Diagnostic procedures for non-small-cell lung cancer (NSCLC): recommendations of the European Expert Group

Background There is currently no Europe-wide consensus on the appropriate preanalytical measures and workflow to optimise procedures for tissue-based molecular testing of non-small-cell lung cancer (NSCLC). To address this, a group of lung cancer experts (see list of authors) convened to discuss and propose standard operating procedures (SOPs) for NSCLC. Methods Based on earlier meetings and scientific expertise on lung cancer, a multidisciplinary group meeting was aligned. The aim was to include all relevant aspects concerning NSCLC diagnosis. After careful consideration, the following topics were selected and each was reviewed by the experts: surgical resection and sampling; biopsy procedures for analysis; preanalytical and other variables affecting quality of tissue; tissue conservation; testing procedures for epidermal growth factor receptor, anaplastic lymphoma kinase and ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) in lung tissue and cytological specimens; as well as standardised reporting and quality control (QC). Finally, an optimal workflow was described. Results Suggested optimal procedures and workflows are discussed in detail. The broad consensus was that the complex workflow presented can only be executed effectively by an interdisciplinary approach using a well-trained team. Conclusions To optimise diagnosis and treatment of patients with NSCLC, it is essential to establish SOPs that are adaptable to the local situation. In addition, a continuous QC system and a local multidisciplinary tumour-type-oriented board are essential

Two Galaxy Clusters: A3565 and A3560

We report 102 new redshifts and magnitudes for a sample of galaxies to RF ~ 15.5 mag in a 2.17 deg x 2.17 deg region centered on the galaxy IC 4296, the most luminous member of the A3565 cluster. Up to the limiting magnitude we find 29 cluster members, and measure a velocity dispersion of 228 km/s. The estimated total mass for this system is ~ 3.0 x h**-1 10**13 Msun (where h = H0/100 km/s/Mpc), and its dynamical properties are quite typical of poor clusters presenting X-ray emission. We also find that galaxies with absorption lines are more concentrated towards the center of the cluster, while systems with emission lines are mainly located in the outer parts. The small velocity dispersion of the cluster, coupled to the known presence of an interacting pair of galaxies, and the large extent of the brightest cluster galaxy, could indicate that galaxy formation through mergers may still be underway in this system. The surveyed region also contains galaxies belonging to the Shapley Concentration cluster A3560. Within 30 arc min of the cluster center, we detect 32 galaxies, for which we measure a velocity dispersion of 588 km/s and a mass of ~2 x h**-1 10**14 Msun. However, because our sample is restricted to galaxies brighter than M*, these values should be considered only as rough estimates.Comment: 33 pages, including 6 tables and 9 postscript figures. Uses AAS Latex macros. Postscript file and ASCII versions of Tables 4 and 6 are available at http://www.dan.on.br/other_surveys/a3565.html. Scheduled for September 1999 issue of The Astronomical Journa

Light scattering from disordered overlayers of metallic nanoparticles

We develop a theory for light scattering from a disordered layer of metal nanoparticles resting on a sample. Averaging over different disorder realizations is done by a coherent potential approximation. The calculational scheme takes into account effects of retardation, multipole excitations, and interactions with the sample. We apply the theory to a system similar to the one studied experimentally by Stuart and Hall [Phys. Rev. Lett. {\bf 80}, 5663 (1998)] who used a layered Si/SiO$_2$/Si sample. The calculated results agree rather well with the experimental ones. In particular we find conspicuous maxima in the scattering intensity at long wavelengths (much longer than those corresponding to plasmon resonances in the particles). We show that these maxima have their origin in interference phenomena in the layered sample.Comment: 19 pages, 12 figure

Precision Measurement of the Neutron Beta-Decay Asymmetry

A new measurement of the neutron $\beta$-decay asymmetry $A_0$ has been carried out by the UCNA collaboration using polarized ultracold neutrons (UCN) from the solid deuterium UCN source at the Los Alamos Neutron Science Center (LANSCE). Improvements in the experiment have led to reductions in both statistical and systematic uncertainties leading to $A_0 = -0.11954(55)_{\rm stat.}(98)_{\rm syst.}$, corresponding to the ratio of axial-vector to vector coupling $\lambda \equiv g_A/g_V = -1.2756(30)$

Search for physics beyond the standard model in events with τ leptons, jets, and large transverse momentum imbalance in pp collisions at [Formula: see text].

A search for physics beyond the standard model is performed with events having one or more hadronically decaying τ leptons, highly energetic jets, and large transverse momentum imbalance. The data sample corresponds to an integrated luminosity of 4.98 fb-1 of proton-proton collisions at [Formula: see text] collected with the CMS detector at the LHC in 2011. The number of observed events is consistent with predictions for standard model processes. Lower limits on the mass of the gluino in supersymmetric models are determined

Measurement of masses in the [Formula: see text] system by kinematic endpoints in pp collisions at [Formula: see text].

A simultaneous measurement of the top-quark, W-boson, and neutrino masses is reported for [Formula: see text] events selected in the dilepton final state from a data sample corresponding to an integrated luminosity of 5.0 fb-1 collected by the CMS experiment in pp collisions at [Formula: see text]. The analysis is based on endpoint determinations in kinematic distributions. When the neutrino and W-boson masses are constrained to their world-average values, a top-quark mass value of [Formula: see text] is obtained. When such constraints are not used, the three particle masses are obtained in a simultaneous fit. In this unconstrained mode the study serves as a test of mass determination methods that may be used in beyond standard model physics scenarios where several masses in a decay chain may be unknown and undetected particles lead to underconstrained kinematics

Determination of the Axial-Vector Weak Coupling Constant with Ultracold Neutrons

A precise measurement of the neutron decay $\beta$-asymmetry $A_0$ has been carried out using polarized ultracold neutrons (UCN) from the pulsed spallation UCN source at the Los Alamos Neutron Science Center (LANSCE). Combining data obtained in 2008 and 2009, we report $A_0 = -0.11966 \pm 0.00089_{-0.00140}^{+0.00123}$, from which we determine the ratio of the axial-vector to vector weak coupling of the nucleon $g_A/g_V = -1.27590_{-0.00445}^{+0.00409}$.Comment: 5 pages, 2 figure