Gingival inflammation, enamel defects, and tooth sensitivity in children with amelogenesis imperfecta: a case-control study

Gingival conditions and tooth sensitivity of young patients with amelogenesis imperfecta lack in depth studies. This case-control study aimed to compare (1) the gingival inflammation, the presence of enamel defects, and tooth sensitivity in young patients with and without amelogenesis imperfecta and (2) to investigate if any difference exists between subtypes of amelogenesis imperfecta. Methodology: We compared forty-two participants with amelogenesis imperfecta with forty-two controls matched for age, gender, and the number of examined sites. Based on interview, clinical examination, and intraoral photography, we collected data on periodontal conditions, enamel defects and the presence of tooth sensitivity. Comparison tests were performed to investigate if any difference existed between cases and controls; and among cases, between the different subtypes of amelogenesis imperfecta. We performed a post-hoc analysis for any significant difference observed. Results: We observed more gingival inflammation, enamel defects and tooth sensitivity among cases (all p<0.05). Participants with hypocalcified amelogenesis imperfecta had more gingival inflammation, enamel defects, and tooth sensitivity than patients with the hypoplastic and hypomature subtypes (all p<0.05). After adjustment for dental plaque, gingival inflammation was associated with the presence of amelogenesis imperfecta (OR (95%CI) = 1.14 (1.05; 1.24). p<0.01). Conclusion: Gingival inflammation, enamel defect and tooth sensitivity are more frequently observed among young patients with amelogenesis imperfecta, and more specifically among children with the hypocalcified subtype

Document, create and translate knowledge: the mission of ReFORM, the Francophone IOC Research Centre for Prevention of Injury and Protection of Athlete Health

The International Olympic Committee (IOC) has supported athletes’ health protection by funding Research Centres dedicated to prevention and treatment of sports-related injuries and illnesses. After establishing four centres in 2009, the IOC Research Centres network expanded to 9 Institutions in 2014 and the 2019 round recognised 11 centres. Here we introduce ReFORM — an international French-speaking network of five institutions.Peer reviewe

Elements of morphology: Standard terminology for the teeth and classifying genetic dental disorders

Dental anomalies occur frequently in a number of genetic disorders and act as major signs in diagnosing these disorders. We present definitions of the most common dental signs and propose a classification usable as a diagnostic tool by dentists, clinical geneticists, and other health care providers. The definitions are part of the series Elements of Morphology and have been established after careful discussions within an international group of experienced dentists and geneticists. The classification system was elaborated in the French collaborative network 'TÊTECOU' and the affiliated O-Rares reference/competence centers. The classification includes isolated and syndromic disorders with oral and dental anomalies, to which causative genes and main extraoral signs and symptoms are added. A systematic literature analysis yielded 408 entities of which a causal gene has been identified in 79%. We classified dental disorders in eight groups: dental agenesis, supernumerary teeth, dental size and/or shape, enamel, dentin, dental eruption, periodontal and gingival, and tumor-like anomalies. We aim the classification to act as a shared reference for clinical and epidemiological studies. We welcome critical evaluations of the definitions and classification and will regularly update the classification for newly recognized conditions

Les Allergies respiratoires (diagnostic, conséquences cliniques et prise en charge thérapeutique)

PARIS7-Odontologie (751062104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Ruptures prématurées des membranes avant 24 SA (issues obstétricales et pédiatriques)

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Patients dysmorphiques : une relecture des signes cliniques mineurs vers un diagnostic

Le chirurgien-dentiste peut se sentir démuni face à une maladie rare : (a) difficultés diagnostiques, (b) complexité thérapeutique, (c) questionnement des parents, sont les trois obstacles majeurs que nous avons à résoudre pour mener à bien notre thérapeutique. Même si la génétique a fait d’énormes progrès ces dernières années, c’est avant tout les connaissances cliniques qui nous orientent vers le diagnostic. Certains syndromes présentent des signes très discrets qui seuls peuvent paraître anodins mais qui, pris ensemble, définissent une entité pathologique. Savoir où trouver ces signes et les reconnaître est donc le premier défi à relever

Le traitement des classes II, division 2, chez l'adulte

Les formes cliniques des malocclusions de la classe II, division 2, sont nombreuses. Leur traitement chez l'adulte, compte tenu des particularités de ce dernier : – âge et absence de croissance ; – passé dentaire ; – pathologies associées, est souvent complexe et pluridisciplinaire. Il peut faire appel notamment à la chirurgie orthognathique. Dans cet article, nous passons en revue les stratégies thérapeutiques chez trois patients adultes, reflétant la diversité des situations cliniques rencontrées

Dysmorphic Patients: A Review of Minor Clinical Signs Leading to a Diagnosis

The dental surgeon can feel inadequate when confronted with a rare disease: (a) difficult diagnosis, (b) therapeutic complexity, (c) and questioning by the parents, are three major obstacles that we have to overcome in order to carry out our therapy. Even if the field of genetics has made major advances during the last few years, it is clinical knowledge, above all, that leads us to a diagnosis. Certain syndromes present with very subtle signs which alone can appear trivial but which, taken together, defines a pathological entity. To know or to discover these signs and to recognize them is therefore the first challenge

Prion versus Doppel Protein Misfolding: New Insights from Replica-Exchange Molecular Dynamics Simulations

The doppel (Dpl) and prion (PrP) proteins share a very similar fold (three helices and two short beta-strands), while they differ significantly in sequence (only 25% homologous) and in disease-related beta-rich conformations that occur for PrP only. In a previous study [Baillod, P., et al. (2012) Biochemistry 51, 9891-9899], we investigated the misfolding and rare, beta-rich folds of monomeric PrP with replica-exchange molecular dynamics (REMD) simulations. In the work presented here, we perform analogous simulations for Dpl with the aim of comparing the two systems and characterizing possible specificities of PrP for misfolding and amyloidogenesis. Our extensive simulations, which allow us to overcome high energy barriers via the REMD approach, sample several beta-rich folds, some of which are stable at room temperature, for both proteins. Per residue secondary structure propensities reveal that novel beta-sheets of Dpl and PrP are formed by amino acids belonging to the helices that are the least stable in the respective native structure, H1 for Dpl and H2 and H3 for PrP, in agreement with experimental data. Using a specific clustering method that allows discrimination against different beta-strand arrangements, seven beta-rich folds could be characterized for PrP and five for Dpl, which are clearly distinct and share only one single similar fold. A major difference between the two proteins is found in the free energy barriers leading to misfolded structures: they are approximately 3 times higher for Dpl than for PrP. This suggests that the difference in amyloidogenic behavior between PrP and Dpl might be due to kinetic reasons