Lichen Planus Pigmentosus with Blaschkoid Distribution

N

Molluscum Contagiosum Over Tattooed Skin

N

Molluscum Contagiosum Over Tattooed Skin

N

Dermatitis artefacta: a disease with difficult diagnosis

La dermatitis artefacta o facticia es una patología de base psicopatológica que usa la piel como modo de expresión, al ser la persona incapaz de verbalizar su malestar interno. Presentamos un caso de esta patología en una mujer de 34 años con lesiones ampollosas en región peribucal de difícil diagnóstico. Este tipo de pacientes acuden en primer lugar a la consulta del dermatólogo constituyendo un reto diagnóstico, ya que niegan cualquier tipo de alteración psíquica. La variabilidad clínica ocasiona gran dificultad diagnóstica y requiere un manejo multidisclipinar y consumo excesivo de recursos y tiempo.Factitious dermatitis is a condition of psychopathological basis using the skin as a means of expression, being the person unable to verbalize their internal unrest. We present a case of this disease in a 34 year old woman with bullous lesions in perioral region are difficult to diagnose. These patients come first consulting dermatologist to constitute a diagnostic challenge because they deny any mental impairment. The clinical variability brings great diagnostic difficulty and requires multidisclipinar handling and excessive consumption of resources and time

Zosteriform morphea: a exceptional pattern

La morfea (esclerodermia localizada) es una enfermedad de causa desconocida en la que se produce edema, esclerosis, induración y atrofia de la piel con desaparición de los pliegues cutáneos y de los folículos pilosos. Presentamos un paciente con una morfea de patrón clínico excepcional

Skin lesions with perimenstrual exacerbation: a diagnosis challenge

La dermatitis herpetiforme (DH) es una dermatosis ampollosa autoinmune subepidérmica de curso crónico, considerada como la expresión cutánea de la intolerancia al gluten. Forma parte de un abanico de patologías que tienen en común la sensibilidad a este componente, aunque solo un bajo porcentaje de pacientes desarrollará un cuadro de enteropatía sensible al gluten con malabsorción clínica. Se manifiesta mediante una erupción papulovesicular pruriginosa de predominio en superficies de extensión y nalgas. El estudio inmunológico puede en algunos casos no ser específico, pero se considera patognomónico los depósitos granulares de IgA en la unión dermoepidérmica. El tratamiento se basa en la dieta estricta libre de gluten (DSG) y el uso adicional de dapsona para las manifestaciones cutáneas. Presentamos dos casos de pacientes con brotes de dermatitis polimorfa e inespecífica de años de evolución y predominio perimenstrual, que precisaron múltiples tratamientos y pruebas complementarias hasta la positividad y confirmación del diagnóstico de DH.Dermatitis herpetiformis (DH) is an autoinmune subepidermal bullous dermatosis of chronic course, considered the cutaneous expression of gluten intolerance. It´s part of a range of pathologies that have in common the sensitivity to this component, but only a small percentage of patients develop gluten sensitive enteropathy with clinical malabsorption. The clinic is manifested by a predominantly papulovesicular rash pruritic, in extension surfaces and buttocks. Immuno-pathological study may not be specific in some cases, but it´s considered pathognomonic the presence of IgA granular deposits in the dermoepidermal junction. Treatment is based on strict gluten free diet (GFD) and the additional use of dapsone for cutaneous manifestations. We present two patients with polymorphous and unspecific dermatitis for years and perimenstrual outbreaks, which required multiple treatments and laboratory tests to confirm the diagnosis of DH

Biocompatibility and Cellular Behavior of TiNbTa Alloy with Adapted Rigidity for the Replacement of Bone Tissue

In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20–30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance)

Nevoid hyperkeratosis of the nipple and the areola

A 25-year-old woman presented to our dermatology unit with progressive diffuse thickening of the both areolas. A skin biopsy was taken from the right areola showing irregular filiform acanthosis with elongation and anastomosis of rete ridges, irregular orthokeratotic hyperkeratosis, pseudocyst formation, and hyperpigmentation of the basal layer. The cause of nevoid hyperkeratosis of the nipple and areola is unknown. Eighty percent of cases occur in women and are often manifested during puberty or pregnancy. The disease may also occur in men receiving hormonal therapy. There is no uniformly effective treatment. Dermatologists, gynecologists, and general practitioners have an important part to play in recognizing this condition that may be underdiagnosed because of lack of awareness

Nevoid hyperkeratosis of the nipple and the areola

A 25-year-old woman presented to our dermatology unit with progressive diffuse thickening of the both areolas. A skin biopsy was taken from the right areola showing irregular filiform acanthosis with elongation and anastomosis of rete ridges, irregular orthokeratotic hyperkeratosis, pseudocyst formation, and hyperpigmentation of the basal layer. The cause of nevoid hyperkeratosis of the nipple and areola is unknown. Eighty percent of cases occur in women and are often manifested during puberty or pregnancy. The disease may also occur in men receiving hormonal therapy. There is no uniformly effective treatment. Dermatologists, gynecologists, and general practitioners have an important part to play in recognizing this condition that may be underdiagnosed because of lack of awareness