The Grizzly, March 21, 2002

Wynton Marsalis Brings Down the House at Ursinus • The True History of St. Patrick\u27s Day • Music Series set for Berman Museum • Ursinus Women\u27s History Month Dedicated to Late Professor • Meistersingers to Perform at Ursinus College • Berman Museum of Art to Feature Hans Moller Retrospective • SERV and Campus Safety to the Rescue • The New Fad Drug that Might be a Thinly Veiled Disaster • Girls Lacrosse Starts out Strong after a Productive Southern Swinghttps://digitalcommons.ursinus.edu/grizzlynews/1510/thumbnail.jp

The Grizzly, April 25, 2002

Pesta Appeals College\u27s Action • O\u27Flaherty Speaks to Ursinus about Human Rights • Diverse and Abundant Research Continues • Sex for Sale: What Drives the Porn Industry? • Final Exam Schedule • Jon Volkmer Named Montgomery County Poet Laureate • Greek Week Change Bad: An Opinion • Commencement and Baccalaureate Speakers Announced • Hockey Intramurals • Family or no Family: That is the Question for Many Career Womenhttps://digitalcommons.ursinus.edu/grizzlynews/1515/thumbnail.jp

The Grizzly, April 18, 2002

From the B-52\u27s to the Beach Boys: Airband was a Huge Success • ProTheatre Stages History with Twilight: Los Angeles this Weekend • Students Rave About the Pat McGee Band in Concert • Adolph Reed to Deliver Pancoast Lecture • Fitness Week a Fitness Blast • Male Birth Control: Latest Medical Breakthrough? • Opinions: Greek Portrayal in Movies Demeaning, not True!; Parking Policy not Fun for Some Residents • Y100\u27s Caseyboy and his Crazy Stunts • The Letters and the Cane • Comparative Pricing Report: Self Tanners • Skin Cancer is not Your Friend • UC Women\u27s Rugby Making a Breakthrough in Women\u27s Sports • Workman\u27s Workouts Paying Off for Field Hockey • Baseball Team Winds Down Season Looking for Top Spot in Centennial Conference Playoffs • Erin Fitzgerald Named Centennial Conference Women\u27s Lacrosse Player of the Week • Dougherty Qualifies in 5000m for NCAA Championships • Another Flawless Season for Women\u27s Lacrosse to Lead Team to Second Consecutive Championship Title • UC Men\u27s LAX Stars: What are they up to Now? • Win, Loss, and Postponement for UC Softball as Season Winds Downhttps://digitalcommons.ursinus.edu/grizzlynews/1514/thumbnail.jp

The Grizzly, April 11, 2002

Students Impressed with the Tour of North Hall • The Dean\u27s Office Announces the Retirement of Martha Takats, Ray Schultz and Keith Hardman • For the Children: How Far is Too Far in Internet Censoring? • Spring is in the Air and so is Carmina Burana • Speakers for Commencement and Baccalaureate Announced • A Talented Night at Ursinus • Pat McGee Band to Perform at Ursinus • Trials and Tribulations of Greek Life • Softball Games Leading to a Good Season • Competition Gets Tough for UC Tennis • Glorious, but Winless • Ursinus Women\u27s Rugby Shows Well in First Tournament of Season • 7th Ranked Women\u27s Lacrosse Crushing The Competitionhttps://digitalcommons.ursinus.edu/grizzlynews/1513/thumbnail.jp

The Grizzly, February 14, 2002

Salt Lake City Says Hello to the 2002 Winter Olympics • Black History Month at Ursinus: How Diverse is the Campus? • Lorelei: Blast or Bust? • All About Enron: Latest in the Scandal • Parking on Campus: Will There be Enough? • Opinions: Is the Bookstore Slighting Us?; New Dance Studio Missing One Thing: Dancers; Women Drinking While Pregnant: Is That Acceptable? • Exclusive Interview with Jamie Kennedy, Host of The Jamie Kennedy Experiment • The Silver-Brown Dance Company Stomps the Night Away • Is Digital TV Coming to Your House? • Introducing the Wellness Center • Black History Month at Ursinus: The Truth • What the Class of 2002 can Expect in the Real World • UC Women\u27s B-Ball Chops Down Washington on Friday, but Kneels to Swarthmore on Sunday • Ursinus Seeks Women\u27s Golf Coach and Prospective Players • UC Invitational Huge Success for Bears • Men\u27s Basketball Clinches Play-off Berth With Two Dominating Wins! • UC Bears Make a Splash in the Pool, Being Out-Touched by a Strong Bryn Mawr Teamhttps://digitalcommons.ursinus.edu/grizzlynews/1507/thumbnail.jp

