides telles que les troubles cognitifs, la dĂ©pendance, la mauvaise qualitĂ© de vie liĂ©e Ă la vision (QVLV) et la fragilitĂ© chez les personnes ĂągĂ©es en ASS. Pour atteindre cet objectif, plusieurs travaux ont Ă©tĂ© menĂ©s sur la base des donnĂ©es issues des programmes EPIDEMCA/FU. Ces travaux ont permis de montrer que la DV Ă©tait trĂšs frĂ©quente chez les personnes ĂągĂ©es au Congo (68,8%) et quâelle altĂ©rait le fonctionnement quotidien et la qualitĂ© de vie liĂ©e Ă la vision dans cette population. Nous avons retrouvĂ© que le milieu de rĂ©sidence expliquait la relation entre la DV et les troubles cognitifs dans notre population dâĂ©tude sans quâaucun mĂ©canisme clinique ne soit mis en cause (OR ajustĂ© = 1,7 ; Intervalle de confiance Ă 95%: 0,6 - 4,7). Enfin, chez les personnes ayant des dysfonctionnements cognitifs, celles qui auto-dĂ©claraient une DV Ă©taient fortement susceptibles de prĂ©senter une fragilitĂ© (OR ajustĂ© = 2,2 ; IC95%: 1,1 â 4,3). Tous ces rĂ©sultats suggĂšrent que des actions de santĂ© publique allant dans le sens de la prĂ©vention et de la promotion de la prise en charge des problĂšmes visuels chez les personnes ĂągĂ©es sont nĂ©cessaires pour rĂ©duire les consĂ©quences de cette dĂ©ficience et pour contribuer au vieillissement en bonne santĂ© de la population. GrĂące Ă un don de lunettes de correction aux personnes ĂągĂ©es au BĂ©nin nous espĂ©rons apporter des Ă©lĂ©ments supplĂ©mentaires qui renforceront nos conclusions. En effet, nous avons rĂ©digĂ© le protocole dâune Ă©tude interventionnelle qui a pour objectif dâĂ©valuer Ă quel point la correction de la DV pourrait rĂ©duire la dĂ©pendance et amĂ©liorer la QVLV chez personnes ĂągĂ©es dans cette population dâASS
Déficience visuelle et ses conséquences (troubles cognitifs, dépendance, mauvaise qualité de vie, fragilité) chez les personnes ùgées en Afrique Sub-Saharienne
Sub-Saharan Africa (SSA) is the second world region that will experience a steep increase in the number of older people within its population (+218% between 2019 and 2050). However, little attention is devoted to health issues related to aging. The main aim of this PhD thesis was to investigate the relationships between Visual Impairment (VI) and other adverse health conditions such as cognitive disorders, dependence, poor Vision-Related Quality of Life (VRQoL), and frailty among older people in SSA. To achieve this goal, several studies were conducted using data from the EPIDEMCA/FU programs. These showed that VI was very common among older people in Congo (68.8%) and that it affected daily functioning and VRQoL in this population. We also found that the residence area explained the relationship between VI and cognitive disorders in our study population without any clinical mechanism being involved (adjusted OR =1.7; 95% confidence interval: 0.6 - 4.7). Finally, focusing on older people with cognitive dysfunction, we observed that those who self-reported visual impairment were highly likely to present frailty (adjusted OR =2.2; 95% CI: 1.1 - 4.3). All these results suggest that public health actions towards prevention and promotion of management of vision issues in older people are needed to reduce the consequences of this impairment and to contribute to healthy aging of the population. Through the donation of corrective eyeglasses to older people living in Benin, we hope to bring additional evidence that will strengthen our above conclusions. Indeed, we have already prepared in this thesis a protocol for an interventional study that aims to assess the extent to which correction of VI could reduce dependence and improve VRQoL among the older people in an SSA setting.LâAfrique subsaharienne (ASS) est la deuxiĂšme rĂ©gion du monde qui va connaĂźtre une hausse spectaculaire du nombre de personnes ĂągĂ©es au sein de sa population (+218% entre 2019 et 2050). Cependant, les problĂ©matiques sanitaires liĂ©es au vieillissement font encore objet de peu dâattention. Lâobjectif gĂ©nĂ©ral de cette thĂšse Ă©tait dâĂ©tudier les relations entre la dĂ©ficience visuelle (DV) et les conditions morbides telles que les troubles cognitifs, la dĂ©pendance, la mauvaise qualitĂ© de vie liĂ©e Ă la vision (QVLV) et la fragilitĂ© chez les personnes ĂągĂ©es en ASS. Pour atteindre cet objectif, plusieurs travaux ont Ă©tĂ© menĂ©s sur la base des donnĂ©es issues des programmes EPIDEMCA/FU. Ces travaux ont permis de montrer que la DV Ă©tait trĂšs frĂ©quente chez les personnes ĂągĂ©es au Congo (68,8%) et quâelle altĂ©rait le fonctionnement quotidien et la qualitĂ© de vie liĂ©e Ă la vision dans cette population. Nous avons retrouvĂ© que le milieu de rĂ©sidence expliquait la relation entre la DV et les troubles cognitifs dans notre population dâĂ©tude sans quâaucun mĂ©canisme clinique ne soit mis en cause (OR ajustĂ© = 1,7 ; Intervalle de confiance Ă 95%: 0,6 - 4,7). Enfin, chez les personnes ayant des dysfonctionnements cognitifs, celles qui