The Langley Ratio method, a new approach for transferring photometer calibration from direct sun measurements [Discussion paper]

This article presents a new method for transferring calibration from a reference photometer, referred to as the "master'', to a secondary photometer, referred to as the "field'', using a synergetic approach when master and field instruments have different spectral bands. The method was first applied between a PFR, (Precision Filter Radiometer) instrument from the World Optical Depth Research and Calibration Center (WORCC) considered the reference by the WMO (World Meteorological Organization), and a CE318-TS photometer, the standard photometer used by AERONET (AErosol RObotic NETwork). These two photometers have different optics, sun-tracking systems and spectral bands. The Langley Ratio method (LR) proposed in this study was used to transfer calibration to the closest spectral bands for 1-minute synchronous data, for airmasses between 2 and 5, and was compared to the state of the art Langley calibration technique. The study was conducted at two different locations, Izaña Observatory (IZO) and Valladolid, where measurements were collected almost simultaneously over a six-month period under different aerosol regimes. In terms of calibration aspects, our results showed very low relative differences and standard deviations in the calibration constant transferred in Izaña from PFR to Cimel, up to 0.29 % and 0.46 %, respectively, once external factors such as different field-of-view between photometers or the presence of calibration issues were considered. However, these differences were higher in the comparison performed at Valladolid (1.04 %) and in the shorter wavelengths spectral bands (up to 0.78 % in Izaña and 1.61 % in Valladolid)

Examining the immune signatures of SARS-CoV-2 infection in pregnancy and the impact on neurodevelopment: Protocol of the SIGNATURE longitudinal study.

The COVID-19 pandemic represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge on pathophysiological mechanisms of neuropsychiatric diseases. One of these opportunities is the study of the relationships between inflammation, brain development and an increased risk of suffering neuropsychiatric disorders. Based on the hypothesis that neuroinflammation during early stages of life is associated with neurodevelopmental disorders and confers a greater risk of developing neuropsychiatric disorders, we propose a cohort study of SARS-CoV-2-infected pregnant women and their newborns. The main objective of SIGNATURE project is to explore how the presence of prenatal SARS-CoV-2 infection and other non-infectious stressors generates an abnormal inflammatory activity in the newborn. The cohort of women during the COVID-19 pandemic will be psychological and biological monitored during their pregnancy, delivery, childbirth and postpartum. The biological information of the umbilical cord (foetus blood) and peripheral blood from the mother will be obtained after childbirth. These samples and the clinical characterisation of the cohort of mothers and newborns, are tremendously valuable at this time. This is a protocol report and no analyses have been conducted yet, being currently at, our study is in the recruitment process step. At the time of this publication, we have identified 1,060 SARS-CoV-2 infected mothers and all have already given birth. From the total of identified mothers, we have recruited 537 SARS-COV-2 infected women and all of them have completed the mental health assessment during pregnancy. We have collected biological samples from 119 mothers and babies. Additionally, we have recruited 390 non-infected pregnant women