Magnetoelastic coupling in triangular lattice antiferromagnet CuCrS2

CuCrS2 is a triangular lattice Heisenberg antiferromagnet with a rhombohedral crystal structure. We report on neutron and synchrotron powder diffraction results which reveal a monoclinic lattice distortion at the magnetic transition and verify a magnetoelastic coupling. CuCrS2 is therefore an interesting material to study the influence of magnetism on the relief of geometrical frustration.Comment: 6 pages, 6 figures, 1 tabl

Digital Transformation of Additional Professional Education: Features of the LK-14 Educational Platform

This article substantiates the relevance of the transformation of the educational environment of additional professional education (APE) in the Republic of Sakha (Yakutia). This study aims to justify the transformation of the educational environment of APE in the context of digitalization and to consider the prospects for targeted professional development of teachers in the republic according to their needs. The authors chose this scientific topic due to the pressing needs of Russian continuing professional education (CPE) and current problems such as the lack of unified approaches and mechanisms for regulating the professional development of teachers in the digital educational environment and the lack of methods for monitoring the effectiveness and efficiency of CPE distance learning programs. Creating an innovative and dynamic CPE system requires the intensive introduction of information technologies into education. These technologies ensure that the learning process is open and of high quality, as well as provide access to global educational resources. This helps learners create “their own individual educational environment” reflecting their needs and requirements. The research methods used to explore this problem were a pedagogical experiment, the analysis of the organization of CPE of teachers in the region, designing a regional model of targeted personalized training of educators and administration. The research results include the specifics of APE modernization in the region and the model of targeted personalized training of teachers of the republic. The qualitative novelty of this model stems from the fact that developing teachers’ competencies involves identifying gaps in their professional knowledge and building individual learning paths

Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder

Bipolar disorder (BD) is a common and highly heritable disorder of mood. Genome-wide association studies (GWAS) have identified several independent susceptibility loci. In order to extract more biological information from GWAS data, multi-locus approaches represent powerful tools since they utilize knowledge about biological processes to integrate functional sets of genes at strongly to moderately associated loci.We conducted gene set enrichment analyses (GSEA) using 2.3 million single-nucleotide polymorphisms, 397 Reactome pathways and 24,025 patients with BD and controls. RNA expression of implicated individual genes and gene sets were examined in post-mortem brains across lifespan.Two pathways showed a significant enrichment after correction for multiple comparisons in the GSEA: GRB2 events in ERBB2 signaling, for which 6 of 21 genes were BD associated (PFDR = 0.0377), and NCAM signaling for neurite out-growth, for which 11 out of 62 genes were BD associated (PFDR = 0.0451). Most pathway genes showed peaks of RNA co-expression during fetal development and infancy and mapped to neocortical areas and parts of the limbic system.Pathway associations were technically reproduced by two methods, although they were not formally replicated in independent samples. Gene expression was explored in controls but not in patients.Pathway analysis in large GWAS data of BD and follow-up of gene expression patterns in healthy brains provide support for an involvement of neurodevelopmental processes in the etiology of this neuropsychiatric disease. Future studies are required to further evaluate the relevance of the implicated genes on pathway functioning and clinical aspects of BD

Magnon mode in α‐MnS Raman spectrum

Представлены спектры комбинационного рассеяния моносульфида марганца (α‐MnS) со структурой NaCl в температурном интервале 5–300 К. При низких темпепературах обнаружен новый пик 22 cm–1. Температурная зависимость этого пика позволяет отнести его к магнонной моде при k = 0. Это хорошо согласуется с волновым числом магнона, рассчитанного с использованием программного пакета Munich SPRKKR

Digital Transformation of Additional Professional Education: Features of the LK-14 Educational Platform

This article substantiates the relevance of the transformation of the educational environment of additional professional education (APE) in the Republic of Sakha (Yakutia). This study aims to justify the transformation of the educational environment of APE in the context of digitalization and to consider the prospects for targeted professional development of teachers in the republic according to their needs. The authors chose this scientific topic due to the pressing needs of Russian continuing professional education (CPE) and current problems such as the lack of unified approaches and mechanisms for regulating the professional development of teachers in the digital educational environment and the lack of methods for monitoring the effectiveness and efficiency of CPE distance learning programs. Creating an innovative and dynamic CPE system requires the intensive introduction of information technologies into education. These technologies ensure that the learning process is open and of high quality, as well as provide access to global educational resources. This helps learners create “their own individual educational environment” reflecting their needs and requirements. The research methods used to explore this problem were a pedagogical experiment, the analysis of the organization of CPE of teachers in the region, designing a regional model of targeted personalized training of educators and administration. The research results include the specifics of APE modernization in the region and the model of targeted personalized training of teachers of the republic. The qualitative novelty of this model stems from the fact that developing teachers’ competencies involves identifying gaps in their professional knowledge and building individual learning paths.Este artículo confirma la relevancia de la transformación del entorno educativo de la educación profesional adicional (APE) en la República de Sakha (Yakutia). Este estudio tiene como objetivo justificar la transformación del entorno educativo de APE en el contexto de la digitalización y considerar las perspectivas de desarrollo profesional dirigido de los docentes en la república de acuerdo con sus necesidades. Los autores eligieron este tema científico debido a las necesidades apremiantes de la educación profesional continua rusa (CPE) y los problemas actuales, como la falta de enfoques y mecanismos unificados para regular el desarrollo profesional de los docentes en el entorno educativo digital y la falta de métodos de monitoreo La efectividad y eficiencia de los programas de educación a distancia CPE La creación de un sistema CPE innovador y dinámico requiere la introducción intensiva de tecnologías de la información en la educación. Estas tecnologías aseguran que el proceso de aprendizaje sea abierto y de alta calidad, y proporcionan acceso a recursos educativos globales. Esto ayuda a los alumnos a crear "su propio entorno educativo individual" que refleja sus necesidades y requisitos. Los métodos de investigación utilizados para explorar este problema fueron un experimento pedagógico, el análisis de la organización de CPE de docentes en la región, el diseño de un modelo regional de capacitación personalizada dirigida de educadores y administración. Los resultados de la investigación incluyen los detalles específicos de la modernización de APE en la región y el modelo de capacitación personalizada dirigida de maestros de la república. La novedad cualitativa de este modelo se deriva del hecho de que desarrollar las competencias de los docentes implica identificar lagunas en su conocimiento profesional y construir caminos de aprendizaje individuales

