Proyecto social choco to dance

Este documento pretendió a través de la sistematización de experiencias, examinar procesos y resultados de la innovación social Choco to Dance como proyecto de financiamiento a través de becas a jóvenes profesionales y lideres aspirantes a especializaciones en áreas del desarrollo y problemática social de las zonas objetivo, y oriundos de estas zonas vulnerables y en conflicto como Quibdó y Buenaventura en la geografía pacifica colombiana. Esta experiencia, Choco to Dance, se ha tipificado: Desde la apropiación de los objetos innovadores en el mundo social (procesos de innovación sociotecnológica). Dado que apalanca la experiencia con el aprendizaje online o e-learning, es decir se vale de la tecnología, internet y todas las herramientas del mundo virtual. La evaluación de la experiencia nos definirá el éxito como proceso o bien tomar los aprendizajes y continuar hacia otro proyecto. Para ello se aplicó como metodología el modelo TRL, (Technology Readiness Levels) que indica la madurez del proyecto a través de determinadas categorías de gestión desde el grado de novedad hasta el acercamiento a la sociedad. La medición dio por resultado que esta innovación se encuentra en un grado de madurez nueve (9) que indica que la innovación puede ser replicada por otros y que cuenta con capacidades para producir alianzas y ampliar su impacto. Este nivel implica que los resultados obtenidos hasta el momento han sido significantes en cuanto al número de becarios favorecidos, que hay en mente nuevos proyectos derivados de este.Through the systematization of experiences, this document intended to examine the process and results of the social innovation Choco to Dance as a project whose aim is to finance scholarships for young professionals and leaders from vulnerable and conflict zones such as Quibdo and Buenaventura in the Colombian Pacific geography, aspirants to specializations in areas of social development. This experience has been characterized using the conceptualization: appropriation of innovative objects in the social world (socio- technological innovation processes) since it leverages the process with E-Learning, ie. it uses technology, internet and all the tools of the virtual world. The evaluation of Choco to Dance will be used to define the success of the project, portray lessons learned and take decisions process regarding the continuity of the process. For this purpose, the TRL model methodology (Technology Readiness Levels) was applied indicating the maturity of the project through certain categories including the degree of novelty and the way how they approach to society. The result of the evaluation was that this innovation is at maturity level nine (9), which indicates that the innovation can be replicated by others and that it has the capacity to produce alliances and broaden its impact. This level implies that the results obtained so far have been significant in terms of the number of grantees favored, and that new projects have derived from this innovation

Proyecto Colciencias UTP - Precisión en la extracción de tumores cerebrales

Video sobre la aplicación creada en el proyecto, busca dar a conocer la aplicación, así como sus ventajas en el tema tratado. contiene las ideas principales de su funcionamiento, y la validación médica plica.Minciencia

Evaluación de la adaptación de Helianthus annuus en asocio con hongos micorrízicos en suelos contaminados con plomo.

Potentially toxic elements such as lead (Pb) have become soil contaminants, and after that transfer is made through food chains. To stabilize this contamination in soils strategies, have been proposed as phytoremediation and bioremediation, because, they represent economic alternatives and easily accessible. Helianthus annuus, is a plant with phytoremediation potential and in association with arbuscular mycorrhizal fungi (AMF) generates a biorremediador effect. In this investigation, the adaptation that has H. annuus in association with HMA to fit a lead-contaminated medium was evaluated. Variables were analyzed in the software Statgraphics CENTURION XV.II stem length, number of leaves, fresh and dry weight to determine the adaptation of the plant to the environment; also, spore count, staining roots and mycorrhizal colonization percentage in inoculated roots was performed. It was found that H. annuus is able to develop in contaminated media with lead and HMA have a high infectivity in the media used.Los elementos potencialmente tóxicos como plomo (Pb), se han convertido en contaminantes del suelo, logrando que su transferencia se realice a través de cadenas tróficas. Para estabilizar esta contaminación en los suelos se han propuesto estrategias como la fitorremediación y la biorremediación, debido a que representan alternativas económicas y de fácil acceso. Helianthus annuus, es una planta con potencial fitorremediador y en asocio con hongos micorrízicos arbusculares (HMA) genera un efecto biorremediador. En el presente estudio, se evaluó la adaptación que tiene el H. annuus en asocio con HMA para adaptarse a un medio contaminado con plomo. Se analizaron variables en el software Statgraphics CENTURION XV.II de longitud de tallo, número de hojas  peso fresco y peso seco para determinar la adaptación de la planta al medio; además, se realizó conteo de esporas, tinción de raíces y porcentaje de colonización micorrizal en las raíces inoculadas. Se detectó que H. annuus es capaz de desarrollarse en medios contaminados con plomo y los HMA tienen una alta capacidad infectiva en los medios utilizados

