Baseline demographics of real-life data from 227 patients.

<p>Baseline demographics of real-life data from 227 patients.</p

Tornado diagram.

<p>Tornado diagram.</p

Data and Markov model overview.

<p>The boxes represent the health states that a neurogenic patient can transition between after having failed standard bowel care (SBC) before and after 2007. SBC alone. After having failed SBC >6 months, a patient can either a) Resume SBC, b) Progress to SNS/SARS/ACE or d) Progress to stoma (absorbing state). TAI in combination with SBC. After having failed SBC >6 months, a patient can either a) Initiate Peristeen TAI, b) Resume SBC, c) Progress to SNS/SARS/ACE or d) Progress to stoma. <i>The model assumes that patients do not transition directly from SBC/TAI to stoma</i>. <i>Transition probabilities have been obtained for each 6-month model cycle using GoalSeek in Excel</i>.</p

Cost-effectiveness plane.

<p>WTP: Willingness to pay: linear threshold corresponds to the WTP value used by NICE in making reimbursement decisions (£30.000 per QALY gained). Each quadrant corresponds to one incremental cost option (cost saving, not cost saving) and one incremental benefit option (more/less benefit than comparator therapy).</p

Costs and resource use.

<p>Costs and resource use.</p

Health State Utility Values (HSUV).

<p>Health State Utility Values (HSUV).</p

Overview of transition probabilities applied in the model.

<p>Overview of transition probabilities applied in the model.</p

Cost-effectiveness results summary.

<p>Cost-effectiveness results summary.</p