67 research outputs found

    Rhodium-Catalyzed Asymmetric Intramolecular Hydroamination of Unactivated Alkenes

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    One for the Rh(oad): The first rhodium-catalyzed asymmetric intramolecular hydroamination of unactivated olefins was developed by using dialkylbiaryl phosphine ligands (see scheme; cod=1,5-cyclooctadiene, Cy=cyclohexyl). A variety of 2-methylpyrrolidines have been synthesized with high enantioselectivities.National Institutes of Health (U.S.) (Grant GM46059)Merck & Co.Boehringer Ingelheim PharmaceuticalsNational Institutes of Health (U.S.) (GM 1S10RR13886-01
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