ppGpp and RNA-Polymerase Backtracking Guide Antibiotic-Induced Mutable Gambler Cells

Antibiotic resistance is a global health threat and often results from new mutations. Antibiotics can induce mutations via mechanisms activated by stress responses, which both reveal environmental cues of mutagenesis and are weak links in mutagenesis networks. Network inhibition could slow the evolution of resistance during antibiotic therapies. Despite its pivotal importance, few identities and fewer functions of stress responses in mutagenesis are clear. Here, we identify the Escherichia coli stringent starvation response in fluoroquinolone-antibiotic ciprofloxacin-induced mutagenesis. Binding of response-activator ppGpp to RNA polymerase (RNAP) at two sites leads to an antibiotic-induced mutable gambler-cell subpopulation. Each activates a stress response required for mutagenic DNA-break repair: surprisingly, ppGpp-site-1-RNAP triggers the DNA-damage response, and ppGpp-site-2-RNAP induces

Mapa para análise qualitativa de risco por BTEX p ou proximidade com postos de gasolina na cidade de Ensenada, Baja California, México

Due to their carcinogenic properties, exposure to volatile organic compounds such as benzene, toluene and xylene (BTEX) has been associated with an increased risk of developing cancer in people living or working near gas stations. This study puts forward a methodological approach to study the problems posed by VOCs on individuals exposed to hydrocarbons. The data obtained indicate that there is a greater presence of VOCs in the areas close to point sources of emission and, therefore, a greater exposure to toxic factors. This paper presents a simple procedure to establish which areas are vulnerable to technological risks within the urban area owing to the presence of BTEX by using GIS technology, which enables spatial analysis of benzene emissions to the atmosphere. These results will serve the agencies involved in decision-making. There is no clear legislation in Mexico to protect people living in the vicinity of gas stations. Therefore, programs should be developed to reduce their impact on the population at the environmental, health and social levels.La exposición a compuestos orgánicos volátiles (COV) presentes en la gasolina, como el benceno, tolueno, etilbenceno y xileno (BTEX), por su capacidad cancerígena se ha asociado con el aumento del riesgo a desarrollar cáncer en las personas que viven o trabajan en las proximidades de las estaciones de servicio. En este trabajo se propone una aproximación metodológica para estudiar la problemática que representan los COV en los individuos expuestos a los hidrocarburos. Los datos obtenidos indican que existe mayor presencia de COV en las zonas ubicadas en la cercanía de las fuentes puntuales de emisión y por ende con mayor exposición a factores tóxicos. Con este trabajo se plantea un procedimiento sencillo para establecer las zonas vulnerables a riesgos tecnológicos dentro del área urbana por presencia de BTEX, utilizando para ello la tecnología SIG que permite realizar un análisis espacial de las emisiones de benceno a la atmósfera. Estos resultados quedarán al servicio de los organismos involucrados en la toma de decisiones. En México no existe una legislación clara que proteja a los habitantes de las cercanías de las estaciones de servicio, por lo tanto se deben desarrollar programas para disminuir el impacto en la población a nivel ambiental, sanitario y social.A exposição a compostos orgânicos voláteis (COV) presentes na gasolina, como o benzeno, tolueno, etilbenzeno e xileno (BTEX), pela sua ação cancerígena foi associada ao aumento do risco de desenvolver cancro, nas pessoas que vivem ou trabalham nas proximidades das estações de serviço. Neste trabalho propõe-se uma abordagem metodológica para estudar a problemática que os COV representam para os indivíduos expostos a hidrocarbonetos. Os dados obtidos indicam que há uma maior presença de COV em áreas localizadas na proximidade de fontes pontuais de emissão e, portanto, mais expostas a fatores tóxicos. Com este trabalho, é proposto um procedimento simples para a definição de zonas vulneráveis a riscos tecnológicos, dentro da área urbana pela presença de BTEX, utilizando a tecnologia SIG que permite uma análise espacial das emissões de benzeno na atmosfera. Estes resultados ficarão à disposição dos organismos envolvidos na tomada de decisões. No México, não existe uma legislação clara que proteja quem vive nas proximidades dos postos de gasolina, motivo pelo qual se devem desenvolver programas que visem diminuir o impacto na população a nível ambiental, sanitário e social