The Grizzly, October 25, 2001

Food and Fun at Family Day 2001 • UC Field Hockey Players React to Move from Division I to Division III • Phi Psi Promotes Breast Cancer Awareness Month with Pink Ribbon Fundraiser • Fall Fun and Friendship with UC Best Buddies • Truth About Dr. Fritz • Gay Straight Alliance Walks for AIDS Fund • First Year Student Coordinator Ed Gildea Helps Students Work to their Fullest Potential • Take Advantage of the Upcoming Internship Fair • Students Learn the Truth about Drinking • Opinions: Athletic Scholarships at Ursinus; Listen up Insurance Companies: Give me my Birth Control! • Stunned in Awe: It\u27s all in the Name • Birth Control Basics • Bears Take Down Wooster • UC Field Hockey Takes on The Capital • Bears Volleyball Falls into a Slump after Beating DeSales • Women\u27s Soccer Builds up Momentum to Beat Villa Julie • Veteran\u27s Day for UC Men\u27s Soccer • Penderghest and Dougherty Run to Bear Pack Victory! • Splish, Splash, UC is Back in a Flash • Outlook for 2002 Lacrosse • Ursinus Cheerleadinghttps://digitalcommons.ursinus.edu/grizzlynews/1498/thumbnail.jp

SARS-CoV-2, influenza A/B and respiratory syncytial virus positivity and association with influenza-like illness and self-reported symptoms, over the 2022/23 winter season in the UK: a longitudinal surveillance cohort

Background Syndromic surveillance often relies on patients presenting to healthcare. Community cohorts, although more challenging to recruit, could provide additional population-wide insights, particularly with SARS-CoV-2 co-circulating with other respiratory viruses. Methods We estimated the positivity and incidence of SARS-CoV-2, influenza A/B, and RSV, and trends in self-reported symptoms including influenza-like illness (ILI), over the 2022/23 winter season in a broadly representative UK community cohort (COVID-19 Infection Survey), using negative-binomial generalised additive models. We estimated associations between test positivity and each of the symptoms and influenza vaccination, using adjusted logistic and multinomial models. Results Swabs taken at 32,937/1,352,979 (2.4%) assessments tested positive for SARS-CoV-2, 181/14,939 (1.2%) for RSV and 130/14,939 (0.9%) for influenza A/B, varying by age over time. Positivity and incidence peaks were earliest for RSV, then influenza A/B, then SARS-CoV-2, and were highest for RSV in the youngest and for SARS-CoV-2 in the oldest age groups. Many test positives did not report key symptoms: middle-aged participants were generally more symptomatic than older or younger participants, but still, only ~ 25% reported ILI-WHO and ~ 60% ILI-ECDC. Most symptomatic participants did not test positive for any of the three viruses. Influenza A/B-positivity was lower in participants reporting influenza vaccination in the current and previous seasons (odds ratio = 0.55 (95% CI 0.32, 0.95)) versus neither season. Conclusions Symptom profiles varied little by aetiology, making distinguishing SARS-CoV-2, influenza and RSV using symptoms challenging. Most symptoms were not explained by these viruses, indicating the importance of other pathogens in syndromic surveillance. Influenza vaccination was associated with lower rates of community influenza test positivity

SARS-CoV-2, influenza A/B and respiratory syncytial virus positivity and 1 association with influenza-like illness and self-reported symptoms, over the 2022/23 winter season in the UK: a longitudinal surveillance cohort

Background Syndromic surveillance often relies on patients presenting to healthcare. Community cohorts, although more challenging to recruit, could provide additional population-wide insights, particularly with SARS-CoV-2 co-circulating with other respiratory viruses. Methods We estimated the positivity and incidence of SARS-CoV-2, influenza A/B, and RSV, and trends in self-reported symptoms including influenza-like illness (ILI), over the 2022/23 winter season in a broadly representative UK community cohort (COVID-19 Infection Survey), using negative-binomial generalised additive models. We estimated associations between test positivity and each of the symptoms and influenza vaccination, using adjusted logistic and multinomial models. Results Swabs taken at 32,937/1,352,979 (2.4%) assessments tested positive for SARS-CoV-2, 181/14,939 (1.2%) for RSV and 130/14,939 (0.9%) for influenza A/B, varying by age over time. Positivity and incidence peaks were earliest for RSV, then influenza A/B, then SARS-CoV-2, and were highest for RSV in the youngest and for SARS-CoV-2 in the oldest age groups. Many test positives did not report key symptoms: middle-aged participants were generally more symptomatic than older or younger participants, but still, only ~ 25% reported ILI-WHO and ~ 60% ILI-ECDC. Most symptomatic participants did not test positive for any of the three viruses. Influenza A/B-positivity was lower in participants reporting influenza vaccination in the current and previous seasons (odds ratio = 0.55 (95% CI 0.32, 0.95)) versus neither season. Conclusions Symptom profiles varied little by aetiology, making distinguishing SARS-CoV-2, influenza and RSV using symptoms challenging. Most symptoms were not explained by these viruses, indicating the importance of other pathogens in syndromic surveillance. Influenza vaccination was associated with lower rates of community influenza test positivity