auto-dĂ©claraient une DV Ă©taient fortement susceptibles de prĂ©senter une fragilitĂ© (OR ajustĂ© = 2,2 ; IC95%: 1,1 â 4,3). Tous ces rĂ©sultats suggĂšrent que des actions de santĂ© publique allant dans le sens de la prĂ©vention et de la promotion de la prise en charge des problĂšmes visuels chez les personnes ĂągĂ©es sont nĂ©cessaires pour rĂ©duire les consĂ©quences de cette dĂ©ficience et pour contribuer au vieillissement en bonne santĂ© de la population. GrĂące Ă un don de lunettes de correction aux personnes ĂągĂ©es au BĂ©nin nous espĂ©rons apporter des Ă©lĂ©ments supplĂ©mentaires qui renforceront nos conclusions. En effet, nous avons rĂ©digĂ© le protocole dâune Ă©tude interventionnelle qui a pour objectif dâĂ©valuer Ă quel point la correction de la DV pourrait rĂ©duire la dĂ©pendance et amĂ©liorer la QVLV chez personnes ĂągĂ©es dans cette population dâASS
Visual impairment and its consequences (cognitive disorders, dependence, poor quality of life, frailty) among older people in Sub-Saharan Africa
LâAfrique subsaharienne (ASS) est la deuxiĂšme rĂ©gion du monde qui va connaĂźtre une hausse spectaculaire du nombre de personnes ĂągĂ©es au sein de sa population (+218% entre 2019 et 2050). Cependant, les problĂ©matiques sanitaires liĂ©es au vieillissement font encore objet de peu dâattention. Lâobjectif gĂ©nĂ©ral de cette thĂšse Ă©tait dâĂ©tudier les relations entre la dĂ©ficience visuelle (DV) et les conditions morbides telles que les troubles cognitifs, la dĂ©pendance, la mauvaise qualitĂ© de vie liĂ©e Ă la vision (QVLV) et la fragilitĂ© chez les personnes ĂągĂ©es en ASS. Pour atteindre cet objectif, plusieurs travaux ont Ă©tĂ© menĂ©s sur la base des donnĂ©es issues des programmes EPIDEMCA/FU. Ces travaux ont permis de montrer que la DV Ă©tait trĂšs frĂ©quente chez les personnes ĂągĂ©es au Congo (68,8%) et quâelle altĂ©rait le fonctionnement quotidien et la qualitĂ© de vie liĂ©e Ă la vision dans cette population. Nous avons retrouvĂ© que le milieu de rĂ©sidence expliquait la relation entre la DV et les troubles cognitifs dans notre population dâĂ©tude sans quâaucun mĂ©canisme clinique ne soit mis en cause (OR ajustĂ© = 1,7 ; Intervalle de confiance Ă 95%: 0,6 - 4,7). Enfin, chez les personnes ayant des dysfonctionnements cognitifs, celles qui auto-dĂ©claraient une DV Ă©taient fortement susceptibles de prĂ©senter une fragilitĂ© (OR ajustĂ© = 2,2 ; IC95%: 1,1 â 4,3). Tous ces rĂ©sultats suggĂšrent que des actions de santĂ© publique allant dans le sens de la prĂ©vention et de la promotion de la prise en charge des problĂšmes visuels chez les personnes ĂągĂ©es sont nĂ©cessaires pour rĂ©duire les consĂ©quences de cette dĂ©ficience et pour contribuer au vieillissement en bonne santĂ© de la population. GrĂące Ă un don de lunettes de correction aux personnes ĂągĂ©es au BĂ©nin nous espĂ©rons apporter des Ă©lĂ©ments supplĂ©mentaires qui renforceront nos conclusions. En effet, nous avons rĂ©digĂ© le protocole dâune Ă©tude interventionnelle qui a pour objectif dâĂ©valuer Ă quel point la correction de la DV pourrait rĂ©duire la dĂ©pendance et amĂ©liorer la QVLV chez personnes ĂągĂ©es dans cette population dâASS.Sub-Saharan Africa (SSA) is the second world region that will experience a steep increase in the number of older people within its population (+218% between 2019 and 2050). However, little attention is devoted to health issues related to aging. The main aim of this PhD thesis was to investigate the relationships between Visual Impairment (VI) and other adverse health conditions such as cognitive disorders, dependence, poor Vision-Related Quality of Life (VRQoL), and frailty among older people in SSA. To achieve this goal, several studies were conducted using data from the EPIDEMCA/FU programs. These showed that VI was very common among older people in Congo (68.8%) and that it affected daily functioning and VRQoL in this population. We also found that the residence area explained the relationship between VI and cognitive disorders in our study population without any clinical mechanism being involved (adjusted OR =1.7; 95% confidence interval: 0.6 - 4.7). Finally, focusing on older people with cognitive dysfunction, we observed that those who self-reported visual impairment were highly likely to present frailty (adjusted OR =2.2; 95% CI: 1.1 - 4.3). All these results suggest that public health actions towards prevention and promotion of management of vision issues in older people are needed to reduce the consequences of this impairment and to contribute to healthy aging of the population. Through the donation of corrective eyeglasses to older people living in Benin, we hope to bring additional evidence that will strengthen our above conclusions. Indeed, we have already prepared in this thesis a protocol for an interventional study that aims to assess the extent to which correction of VI could reduce dependence and improve VRQoL among the older people in an SSA setting