Junction of three off-critical quantum Ising chains and two-channel Kondo effect in a superconductor

We show that a junction of three off-critical quantum Ising chains can be regarded as a quantum spin chain realization of the two-channel spin-1/2 overscreened Kondo effect with two superconducting leads. We prove that, as long as the Kondo temperature is larger than the superconducting gap, the equivalent Kondo model flows towards the 2 channel Kondo fixed point. We argue that our system provides the first controlled realization of 2 channel Kondo effect with superconducting leads. This, besides its the theoretical interest, is of importance for potential applications to a number of context, including the analysis of the quantum entanglement properties of a Kondo system.Comment: 14 pages, 4 .eps figure

Perturbative evaluation of circular 1/2 BPS Wilson loops in N = 6 Super Chern-Simons theories

We present a complete two-loop analysis of the quantum expectation value for circular BPS Wilson loops in ABJ(M) theories. We examine in details the 1/2 BPS case, that requires non-trivial fermionic couplings with the contour, finding perfect agreement with the exact matrix model answer at zero framing. The result is obtained through a careful application of DRED regularization scheme, combined with a judicious rearrangement of the relevant perturbative contributions that reduces the computation to simple integrals. We carefully analyze the contribution of fermions that is crucial for the consistency with the localization procedure and point out the arising of pivotal evanescent terms, discussing their meaning in relation to Ward identities.Comment: 32 pages, 5 figures, Referemces adde

A Z2 invariant for chiral and particle–hole symmetric topological chains

We define a Z2-valued topological and gauge invariant associated with any one-dimensional, translation-invariant topological insulator that satisfies either particle–hole symmetry or chiral symmetry. The invariant can be computed from the Berry phase associated with a suitable basis of Bloch functions that is compatible with the symmetries. We compute the invariant in the Su–Schrieffer–Heeger model for chiral symmetric insulators and in the Kitaev model for particle–hole symmetric insulators. We show that in both cases, the Z2 invariant predicts the existence of zero-energy boundary states for the corresponding truncated models

Relaxed micromorphic model of transient wave propagation in anisotropic band-gap metastructures

In this paper, we show that the transient waveforms arising from several localised pulses in a micro-structured material can be reproduced by a corresponding generalised continuum of the relaxed micromorphic type. Specifically, we compare the dynamic response of a bounded micro-structured material to that of bounded continua with special kinematic properties: (i) the relaxed micromorphic continuum and (ii) an equivalent Cauchy linear elastic continuum. We show that, while the Cauchy theory is able to describe the overall behaviour of the metastructure only at low frequencies, the relaxed micromorphic model goes far beyond by giving a correct description of the pulse propagation in the frequency band-gap and at frequencies intersecting the optical branches. In addition, we observe a computational time reduction associated with the use of the relaxed micromorphic continuum, compared to the sensible computational time needed to perform a transient computation in a micro-structured domain

A simple PSA-based computational approach predicts the timing of cancer relapse in prostatectomized patients

Abstract Recurrences of prostate cancer affect approximately one quarter of patients who have undergone radical prostatectomy. Reliable factors to predict time to relapse in specific individuals are lacking. Here, we present a mathematical model that evaluates a biologically sensible parameter (α) that can be estimated by the available follow-up data, in particular by the PSA series. This parameter is robust and highly predictive for the time to relapse, also after administration of adjuvant androgen deprivation therapies. We present a practical computational method based on the collection of only four postsurgical PSA values. This study offers a simple tool to predict prostate cancer relapse. Cancer Res; 76(17); 4941–7. ©2016 AACR.</jats:p

Geomorphic signal of active faulting at the northern edge of Lut Block. Insights on the kinematic scenario of Central Iran

