Feature-rich networks: going beyond complex network topologies.

Abstract The growing availability of multirelational data gives rise to an opportunity for novel characterization of complex real-world relations, supporting the proliferation of diverse network models such as Attributed Graphs, Heterogeneous Networks, Multilayer Networks, Temporal Networks, Location-aware Networks, Knowledge Networks, Probabilistic Networks, and many other task-driven and data-driven models. In this paper, we propose an overview of these models and their main applications, described under the common denomination of Feature-rich Networks, i. e. models where the expressive power of the network topology is enhanced by exposing one or more peculiar features. The aim is also to sketch a scenario that can inspire the design of novel feature-rich network models, which in turn can support innovative methods able to exploit the full potential of mining complex network structures in domain-specific applications

Enterocyte Proliferation and Signaling Are Constitutively Altered in Celiac Disease

Celiac disease (CD) occurs frequently, and is caused by ingestion of prolamins from cereals in subjects with a genetic predisposition. The small intestinal damage depends on an intestinal stress/innate immune response to certain gliadin peptides (e.g., A-gliadin P31-43) in association with an adaptive immune response to other gliadin peptides (e.g., A-gliadin P57-68). Gliadin and peptide P31-43 affect epithelial growth factor receptor (EGFR) signaling and CD enterocyte proliferation. The reason why the stress/innate immune and proliferative responses to certain gliadin peptides are present in CD and not in control intestine is so far unknown. The aim of this work is to investigate if, in CD, a constitutive alteration of enterocyte proliferation and signaling exists that may represent a predisposing condition to the damaging effects of gliadin. Immunofluorescence and immunohistochemistry were used to study signaling in CD fibroblasts and intestinal biopsies. Western blot (WB) analysis, immunoprecipitation, and quantitative PCR were also used. We found in CD enterocytes enhancement of both proliferation and Epidermal Growth Factor Receptor (EGFR)/ligand system. In CD enterocytes and fibroblasts we found increase of the phosphorylated downstream signaling molecule Extracellular Signal Regulated Kinase (ERK); block of the ERK activation normalizes enterocytes proliferation in CD mucosa. In conclusion the same pathway, which gliadin and gliadin peptide P31-43 can interfere with, is constitutively altered in CD cells. This observation potentially explains the specificity of the damaging effects of certain gliadin peptides on CD intestine.</p

Modeling, analyzing and mining feature-rich networks

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A Graph-Coarsening Approach for Tag Recommendation

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International Workshop on Mining Attributed Networks (MATNET 2018) Chairs' Welcome

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INSTRUÇÃO PÚBLICA NA PROVÍNCIA DE GOYAZ: DISCURSO E MEMÓRIA HISTÓRICA

Made available in DSpace on 2016-07-27T13:44:39Z (GMT). No. of bitstreams: 1 MARIA DAS GRACAS SIMAO DIAS LEITE.pdf: 721063 bytes, checksum: 2ed6839a66f8882e9baafa637c6272a8 (MD5) Previous issue date: 2011-03-31This search is integrated into the line of research education, society and culture of the graduate program in Education Doctorate from PUC-Goiás, highlighting the history of public instruction in Goyaz in the 19th century, from its frame and the presence of dominant discursividades producing a memory and history. With theoretical foundation in reasoned discourse analysis proposed by Michel Pêcheux, Eni P. Orlandi and other scholars in the area, this research aims to examine the reports of the Presidents of the province of Goyaz, the presence of discursividades which are decisive in the history of public instruction in the province of Goyaz in 1835 to 1856. Guiding element with the concept of discourse founder, presented by Orlandi (1993), in the book: Discurso Fundador a formação do país e a construção da identidade nacional, our work reflects on the discursividades made in the process of construction of public instruction in Goyaz Public statement was at that time meant Goyaz by our leaders. Is still the documentary from this set that one can understand the importance of the creation and founding of Lyceu for the province of Goyaz, meaning at that time as an instrument of speech enablement expansion of secondary education and as a promoter element of development expected by the Imperial Government.Esta pesquisa está integrada à linha de pesquisa Educação, Sociedade e Cultura do Programa de Pós-Graduação em Educação Doutorado pela PUC- Goiás, evidenciando a história da Instrução Pública em Goyaz no século XIX, a partir de seu referencial e da presença de discursividades dominantes produtoras de uma memória e história. Com embasamento teórico fundamentado na Análise de Discurso proposta por Michel Pêcheux, Eni P. Orlandi e outros estudiosos da área, esta pesquisa tem como objetivo analisar nos Relatórios dos Presidentes da Provincia de Goyaz, a presença de discursividades que são determinantes na história da Instrução Pública na Província de Goyaz nos períodos de 1835 a 1856. Tendo como elemento norteador o conceito de discurso fundador, apresentado por Orlandi (1993), no livro: Discurso Fundador a formação do país e a construção da identidade nacional, nosso trabalho reflete sobre as discursividades apresentadas no processo de construção da Instrução Pública em Goyaz, considerando a importância dessa memória na produção de certo imaginário sobre a população e a educação goiana. Assim, lançamos mão dos Relatórios produzidos pelos Presidentes para pensar como se de deu a construção desse sistema público de ensino. Selecionamos, então, o material da Revista Memórias Goianas, publicada pela Universidade Católica de Goiás, hoje PUC Goiás e, de posse do mesmo, fizemos um recorte histórico envolvendo os períodos de 1835 a 1856, nos quais estão em vigência as medidas evidenciadas pelo Ato Adicional de 1834, considerado como grande marco, principalmente no campo educacional, de medidas descentralizadoras realizadas pelo Governo Imperial. A escolha desse período se deu em função dos efeitos produzidos por este Ato na organização política, cultural e social das Províncias, e, entre eles a necessidade de uma maior estruturação do sistema de Instrução Pública. Do conjunto de pessoas que atuam na organização das Províncias, os Presidentes são as vozes que nos chegam por meio dos relatórios e, é sob a ótica das discursividades apresentadas nos relatórios, que procuramos apreender o modo como a organização da Instrução Pública em Goyaz foi nesse momento significada por nossos dirigentes. É ainda a partir desse conjunto documental que se pode compreender a importância da criação e fundação do Lyceu para a Província de Goyaz, significado nesse momento como instrumento de viabilização do discurso de expansão da instrução pública secundária e como elemento promotor do desenvolvimento esperado pelo Governo Imperial

