Chemical composition and in vitro dry matter digestibility of lichens

The chemical composition and in vitro dry matter digestibility of 45 samples of different species of lichen are reported. Mean content (g/100 g dry matter) of the main nutrients was: crude protein 4.2, crude fat 3.2, crude fibre 16.6, ash 1.9, Ca 0.15, P 0.09, Mg 0.05, K 0.13, Na 0.035, S 0.07. The content of microminerals (mg/kg dry matter) was: Cu 2.5, Mo 0.11, Zn 27.2, Se 0.12, Fe 898, Mn 154. The mean in vitro dry matter digestibility was 35%. However, the in vitro method do underestimate the dry matter digestibility of lichens. Stereocaulon spp. showed higher levels of crude protein, P, S, Cu and Mo than Cetraria spp. and Cladonia spp. Cetraria nivalis showed higher digestibility and contained more NFE, ash, Ca, Mg, but less crude fibre than Cladonia stellaris. Lichens contained less amounts of most nutrients compared with grasses (Fig. 1), exept for crude fat, NFE, Se and Fe.Kjemisk innhald og in vitro fordøyelsesgrad av lav.Abstract in Norwegian / Samandrag: Kjemisk innhald og in vitro fordøyelsesgrad av tørrstoffet er bestemt i 45 prøver av beitelav frå to stader i Sør-Noreg. Middel innhald (g/100g tørrstoff) av følgjande næringsstoff var: protein 4.2, feitt 3.2, trevlar 16.6, oske 1.9, kalsium 0.15, fosfor 0.09, magnesium 0.05, kalium 0.13, natrium 0.035, svovel 0.07. Innhaldet (mg/kg tørrstoff) av mikronæringsstoffa var: kopar 2.5, molybden 0.11, sink 27.2, selen 0.12, jern 898 og mangan 154. Den midlare fordøyelsesgraden av tørrstoffet i lav-prøvene var 35%, men in vitro fordøyelsesanalyser undervurderer fordøyelsesgraden av lav. Det var ein stor variasjon mellom dei ulike lavartane for dei fleste næringsstoffa og fordøyelsesgraden. Stereocaulon spp. inneheldt meir protein, fosfor, svovel, kopar og molybden enn Cetraria spp. og Cladonia spp. Gulskinn hadde høgare fordøyelsesgrad, og innehaldet av NFE, oske, kalsium og magnesium var høgre enn i kvitkrull, medan trevleinnhaldet var størst i kvitkrull. Lav inneheldt mindre av dei fleste næringsstoffa samanlikna med gras, unnateke feitt, NFE, selen og jern.Jäkälien kemiallinen sisältö ja in vitro sulatuksen aste.Abstract in Finnish / Yhteenveto: Kuiva-aineen kemiallinen sisalto ja in vitro sulatusaste on mååråtty 45:ssa kokeessa tårkeistå laidunjåkålistå kahdella paikkakunnalla Etelå — Norjassa. Keskimååråinen sisalto (g/100 g kuiva-ainetta) seuraavissa ravintoaineissa oli: valkuaisainetta 4.2, rasvaa 3.2, kuituja 16.6, tuhkaa 1.9, kalsiumia 0.15, fosforia 0.09, magnesiumia 0.05, kaliumia 0.13, natriumia 0.035, rikkia 0.07. Hivenainepitoisuus (mg/kg kuiva-ainesta) oli: kuparia 2.5, molybdeenia 0.11, sinkkia 27.2, seleeniå 0.12, rautaa 898 ja mangaania 154. Kuiva-aineiden keskimååråinen sulatusaste jåkålåkokeissa oli 35%. Eri jåkålåajien vålillå oli suuri vaihtelu eisimmissa ravintoaineissa ja sulatusasteessa. Stereocaulon spp. sisålsi enemmån valkuaisainetta, fosforia, rikkiå kuparia ja typettomien uuteaineiden, molybdeeniå kuin Cetraria spp. ja Cladonia spp. Lapalumijåkålållå oli korkeampi sulatusaste, ja tuhkan, kalsiumin ja magnesiumin sisålto oli korkeampi kuin Cladonia alpestris-jäkälässä, mutta kuitusisålto oli korkein Cladonia alpestris-jäkälässä. Jåkålå sisålsi våhemmån useimmista ravintoaineista ruohoon verrattuna lukuunottamatta rasvaa, typettomiå uuteaineita, seleeniå ja rautaa

Radiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke

The aim of this study was to assess whether adjuvant treatment of breast cancer (BC) affects the risk of stroke, and to explore radiation targets and fraction doses regarding risk and location of stroke. In a Swedish BC cohort diagnosed during 1970–2003, we carried out a nested case–control study of stroke after BC, with relevant details extracted from medical records. The odds ratio (OR) for radiotherapy (RT) vs that of no RT did not differ between cases and controls (OR=0.85; confidence interval, CI=0.6–1.3). Radiotherapy to internal mammary chain (IMC) and supraclavicular (SCL) lymph nodes vs that of no RT was associated with a higher, although not statistically significant, risk of stroke (OR=1.3; CI=0.8–2.2). In a pooled analysis, RT to IMC and SCL vs the pooled group of no RT and RT to breast/chest wall/axilla (but not IMC and SCL), showed a significant increase of stroke (OR=1.8; CI=1.1–2.8). There were no associations between cancer laterality, targets of RT, and location of stroke. The radiation targets, IMC and SCL, showed a statistically significant trend for an increased risk of stroke with daily fraction dose. Our finding of a target-specific increased risk of stroke and a dose-response relationship for daily fraction dose, indicate that there may be a causal link between RT to the IMC and SCL and risk of stroke

Effekt av rødkløverbeite eller botanisk allsidig beite på kvalitetsegenskaper hos melk i økologisk drift

Et kontinuerlig beiteforsøk med 3 perioder à 3 uker ble gjennomført med 16 NRF-kyr i midtlaktasjonen. Målsetningen var å sammenligne melkequalitet når kyrne beitet rødkløvergras (RB) eller botanisk allsidig beite (AB). beitetype hadde ingen effekt på ytelse, melkas fettinnhold eller proteininnhold. Kyr som beitet RB hadde en høyere andel av fettsyrene C18:0 (22.41 vs. 9.96, P<0.05) og C18:1t11 (0.58 vs. 0.44 g/100g FAME, P<0.05) og lavere andel C16:0 (27.83 vs. 30.92, P<0.05) i melkefettet sammenlignet med kyr som beitet AB. Innholdet av alfatokoferol var høyere i melk fra RB enn AB (3.01 vs. 2.64 µg/ml, P<0.05). Den oksidative stabiliteten av melkas lipider ble bare i mindre grad påvirket av beitetype

Effect of pasture botanical composition on milk quality in organic production

A continuous grazing experiment with three measurement periods, 3 weeks each, was conducted with 16 Norwegian Red dairy cows in mid lactation to compare milk quality when grazing red clover-grass (R) or botanical diverse pasture (D). The cows were offered either R or D from the start of grazing season in mid May until beginning of September 2008. Milk yield was measured and milk samples were collected in the last week in each period (end of June, beginning of August and end of August). Pasture type had no effect on milk yield and milk content of fat or protein. Cows grazing R had higher proportion of the fatty acids C18:0 (22.41 vs. 9.96, P<0.05) and C18:1t11 (0.58 vs. 0.44 g/100g FAME, P<0.05) and lower proportion of C16:0 (27.83 vs. 30.92, P<0.05) in their milk fat than the cows grazing D. The milk content of α-tocopherol was higher in milk from R than D (3.01 vs. 2.64 μg/ml,P<0.05). The oxidative stability of the milk lipids were only minor affected by pasture typ

Risk of coronary stenosis after adjuvant radiotherapy for breast cancer

Purpose Adjuvant radiotherapy (RT) for breast cancer is associated with an increased risk of ischemic heart disease. We examined the risk of coronary artery stenosis in a large cohort of women with breast cancer receiving adjuvant RT. Methods A cohort of women diagnosed with breast cancer between 1992 and 2012 in three Swedish health care regions (n = 57,066) were linked to the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) to identify women receiving RT who subsequently underwent a percutaneous coronary intervention (PCI) due to coronary stenosis. Cox regression analyses were performed to examine risk of a coronary intervention and competing risk analyses were performed to calculate cumulative incidence. Results A total of 649 women with left-sided breast cancer and 494 women with right-sided breast cancer underwent a PCI. Women who received left-sided RT had a significantly higher risk of a PCI in the left anterior descending artery (LAD) compared to women who received right-sided RT, hazard ratio (HR) 1.44 (95% confidence interval [CI] 1.21-1.77, p < 0.001). For the proximal, mid, and distal LAD, the HRs were 1.60 (95% CI 1.22-2.10), 1.38 (95% CI 1.07-1.78), and 2.43 (95% CI 1.33-4.41), respectively. The cumulative incidence of coronary events at 25 years from breast cancer diagnosis were 7.0% in women receiving left-sided RT and 4.4% in women receiving right-sided RT. Conclusion Implementing and further developing techniques that lower cardiac doses is important in order to reduce the risk of long-term side effects of adjuvant RT for breast cancer.Peer reviewe