Recent works documented Neogene to Quaternary dextral strike-slip tectonics along the Kuh-e-Sarhangi and Kuh-e-Faghan intraplate strike-slip faults at the northern edge of the Lut Block of Central Iran, previously thought to be dominated by sinistral strike-slip deformation. This work focuses on the evidence of Quaternary activity of one of these fault systems, in order to provide new spatio-temporal constraints on their role in the active regional kinematic scenario. Through geomorphological and structural investigation, integrated with Optically Stimulated Luminescence (OSL) dating of three generations of alluvial fans and fluvial terraces (at ~53, ~25 and ~6 ka), this study documents (i) the topographic inheritance of the long-term (Myr) punctuated history of fault nucleation, propagation, and exhumation along the northern edge of Lut Block; (ii) the tectonic control on drainage network evolution, pediment formation, fluvial terraces, and alluvial-fan architecture; (iii) the minimum Holocene age of Quaternary dextral strike-slip faulting; and (iv) the evidence of Late Quaternary fault-related uplift localized along the different fault strands. The documented spatial and temporal constraints on the active dextral strike-slip tectonics at the northern edge of Lut Block provided new insights on the kinematic model for active faulting in Central Iran, which has been reinterpreted in an escape tectonic scenario

Use of Medicinal Cannabis and Synthetic Cannabinoids in Posttraumatic Stress Disorder (PTSD): a systematic review

Background and Objectives: Post-traumatic stress disorder (PTSD) is a common psychiatric disorder resulting from a traumatic event, is manifested through hyperarousal, anxiety, depressive symptoms, and sleep disturbances. Despite several therapeutic approaches being available, both pharmacological and psychological, recently a growing interest has developed in using cannabis and synthetic cannabinoids stems from their consideration as more efficient and better tolerated alternatives for the treatment of this condition. The present paper aims to evaluate the clinical and therapeutic potentials of medical cannabis and synthetic cannabinoids in treating PTSD patients. Methods: A systematic electronic search was performed, including all papers published up to May 2019, using the following keywords (((cannabis[Title/Abstract]) OR (synthetic cannabinoids [Title/Abstract])) AND ((PTSD[Title/Abstract]) OR (Posttraumatic stress disorder[Title/Abstract]))) for the topics ‘Cannabis’, ‘Synthetic Cannabinoids’, ‘PTSD’, and MESH terms, on the PubMed, Cochrane Library, and Web of Science online databases. For data gathering purposes, PRISMA guidelines were followed. Results were organized into two groups, considering cannabis and synthetic cannabinoids as different therapeutic approaches for PTSD. Results: Present data show that cannabis and synthetic cannabinoids, both acting on the endocannabinoids system, may have a potential therapeutic use for improving PTSD symptoms, e.g., reducing anxiety, modulating memory-related processes, and improving sleep. Conclusions: Even though the current literature suggests that cannabis and synthetic cannabinoids may have a role in the treatment of PTSD, there is currently limited evidence regarding their safety and efficacy. Therefore, additional research is needed in order to better understand the effectiveness and therapeutic usage of these drug classes and monitor their safety.Peer reviewe

ErbB3 Phosphorylation as Central Event in Adaptive Resistance to Targeted Therapy in Metastatic Melanoma. Early Detection in CTCs during Therapy and Insights into Regulation by Autocrine Neuregulin

In recent years the introduction of target therapies with BRAF and MEK inhibitors (MAPKi) and of immunotherapy with anti-CTLA-4 and anti-PD-1 monoclonal antibodies have dramatically improved survival of metastatic melanoma patients. Despite these changes drug resistance remains a major hurdle. Several mechanisms are at the basis of drug resistance. Particular attention has been devoted over the last years to unravel mechanisms at the basis of adaptive/non genetic resistance occurring in BRAF mutated melanomas upon treatment with to MAPKi. In this paper we focus on the involvement of activation of ErbB3 receptor following early exposure of melanoma cells to BRAF or MEK inhibitors, and the following induction of PI3K/AKT pathway. Although different mechanisms have been invoked in the past at the basis of this activation we show here with a combination of approaches that autocrine production of neuregulin by melanoma cells is a major factor responsible for ErbB3 phosphorylation and downstream AKT activation. Interestingly the kinetic of neuregulin production and of the ensuing ErbB3 phosphorylation is different in different melanoma cell lines which underscores the high degree of tumor heterogeneity. Moreover, heterogeneity is further highlighted by the evidence that in different cell lines neuregulin upregulation can occur at the transcriptional or at the post-transcritpional level. Finally we complement our study by showing with a liquid biopsy assay that circulating tumor cells (CTCs) from melanoma patients undergo upregulation of ErbB3 phosphorylation in vivo shortly after initiation of therapy