461 research outputs found
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Scaling and dynamics of turbulence over sparseA canopies
Turbulent flows within and over sparse canopies are investigated using direct
numerical simulations. We focus on the effect of the canopy on the background
turbulence, the part of the flow that remains once the element-induced flow is
filtered out. In channel flows, the distribution of the total stress is linear
with height. Over smooth walls, the total stress is only the `fluid stress'
, the sum of the viscous and the Reynolds shear stresses. In canopies,
in turn, there is an additional contribution from the canopy drag, which can
dominate within. We find that, for sparse canopies, the ratio of the viscous
and the Reynolds shear stresses in at each height is similar to that
over smooth-walls, even within the canopy. From this, a height-dependent
scaling based on is proposed. Using this scaling, the background
turbulence within the canopy shows similarities with turbulence over smooth
walls. This suggests that the background turbulence scales with ,
rather than with the conventional scaling based on the total stress. This
effect is essentially captured when the canopy is substituted by a drag force
that acts on the mean velocity profile alone, aiming to produce the correct
, without the discrete presence of the canopy elements acting directly
on the fluctuations. The proposed mean-only forcing is shown to produce better
estimates for the turbulent fluctuations compared to a conventional,
homogeneous-drag model. The present results thus suggest that a sparse canopy
acts on the background turbulence primarily through the change it induces on
the mean velocity profile, which in turn sets the scale for turbulence, rather
than through a direct interaction of the canopy elements with the fluctuations.
The effect of the element-induced flow, however, requires the representation of
the individual canopy elements.Cambridge Commonwealth, European and International Trust
PRACE DECI-15
European Research Counci
Turbulent flows over dense filament canopies
Turbulent flows over dense canopies of rigid filaments of small size are
investigated for different element heights and spacings using DNS. The flow can
be decomposed into the element-coherent, dispersive flow, the
Kelvin--Helmholtz-like rollers typically reported over dense canopies, and the
background, incoherent turbulence. The canopies studied have spacings --, which essentially preclude the background turbulence from penetrating
within. The dispersive velocity fluctuations are also mainly determined by the
spacing, and are small deep within the canopy, where the footprint of the
Kelvin--Helmholtz-like rollers dominates. Their typical streamwise wavelength
is determined by the mixing length, which is essentially the sum of its height
above and below the canopy tips. For the present dense canopies, the former
remains roughly the same in wall-units, and the latter, which scales with the
drag length, depends linearly on the spacing. This is the result of the drag
being essentially viscous and governed by the planar layout of the canopy. In
shallow canopies, the proximity of the canopy floor inhibits the formation of
Kelvin--Helmholtz-like rollers, with essentially no signature for
height-to-spacing ratios , and no further inhibition beyond . Very small spacings also inhibit the rollers, due to their
obstruction by the canopy elements. The obstruction decreases with increasing
spacing and the signature of the instability intensifies, even if for canopies
sparser than those studied here the instability eventually breaks down. Simple
models based on linear stability can capture some of the above effects.Cambridge Commonwealth, European and International Trust
EPSRC Tier-2 grant EP/P020259/
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Turbulent Drag Reduction Using Anisotropic Permeable Substrates.
The behaviour of turbulent flow over anisotropic permeable substrates is studied using linear stability analysis and direct numerical simulations (DNS). The flow within the permeable substrate is modelled using the Brinkman equation, which is solved analytically to obtain the boundary conditions at the substrate-channel interface for both the DNS and the stability analysis. The DNS results show that the drag-reducing effect of the permeable substrate, caused by preferential streamwise slip, can be offset by the wall-normal permeability of the substrate. The latter is associated with the presence of large spanwise structures, typically associated to a Kelvin-Helmholtz-like instability. Linear stability analysis is used as a predictive tool to capture the onset of these drag-increasing Kelvin-Helmholtz rollers. It is shown that the appearance of these rollers is essentially driven by the wall-normal permeability Ky+ . When realistic permeable substrates are considered, the transpiration at the substrate-channel interface is wavelength-dependent. For substrates with low Ky+ , the wavelength-dependent transpiration inhibits the formation of large spanwise structures at the characteristic scales of the Kelvin-Helmholtz-like instability, thereby reducing the negative impact of wall-normal permeability
Polytopic bis(oxazoline)-based ligands for recoverable catalytic systems applied to the enantioselective Henry reaction
Several kinds of polytopic chiral ligands (including ditopic, tritopic and tetratopic), based on the bis(oxazoline) and azabis(oxazoline) motifs, have been tested in the preparation of recoverable catalytic systems for the Henry reaction. The results obtained with the different ligands are, in general, good, but they point to the existence of a delicate balance between the coordinating ability of the ligand, the catalytic activity and the recovery of the catalyst by formation of the coordination polymer, related to the easiness to form oligomeric species in solution
Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding
The AU-rich element (ARE)-mediated mRNA-degradation activity of the RNA binding K-homology splicing regulator protein (KSRP) is regulated by phosphorylation of a serine within its N-terminal KH domain (KH1). In the cell, phosphorylation promotes the interaction of KSRP and 14-3-3ζ protein and impairs the ability of KSRP to promote the degradation of its RNA targets. Here we examine the molecular details of this mechanism. We report that phosphorylation leads to the unfolding of the structurally atypical and unstable KH1, creating a site for 14-3-3ζ binding. Using this site, 14-3-3ζ discriminates between phosphorylated and unphosphorylated KH1, driving the nuclear localization of KSRP. 14-3-3ζ –KH1 interaction regulates the mRNA-decay activity of KSRP by sequestering the protein in a separate functional pool. This study demonstrates how an mRNA-degradation pathway is connected to extracellular signaling networks through the reversible unfolding of a protein domain.European Molecular Biology Organization 240-2005Italian CIPE-200
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Turbulent flows over superhydrophobic surfaces: Flow-induced capillary waves, and robustness of air-water interfaces
Superhydrophobic surfaces can retain gas pockets within their microscale textures when submerged in water. This property reduces direct contact between water and solid surfaces and presents opportunities for improving hydrodynamic performance by decreasing viscous drag. In most realistic applications, however, the flow regime is turbulent and retaining the gas pockets is a challenge. In order to overcome this challenge, it is crucial to develop an understanding of physical mechanisms that can lead to the failure of superhydrophobic surfaces in retaining gas pockets when the overlying liquid flow is turbulent. We present a study of the onset of failure in gas retention by analysing direct numerical simulations (DNS) of turbulent flows over superhydrophobic surfaces coupled with the deformation of air–water interfaces that hold the gas pockets. The superhydrophobic surfaces are modelled as periodic textures with patterned slip and no-slip boundary conditions on the overlying water flow. The liquid–gas interface is modelled via a linearized Young–Laplace equation, which is solved coupled with the overlying turbulent flow. A wide range of texture sizes and interfacial Weber numbers are considered in this study. Our analysis identifies flow-induced upstream-travelling capillary waves that are coherent in the spanwise direction as one mechanism for failure in retention of gas pockets. To confirm physical understanding of these waves, a semianalytical inviscid linear analysis is developed; the wave speeds obtained from the space–time correlations in the DNS data were found to match with the predictions of the semianalytical model. The magnitude of the pressure fluctuations due to these waves was found to increase with decreasing surface tension, and increase with a much stronger dependence on the slip velocity, when all numbers are reported in wall units. Based on a fitted scaling, a threshold criterion for the failure of superhydrophobic surfaces is developed that is based on estimates of the onset condition required for the motion of contact lines. The second contribution of this work is the development of boundary maps that identify stable and unstable zones in a parameter space consisting of working parameter and design parameters including texture size and material contact angle. We provide a brief description of previously identified failure modes of superhydrophobic surfaces, namely the stagnation pressure and shear-driven drainage mechanisms. In an overlay map, the stable and unstable zones due to each mechanism are presented. For various input conditions, we provide scaling laws that identify the most critical mechanism limiting the stability of gas retention by superhydrophobic surfaces.</jats:p
Interventions of computerized psychotherapies for depression in Primary Care in Spain
Currently, depression is a global health problem recognized by the WHO. The prevalence of this pathology in Primary Care is estimated at 19.5% worldwide, and 20.2% in Spain. In addition, the current intervention policies and protocols involve significant costs, both personal and economic, for people suffering from this disorder, as well as for society in general. On the other hand, the relapse rates after pharmacological interventions that are currently applied and the lack of effective specialized attention in mental health services reflect the need to develop new therapeutic strategies that are more accessible and profitable. Therefore, one of the proposals that are being investigated in different parts of the world is the design and evaluation of therapeutic protocols applied through Information and Communication Technologies, especially through the Internet and computer programs. The objective of this work was to present the current situation in Spain regarding the use of these interventions for the treatment of depression in Primary Care. The main conclusion is that although there is scientific evidence on the effectiveness of these programs, there are still important barriers that hinder their application in the public system, and also the need to develop implementation studies that facilitate the transition from research to clinical practice
Mujer e investigación en el CSIC de Aragón
2011: Año de la mujer investigadora.Peer Reviewe
Electrochemical synthesis and magnetic properties of MFe_2O_4 (M = Fe, Mn, Co, Ni) nanoparticles for potential biomedical applications
In this study, we evaluate the magnetic properties and cytotoxic effect of magnetic nanoparticles (MNPs) based on magnetite and Mn, Co and Ni ferrites, obtained by electrochemical synthesis. These nanoparticles have almost spherical shape and an mode size of 9 +/- 1 nm. The electrochemical synthesis produces a single crystallographic phase with a spinel-like structure in all cases. Magnetization saturation at room temperature varies with the composition of the ferrites from M_S (Fe_3O_4) > M_S (MnFe_2O_4) > M_S (CoFe_2O_4) > M_S (NiFe_2O_4). Ferrite MNPs present low magnetic remanence indicating a superparamagnetic-like response at room temperature. However, the different values of magnetic anisotropy and size produce variations in the values of coercivity and susceptibility of the ferrite MNPs. The cytotoxicity of the different ferrites was evaluated by internalizing MNP in HeLa cancer cells. Although magnetite and Mn ferrite present low toxicity for all the concentrations studied, significant cytotoxic effect were observed when incubating the cells with high concentration of Co and Ni ferrites
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