Variation in RNA Virus Mutation Rates across Host Cells

It is well established that RNA viruses exhibit higher rates of spontaneous mutation than DNA viruses and microorganisms. However, their mutation rates vary amply, from 10−6 to 10−4 substitutions per nucleotide per round of copying (s/n/r) and the causes of this variability remain poorly understood. In addition to differences in intrinsic fidelity or error correction capability, viral mutation rates may be dependent on host factors. Here, we assessed the effect of the cellular environment on the rate of spontaneous mutation of the vesicular stomatitis virus (VSV), which has a broad host range and cell tropism. Luria-Delbrück fluctuation tests and sequencing showed that VSV mutated similarly in baby hamster kidney, murine embryonic fibroblasts, colon cancer, and neuroblastoma cells (approx. 10−5 s/n/r). Cell immortalization through p53 inactivation and oxygen levels (1–21%) did not have a significant impact on viral replication fidelity. This shows that previously published mutation rates can be considered reliable despite being based on a narrow and artificial set of laboratory conditions. Interestingly, we also found that VSV mutated approximately four times more slowly in various insect cells compared with mammalian cells. This may contribute to explaining the relatively slow evolution of VSV and other arthropod-borne viruses in nature

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis

Induction of atrazine tolerance in a natural soil assemblage of microalgae reared in the laboratory

International audienceWe investigated the occurrence of tolerance to atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) in soil microalgae by means of the pollution-induced community tolerance methodology. To this end, a natural soil assemblage of microalgae, reared under laboratory conditions, was used as experimental model. Experimental cultures were exposed to 0.46, 0.93, 1.85, 2.70, and 5.40 mg atrazine/L medium for 40 days. After this chronic exposure, both untreated and atrazine-pretreated cultures were subjected to a short-term dose–effect study with atrazine using average growth rate as endpoint. Results showed that chronic exposure to atrazine induced significant changes at the community level, increasing its atrazine tolerance. In addition, atrazine-pretreated assemblages seemed to display, on average, a reduced growth rate compared with untreated assemblages in the absence of atrazine. Response to the presence of atrazine could thus be achieved with some fitness cost. This suggests that the soil microalgal productivity could be diminished after exposure to atrazine

Reología de masas de maíz reforzadas con manitol y cmc

Se estandarizó la producción de masas de maíz y se modificaron estas conmanitol y CMC. Las pruebas reológicas de compresibilidad y porcentaje dedeformación revelaron que la combinación de aditivo que mejoró las pro-piedades de la masa con respecto al blanco fue la adición de 0.2% en pesode la mezcla 30% CMC - 70% Manitol. Se encontró también, que en ladeformación de las masas solo influyó el tipo de aditivo empleado, pero enel punto de fluencia, interaccionaron tanto el aditivo utilizado como la can-tidad del mismo. Este mejoramiento en las propiedades de la masa, se dapor la acción plastificante de los aditivos, los cuales se incluyen dentro de laestructura tridimensional del almidón y reducen la fricción entre las estruc-turas lineales de amilosa. Así, el suavizamiento ante los esfuerzos cortantes,aumenta la resistencia de las masas y sus productos ante los maltratos deltransporte y la manipulación