Investigation of Magnitude and Phase Errors in Waveguide Samples for the Nicolson-Ross-Weir Permittivity Technique

The Nicolson-Ross-Weir (NRW) technique is a commonly-used method for measuring the electromagnetic properties of low-loss materials. The technique entails placing the material under test in a waveguide, and then inferring the electromagnetic properties of that material from the reflection and transmission coefficients measured at the ends of the guide. While NRW technique generally provides reliable and accurate results, there are conditions where errors can arise. Some of the known errors are attributed to sample preparation, although errors have been observed even with perfectly-prepared samples. Those errors generally result in an overestimation of loss and unrealistic values for permeability, and they are shown to be associated with phase errors in the reflection and transmission coefficients. The work reported here shows the relationship between measurement phase errors and how they impact estimated electromagnetic property values. Further, an approach to correct for those errors when evaluating non-magnetic materials is given

Factoring complete graphs and hypergraphs into factors with few maximal cliques

For integers $r,t\geq2$ and $n\geq1$ let $f_r(t,n)$ be the minimum, over all factorizations of the complete $r$-uniform hypergraph of order $n$ into $t$ factors $H_1,\dots,H_t$, of $\sum_{i=1}^tc(H_i)$ where $c(H_i)$ is the number of maximal cliques in $H_i$. It is known that $f_2(2,n)=n+1$; in fact, if $G$ is a graph of order $n$, then $c(G)+c(\overline G)\geq n+1$ with equality iff $\omega(G)+\alpha(G)=n+1$ where $\omega$ is the clique number and $\alpha$ the independence number. In this paper we investigate $f_r(t,n)$ when $r>2$ or $t>2$. We also characterize graphs $G$ of order $n$ with $c(G)+c(\overline G)=n+2$.Comment: 22 page

A Study of the Problems of Cost Analysis in the Petroleum Industry

The significance of the subject of the present study-the cost of finding, developing and producing petroleum-can be better understood by placing it against a summary view of the supply situation in the postwar world. The most striking fact is the appearance of vast new reserves of oil in various parts of the world. Earlier concern over conservation was aroused by the fear of depletion of the available supply. Taking a long view, this possibility is not to be dismissed. But in recent years the practical problems of the industry, and of public policy toward it, are of a different sort. The capacity of the industry to produce in the countries of the free world greatly exceeds the current rates of consumption. From the sellers\u27 point of view, at least, it seems self-evident that too much oil exists today

Imaging of adult ocular and orbital pathology - a pictorial review

Orbital pathology often presents a diagnostic challenge to the reporting radiologist. The aetiology is protean, and clinical input is therefore often necessary to narrow the differential diagnosis. With this manuscript, we provide a pictorial review of adult ocular and orbital pathology.peer-reviewe

Reactions to imagery generated using computational aesthetic measures

This article examines whether textural generation system imagery evolved with computational aesthetic support can be judged as having aesthetic attributes, both when knowing and not knowing its true origin. Such a generation, depicting a digital landscape, is offered to two groups of participants to appraise. It is hypothesized that there will be no statistically significant difference between the groups on their appraisal of the image. Results from statistical analysis prove to be consistent with this hypothesis. A minority of participants, however, do exhibit significant differences in their perception of the image based on its means of production. This article explores and illustrates these differences

Flexible substrate sensors for multiplex biomarker monitoring

Wearable healthcare technologies should be non-invasive, robust to daily activity/environments, easy to use, and comfortable to wear. Flexible substrate devices for biomarker monitoring can contribute to wearable diagnostic applications. Single-target biosensors have extensively been developed for health-monitoring applications; however, recently multiplex biomarker tests have generated clinical interest. Targeting multiple biomarkers in diagnostic systems (wearable or point of care) offers more focused diagnosis and treatment as changes in a single biomarker can be caused by a series of physiologic conditions. This review highlights flexible substrates that have been successfully demonstrated for multiplex biomarker detection with potential for healthcare monitoring

A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes

Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological functions. The process is catalyzed by myristoyl-CoA:protein N-myristoyltransferase (NMT), an enzyme which has been validated as a drug target in human cancers, and for infectious diseases caused by fungi, viruses and protozoan parasites. We purified Caenorhabditis elegans and Brugia malayi NMTs as active recombinant proteins and carried out kinetic analyses with their essential fatty acid donor, myristoyl-CoA and peptide substrates. Biochemical and structural analyses both revealed that the nematode enzymes are canonical NMTs, sharing a high degree of conservation with protozoan NMT enzymes. Inhibitory compounds that target NMT in protozoan species inhibited the nematode NMTs with IC50 values of 2.5-10 nM, and were active against B. malayi microfilariae and adult worms at 12.5 µM and 50 µM respectively, and C. elegans (25 µM) in culture. RNA interference and gene deletion in C. elegans further showed that NMT is essential for nematode viability. The effects observed are likely due to disruption of the function of several downstream target proteins. Potential substrates of NMT in B. malayi are predicted using bioinformatic analysis. Our genetic and chemical studies highlight the importance of myristoylation in the synthesis of functional proteins in nematodes and have shown for the first time that NMT is required for viability in parasitic nematodes. These results suggest that targeting NMT could be a valid approach for the development of chemotherapeutic agents against nematode diseases including filariasis