112 research outputs found
Microcalorimetry and spectroscopic studies on the binding of dye janus green blue to deoxyribonucleic acid
- Author
- A Cooper
- A Das
- A Safavi
- AY Khan
- AY Khan
- B Lee
- Baishakhi Saha
- CZ Huang
- D Bhowmik
- D Debnath
- D Sarkar
- FV Murphy
- G Suresh Kumar
- Gopinatha Suresh Kumar
- GS Kumar
- HE Johansson
- I Saha
- I Saha
- I Saha
- I Saha
- J Ha
- J Ren
- JB Chaires
- JB Chaires
- JB Chaires
- JB Chaires
- JE Ladbury
- JL Vennerstrom
- K Bhadra
- K Bhadra
- KM Guthrie
- M Hossain
- MK Dutt
- MM Islam
- MM Islam
- MT Record Jr
- MT Record Jr
- MT Record Jr
- P Paul
- P Paul
- RF Pasternack
- RS Spolar
- S Chatterjee
- S Das
- S Roy Chowdhury
- YJ Long
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
The interaction of the phenazinium dye janus green blue (JGB) with deoxyribonucleic acid was investigated using isothermal titration calorimetry and thermal melting experiments. The calorimetric data were supplemented by spectroscopic studies. Calorimetry results suggested the binding affinity of the dye to DNA to be of the order of 105 M-1. The binding was predominantly entropy driven with a small negative favorable enthalpy contribution to the standard molar Gibbs energy change.The binding became weaker as the temperature and salt concentration was raised. The temperature dependence of the standard molar enthalpy changes yielded negative values of standard molar heat capacity change for the complexation revealing substantial hydrophobic contribution in the DNA binding. An enthalpy–entropy compensation behavior was also observed in the system. The salt dependence of the binding yielded the release of 0.69 number of cations on binding of each dye molecule. The non-polyelectrolytic contribution was found to be the predominant force in the binding interaction. Thermal melting studies revealed that the DNA helix was stabilized against denaturation by the dye. The binding was also characterized by absorbance, resonance light scattering and circular dichroism spectral measurements. The binding constants from the spectral results were close to those obtained from the calorimetric data. The energetic aspects of the interaction of the dye JGB to double stranded DNA are supported by strong binding revealed from the spectral data
Stochastic Drift in Mitochondrial DNA Point Mutations: A Novel Perspective Ex Silico
- Author
- A Bender
- A Kowald
- A Kowald
- A Terman
- A Trifunovic
- A Trifunovic
- ADNJ Grey
- AF Davis
- ARJ Cadet
- B Halliwell
- B Halliwell
- Barry Halliwell
- C Karatza
- CT Moraes
- CW Gardiner
- D Harman
- D Wang
- D Zhang
- DA Clayton
- DC Montgomery
- DM Turnbull
- DT Gillespie
- DT Gillespie
- DT Gillespie
- GC Kujoth
- GK Michalopoulos
- GS Shadel
- H Chen
- H Korr
- HH McAdams
- J Gruber
- J St-Pierre
- J Wanagat
- Jan Gruber
- JH Bielas
- JL Elson
- JN Weiss
- Joel S. Bader
- K Elliott
- KB Beckman
- KS Lim
- L Piko
- L Piko
- LA Herndon
- M Calleja
- M Limson
- M Vermulst
- M Vermulst
- ML Collins
- ML Hamilton
- N Steuerwald
- NG Larsson
- NG Larsson
- NJ Gross
- NJ Sissman
- PF Chinnery
- R Rossigol
- RA Menzies
- RB Cervantes
- RJ Wiesner
- RJ Wiesner
- Rudiyanto Gunawan
- S Chanda
- S Miwa
- SE Schriner
- Suresh Kumar Poovathingal
- TA Kunkel
- Z Liu
- Publication venue
- Public Library of Science
- Publication date
- 01/11/2009
- Field of study
The mitochondrial free radical theory of aging (mFRTA) implicates Reactive Oxygen Species (ROS)-induced mutations of mitochondrial DNA (mtDNA) as a major cause of aging. However, fifty years after its inception, several of its premises are intensely debated. Much of this uncertainty is due to the large range of values in the reported experimental data, for example on oxidative damage and mutational burden in mtDNA. This is in part due to limitations with available measurement technologies. Here we show that sample preparations in some assays necessitating high dilution of DNA (single molecule level) may introduce significant statistical variability. Adding to this complexity is the intrinsically stochastic nature of cellular processes, which manifests in cells from the same tissue harboring varying mutation load. In conjunction, these random elements make the determination of the underlying mutation dynamics extremely challenging. Our in silico stochastic study reveals the effect of coupling the experimental variability and the intrinsic stochasticity of aging process in some of the reported experimental data. We also show that the stochastic nature of a de novo point mutation generated during embryonic development is a major contributor of different mutation burdens in the individuals of mouse population. Analysis of simulation results leads to several new insights on the relevance of mutation stochasticity in the context of dividing tissues and the plausibility of ROS ”vicious cycle” hypothesis