Acute kidney injury in patients treated with immune checkpoint inhibitors

Background: Immune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI) has emerged as an important toxicity among patients with cancer. Methods: We collected data on 429 patients with ICPi-AKI and 429 control patients who received ICPis contemporaneously but who did not develop ICPi-AKI from 30 sites in 10 countries. Multivariable logistic regression was used to identify predictors of ICPi-AKI and its recovery. A multivariable Cox model was used to estimate the effect of ICPi rechallenge versus no rechallenge on survival following ICPi-AKI. Results: ICPi-AKI occurred at a median of 16 weeks (IQR 8-32) following ICPi initiation. Lower baseline estimated glomerular filtration rate, proton pump inhibitor (PPI) use, and extrarenal immune-related adverse events (irAEs) were each associated with a higher risk of ICPi-AKI. Acute tubulointerstitial nephritis was the most common lesion on kidney biopsy (125/151 biopsied patients [82.7%]). Renal recovery occurred in 276 patients (64.3%) at a median of 7 weeks (IQR 3-10) following ICPi-AKI. Treatment with corticosteroids within 14 days following ICPi-AKI diagnosis was associated with higher odds of renal recovery (adjusted OR 2.64; 95% CI 1.58 to 4.41). Among patients treated with corticosteroids, early initiation of corticosteroids (within 3 days of ICPi-AKI) was associated with a higher odds of renal recovery compared with later initiation (more than 3 days following ICPi-AKI) (adjusted OR 2.09; 95% CI 1.16 to 3.79). Of 121 patients rechallenged, 20 (16.5%) developed recurrent ICPi-AKI. There was no difference in survival among patients rechallenged versus those not rechallenged following ICPi-AKI. Conclusions: Patients who developed ICPi-AKI were more likely to have impaired renal function at baseline, use a PPI, and have extrarenal irAEs. Two-thirds of patients had renal recovery following ICPi-AKI. Treatment with corticosteroids was associated with improved renal recovery

Effectiveness of a national quality improvement programme to improve survival after emergency abdominal surgery (EPOCH): a stepped-wedge cluster-randomised trial

Background: Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to implement a care pathway to improve survival for these patients. Methods: We did a stepped-wedge cluster-randomised trial of patients aged 40 years or older undergoing emergency open major abdominal surgery. Eligible UK National Health Service (NHS) hospitals (those that had an emergency general surgical service, a substantial volume of emergency abdominal surgery cases, and contributed data to the National Emergency Laparotomy Audit) were organised into 15 geographical clusters and commenced the QI programme in a random order, based on a computer-generated random sequence, over an 85-week period with one geographical cluster commencing the intervention every 5 weeks from the second to the 16th time period. Patients were masked to the study group, but it was not possible to mask hospital staff or investigators. The primary outcome measure was mortality within 90 days of surgery. Analyses were done on an intention-to-treat basis. This study is registered with the ISRCTN registry, number ISRCTN80682973. Findings: Treatment took place between March 3, 2014, and Oct 19, 2015. 22 754 patients were assessed for elegibility. Of 15 873 eligible patients from 93 NHS hospitals, primary outcome data were analysed for 8482 patients in the usual care group and 7374 in the QI group. Eight patients in the usual care group and nine patients in the QI group were not included in the analysis because of missing primary outcome data. The primary outcome of 90-day mortality occurred in 1210 (16%) patients in the QI group compared with 1393 (16%) patients in the usual care group (HR 1·11, 0·96–1·28). Interpretation: No survival benefit was observed from this QI programme to implement a care pathway for patients undergoing emergency abdominal surgery. Future QI programmes should ensure that teams have both the time and resources needed to improve patient care. Funding: National Institute for Health Research Health Services and Delivery Research Programme