(0,2) Mirror Symmetry on homogeneous Hopf surfaces

In this work we find the first examples of (0,2) mirror symmetry on compact non-K\"ahler complex manifolds. For this we follow Borisov's approach to mirror symmetry using vertex algebras and the chiral de Rham complex. Our examples of (0,2) mirrors are given by pairs of Hopf surfaces endowed with a Bismut-flat pluriclosed metric. Requiring that the geometry is homogeneous, we reduce the problem to the study of Killing spinors on a quadratic Lie algebra and the construction of associated $N=2$ superconformal structures on the superaffine vertex algebra, combined with topological T-duality.Comment: 55 pages. Minor changes and corrections. References update

ProjectZero : Gestión de una arquitectura de microservicios con Istio

El proyecto consiste en el estudio de varios casos de uso que nos permite hacer Istio junto con Kubernetes. Para poder realizar estas pruebas, se llevará a cabo la creación de un pequeño cluster virtualizado con Virtualbox. Kubernetes será utilizado como orquestador de los contenedores, mientras que Docker contendrá los microservicios que gestionaremos con Istio. El principal objetivo de este trabajo es diseñar y construir un entorno donde poder desplegar microservicios y gestionarlos de forma independiente.The project consists in the study of several use cases that allow us to make Istio together with Kubernetes. In order to perform these tests, the creation of a virtualized cluster with Virtualbox will be carried out. Kubernetes will be used as a container orchestrator, while Docker will contain the microservices that we will manage with Istio. The main objective of this work is to de- sign and build an environment where you can deploy microservices and manage them independently.El projecte consisteix en l'estudi de diversos casos d'ús que ens permet fer Istio juntament amb Kubernetes. Per poder realitzar aquestes proves, es durà a terme la creació d'un petit clúster virtualitzat amb Virtualbox. Kubernetes serà utilitzat com orquestrador dels contenidors, mentre que Docker contindrà els microserveis que gestionarem amb Istio. El principal objectiu d'aquest treball és dissenyar i construir un entorn on poder desplegar microserveis i gestionar-los de forma independent

Vaginal hormone-free moisturising cream is not inferior to an estriol cream for treating symptoms of vulvovaginal atrophy: Prospective, randomised study.

This prospective, open-label, multicentre, multinational, randomised trial investigated the non-inferiority of treatment with a vaginal hormone-free moisturising cream compared to a vaginal estriol (0.1%) cream in a panel of post-menopausal women suffering from symptoms of vulvovaginal dryness in a parallel group design. In total, 172 post-menopausal women were randomly allocated to either one of the two treatments, each administered for 43 days. The primary endpoint was the total severity score of subjective symptoms (dryness, itching, burning and pain unrelated to sexual intercourse) of the respective treatment period. Secondary endpoints were severity of single subjective symptoms (including dyspareunia if sexually active), impairment of daily life, Vaginal Health Index, as well as assessment of safety. In both groups, women treated with hormone-free moisturising cream and those treated with estriol cream, total severity score improved significantly compared to baseline by 5.0 (from 6.1 to 1.1) and by 5.4 (from 6.0 to 0.6), respectively, after 43 days of treatment (p < 0.0001). One-sided test of baseline differences (for a clinically relevant difference Δ = 1.5) confirmed the hormone-free moisturising cream to be non-inferior to the estriol cream. Severity of dyspareunia as well as impairment of daily life due to subjective symptoms, significantly improved for both treatment groups (p<0.0001). Subgroup analysis of women with mild or moderate impairment of daily life at baseline caused by "vaginal dryness" symptoms benefited from both creams, while women with severe impairment showed a significantly greater benefit from the estriol cream (p = 0.0032). Both treatments were well tolerated with no serious adverse events occurring. This study provides clinical evidence that a hormone-free vaginal moisturising cream cannot only improve vaginal dryness compared to an 0.1% estriol cream but also can relieve dyspareunia as well as improve woman's impairment of daily life, justifying its use as a first choice for mild or moderate vulvovaginal dryness symptoms

Te-doped MoV-Oxide (M1 phase) for ethane ODH. The role of tellurium on morphology, thermal stability and catalytic behaviour

