Social and Environmental Life Cycle Assessment (SELCA) Method for Sustainability Analysis:The Jeans Global Value Chain as a Showcase

In this chapter the concepts of social life cycle assessment and combined social and environmental LCA were explored through the application of existing LCA methods to the global value chain of jeans. The social and environmental life cycle assessment (SELCA) method resulted from this explorative research that aims to contribute to the battery of impact assessment tools of products whose value chain scope is multinational (global). From a broader perspective, SELCA has a double-folded purpose to (i) identify opportunities for environmental and social improvement at any of the value chain phases of products, for remediation goals, and (ii) predict the environmental and social performance of different ways (scenarios) to produce the same product, using it as a product design tool. To simplify SELCA development, it was decided to use a single product (jeans) as a showcase from the global textile sector. In this showcase, four scenarios for jeans assembly were compared; three of them were defined under the circular economy principles by including recycled materials (cotton, PET and nylon 6) during the yarn production. During the application of the SELCA method, some new challenges were encountered related to inventory analysis, in particular during data acquisition for social inventories. This is later mainly due to the extensive list of key stakeholders for the showcase and the qualitative nature of social metrics. This list starts with cotton cultivators from different countries where regulations and codes of conduct seem to have contextualised interpretations and consequently different levels of implementation. In this regard, governmental intervention to instrument the transition towards suitable social/environmental performance along the global jeans value chain was also discussed in this chapter

De la Expansion Desarrollista a las Extensiones Aulicas : Un Desafío Para la Gestión del Conocimiento en la Universidad Argentina

En esta ponencia nos proponemos abordar algunas consideraciones sobre la universidad como objeto de estudio en relación a los modos de producción y distribución del conocimiento. Para este propósito revisamos las transformaciones cuanti - cualitativas de la educación superior latinoamericana acaecidas desde mediados de los años 1950, momento en el que las universidades diseñadas para las élites comienzan una apertura hacia sectores sociales medios y bajos. Esta expansión matricular y diversificación institucional configuró lo que hoy conocemos como sistemas universitarios, modificando las condiciones de producción, organización y distribución del conocimiento; cambios que a lo largo de la segunda mitad del siglo XX plantean diferentes y complejos desafíos para la gestión de las universidades. En el caso argentino la universidad pública resultó atravesada por demandas de acceso que fueron canalizadas a través de nuevas creaciones localizadas fuera de los grandes centros urbanos. Esa modalidad visible hasta mediados de los años 1970 hacia fines de los años 1980 comienza a adquirir una nueva dinámica a raíz del corrimiento del estado, la fuerte participación de la iniciativa privada y la generación de criterios de mercado que introducen nuevas reglas en la creación - difusión del conocimiento y sus modos de gestión

The role of heart rate on the associations between body composition and heart rate variability in children with overweight/obesity : the ActiveBrains project

Background: Heart rate variability (HRV) is negatively associated with body mass index and adiposity in several populations. However, less information is available about this association in children with overweight and obesity, especially severe/morbid obesity, taking into consideration the dependence of HRV on heart rate (HR). Objectives: (1) to examine associations between body composition measures and HRV, (2) to study differences in HRV between children with overweight and severe/morbid obesity; and (3) to test whether relationships and differences tested in objectives 1 and 2, respectively are explained by the dependency of HRV on HR. Methods: A total of 107 children with overweight/obesity (58% boys, 10.03 +/- 1.13 years) participated in this study. Body composition measures were evaluated by Dual-energy X-ray absorptiometry (DXA). HRV parameters were measured with Polar RS800CXR (R). Results: Body composition measures were negatively associated with HRV indicators of parasympathetic activity (beta values ranging from -0.207 to -0.307, all p 0.05). Conclusion: All associations between adiposity/obesity and HRV could be explained by HR, suggesting a key confounding role of HR in HRV studies in children with weight disturbances

On Chern-Simons Quivers and Toric Geometry

We discuss a class of 3-dimensional N=4 Chern-Simons (CS) quiver gauge models obtained from M-theory compactifications on singular complex 4-dimensional hyper-Kahler (HK) manifolds, which are realized explicitly as a cotangent bundle over two-Fano toric varieties V^2. The corresponding CS gauge models are encoded in quivers similar to toric diagrams of V^2. Using toric geometry, it is shown that the constraints on CS levels can be related to toric equations determining V^2.Comment: 14pg, 1 Figure, late

Nanomedicines for the delivery of antimicrobial peptides (AMPs)