There is an effect of the digital belt in the quality of Internet access in public schools in CearÃ? an analysis on the perception of directors

nÃo hÃO Projeto CinturÃo Digital do Cearà (CDC) à uma iniciativa do Governo local, em parceria com o MinistÃrio da CiÃncia, Tecnologia e InovaÃÃo (MCTI), para prover internet de alta velocidade, com qualidade, objetivando universalizar o acesso à informaÃÃo. Este trabalho objetiva analisar se existe efeito do CinturÃo Digital quanto à qualidade do acesso à internet nas escolas pÃblicas estaduais do CearÃ. Esta medida de qualidade à definida pelas percepÃÃes dos diretores, extraÃdas dos questionÃrios socioeconÃmicos contidos na Prova Brasil (INEP) referentes aos perÃodos de 2009 (antes do projeto), e de 2011 (apÃs a implementaÃÃo do CDC). Como nem todas as escolas foram beneficiadas pelo CDC, foi possÃvel empregar o mÃtodo de diferenÃas em diferenÃas, para avaliar os resultados e impactos ocasionados pelo projeto. Verificou-se pela estatÃstica descritiva que os diretores das escolas beneficiadas perceberam uma melhora absoluta e relativa quanto à qualidade do acesso à internet para uso dos alunos. O diferencial em favor destas foi de 7,4 pontos percentuais nas mÃdias. No entanto, no modelo logit estimado, o diferencial positivo a favor das escolas beneficiadas nÃo foi estatisticamente significante, fazendo com que os resultados de impacto nÃo sejam robustos.Digital Belt design of Cearà (CDC) is an initiative of the local government, in partnership with the Ministry of science, technology and innovation (MCTI), to provide high-speed internet, with quality, aiming to universalize the access to information. This work aims to analyze whether there is Digital belt effect on the quality of internet access in public schools State of CearÃ. This measure of quality is defined by perceptions of Directors, drawn from socio-economic questionnaires contained in Brazil (INEP) relating to periods of 2009 (before the project), and 2011 (after implementation of the CDC). As not all schools were benefited by the CDC, it has been possible to employ the method of differences in differences, to assess the results and impacts caused by the project. It was found by descriptive statistics that the directors of the schools benefited realized an improvement absolute and relative quality of internet access for use of the student use. The differential in favour of these was 7.4 percentage points in the medium. In estimated logit model, however, the positive differential in favour of schools benefited was not statistically significant, causing the impact results are not robust

Enterocyte proliferation and signaling are constitutively altered in celiac disease.

Celiac disease (CD) occurs frequently, and is caused by ingestion of prolamins from cereals in subjects with a genetic predisposition. The small intestinal damage depends on an intestinal stress/innate immune response to certain gliadin peptides (e.g., A-gliadin P31-43) in association with an adaptive immune response to other gliadin peptides (e.g., A-gliadin P57-68). Gliadin and peptide P31-43 affect epithelial growth factor receptor (EGFR) signaling and CD enterocyte proliferation. The reason why the stress/innate immune and proliferative responses to certain gliadin peptides are present in CD and not in control intestine is so far unknown. The aim of this work is to investigate if, in CD, a constitutive alteration of enterocyte proliferation and signaling exists that may represent a predisposing condition to the damaging effects of gliadin. Immunofluorescence and immunohistochemistry were used to study signaling in CD fibroblasts and intestinal biopsies. Western blot (WB) analysis, immunoprecipitation, and quantitative PCR were also used. We found in CD enterocytes enhancement of both proliferation and Epidermal Growth Factor Receptor (EGFR)/ligand system. In CD enterocytes and fibroblasts we found increase of the phosphorylated downstream signaling molecule Extracellular Signal Regulated Kinase (ERK); block of the ERK activation normalizes enterocytes proliferation in CD mucosa. In conclusion the same pathway, which gliadin and gliadin peptide P31-43 can interfere with, is constitutively altered in CD cells. This observation potentially explains the specificity of the damaging effects of certain gliadin peptides on CD intestine