Restoration of the church of San Francesco in Fano (Italy)

[EN] The church of St Francis in Fano, in ruins for decades, possesses enormous power of evocation at home and abroad. The intervention carried out has maintained it in its incomplete and fragmentary condition, shunning rehabilitation works that would have been relatively feasible thanks to the existence of abundant documentation and the remains conserved. The restoration was limited to securing the fallen fabrics, consolidating the remaining decoration and installing the facilities strictly necessary to maintain the pavement of natural grass and illuminate the space so that it could be used as a venue for public events or simply as a museum recording the vicissitudes of its history.[ES] La iglesia de San Francisco de Fano expuesta a cielo abierto desde hace décadas posee una gran capacidad de evocación para propios y extraños. La intervención llevada a cabo ha asumido su condición incompleta y fragmentaria evitando una repristinación que era relativamente fácil por la existencia de abundante documentación y restos conservados. La restauración ha acometido la tarea de afianzar sus fábricas desplomadas, consolidar la decoración remanente e insertar las instalaciones estrictamente necesarias para el mantenimiento del césped natural como pavimento y la iluminación del espacio para su uso como foro de actos públicos o, simplemente, como museo de los avatares de su propia historia construida.Galli, C. (2014). Restauración de la Iglesia de San Francesco en Fano (Italia). Loggia, Arquitectura & Restauración. (26):74-99. doi:10.4995/loggia.2013.3169SWORD74992

Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells

In the monocytic THP-1 cells, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor simvastatin (5 microM) enhances the conversion of exogenous linoleic (18:2 n-6) and eicosapentaenoic (20:5 n-3) acids to their long-chain polyunsaturated fatty acid (LC-PUFA) derivatives, and this effect is associated with changes in the desaturation steps. In addition, formation of monounsaturated fatty acids from endogenously synthesized precursors is increased. These metabolic changes lead to elevated LC-PUFA and fatty acid (FA) unsaturation in cells. The effects of simvastatin on FA metabolism are associated with increased synthesis of triglycerides from glycerol. The dose-effect relationships for the activity of simvastatin on total linoleic acid (LA) conversion and cholesterol synthesis reveal that enhancement of PUFA metabolism is already maximal at 0.5 microM simvastatin, whereas cholesterol synthesis is further inhibited by concentrations of simvastatin up to 5 microM. The effects of 5 microM simvastatin on PUFA metabolism are partially prevented by mevalonate (1 mM) and geranylgeraniol (5 microM) but not by farnesol (10 microM). These data indicate that HMG-CoA inhibitors have profound effects on PUFA metabolism, and that the pathways for cholesterol and PUFA synthesis are mutually modulated

Contributo per una conoscenza analitica delle Mura Bolognesi: Il rilievo critico

Per la prima volta viene affrontato in modo critico e definito il rilievo diretto delle mura e delle porte della terza cerchia di Bologna. La restituzione grafica del testo architettonico è fondamentale non solo per gli studi sui materiali e sulle tecniche che compongono i vari manufatti afferenti al sistema fortificato, ma anche per una lettura cronologica delle stratificazioni che si sono sedimentate nel corso dei secoli. In particolare vengono analizzate direttamente sul testo architettonico le fasi costruttive di Porta Mascarella e Porta San Donato e vengono comparate fra loro cartografie inedite relative alla struttura geometrica delle mura con i relativi elementi accessori, quali cancella, fossato, terrapieni, ecc.

Reuse of an ancient church: thermal aspect for integrated solutions

Abstract The definition of intervention strategies for the restoration and the functional actualization of historic and high artistic quality artifacts, postulates a systemic approach for the different variables that contribute to the definition of the project. This paper presents an emblematic case study of an historic building, the church of St. Francis in San Giovanni in Persiceto near Bologna, one of the most representative of the architectural construction of Bolognese Baroque, built by Alfonso Torreggiani. The expected new functions as exhibition hall and/or concert activities, requires a search for integrated strategies to ensure indoor comfort requirements (thermo-hygrometric, acoustics) and to define HVAC plant equipment for the reduction of energy consumption without affecting the historic values and artistic perception of the building. Therefore, the analysis of the church in the survey phase, besides the usual historical and architectural investigations, should investigate the potential issues and the critical aspects of structures, like the multilayered floor and refined decorations that lines the walls of the nave. Understanding the intimate rationality of the building (presence of any shafts, steps etc .) is a prerequisite for the inclusion of plant components without altering the visual perception and to optimize the acoustic and the climatization plant systems. Although the use of renewable energy are required today for all new plant systems, in this case it was decided to exclude invasive elements that could have altered the image of the entire monumental complex of which the church belongs. The proposed HVAC plant, after an analysis of dynamic thermal behaviour of the building, is an air-conditioning system coupled to radiant heating system to ensure, in a climate context with high humidity levels, the optimal temperature and humidity not only for comfort conditions but also for preservation of the building itself and of artistic works

Business Intelligence INFN: Introduzione ai Nuovi Report di Bilancio INFN

L’obiettivo di questo elaborato è descrivere le scelte progettuali che hanno portato nel 2020 alla ristrutturazione della reportistica dedicata al Bilancio INFN presente sull’impianto di Business Intelligence (BI) INFN. Nello specifico vengono presentate le motivazioni della dismissione dei vecchi report multidimensionali basati su Viste OLAP in favore degli attuali report JRXML. Vengono anche presentati alcuni aspetti peculiari delle soluzioni implementate sul data warehouse che offre funzionalità di backend per l’impianto volte a garantire il giusto layer autorizzativo nell’accesso ai dati ed alle risorse