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa AO
- Adisa AO
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguado Suarez N
- Aguilar-Jimenez J
- Aguilera M
- Aguilera ML
- Aguilera ML
- Aguilera ML
- Aguilera O
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
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- Ahmed H
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- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
- Al-Saqqa SW
- Al-Saqqa SW
- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
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- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
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- Alihonou T
- Alimi Q
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- Aljboor K
- Aljiffry M
- Aljiffry M
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- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
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- Alomar IN
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- Alrifaie A
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- Alsaggaf M
- Alsaggaf MU
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- Alser OH
- Alshareef R
- Altaf A
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- Altamimi A
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- Altamimi A
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- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
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- Altoe F
- Altwigry AM
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- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
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- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
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- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
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- Antezana D
- Anthoulakis C
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- Antoniozzi A
- Anwar AW
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- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
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- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
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- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
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- Asele FA
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- Azmitia Mendizabal CA
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- Baltrunas R
- Baluch F
- Bamford R
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- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eid MM
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
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- Falaschi F
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- Falzon M
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- Farag S
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- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
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- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
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- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
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- Firdouse M
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- Firwana A
- Fitsum A
- Fitzgerald JE
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- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
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- Forno W
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- Fouad D
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- Fourcade L
- Fowler AJ
- Fozard T
- Fozard T
- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
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- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
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- Galiqi G
- Galleano R