Identification of shared risk loci and pathways for bipolar disorder and schizophrenia

Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (p = 1.46x10-8 ). This provides further evidence that SCZassociated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near TRANK1, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders

REPORT Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder

We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 autosomal and 12,484 X-chromosomal SNPs in 682 patients with BD and in 1300 controls. In the first follow-up step, we tested the most significant 48 SNPs in 1729 patients with BD and in 2313 controls. Eight SNPs showed nominally significant association with BD and were introduced to a meta-analysis of the GWAS and the first follow-up samples. Genetic variation in the neurocan gene (NCAN) showed genome-wide significant association with BD in 2411 patients and 3613 controls (rs1064395, p ¼ 3.02 3 10 À8 ; odds ratio ¼ 1.31). In a second follow-up step, we replicated this finding in independent samples of BD, totaling 6030 patients and 31,749 controls (p ¼ 2.74 3 10 À4 ; odds ratio ¼ 1.12). The combined analysis of all study samples yielded a p value of 2.14 3 10 À9 (odds ratio ¼ 1.17). Our results provide evidence that rs1064395 is a common risk factor for BD. NCAN encodes neurocan, an extracellular matrix glycoprotein, which is thought to be involved in cell adhesion and migration. We found that expression in mice is localized within cortical and hippocampal areas. These areas are involved in cognition and emotion regulation and have previously been implicated in BD by neuropsychological, neuroimaging, and postmortem studies

Genome-wide association study reveals two new risk loci for bipolar disorder

Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD

Genome-wide Association Study Identifies Genetic Variation in Neurocan as a Susceptibility Factor for Bipolar Disorder

We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 autosomal and 12,484 X-chromosomal SNPs in 682 patients with BD and in 1300 controls. In the first follow-up step, we tested the most significant 48 SNPs in 1729 patients with BD and in 2313 controls. Eight SNPs showed nominally significant association with BD and were introduced to a meta-analysis of the GWAS and the first follow-up samples. Genetic variation in the neurocan gene (NCAN) showed genome-wide significant association with BD in 2411 patients and 3613 controls (rs1064395, p = 3.02 × 10(-8); odds ratio = 1.31). In a second follow-up step, we replicated this finding in independent samples of BD, totaling 6030 patients and 31,749 controls (p = 2.74 × 10(-4); odds ratio = 1.12). The combined analysis of all study samples yielded a p value of 2.14 × 10(-9) (odds ratio = 1.17). Our results provide evidence that rs1064395 is a common risk factor for BD. NCAN encodes neurocan, an extracellular matrix glycoprotein, which is thought to be involved in cell adhesion and migration. We found that expression in mice is localized within cortical and hippocampal areas. These areas are involved in cognition and emotion regulation and have previously been implicated in BD by neuropsychological, neuroimaging, and postmortem studies

Identification of shared risk loci and pathways for bipolar disorder and schizophrenia

Bipolar disorder (BD) is a highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. BD shows substantial clinical and genetic overlap with other psychiatric disorders, in particular schizophrenia (SCZ). The genes underlying this etiological overlap remain largely unknown. A recent SCZ genome wide association study (GWAS) by the Psychiatric Genomics Consortium identified 128 independent genome-wide significant single nucleotide polymorphisms (SNPs). The present study investigated whether these SCZ-associated SNPs also contribute to BD development through the performance of association testing in a large BD GWAS dataset (9747 patients, 14278 controls). After re-imputation and correction for sample overlap, 22 of 107 investigated SCZ SNPs showed nominal association with BD. The number of shared SCZ-BD SNPs was significantly higher than expected (p = 1.46x10-8). This provides further evidence that SCZ-associated loci contribute to the development of BD. Two SNPs remained significant after Bonferroni correction. The most strongly associated SNP was located near TRANK1, which is a reported genome-wide significant risk gene for BD. Pathway analyses for all shared SCZ-BD SNPs revealed 25 nominally enriched gene-sets, which showed partial overlap in terms of the underlying genes. The enriched gene-sets included calcium- and glutamate signaling, neuropathic pain signaling in dorsal horn neurons, and calmodulin binding. The present data provide further insights into shared risk loci and disease-associated pathways for BD and SCZ. This may suggest new research directions for the treatment and prevention of these two major psychiatric disorders