Risk of ischemic heart disease after radiotherapy for ductal carcinoma in situ

The use of adjuvant radiotherapy (RT) in the management of ductal carcinoma in situ (DCIS) is increasing. Left-sided breast irradiation may involve exposure of the heart to ionising radiation, increasing the risk of ischemic heart disease (IHD). We examined the incidence of IHD in a population-based cohort of women with DCIS. The Breast Cancer DataBase Sweden (BCBase) cohort includes women registered with invasive and in situ breast cancers 1992-2012 and age-matched women without a history of breast cancer. In this analysis, 6270 women with DCIS and a comparison cohort of 31,257 women were included. Through linkage with population-based registers, data on comorbidity, socioeconomic status and incidence of IHD was obtained. Hazard ratios (HR) for IHD with 95% confidence intervals (CI) were analysed. Median follow-up time was 8.8 years. The risk of IHD was not increased for women with DCIS versus women in the comparison cohort (HR 0.93; 95% CI 0.82-1.06), after treatment with radiotherapy versus surgery alone (HR 0.77; 95% CI 0.60-0.98) or when analysing RT by laterality (HR 0.85; 95% CI 0.53-1.37 for left-sided versus right-sided RT). The risk of IHD was lower for women with DCIS allocated to RT compared to non-irradiated women and to the comparison cohort, probably due to patient selection. Comparison of RT by laterality did not show any over-risk for irradiation of the left breast.Peer reviewe

Serum Calcium and the Risk of Breast Cancer: Findings from the Swedish AMORIS Study and a Meta-Analysis of Prospective Studies

To investigate the association between serum calcium and risk of breast cancer using a large cohort and a systematic review with meta-analysis. From the Swedish Apolipoprotein Mortality Risk (AMORIS) Study we included 229,674 women who had baseline measurements of serum total calcium and albumin. Multivariable Cox regression was used to assess the association between total and albumin-corrected calcium and breast cancer risk. For the systematic review, an electronic search of MEDLINE and EMBASE databases was performed to identify other prospective cohorts assessing the relationship between serum calcium and breast cancer risk. We pooled the results of our AMORIS cohort with other eligible studies in a meta-analysis using a random effects model. I² test was used to assess heterogeneity. In the AMORIS study, 10,863 women were diagnosed with breast cancer (mean follow-up: 19 years). We found an inverse association between total serum calcium and breast cancer when comparing the fourth quartile to the first quartile (HR: 0.94, 95% CI: 0.88-0.99, p value for trend 0.04) and similar results using albumin-corrected calcium. In the systematic review, we identified another two prospective cohorts evaluating pre-diagnostic serum total calcium and breast cancer. Combining these studies and our findings in AMORIS in a meta-analysis showed a protective effect of serum calcium against breast cancer, with a summary RR of 0.80 (95% CI: 0.66-0.97). No substantial heterogeneity was observed. Our findings in AMORIS and the meta-analysis support an inverse association between serum calcium and breast cancer risk, which warrants mechanistic investigations

A latent class model for competing risks

Survival data analysis becomes complex when the proportional hazards assumption is violated at population level or when crude hazard rates are no longer estimators of marginal ones. We develop a Bayesian survival analysis method to deal with these situations, on the basis of assuming that the complexities are induced by latent cohort or disease heterogeneity that is not captured by covariates and that proportional hazards hold at the level of individuals. This leads to a description from which risk-specific marginal hazard rates and survival functions are fully accessible, 'decontaminated' of the effects of informative censoring, and which includes Cox, random effects and latent class models as special cases. Simulated data confirm that our approach can map a cohort's substructure and remove heterogeneity-induced informative censoring effects. Application to data from the Uppsala Longitudinal Study of Adult Men cohort leads to plausible alternative explanations for previous counter-intuitive inferences on prostate cancer. The importance of managing cardiovascular disease as a comorbidity in women diagnosed with breast cancer is suggested on application to data from the Swedish Apolipoprotein Mortality Risk Study. Copyright © 2017 John Wiley & Sons, Ltd