Analysis of the Spectral Energy Distributions of Fermi bright blazars

Blazars are a small fraction of all extragalactic sources but, unlike other objects, they are strong emitters across the entire electromagnetic spectrum. In this study we have conducted a detailed investigation of the broad-band spectral properties of the gamma-ray selected blazars of the Fermi-LAT Bright AGN Sample (LBAS). By combining the accurately estimated Fermi gamma-ray spectra with Swift, radio, NIR-Optical and hard-X/gamma-ray data, collected within three months of the LBAS data taking period, we were able to assemble high-quality and quasi-simultaneous Spectral Energy Distributions (SED) for 48 LBAS blazars.Comment: 6 pages, 8 figures, "2009 Fermi Symposium", "eConf Proceedings C091122

Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography

By using the Inverted Chirality Columns Approach (ICCA) we have developed an enantioselective UHPSFC method to determine the enantiomeric excess (ee) of (-)-Δ(9)-THC in medicinal marijuana (Bedrocan®). The ee was high (99.73%), but the concentration of the (+)-enantiomer (0.135%) was not negligible, and it is worth a systematic evaluation of bioactivity

Study of microwave/gamma-ray properties for Fermi-LAT bright AGNs

Blazars are a small fraction of all extragalactic sources but, unlike other objects, they are strong emitters across the entire electromagnetic spectrum. Recent data in the microwave region of the electromagnetic spectrum have become available to allow for systematic studies of blazars over large cosmological volumes. This frequency band is indeed particularly suited for the selection of blazars since at these frequencies the contamination from radio extended components with steep spectra is no longer present and the emission from the accretion process is negligible. During the first 3 months of scientific operations Fermi-LAT detected 106 bright, high-galactic latitude (| b |> 10 deg) AGNs with high significance. In this study we investigate the possible relations between the microwave and the gamma-ray emissions for Fermi-LAT detected AGNs belonging to WMAP 5th year bright source catalog.Comment: 3 pages, 3 ps figures, "2009 Fermi Symposium", "eConf Proceedings C091122

Chiral azole derivatives. 4. Enantiomers of bifonazole and related antifungal agents: synthesis, configuration assignment, and biological evaluation

The first synthesis, full stereochem. characterization and biol. evaluation of of both enantiomers of bifonazole (I) and the related II, III and IV are described

A new approach to geobarometry by combining fluid inclusion and clumped isotope thermometry in hydrothermal carbonates

This study presents a new approach to geobarometry by combining fluid inclusion and clumped isotope (\u39447) thermometry on carbonate minerals. The offset between homogenisation temperatures of primary fluid inclusions with known composition and \u39447 temperatures of the host mineral allows a direct estimation of the fluid pressure at the time of carbonate crystallisation. This new approach is illustrated via hydrothermal dolomite samples from the Variscan foreland fold-and-thrust belt in northern Spain. Clumped isotope analyses yield crystallisation temperatures (107\u2013168\ub0C) which are higher than homogenisation temperatures in corresponding samples (95\u2013145\ub0C). The calculated pressure values suggest that dolomitizing fluids were overpressured during formation of zebra dolomite textures, whereas lower pressures are obtained for dolomite cement from breccia textures. This new approach to geobarometry opens up the possibility of estimating the pressure of carbonate crystallisation and has potential applications in diagenesis, basin analysis, ore geology and tectonics

Dynamic HPLC on chiral stationary phases: a powerful tool for the investigation of stereomutation processes

Dynamic HPLC on enantioselective stationary phases has become a well-established technique to investigate chiral molecules with internal motions that result in stereoinversion and occur on the time scale of the separation process. Kinetic parameters for the on-column interconversion phenomena can be extracted from experimental peak profiles by computer simulation or by direct calculation methods. The technique has been used in a wide range of temperatures and is complementary in scope to dynamic NMR spectroscopy

Conformation, Stereodynamics, and Chiral Separation of the Rotational Enantiomers of Hindered Naphthyl Ketones.