[EN] Undoped and Te-doped MoV-Oxide (M1 phase) catalysts have been prepared hydrothermally (Te/Mo ratio in the synthesis gel from 0 to 0.17; and heat-treated at 400 or 600ºC in N2 atmosphere), characterized by several physicochemical techniques and tested in the oxidative dehydrogenation (ODH) of ethane. The morphology and microporosity of the catalysts, the nature of V-species on the catalyst surface and the catalytic performance strongly depend on the composition and the heat-treatment temperature. When calcined at 400ºC, the selectivity to ethylene decreases when the amount of tellurium increases, whereas when heat treated at 600ºC, the selectivity to ethylene increases when the Te-loading increases. These trends have been explained on the basis of the good correlation between selectivity to ethylene and the concentration of V4+ species on the surface of catalysts, in which the most selective catalyst is that prepared with a Te/Mo ratio of 0.17 and heat-treated at 600ºC.The authors would like to thank the Spanish Ministry of Economy and Competitiveness for funding the projects (MINECO/FEDER) : CRTl2018-099668-B-C21, PID2019-106662RBC44, MAT2017-84118- C2-1-R and SEV-2016-0683. A.A. acknowledges Severo Ochoa Excellence Program for his fellowship (BES-2017-080329) . Authors would also like to acknowledge the "A -Team" of the ITQ (Dr. Miguel Palomino, Dr. Susana Valencia and Prof. Fernando Rey) for their assistance in the performance of the adsorption experiments.De Arriba-Mateos, A.; Solsona, B.; Garcia-Gonzalez, E.; Concepción Heydorn, P.; López Nieto, JM. (2022). Te-doped MoV-Oxide (M1 phase) for ethane ODH. The role of tellurium on morphology, thermal stability and catalytic behaviour. Applied Catalysis A General. 643:1-13. https://doi.org/10.1016/j.apcata.2022.11878011364

Evaluación de la formación sobre el programa de optimización del uso de antimicrobianos en médicos residentes de la provincia de Las Palmas

Trabajo de Fin de Máster. Máster en Salud Pública. Curso 2019-2020.[ES] Contexto. La resistencia a los antibióticos es una amenaza para la salud pública mundial. Esta situación hace imprescindible el establecimiento de programas de optimización del uso de antimicrobianos (PROA). Se identifican las necesidades formativas en el PROA de los médicos residentes y se exponen los resultados del análisis de las asociaciones entre las variables de estudio y la formación en el uso racional y prudente de antibióticos. Métodos. Estudio transversal y analítico a través de un cuestionario auto administrado a un colectivo de 506 médicos residentes de la provincia de Las Palmas. Las diferencias relativas en el uso racional y prudente de antibióticos se resumieron utilizando los odds ratios obtenidos de la regresión logística y ajustados por variables sociodemográficas. Resultados. Las asociaciones entre la varianza de las respuestas y el tipo de especialidad se observaron en la mayoría de los análisis de los componentes principales (oportunidad p=0,003, entrenamiento p=0,007, motivación p=0,055 e higiene de manos p=0,044), seguidas de la varianza según el sexo (capacidad p=0,028, conocimientos teóricos p=0,013, higiene de manos p=0,002). Muy pocas diferencias se asociaron con la edad (capacidad p=0,051 e higiene de manos p=0,054) o el año de especialidad (higiene de manos p=0,032). Conclusiones. Las principales necesidades formativas de los médicos residentes incluyen salud integral, motivación, entrenamiento, higiene de manos e información. El tipo de especialidad seguido del sexo son los determinantes más importantes de las perspectivas sobre el uso y la resistencia a los antibióticos. [EN] Context. Antibiotic resistance is a threat to global public health. This situation makes essential to establish programs to optimize antimicrobial use (PROA). Training needs are identified in the PROA of resident physicians and the results of the analysis of the associations between study variables and training in the rational and prudent use of antibiotics are presented in this analysis. Methods. Cross-sectional and analytical study through a selfadministered questionnaire to a group of 506 medical residents of the province of Las Palmas. Relative differences in the rational and prudent use of antibiotics were summarized using odds ratios (OR) obtained from logistic regression and adjusted for sociodemographic variables. Results. The associations between response variance and speciality were observed in most of the core component analysis (opportunity p-0.003, training p-0.007, motivation p-0.055 and hand hygiene p-0.044), followed by variance according to sex (capacity p-0.028, theoretical knowledge p-0.013, hand hygiene p-0.002). Very few differences were associated with age (capacity p-0,051 and hand higiene p-0,054) or the year of expertise (hand higiene p-0,032). Conclusions. The main training needs of resident physicians include one health, motivation, training, hand higiene and information. The type of speciality followed by sex are the most important determinants on antibiotic use and resistance for resident physicians.Introducción: Hipótesis. Objetivos. Metodología: Diseño del estudio. Tamaño de la muestra. Desarrollo de la encuesta. Distribución de la encuesta. Criterios de inclusión/exclusión. Responsabilidades éticas. Análisis estadístico. Resultados. Discusión: Hallazgos principales. Comparación con otros estudios. Implicaciones en salud pública. Fortalezas y limitaciones. Conclusiones y perspectivas. Conflicto de intereses y financiamiento. Bibliografía. Anexo I. Tablas y figuras. Anexo II. Autoría y contribución. Anexo III. Consentimiento informado y encuesta. Tabla 1. Características de los médicos residentes incluidos en el análisis. Tabla 2. Componentes del cuestionario de percepciones, necesidades formativas y conocimientos teóricos de los residentes médicos sobre el programa de optimización del uso de antimicrobianos (PROA). Tabla 3. Descripción de los componentes principales de la encuesta. Dimensiones de la cultura de prescripción de antibióticos. Tabla 4. Distribución de las características de los residentes en función de los componentes de la encuesta. Tabla 5. Asociación entre las características de los residentes y los componentes de la encuesta. Figura 1. Diagrama de Pareto. Asignación orden de prioridades.N

