3,386 research outputs found
An algorithm for feedback linearization
AbstractPrevious methods for exact linearization by feedback have relied on solving Frobenius systems of partial differential equations of dimensions equal to the Kronecker indices. We will describe an algorithm whereby one may find the linearizing feedback for any controlable linearizable system having distinct Kronecker indices with p-controls by purely algebraic calculations and integration of at most p one-dimensional Frobenius systems. The paper concludes with a concrete example considered by Hunt-Su-Meyer in their paper [3]
The Neuroscience Information Framework: A Data and Knowledge Environment for Neuroscience
With support from the Institutes and Centers forming the NIH Blueprint for Neuroscience Research, we have designed and implemented a new initiative for integrating access to and use of Web-based neuroscience resources: the Neuroscience Information Framework. The Framework arises from the expressed need of the neuroscience community for neuroinformatic tools and resources to aid scientific inquiry, builds upon prior development of neuroinformatics by the Human Brain Project and others, and directly derives from the Society for Neuroscience’s Neuroscience Database Gateway. Partnered with the Society, its Neuroinformatics Committee, and volunteer consultant-collaborators, our multi-site consortium has developed: (1) a comprehensive, dynamic, inventory of Web-accessible neuroscience resources, (2) an extended and integrated terminology describing resources and contents, and (3) a framework accepting and aiding concept-based queries. Evolving instantiations of the Framework may be viewed at http://nif.nih.gov, http://neurogateway.org, and other sites as they come on line
The Ursinus Weekly, February 16, 1953
Dean\u27s Office reveals list of 76 students • Elections for May queen, scheduled for Wednesday • Frosh reps given charge on Color Day • Rules revealed for Alpha Psi • Male quartet to sing for PTA, February 19 • Rules clarified at senate meeting • Y dinner held; SRC to conduct seminar tonight • Janet Glaser crowned queen of freshman dance, Friday • Junior class begins casting for original musical show • Sororities choose dinner dance clubs • Seniors make plans for this weekend • Hudock tells pre-med society about heart ills • Sun Oil pres. speaks tonight • Music Club plans tour • Editorials: Plea to 57 students; Mountains out of molehills • WAA show merits good comments • Newman convention to be held • Letters to the editor • Canterbury Club holds dinner • Florida affords adventure for venturesome trekking trio • J. Alexander \u2701 is one of Boy Scout founders • An old Ursinus institution perpetuated by Grecian gods • Girls\u27 court team hands Beaver double defeat • Swarthmore upsets Bears despite Herb Knull\u27s 28 • Blue Hens defeat Bears with late surge, 83-52 • U. of P. defeats badminton team • Duryea and Hobson victorious • Wrestlers bounce Muhlenberg 21-9 • Delaware beats grapplers 24-8; Dawkins wins again • Music room closed • Chi Alpha to hear speaker • IRC to sponsor collection for flood reliefhttps://digitalcommons.ursinus.edu/weekly/1512/thumbnail.jp
Linking goniometer measurements to hyperspectral and multi-sensor imagery for retrieval of beach properties and coastal characterization
In June 2011, a multi-sensor airborne remote sensing campaign was flown at the Virginia Coast Reserve Long Term Ecological Research site with coordinated ground and water calibration and validation (cal/val) measurements. Remote sensing imagery acquired during the ten day exercise included hyperspectral imagery (CASI-1500), topographic LiDAR, and thermal infra-red imagery, all simultaneously from the same aircraft. Airborne synthetic aperture radar (SAR) data acquisition for a smaller subset of sites occurred in September 2011 (VCR\u2711). Focus areas for VCR\u2711 were properties of beaches and tidal flats and barrier island vegetation and, in the water column, shallow water bathymetry. On land, cal/val emphasized tidal flat and beach grain size distributions, density, moisture content, and other geotechnical properties such as shear and bearing strength (dynamic deflection modulus), which were related to hyperspectral BRDF measurements taken with the new NRL Goniometer for Outdoor Portable Hyperspectral Earth Reflectance (GOPHER). This builds on our earlier work at this site in 2007 related to beach properties and shallow water bathymetry. A priority for VCR\u2711 was to collect and model relationships between hyperspectral imagery, acquired from the aircraft at a variety of different phase angles, and geotechnical properties of beaches and tidal flats. One aspect of this effort was a demonstration that sand density differences are observable and consistent in reflectance spectra from GOPHER data, in CASI hyperspectral imagery, as well as in hyperspectral goniometer measurements conducted in our laboratory after VCR\u2711
The Ursinus Weekly, January 12, 1953