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- Galvez CP
- Gamal D
- Gamal E
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- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
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- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
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- Gerosa A
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- Geuoshy A
- Ghaben A
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- Ghannam M
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- Ghetia M
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- Giavarini L
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- Guevara Torres S
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- Halicioglu I
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- Mironescu A
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- Mironescu AS
- Mironescu AS
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
- Mitul AR
- Mitul AR
- Miyarde Leon A
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo MM
- Modolo MM
- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok YT
- Mokhtar A
- Molina G
- Monaghan E
- Monaghan E
- Monrad-Hansen PW
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora JJV
- Morales C
- Morandi E
- Moreira G
- Moreno SC
- Morgan C
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- Morshedy EM
- Morsi A
- Morsi M
- Morton D
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- Morton R
- Mosad A
- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe AM
- Mshelbwala P
- Msiska N
- Msosa V
- Msosa V
- Muddebihal U
- Mukin ADF
- Muktar U
- Mukuzunga C
- Muller C
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- Muller J
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- Munhoz MM
- Munipalle PC
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- Muntean LI
- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa AEK
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- Musowoya J
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- Musyoka CK
- Mutabazi A
- Mutabazi AZ
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- Mutlu D
- Mutlu V
- Muzio E
- Myers J
- Mykoniatis I
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- Nada F
- Nadeem N
- Nadkarni S
- Naess PA
- Nagy GS
- Nahar SN
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- Najjar M
- Nanthakumaran S
- Napolitano L
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- Naqvi SA
- Naqvi T
- Naranjo Aristizaibal FA
- Narayanan R
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- Narvestad JK
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- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
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- Nasir WNWM
- Nasr A
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- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
- Nawawi A
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- Nayel AR
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu SR
- Ndwambi P
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo YN
- Neo YT
- Neophytou C
- Nepogodiev D
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- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
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- Ngayu N
- Ngwa TE
- Niazi AK
- Nicholson L
- Nighat B
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- Nikberg M
- Nikoloudis N
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- Niragire A
- Niranjan N
- Nirumal MK
- Niska K
- Nita GE
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
- Nocito A
- Nofal E
- Noor F
- Normile C
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- North AS
- Notarnicola M
- Notarnicola M
- Nouh T
- Nouh T
- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana VJP
- Nsengiyumva C
- Ntirenganya F
- Ntirenganya F
- Nurqistan HD
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
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- O'neill M
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- Palomino Castillo VD
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- Papaskarlatos I-A
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- Qureshi AU
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- Rutkowski W
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- Saad MM
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- Saadeh R