Scouting tecnologico e primi test del nuovo servizio di Business Analytics della Direzione Sistemi Informativi INFN

Dalla fine del 2021 in poi sempre più utenti hanno espresso la necessità di analizzare i dati provenienti dai sistemi della Direzione Sistemi Informativi (DSI) con maggior autonomia rispetto a quanto non fosse possibile fino a quel momento. Per dare una risposta adeguata a tali richieste è stata avviata una fase di scouting tecnologico coinvolgendo diversi competitor internazionali nel settore Business Analytics. L’obiettivo era identificare quale soluzione potesse meglio rispondere alle nuove esigenze, nel rispetto delle linee guida dell’Agenzia per L’Italia Digitale (AGID) per la transizione digitale delle pubbliche amministrazioni (PA). Un requisito fondamentale è stato il grado di integrazione che tali prodotti garantivano. Si è valutato quindi la capacità di connettersi con altre tecnologie impiegate nella direzione, la sostenibilità infrastrutturale (risorse, attività di DevOps ...) e quanto si integrassero con gli strumenti usati abitualmente dalle altre direzioni ed utenti INFN. Dopo una breve introduzione, questo elaborato si concentra sul prodotto scelto, Microsoft Power BI Premium, le funzionalità più importanti che offre in associazione con il Tenant 365 dell’INFN ed il setup del nuovo servizio di Self Service BI

Monitoraggio delle risorse forestali in ambiente mediterraneo mediante telerilavamento

Monitoring forest resources in Mediterranean environment using remote sensing techniques. Since the Neolithic pastoralism has played a major role in the landscape changes of the Mediterranean basin; during the last century the increased anthropic pressure on Mediterranean ecosystems (overgrazing, fires, overcultivation of unsuitable areas) led to severe land degradation phenomena. The typical Mediterranean forest ecosystems have undergone a progressive and steady depletion, resulting in very fragmented and heterogeneous landscapes. In this context monitoring forest resources at regional scale represents a major issue towards the identification of areas threatened by land degradation where mitigation actions have to be carried out. Remote sensing is a powerful tool for monitoring natural and forest resources due to its synoptic and multitemporal characteristics. Nevertheless, the heterogeneity and rapid dynamics of secondary vegetation after disturbances (overgrazing or fires) make complex the use of the traditional classification techniques of remote sensed images. In this study we present preliminary results obtained with the application of traditional and innovating procedures for land cover classification (Maximum Likelihood Classification, Spectral Mixture Analysis) in central-eastern Sardinia

Olive oil and oxidative stress

In addition to the fatty acid profile of olive oil, which is high in the monounsaturated oleic acid and appears to be beneficial in reducing several risk factors for coronary heart disease and certain cancers, extra virgin olive oil contains a considerable amount of phenolic compounds, e.g. hydroxytyrosol and oleuropein, that are responsible for its peculiar taste and for its high stability. A body of evidence demonstrates that olive oil phenolics are powerful antioxidants. Although most of these studies have been carried out in vitro, some in vivo experiments confirm that olive oil phenolics are dose-dependently absorbed and that they retain their biological activities after ingestion. These data could in part explain the lower incidence of coronary heart disease in the Mediterranean area, where (extra virgin) olive oil is the principal source of fat.La composición del aceite de oliva virgen extra se caracteriza por su contenido en ácidos grasos, fundamentalmente monoinsaturados (ácido oleico) beneficiosos para reducir el riesgo de enfermedad coronaria, y en componentes menores, particularmente polifenoles (p.e. hidroxitirosol y oleuropeína) responsables de su sabor y estabilidad. Diversos estudios demuestran el poder antioxidante de los compuestos fenólicos del aceite de oliva (virgen extra). Aunque la mayoría de ellos se han realizado in vitro, algunos in vivo parecen confirmar que los polifenoles se absorben dependiendo de la dosis y que retienen las actividades biológicas después de su ingestión. Estos resultados pueden explicar en parte la menor incidencia de enfermedad coronaria en los países del área Mediterránea, donde el aceite de oliva (extra virgen) es la principal fuente de grasas

MENTAL STRESS INFLUENCE ON MOVEMENT

The main aim of this work is the analysis of movement alterations under mental stress conditions. The right leg extension movement of 8 seated subjects. in different load situations, in normal and mental stress conditions, was analyzed. The mental stress situation refers to a numerical countdown computed by the subject during the movement execution. The movement analysis was carried out using the ELITE system that provides for the.complete kinematic analysis of the movements, allowing the quantitative study of 3-D markers' trajectories, displacements, velocities and accelerations. The muscular activity of rectus femoris and vastus medialis, that are the most important muscles for the extensional movement, was controlled with the EMG analysis. Particularly the markers' position are shown in fig. 1 For each movement and muscular acquisition the maximal height (H,,,,,) reached by the ankle together its trajectory, velocity, and accelerations were computed. Besides the interval time between each mental count and the subsequent was recorded. Finally the EMG signals were analyzed. This experimental study shows that the mental stress situation limits the normal execution of movement. In fact Hmax decreases when load and mental stress increase