Microbial infections are still among the major public health concerns since several yeasts and fungi, and other pathogenic microorganisms, are responsible for continuous growth of infections and drug resistance against bacteria. Antimicrobial resistance rate is fostering the need to develop new strategies against drug-resistant superbugs. Antimicrobial peptides (AMPs) are small peptide-based molecules of 5–100 amino acids in length, with potent and broad-spectrum antimicrobial properties. They are part of the innate immune system, which can represent a minimal risk of resistance development. These characteristics contribute to the description of these molecules as promising new molecules in the development of new antimicrobial drugs. However, efforts in developing new medicines have not resulted in any decrease of drug resistance yet. Thus, a technological approach on improving existing drugs is gaining special interest. Nanomedicine provides easy access to innovative carriers, which ultimately enable the design and development of targeted delivery systems of the most efficient drugs with increased efficacy and reduced toxicity. Based on performance, successful experiments, and considerable market prospects, nanotechnology will undoubtedly lead a breakthrough in biomedical field also for infectious diseases, as there are several nanotechnological approaches that exhibit important roles in restoring antibiotic activity against resistant bacteria.Elena Sanchez-Lopez belongs to 2017SGR-1477. Elena Sanchez-Lopez, Marta Espina and Maria L. GarciaacknowledgethesupportfromtheInstituteofNanoscienceandNanotechnology(ART2018project). Eliana B. Souto acknowledges the Portuguese Science and Technology Foundation (FCT/MCT) and European Funds (PRODER/COMPETE) for the projects M-ERA-NET-0004/2015-PAIRED and UIDB/04469/2020 (strategic fund), co-funded by FEDER, under the partnership Agreement PT2020. Maria C. Teixeira wishes to acknowledge FCT for the individual fellowship (PD/BDE/135086/2017).info:eu-repo/semantics/publishedVersio

Multiwavelength study of the starburst galaxy NGC7714. I: Ultraviolet-Optical spectroscopy

We have studied the physical conditions in the central 300 pc of the proto-typical starburst galaxy NGC 7714. Our analysis is based on ultraviolet spectroscopy with the HST+GHRS and ground-based optical observations.The data are interpreted using evolutionary models optimized for young starburst regions. The massive stellar population is derived in a self-consistent way using the continuum and stellar absorption lines in the ultraviolet and the nebular emission line optical spectrum. The central starburst has an age of about 4.5 Myr, with little evidence for an age spread. Wolf-Rayet features at the ultraviolet indicates a stellar population of $\sim$ 2000 Wolf-Rayet stars. The overall properties of the newly formed stars are quite similar to those derived, e.g., in 30 Doradus. A standard Salpeter IMF is consistent with all observational constraints. We find evidence for spatial structure within the central 300 pc sampled. Therefore it is unlikely that the nucleus of NGC 7714 hosts a single star cluster exceeding the properties of other known clusters. Contrary to previous suggestions, we find no evidence for a nuclear supernova rate that would significantly exceed the total disk-integrated rate. About one supernova event per century is predicted.Comment: 19 pages, 9 figures in a tar file. Accepted for publication in ApJ, 1999, March, issue 51

Accurate crab cavity modeling for the high luminosity Large Hadron Collider

As part of the Large Hadron Collider high luminosity upgrade it is proposed to include crab cavities in the lattice in order to enhance the luminosity. For one proposed cavity design the dynamics of the cavity is considered in terms of its impact upon the dynamic aperture of the machine. Taylor maps of the cavity are created and used to perform this analysis with a full assessment of their validity. Furthermore from these Taylor maps, symplectic methods are developed further, guided by the knowledge gained in the study of the physics contained in them

Insulin-like growth factor-I gene delivery to astrocytes reduces their inflammatory response to lipopolysaccharide

<p>Abstract</p> <p>Background</p> <p>Insulin-like growth factor-I (IGF-I) exerts neuroprotective actions in the central nervous system that are mediated at least in part by control of activation of astrocytes. In this study we have assessed the efficacy of exogenous IGF-I and IGF-I gene therapy in reducing the inflammatory response of astrocytes from cerebral cortex.</p> <p>Methods</p> <p>An adenoviral vector harboring the rat IGF-I gene and a control adenoviral vector harboring a hybrid gene encoding the herpes simplex virus type 1 thymidine kinase fused to <it>Aequorea victoria </it>enhanced green fluorescent protein were used in this study. Primary astrocytes from mice cerebral cortex were incubated for 24 h or 72 h with vehicle, IGF-I, the IGF-I adenoviral vector, or control vector; and exposed to bacterial lipopolysaccharide to induce an inflammatory response. IGF-I levels were measured by radioimmunoassay. Levels of interleukin 6, tumor necrosis factor-α, interleukin-1β and toll-like receptor 4 mRNA were assessed by quantitative real-time polymerase chain reaction. Levels of IGF-I receptor and IGF binding proteins 2 and 3 were assessed by western blotting. The subcellular distribution of nuclear factor κB (p65) was assessed by immunocytochemistry. Statistical significance was assessed by one way analysis of variance followed by the Bonferroni pot hoc test.</p> <p>Results</p> <p>IGF-I gene therapy increased IGF-I levels without affecting IGF-I receptors or IGF binding proteins. Exogenous IGF-I, and IGF-I gene therapy, decreased expression of toll-like receptor 4 and counteracted the lipopolysaccharide-induced inflammatory response of astrocytes. In addition, IGF-I gene therapy decreased lipopolysaccharide-induced translocation of nuclear factor κB (p65) to the cell nucleus.</p> <p>Conclusion</p> <p>These findings demonstrate efficacy of exogenous IGF-I and of IGF-I gene therapy in reducing the inflammatory response of astrocytes. IGF-I gene therapy may represent a new approach to reduce inflammatory reactions in glial cells.</p