1 research outputs found
Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.
Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations
(TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable
clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p−) and gains
of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs www.impactjournals.com/oncotarget 80917 Oncotarget
However, the reported series were small, thus hindering definitive conclusions. To
gain insight into this issue, we assessed a series of 101 CLL patients harboring
TP53 disruption. The frequency of 8p− and 8q+ was 14.7% and 17.8% respectively.
Both were associated with a significantly (P < 0.05) higher incidence of a complex
karyotype (CK, ≥3 abnormalities) detected by chromosome banding analysis (CBA)
compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate
analysis for 10-year overall survival (OS), 8p− (P = 0.002), 8q+ (P = 0.012) and CK
(P = 0.009) were associated with shorter OS. However, in multivariate analysis only
CK (HR = 2.47, P = 0.027) maintained independent significance, being associated
with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our
results highlight the association of chromosome 8 abnormalities with CK amongst
CLL patients with TP53abs, while also revealing that CK can further aggravate the
prognosis of this aggressive subgroup.Instituto Carlos III, Ministerio de EconomÃa y Competitividad, Unión Europea PI11/01621, PI15/00437, RD09/0076/00036, RD12/0036/0044, RD12/0036/0069 and PT13/0010/0005Generalitat de Catalunya 2014/SGR58