A no. of α-naphthyl ketones bearing a Me group in the 2-position of the naphthalene ring adopt a twisted conformation, yielding a pair of rotational enantiomers owing to the restricted rotation about the naphthalene-carbonyl bond. NOE measurements indicate that the twisted conformation is almost exactly orthogonal. The enantiomerization barriers were detd. by variable-temp. dynamic NMR spectroscopy, with monitoring of either the anisochronous signals of prochiral substituents or the pairs of signals of the enantiomers themselves, made detectable at low temp. by the addn. of a chiral auxiliary agent. The free energies of activation cover a range of 8-20 kcal mol-1, depending on the steric hindrance of the various acyl groups. Mol. mechanics calcns. suggest that enantiomerization occurs through a pathway where the carbonyl function passes position 2, rather than position 8, of the naphthalene ring. In the case of a 1,5-disubstituted acyl deriv. contg. the tert-Bu moiety (I), the expected meso and racemic conformers were both obsd. in soln., whereas only the meso structure was present in the crystals (obtained by the usual slow crystn. procedure) as judged by CP MAS solid-state NMR spectra and by low-temp. soln. spectra in nonequil. conditions. Low-temp. (-15°) chiral high-performance liq. chromatog. (LT-ChirHPLC) was employed to sep., identify, and det. the yields of the two enantiomers of 2-methyl-1-naphthyl tert-Bu ketone (II) as well as the three conformers (meso, SS, and RR) of I. The low-temp. CD spectra of the rotational enantiomers of II and I were obtained and the abs. configurations assigned by connecting online a CD spectrometer to the LT-ChirHPLC app. Resp., the S and SS configurations were found to correspond to the conformational enantiomers with the shorter retention times [(R,R)-DAC-DNB column]

Conformational Assignement, Absolute Configuration and Chiral Separation of all the Stereoisomers Created by the Combined Presence of Stereogenic Centers and Stereogenic Conformational Axes in a Highly Hindered 1,5-Naphthyl Sulfoxide.

The presence of two stereogenic centers and of two stereogenic conformational axes in 2,6-dimethyl-1,5-bis(2-methyl-2-propylsulfinyl)naphthalene (1) entails the existence of 10 stereoisomers. In particular, both the meso form (1a) and the racemic form (1b) are constituted by three atropisomers; in the case of the latter (1b) each of them entails a pair of enantiomers (total of six species), whereas owing to the symmetry only one of the three atropisomers of the meso form (1a) yields a pair of enantiomers (a total of four species). Despite the low conformational interconversion barrier (18.5 kcal/mol) all of them have been separated by low temperature (-45°C) chiral HPLC. Their configurational and conformational assignment has been achieved by a combined use of NMR (both in solution and solid state) and on-line CD-detected chiral HPLC. The single crystal X-ray diffraction yielded the absolute configuration of one of the stereoisomers ((ZR,ER)-1b) from which all the others could be obtained by CD relationship

Investigation of corrosion-erosion phenomena in the primary cooling system of SPIDER

SPIDER dedicated cooling plant has to remove up to 10 MW thermal power from in-vessel components and auxiliary systems. The circuit is characterized by three main heat transfer systems: primary, secondary and tertiary systems. The primary system is made of four circuits, with only three operating so far, these are called PC01, PC02 and PC03. These three circuits respectively cool SPIDER power supplies and the beam source components using ultrapure water. During 2019 SPIDER experimental campaigns, it was observed that electrical resistivity of water degraded considerably and more quickly (∼25 MΩ cm h−1 in PC01) than estimated by design. To overcome this issue, water had to be restored very frequently to maintain the desired characteristics and avoid possible detrimental leakage currents throughout the circuit. The reason for this severe water degradation has to be better understood before issues such as abrupt failures may arise. This work presents a preliminary analysis of the two main circuits (PC01 and PC02) where an estimation of water degradation induced by general corrosion of stainless steels and copper components was made. This preliminary estimation showed that PC01 could be more prone to general corrosion than PC02; however, the rate of water conductivity increase was 5.3 times smaller than that observed during experiments in 2019 and 2020