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- Sahel S
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- Samalavicius NE
- Samaraweera DI
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- Samir A
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- Sandoval Barrantes AM
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- Sokratous A
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- Yolcu S
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- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
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- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
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- Zielinski M
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- Zil-E-Ali A
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- Zilinskiene R
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- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Multi-messenger observations of a binary neutron star merger
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- Yodh GB
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- Yoshida A
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- Zhao XF
- Zheng SJ
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- Zhou M
- Zhou Z
- Zhu SJ
- Zhu XJ
- Zhu Y
- Zhu YX
- Zhu Z
- Ziegler A
- Zimmerman AB
- Zimmermann B
- Zimnukhov DS
- Ziolkowski M
- Zoll M
- Zong Z
- Zorn J
- Zornoza JD
- Zou CL
- Zuccarello F
- Zucker ME
- Zuniga J
- Zweizig J
- Zywucka N
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2017
- Field of study
On 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of ~1.7 s with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg2 at a luminosity distance of 40+8-8 Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 Mo. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at ~40 Mpc) less than 11 hours after the merger by the One- Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ~10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position ~9 and ~16 days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
- Elbanby Es
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
- Eldamaty L
- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy Ms
- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
- Gü
- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
- Garcí
- Garcí
- Garcí
- Garcia-Florez L
- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi Dg
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy Aa
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim Ma
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino Fr
- Giavarini L
- Giglio Mc
- Gilbert R
- Gilbert Rw
- Giles J
- Gillespie M
- Gimzewska M
- Giraldo Rsr
- Giuliani S
- Giuliani S
- Giuriato Tf
- Gkiokas G
- Glasbey J
- Glasbey J
- Glasbey Jc
- Glasbey Jc
- Glover Te
- Glover-Addy H
- Glynn M
- Gobin N
- Gobin N
- Goh Cc
- Goh Cc
- Goh W
- Gohar Meam
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzalez M
- Gonzalez Sc
- Goodstein M
- Gosling S
- Gosling Sg
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Gouws J
- Graffeille V
- Graffieille V
- Gran M
- Grandinetti Pp
- Grant A
- Grasset E
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Gravante G
- Gray D
- Grech N
- Green N
- Grella Mg
- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
- Grima T
- Grisin E
- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
- Guasti Bpsj
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
- Gumar M
- Gunaseelan K
- Gunawan R
- Guner A
- Gunnarsson U
- Guo W
- Gupta A
- Gustafsson U
- Gyamfi Fe
- Gyanchandani N
- Gyedu A
- Habeeb Ma
- Habeeb O
- Habeebullah A
- Hache-Marliere M
- Haddad N
- Hafez At
- Hafez M
- Hafez M
- Hafez S
- Haffreingue A
- Hafiz S
- Hagan R
- Hagar A
- Haines M
- Haines S
- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
- Hall Nj
- Hall Tf
- Hallam S
- Haloho A
- Hamad Mgm
- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
- Hamdan A
- Hamdan M
- Hamed Mf
- Hamill D
- Hammad A
- Hammad A
- Hammad Am
- Hampton M
- Hampton Mi
- Hamsho W
- Hanafy M
- Hand C
- Hanks A
- Hanley I
- Hanoun S
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hantour U
- Hantour U
- Hany E
- Haque M
- Har Pa
- Haraux E
- Harbord P
- Haroun A
- Harper E
- Harrison Em
- Harrison Em
- Harrison N
- Harrison P
- Harrison R
- Hartford L
- Harvey N
- Hasan A
- Hasan A
- Hasan D
- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
- Hashish M
- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
- Hassan M
- Hassan Omm
- Hassan S
- Hassan Z
- Hassanain M
- Hassanain M
- Hassanein Ab
- Havemann I
- Hawkins W
- Heard R
- Heath J
- Heffernan D
- Hegazy Em
- Hegazy Y
- Helene Fc
- Helguero-Santin Lm
- Hemeda D
- Hemingway D
- Hemmila M
- Hemmila M
- Henderson L
- Henderson L
- Heng He
- Henric N
- Henry F
- Henshall De
- Herebat A
- Herikstad R
- Herrera N
- Herrera-Matta J
- Herrod P
- Hervieux E
- Hervieux E
- Hesham O
- Hettiarachchi Ts
- Hewage K
- Heywood Eg
- Highcock S
- Hilal K
- Hinojosa C
- Hjertberg M
- Hjertberg M
- Hmila S
- Ho A
- Ho Cw
- Ho W
- Ho Wc
- Hodonou F
- Hogea M
- Holte S
- Holton P
- Homeida A
- Hoogakker E
- Horobjowsky A
- Hosein Sp
- Hosh M
- Hossaini S
- Hossameldin A
- Houlden C
- Howells L
- Howie Ee
- Hrora A
- Huaman E
- Huaraya Rc
- Humm G
- Hunter K
- Hussain M
- Hussein A
- Hussein S
- Husseini M
- Husseiny R
- Hutch W
- Huwait A
- Iş
- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
- Ibrahim A
- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
- Iftikhar Z
- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire Jca
- Ingabire Jca
- Ingabire Jca
- Ioannidis O
- Iordache Fm
- Iqbal Fm
- Iqbal Mr
- Ireland P
- Irtan S
- Irtan S
- Irwin G
- Irwin G
- Irwin G
- Irwin G
- Ishak N
- Iskandar F
- Ismaï
- Ismaï
- Ismaï
- Ismaï
- Ismail A
- Ismail M
- Ismail M
- Ismail Mjb
- Ismail Mk
- Ismail Sa
- Israelsson L
- Ivros N
- Iyer D
- Iyer D
- Iyer D
- Jabal Ms
- Jabbar A
- Jaber S
- Jackson P
- Jacobe M
- Jaffry Z
- Jaffry Z
- Jaich R
- Jain P
- Jama Gm
- Jamal L
- Janardha Kc
- Janik M
- Jankus T
- Jaradat D
- Jaramillo Ra
- Jarmin M
- Jasaitis K
- Javaid M
- Javed O
- Javed O
- Jawaid M
- Jayathilake Ab
- Jck Ng
- Jean-Francois C
- Jeffery A
- Jeffery A
- Jenner E
- Jennings L
- Jennings V
- Jennings V
- Jensen E
- Jenvey C
- Jeo Ws
- Jeon H
- Jeremic L
- Jethwani Dl
- Jeyakumar J
- Jeyakumar J
- Jha M
- Jimenez J
- Jimenez-Morillas P
- Joel Lwl
- Johanna N
- Johnson K
- Johnston R
- Jokubauskas M
- Jokubauskas M
- Jokubonis K
- Jones C
- Jones C
- Jones E
- Jones Tf
- Jonnalagadda R
- Joosten J
- Jordan H
- Jotautas V
- Jotautas V
- Jovine E
- Jovine E
- Jubran Af
- Juciute S
- Julaihi R
- Jurdell E
- Kaafarani H
- Kabariti R
- Kabariti R
- Kabba J
- Kabongo K
- Kache S
- Kaci Aa
- Kadiwar S
- Kalakouti E
- Kalles V
- Kalles V
- Kalles V
- Kamarajah Sk
- Kamarulzamil Sna
- Kamil R
- Kamya S
- Kanani A
- Kandil Am
- Kandil H
- Kang Mk
- Kanta Th
- Karabacak U
- Karabelias G
- Karabulut K
- Karahan Sr
- Karakahya M
- Karandikar S
- Karandikar S
- Kariem N
- Karim A
- Karim R
- Karim S
- Karismaningtyas H
- Karjiker P
- Karkeet M
- Karkeet M
- Karlo R
- Karlo R
- Karousos D
- Karumnas P
- Kaselis N
- Kaselis N
- Kasem E
- Kasem Ea
- Kasputyte S
- Kaul A
- Kazanavicius D
- Kedar A
- Kefalidi E
- Keke Kr
- Kelany M
- Kenibar A
- Kennedy Ed
- Kennedy M
- Kennedy R
- Keogh K
- Kerley R
- Kershaw S
- Kesinger M
- Khafagy T
- Khairy H
- Khairy H
- Khajanchi M
- Khaled H
- Khalifah E
- Khalili M
- Khalique A
- Khallaf S
- Khamajeet A
- Khan A
- Khan K
- Khan Ma
- Khan R
- Khan S
- Khan T
- Khan Za
- Kharsa S
- Khatri C
- Khatri C
- Khattab K
- Khedr Aeh
- Khg Li
- Khoja A
- Khoja A
- Khokha D
- Khokha V
- Khosla S
- Khreishi R
- Khreishi R
- Khulu Lb
- Khyrallh A
- Kiasat A
- Kidd T
- Kielty P
- Kim My
- Kim Sb
- Kim Sh
- Kimaro M
- Kinandu K
- King R
- King S
- King S
- Kinnera Sv
- Kiran Rp
- Kirby A
- Kirishnan A
- Kirupagaran A
- Kiudelis M
- Kjellin A
- Kkk Li
- Klappenbach R
- Knight S
- Koay Kl
- Kobal Bb
- Koh C
- Koh H
- Koh Py
- Koh S
- Koh S
- Kojo Att
- Kojo Att
- Kojo Att
- Kolosov A
- Komolafe O
- Kondrotas P
- Kong C
- Kong Sn
- Kong V
- Kong V
- Konstantina K
- Kontos M
- Kordorwu Hek
- Korkolis D
- Kosai Nr
- Kosai Nr
- Kose E
- Koskenvuo L
- Kostov E
- Kotb Ahe
- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
- Kourdouli A
- Kourdouli A
- Kretzmann H
- Krishna K
- Kruspi S
- Kufeji D
- Kulasabanathan K
- Kuliavas J
- Kumar B
- Kumar B
- Kumar B
- Kumar Bs
- Kumar Mn
- Kumar S
- Kumar S
- Kumar S
- Kumar S
- Kumar T
- Kumwenda D
- Kushwaha S
- Kushwaha S
- Kusi K
- Kutkevicius J
- Kwakyeafriyie P
- Kwatiwani C
- Kwizera S
- Kwok Sh
- Kyereh M
- Kyriazanos I
- Kyrou G
- Kyziridis D
- Ló
- L&apos
- La Brocca A
- la Medina AR
- la Medina AR
- la Medina AR
- Labib P
- Ladukas A
- Lafferty K
- Lagunavicius K
- Lai Ac
- Lakhani Sm
- Lakshmi Hn