Petitions for May queen to start Feb. 2 • Revised final exam schedule • 11 students to graduate this January • Over 200 people hear Earle Spicer sing ballads Wed. • Lucas, Scott join cast of Alpha Psi • Pettit discovers fire in Bomberger chapel • Library has new collection of great books of western world • Campus Chest total is $955.23 • Y commission holds vespers • Frosh class discusses plans; Sets tentative dance date • Chem group to hear speech • Turkish speaker addresses classes Tuesday morning • Frats hold meetings, set date for dances • Movie to be shown in S-12 • 32 girls invited to Rosie dessert • Ruby wants snaps brought to Hobson • New rules regulate use of Alumni office machines • Editorials: New year suggestion • Goodbye H.S.T. • Letters to the editor • Engagements • Weddings • What are ex-student-teachers doing with their free time? • January graduates reveal variety of future plans • Resolutions of eager frosh contrast to humble seniors • F&M routs Bears 90-65 with second half splurge • Grizzlies rally to smother alumni 96-75 for fifth • Belles drub Moravian 75-22; Kuhn scores 21 • Grapplers down Swarthmore team • Herb Knull tabs record 46 as Ursinus routs Fords • French Club gives moviehttps://digitalcommons.ursinus.edu/weekly/1510/thumbnail.jp
The Ursinus Weekly, November 17, 1952
Faculty show is considered huge success • Dean addresses freshman class • Bus. Ad. Club sponsors debate on current economic issues • Y cabinet hears program plans of commissions • Dorm reps chosen to sell yearbooks • Speaker explains international bank • 11 articles, three books left in lost and found department • Ruby to give show on Friday • Benefit fashion show enjoyed by audience • I.R.C. attends model U.N. • Chest Drive opens today; $1300 set as final goal • Two Messiah soloists chosen • Lord to speak at Forum on November 25 • Freshmen petition to give breakage fees to Union • Rev. James tells What on earth God is doing • Alpha Psi sees play • Kratz, Moser describe Paris to French Club • Marine captain to speak • Editorials: Fashionable trend?; Let\u27s all give • No more expansiveness • Don Juan in Hell judged fine show • Engagements • Scribe reviews Russian movie • F.T.A. holds roast • Not as dead as you think claims fightin\u27st college • Time for change; Ursinus in 1870 • Go west young man ; Dawkins finds rare rattler • Snell\u27s Belles defeat Chestnut Hill in shutout • Court men begin pre-season drills • Drexel defeats Ursinus in final home tilt, 7-1 • Bakermen close season with 7-2 loss to Lehigh • Bears to try for equalizing victory • Juniata topples Bears in rain and mud, 7-0 • Two Ursinus Belles honored • Playoffs to decide champhttps://digitalcommons.ursinus.edu/weekly/1506/thumbnail.jp
An Observational Descriptive Study of IRB Decision Making
Background:
Institutional Review Boards (IRBs) are the primary organizations designed to protect research subjects from harm and assure that they participate voluntarily. At the same time, many researchers feel that they intrude into the research process without making research safer.
Goals:
• Identify which issues about applications are the focus of IRB attention; e.g., the scientific validity of a protocol, issues of risk, informed consent
• Clarify how, if at all, the occupants of different roles (chair, community member, attorney, scientific expert, etc.) differ in their discussion of applications
• Describe how IRB members identify problems in applications; what information resources they use and how they use them
• Identify how IRBs organize the work of application review through the use of staff, pre-meeting review, and formatl meeting
An Unbiased Systems Genetics Approach to Mapping Genetic Loci Modulating Susceptibility to Severe Streptococcal Sepsis
Striking individual differences in severity of group A streptococcal (GAS) sepsis have been noted, even among patients infected with the same bacterial strain. We had provided evidence that HLA class II allelic variation contributes significantly to differences in systemic disease severity by modulating host responses to streptococcal superantigens. Inasmuch as the bacteria produce additional virulence factors that participate in the pathogenesis of this complex disease, we sought to identify additional gene networks modulating GAS sepsis. Accordingly, we applied a systems genetics approach using a panel of advanced recombinant inbred mice. By analyzing disease phenotypes in the context of mice genotypes we identified a highly significant quantitative trait locus (QTL) on Chromosome 2 between 22 and 34 Mb that strongly predicts disease severity, accounting for 25%–30% of variance. This QTL harbors several polymorphic genes known to regulate immune responses to bacterial infections. We evaluated candidate genes within this QTL using multiple parameters that included linkage, gene ontology, variation in gene expression, cocitation networks, and biological relevance, and identified interleukin1 alpha and prostaglandin E synthases pathways as key networks involved in modulating GAS sepsis severity. The association of GAS sepsis with multiple pathways underscores the complexity of traits modulating GAS sepsis and provides a powerful approach for analyzing interactive traits affecting outcomes of other infectious diseases
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