Treatment of Dyspareunia with Botulinum Neurotoxin Type A: Clinical Improvement and Influence of Patients' Characteristics

[EN] The treatment of chronic pelvic pain (CPP) with botulinum neurotoxin type A (BoNT/A) has increased lately, but more studies assessing its effect are needed. This study aimed to evaluate the evolution of patients after BoNT/A infiltration and identify potential responders to treatment. Twenty-four women with CPP associated with dyspareunia were treated with 90 units of BoNT/A injected into their pelvic floor muscle (PFM). Clinical status and PFM activity were monitored in a previous visit (PV) and 12 and 24 weeks after the infiltration (W12, W24) by validated clinical questionnaires and surface electromyography (sEMG). The influence of patients' characteristics on the reduction in pain at W12 and W24 was also assessed. After treatment, pain scores and the impact of symptoms on quality of life dropped significantly, sexual function improved and sEMG signal amplitude decreased on both sides of the PFM with no adverse events. Headaches and bilateral pelvic pain were risk factors for a smaller pain improvement at W24, while lower back pain was a protective factor. Apart from reporting a significant clinical improvement of patients with CPP associated with dyspareunia after BoNT/A infiltration, this study shows that clinical characteristics should be analyzed in detail to identify potential responders to treatment.This study was funded by Universitat Politecnica de Valencia in Programa de Ayudas de Investigacion y Desarrollo (PAID-01-20), ISCIII, MCIU, VLC Campus in Convocatoria Ayudas: UPV-La Fe (INBIO): 2016 SPEHG (ID:C18), 2019 sEMG_BONTAv (ID:C06) and funds from private contracts with Merz Pharmaceuticals GmbH S.L.Tarazona-Motes, M.; Albaladejo-Belmonte, M.; Nohales-Alfonso, FJ.; De-Arriba, M.; Garcia-Casado, J.; Alberola-Rubio, J. (2021). Treatment of Dyspareunia with Botulinum Neurotoxin Type A: Clinical Improvement and Influence of Patients' Characteristics. International Journal of Environmental research and Public Health. 18(16):1-12. https://doi.org/10.3390/ijerph18168783S112181

Characterization of Pelvic Floor Activity in Healthy Subjects and with Chronic Pelvic Pain: Diagnostic Potential of Surface Electromyography

[EN] Chronic pelvic pain (CPP) is a highly disabling disorder in women usually associated with hypertonic dysfunction of the pelvic floor musculature (PFM). The literature on the subject is not conclusive about the diagnostic potential of surface electromyography (sEMG), which could be due to poor signal characterization. In this study, we characterized the PFM activity of three groups of 24 subjects each: CPP patients with deep dyspareunia associated with a myofascial syndrome (CPP group), healthy women over 35 and/or parous (>35/P group, i.e., CPP counterparts) and under 35 and nulliparous (RMS), a predominance of low-frequency components (DI), greater complexity (>SampEn) and lower synchronization on the same side (35/P group. The same trend in differences was found between healthy women (35/P) associated with aging and parity. These results show that sEMG can reveal alterations in PFM electrophysiology and provide clinicians with objective information for CPP diagnosis.This study was funded by Universitat Politecnica de Valencia in Programa de Ayudas de Investigacion y Desarrollo (PAID-01-20), ISCIII, MCIU, VLC Campus in Convocatoria Ayudas: UPV-La Fe (INBIO): 2016 SPEHG (ID:C18), 2019 sEMG_BONTAv (ID:C06) and funds from private contracts with Merz Pharmaceuticals GmbH S.Albaladejo-Belmonte, M.; Tarazona-Motes, M.; Nohales-Alfonso, FJ.; De-Arriba, M.; Alberola-Rubio, J.; Garcia-Casado, J. (2021). Characterization of Pelvic Floor Activity in Healthy Subjects and with Chronic Pelvic Pain: Diagnostic Potential of Surface Electromyography. Sensors. 21(6):1-17. https://doi.org/10.3390/s21062225S11721