- Lam Fy
- Lam Jcy
- Lam Wh
- Lamanna Gl
- Lanau Miv
- Lando J
- Landolfo G
- Landolfo G
- Lap G
- Lapitan Mc
- Lapitan Mc
- Larsen Jw
- Lasek A
- Lasheen A
- Lasheen Kt
- Latif A
- Laufer Lav
- Laugzemys E
- Laugzemys E
- Laurie K
- Lauzikas G
- Law Jh
- Lawal A
- Lawal Ao
- Lawal T
- Lawal Ta
- Lawani I
- Lawther R
- Lazzari G
- Lazzari V
- Leal A
- Leal M
- Lecompte Jf
- Lee C
- Lee Ex
- Lee F
- Lee K
- Lee Kc
- Lee Ky
- Lee Tsb
- Lemaire Sb
- Leone N
- Leong Fqh
- Leppä
- Leppä
- Leroux J
- Leung Kw
- Leung Mf
- Leusink A
- Lewis J
- Li Ws
- Licari L
- Lieske B
- Lieske B
- Liew I
- Liew I
- Lilford R
- Lilford R
- Lilford Rj
- Lim G
- Lim H
- Lim J
- Lim Pj
- Lim Sj
- Lim Sj
- Lim Sy
- Limache S
- Limaye N
- Limoges B
- Lintin L
- Lipnickas V
- Litvin A
- Liu Q
- Liu Q
- Livesey A
- Livingston M
- Ljuhar D
- Lo Conte A
- Loaloa Mr
- Lockey J
- Lohse Has
- Lohse Has
- Loizides S
- Lokman Maa
- Longstaff L
- Lopez Ce
- Lopez Lip
- Lopez M
- Lopez M
- Lopez-Arevalo C
- Lorenzon L
- Lossius Wj
- Loughran D
- Low X
- Luc Ar
- Luck J
- Luck J
- Luck J
- Luglio G
- Lund J
- Lund J
- Lundgren Po
- Luque Gb
- Luque L
- Luque L
- Lytras D
- Lytras D
- Má
- Mé
- Mü
- Mañ
- Ma J
- Mabitsela Me
- Mabrouk M
- Macchiavello R
- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald L
- Maceviciute K
- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi Aa
- Magri D
- Mahamood Ab
- Mahanty S
- Maharaj G
- Mahdi A
- Mahdi S
- Mahdi S
- Maher Me
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud Ma
- Mahmoud Mi
- Mahmoud S
- Mahmoud Sme
- Mahmud K
- Maillot B
- Maimbo M
- Maimbo M
- Mairs Ng
- Maison K
- Maistry N
- Majauskyté
- Majbar A
- Majid Ahha
- Majid K
- Major Cp
- Major P
- Major P
- Mak T
- Mak T
- Makama J
- Makinde M
- Makupe A
- Malavenda M
- Malik K
- Malik P
- Malik Ta
- Mamdouh E
- Mamdouh R
- Manatakis Dk
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal Ce
- Maniscalco A
- Mann T
- Mannu Gs
- Manriquez-Reyes M
- Mansor Ey
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marey A
- Marey As
- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
- Mason C
- Mata Lps
- Matheu A
- Mathew Sw
- Matos-Puig R
- Matta Jjh
- Mattar O
- Matter Sm
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
- Mcaleer E
- Mcaleer S
- Mccarthy K
- Mccarthy M
- Mccarthy M
- McCullagh D
- Mcdonald R
- McGarvie S
- Mcguigan A
- McIntosh K
- Mcintosh R
- Mcintyre Cj
- Mcintyre N
- Mcintyre R
- Mckechnie D
- Mclachlan G
- Mclean Al
- Mclean K
- McMorran D
- Mcnish D
- Mcphee A
- Mealy K
- Mehdi A
- Mehrez S
- Mejia Agv
- Melo R
- Melo R
- Mendel H
- Mendez M
- Mendez N
- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mericliler M
- Merlini D
- Merlini D
- Merlo Ms
- Mesbah N
- Meshref A
- Metwally Mm
- Migliore M
- Miguel Gps
- Mihaljevic Al
- Mihanovic J
- Mihanovic J
- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
- Mikwar Z
- Milligan W
- Milligan W
- Mingrone P
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu As
- Mironescu As
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
- Mitul Ar
- Mitul Ar
- Miyasato Hs
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
- Mohamed A
- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
- Monaghan E
- Monaghan E
- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Search for gravitational waves associated with gamma-ray bursts detected by Fermi and Swift during the LIGO–Virgo run O3b
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- Slagmolen BJJ
- Slaven-Blair TJ
- Smetana J
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- Soldateschi J
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- Srinivasan R
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- Stachie C
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- Steinlechner J
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- Strain KA
- Strang LC
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- Sturani R
- Stuver AL
- Subrahmanya SC
- Sudhagar S
- Sudhir V
- Sugimoto R
- Suh HG
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- Thirugnanasambandam MP
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- Thompson JE
- Thondapu SR
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- Washington NY
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- Weller CM
- Wellmann F
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- Yamazaki R
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- Yang Y
- Yang Z
- