A New Extension of Two Parameter Pranav Distribution with Applications in Industrial and Medical Sciences

In this study, a new distribution has been proposed called as weighted three parameter Pranav distribution. The different statistical properties of new distribution have been obtained which include moments, harmonic mean, order statistics, survival analysis, entropies, bonferroni and Lorenz curves. For estimating the model parameters of the new distribution, the technique of maximum likelihood estimation has been used. Finally, three real life data sets have been fitted in new distribution to discuss its goodness of fit

An ethnomedicinal survey of traditionally used medicinal plants from Charkhi Dadri district, Haryana: an attempt towards documentation and preservation of ethnic knowledge

436-450Medicinal plants have remained an integral source of therapeutics for primary healthcare since antiquity. The information pertaining to usage of plants is either inherited from elders or acquired through trials or the experience of others but is not documented frequently. South Haryana is one such rich storehouse of ethnomedicinal knowledge. Hence, ethnomedicinally important plants from Charkhi Dadri district of Haryana state were documented in the present study. The data was collected through field surveys and in-depth interviews organized in the fields during the years 2018-19. Factor of informant consensus was also calculated. A total of 90 ethnomedicinal plants were identified, belonging to 41 families and 79 genera. Majority of plants were herbs (47.7%), followed by trees (30%). Leguminosae (10%) represented the maximum number of plants, followed by Solanaceae (6.6% each) and Amaranthaceae, Lamiaceae and Poaceae (5.5% each). A total of 64 ailments were reported to be treated traditionally by ethnomedicinal plants in the area. The most commonly treated diseases were menorrhagia, skin boils, typhoid, diabetes, piles and diarrhoea. It was observed that the majority of plants were used freshly to extract juice, followed by powder and decoction and rarely as tea or oil forms. The present study provides comprehensive ethnomedicinal data including vernacular and botanical names, names of the family, mode of preparation, administration and dosage of plant drugs and diseases treated. It was concluded that this region still possesses numerous useful ethnomedicinal knowledge and may contribute to further herbal drug development programs

An ethnomedicinal survey of traditionally used medicinal plants from Charkhi Dadri district, Haryana: an attempt towards documentation and preservation of ethnic knowledge

Medicinal plants have remained an integral source of therapeutics for primary healthcare since antiquity. The information pertaining to usage of plants is either inherited from elders or acquired through trials or the experience of others but is not documented frequently. South Haryana is one such rich storehouse of ethnomedicinal knowledge. Hence, ethnomedicinally important plants from Charkhi Dadri district of Haryana state were documented in the present study. The data was collected through field surveys and in-depth interviews organized in the fields during the years 2018-19. Factor of informant consensus was also calculated. A total of 90 ethnomedicinal plants were identified, belonging to 41 families and 79 genera. Majority of plants were herbs (47.7%), followed by trees (30%). Leguminosae (10%) represented the maximum number of plants, followed by Solanaceae (6.6% each) and Amaranthaceae, Lamiaceae and Poaceae (5.5% each). A total of 64 ailments were reported to be treated traditionally by ethnomedicinal plants in the area. The most commonly treated diseases were menorrhagia, skin boils, typhoid, diabetes, piles and diarrhoea. It was observed that the majority of plants were used freshly to extract juice, followed by powder and decoction and rarely as tea or oil forms. The present study provides comprehensive ethnomedicinal data including vernacular and botanical names, names of the family, mode of preparation, administration and dosage of plant drugs and diseases treated. It was concluded that this region still possesses numerous useful ethnomedicinal knowledge and may contribute to further herbal drug development programs

Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1

Oropouche orthobunyavirus (OROV

Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice

Rift Valley fever virus (RVFV) is an emerging arbovirus found in Africa. While RVFV is pantropic and infects many cells and tissues, viral replication and necrosis within the liver play a critical role in mediating severe disease. The low-density lipoprotein receptor-related protein 1 (Lrp1) is a recently identified host factor for cellular entry and infection by RVFV. The biological significance of Lrp1, including its role in hepatic disease in vivo, however, remains to be determined. Because Lrp1 has a high expression level in hepatocytes, we developed a mouse model in which Lrp1 is specifically deleted in hepatocytes to test how the absence of liver Lrp1 expression affects RVF pathogenesis. Mice lacking Lrp1 expression in hepatocytes showed minimal RVFV replication in the liver, longer time to death, and altered clinical signs toward neurological disease. In contrast, RVFV infection levels in other tissues showed no difference between the two genotypes. Therefore, Lrp1 is essential for RVF hepatic disease in mice

An overview of the recent developments on fructooligosaccharide production and applications

Over the past years, many researchers have suggested that deficiencies in the diet can lead to disease states and that some diseases can be avoided through an adequate intake of relevant dietary components. Recently, a great interest in dietary modulation of the human gut has been registered. Prebiotics, such as fructooligosaccharides (FOS), play a key role in the improvement of gut microbiota balance and in individual health. FOS are generally used as components of functional foods, are generally regarded as safe (generally recognized as safe status—from the Food and Drug Administration, USA), and worth about 150€ per kilogram. Due to their nutrition- and health-relevant properties, such as moderate sweetness, low carcinogenicity, low calorimetric value, and low glycemic index, FOS have been increasingly used by the food industry. Conventionally, FOS are produced through a two-stage process that requires an enzyme production and purification step in order to proceed with the chemical reaction itself. Several studies have been conducted on the production of FOS, aiming its optimization toward the development of more efficient production processes and their potential as food ingredients. The improvement of FOS yield and productivity can be achieved by the use of different fermentative methods and different microbial sources of FOS producing enzymes and the optimization of nutritional and culture parameter; therefore, this review focuses on the latest progresses in FOS research such as its production, functional properties, and market data.Agencia de Inovacao (AdI)-Project BIOLIFE reference PRIME 03/347. Ana Dominguez acknowledges Fundacao para a Ciencia e a Tecnologia, Portugal, for her PhD grant reference SFRH/BD/23083/2005

Genetic Basis of Myocarditis: Myth or Reality?

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