Stereospecific synthesis of the aglycone of pseudopterosin E

No description supplie

MELK-a conserved kinase: functions, signaling, cancer, and controversy.

Maternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control. Recent evidence has identified a broader spectrum of tissue expression pattern for this kinase than previously appreciated. MELK is expressed in several human cancers and stem cell populations. Unique spatial and temporal patterns of expression within these tissues suggest that MELK plays a prominent role in cell cycle control, cell proliferation, apoptosis, cell migration, cell renewal, embryogenesis, oncogenesis, and cancer treatment resistance and recurrence. These findings have important implications for our understanding of development, disease, and cancer therapeutics. Furthermore understanding MELK signaling may elucidate an added dimension of stem cell control

Self Interacting Dark Matter in the Solar System

Weakly coupled, almost massless, spin 0 particles have been predicted by many extensions of the standard model of particle physics. Recently, the PVLAS group observed a rotation of polarization of electromagnetic waves in vacuum in the presence of transverse magnetic field. This phenomenon is best explained by the existence of a weakly coupled light pseudoscalar particle. However, the coupling required by this experiment is much larger than the conventional astrophysical limits. Here we consider a hypothetical self-interacting pseudoscalar particle which couples weakly with visible matter. Assuming that these pseudoscalars pervade the galaxy, we show that the solar limits on the pseudoscalar-photon coupling can be evaded.Comment: 17 pages, 2 figure

Efficacy of Some Common Aquarium Fishes as Biocontrol Agent of Preadult Mosquitoes

Predation experiment using Betta splendens, Pseudotropheus tropheops, Osphronemus gorami and Pterophyllum scalare were conducted against IVth instar Anopheline larvae and pupae with varying prey and predator densities. Ranking of individual predatory efficacy showed the sequence: P. tropheops > B. splendens > O. gorami > P. scalare against larva/form and B. splendens > O. gorami > P. tropheops > P. scalare against pupal form of Anopheles stephensi during 24 hours experiment in laboratory condition. Predation under co-existence in interspecific and intraspecific combinations revealed the significance of predatory efficacy with reference to prey density and water volume (search area)

Identification of Gain and Loss of Function Missense Variants in MRGPRX2’s Transmembrane and Intracellular Domains for Mast Cell Activation by Substance p

The neuropeptide substance P (SP) contributes to neurogenic inflammation through the activation of human mast cells via Mas-related G protein-coupled receptor-X2 (MRGPRX2). Using pertussis toxins and YM-254890, we demonstrated that SP induces Ca2+ mobilization and degranulation via both the Gαi and Gαq family of G proteins in rat basophilic leukemia (RBL-2H3)cells stably expressing MRGPRX2. To determine the roles of MRGPRX2’s transmembrane (TM) and intracellular domains on SP-induced responses, we utilized information obtained from both structural modeling and naturally occurring MRGPRX2 missense variants. We found that highly conservedresidues in TM6 (I225) and TM7 (Y279) of MRGPRX2 are essential for SP-induced Ca2+ mobilization and degranulation in transiently transfected RBL-2H3 cells. Cells expressing missense variants in the receptor’s conserved residues (V123F and V282M) as well as intracellular loops (R138C andR141C) failed to respond to SP. By contrast, replacement of all five Ser/Thr residues with Ala and missense variants (S325L and L329Q) in MRGPRX2’s carboxyl-terminus resulted in enhanced mast cell activation by SP when compared to the wild-type receptor. These findings suggest that MRGPRX2utilizes conserved residues in its TM domains and intracellular loops for coupling to G proteins and likely undergoes desensitization via phosphorylation at Ser/Thr residues in its carboxyl-terminus. Furthermore, identification of gain and loss of function MRGPRX2 variants has important clinical implications for SP-mediated neurogenic inflammation and other chronic inflammatory diseases

Photon & Axion Oscillation In a Magnetized Medium: A Covariant Treatment

Pseudoscalar particles, with almost zero mass and very weak coupling to the visible matter, arise in many extensions of the standard model of particle physics. Their mixing with photons in the presence of an external magnetic field leads to many interesting astrophysical and cosmological consequences. This mixing depends on the medium properties, the momentum of the photon and the background magnetic field. Here we give a general treatment of pseudoscalar-photon oscillations in a background magnetic field, taking the Faraday term into account. We give predictions valid in all regimes, under the assumption that the frequency of the wave is much higher than the plasma frequency of the medium. At sufficiently high frequencies, the Faraday effect is negligible and we reproduce the standard pseudoscalar-photon mixing phenomenon. However at low frequencies, where Faraday effect is important, the mixing formulae are considerably modified. We explicitly compute the contribution due to the longitudinal mode of the photon and show that it is negligible.Comment: 16 pages, no figure

Optical Activity From Extra Dimension

Optical activity, like Faraday effect, is a rotation of the plane of polarization of propagating light in a medium and can be attributed to different sources with distinct signatures. In this note we discuss the effect of optical activity {\it{in vacuum}} due to Kaluza-Klein scalar field $\phi$, in the presence of an external electro-magnetic field. The astrophysical implication of this effect is indicated. We also point out the possibility of observing the same in laboratory conditions.Comment: Four Page

Spectral shape of the UV ionizing background and HeII absorption at redshifts 1.8 < z < 2.9

The shape of the UV ionizing background is reconstructed from optically thin metal absorption-line systems identified in spectra of HE2347-4342, Q1157+3143, and HS1700+6416 in the redshift interval 1.8 < z < 2.9. The systems are analyzed by means of the Monte Carlo Inversion method completed with the spectral shape recovering procedure. The UVB spectral shape fluctuates at 2.4 < z < 2.9 mostly due to radiative transfer processes in the clumpy IGM. At z < 1.8, the IGM becomes almost transparent both in the HI and HeII Lyman continua and the variability of the spectral shape comes from diversity of spectral indices describing the QSO/AGN intrinsic radiation. At z > 2.4, the recovered spectral shapes show intensity depression between 3 and 4 Ryd due to HeII Ly-alpha absorption in the IGM clouds (line blanketing) and continuous medium (true Gunn-Petersen effect). The mean HeII Ly-alpha opacity estimated from the depth of this depression corresponds within 1-2sigma to the values directly measured from the HI/HeII Ly-alpha forest towards the quasars studied. The observed scatter in eta = N(HeII)/N(HI) and anti-correlation between N(HI) and eta can be explained by the combined action of variable spectral softness and differences in the mean gas density between the absorbing clouds. Neither of the recovered spectral shapes show features which can be attributed to the putative input of radiation from soft sources like starburst galaxies.Comment: 20 pages, 20 figures. Accepted for publication in A&