A Comparative Study of Vaginal Labor and Caesarean Section Postpartum Uterine Myoelectrical Activity

[EN] Postpartum hemorrhage (PPH) is one of the major causes of maternal mortality and morbidity worldwide, with uterine atony being the most common origin. Currently there are no obstetrical techniques available for monitoring postpartum uterine dynamics, as tocodynamometry is not able to detect weak uterine contractions. In this study, we explored the feasibility of monitoring postpartum uterine activity by non-invasive electrohysterography (EHG), which has been proven to outperform tocodynamometry in detecting uterine contractions during pregnancy. A comparison was made of the temporal, spectral, and non-linear parameters of postpartum EHG characteristics of vaginal deliveries and elective cesareans. In the vaginal delivery group, EHG obtained a significantly higher amplitude and lower kurtosis of the Hilbert envelope, and spectral content was shifted toward higher frequencies than in the cesarean group. In the non-linear parameters, higher values were found for the fractal dimension and lower values for Lempel-Ziv, sample entropy and spectral entropy in vaginal deliveries suggesting that the postpartum EHG signal is extremely non-linear but more regular and predictable than in a cesarean. The results obtained indicate that postpartum EHG recording could be a helpful tool for earlier detection of uterine atony and contribute to better management of prophylactic uterotonic treatment for PPH prevention.This work was supported by the Spanish Ministry of Economy and Competitiveness, the European Regional Development Fund (MCIU/AEI/FEDER, UE RTI2018-094449-A-I00-AR) and the Generalitat Valenciana (GV/2018/104 and AICO/2019/220).Díaz-Martínez, MDA.; Mas-Cabo, J.; Prats-Boluda, G.; Garcia-Casado, J.; Cardona-Urrego, K.; Monfort-Ortiz, R.; Lopez-Corral, A.... (2020). A Comparative Study of Vaginal Labor and Caesarean Section Postpartum Uterine Myoelectrical Activity. 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Transcriptomic Analysis of a Diabetic Skin-Humanized Mouse Model Dissects Molecular Pathways Underlying the Delayed Wound Healing Response

Defective healing leading to cutaneous ulcer formation is one of the most feared complications of diabetes due to its consequences on patients’ quality of life and on the healthcare system. A more in-depth analysis of the underlying molecular pathophysiology is required to develop effective healing-promoting therapies for those patients. Major architectural and functional differences with human epidermis limit extrapolation of results coming from rodents and other small mammal-healing models. Therefore, the search for reliable humanized models has become mandatory. Previously, we developed a diabetes-induced delayed humanized wound healing model that faithfully recapitulated the major histological features of such skin repair-deficient condition. Herein, we present the results of a transcriptomic and functional enrichment analysis followed by a mechanistic analysis performed in such humanized wound healing model. The deregulation of genes implicated in functions such as angiogenesis, apoptosis, and inflammatory signaling processes were evidenced, confirming published data in diabetic patients that in fact might also underlie some of the histological features previously reported in the delayed skin-humanized healing model. Altogether, these molecular findings support the utility of such preclinical model as a valuable tool to gain insight into the molecular basis of the delayed diabetic healing with potential impact in the translational medicine field

Prognostic utility of serum free light chain ratios and heavy-light chain ratios in multiple myeloma in three PETHEMA/GEM phase III clinical trials

We investigated the prognostic impact and clinical utility of serum free light chains (sFLC) and serum heavy-light chains (sHLC) in patients with multiple myeloma treated according to the GEM2005MENOS65, GEM2005MAS65, and GEM2010MAS65 PETHEMA/GEM phase III clinical trials. Serum samples collected at diagnosis were retrospectively analyzed for sFLC (n = 623) and sHLC (n = 183). After induction or autologous transplantation, 309 and 89 samples respectively were available for sFLC and sHLC assays. At diagnosis, a highly abnormal (HA) sFLC ratio (sFLCr) (32) was not associated with higher risk of progression. After therapy, persistence of involved-sFLC levels >100 mg/L implied worse survival (overall survival [OS], P = 0.03; progression-free survival [PFS], P = 0.007). Among patients that achieved a complete response, sFLCr normalization did not necessarily indicate a higher quality response. We conducted sHLC investigations for IgG and IgA MM. Absolute sHLC values were correlated with monoclonal protein levels measured with serum protein electrophoresis. At diagnosis, HA-sHLCrs (73) showed a higher risk of progression (P = 0.006). Additionally, involved-sHLC levels >5 g/L after treatment were associated with shorter survival (OS, P = 0.001; PFS, P = 0.018). The HA-sHLCr could have prognostic value at diagnosis; absolute values of involved-sFLC >100 mg/L and involved-sHLC >5 g/L could have prognostic value after treatment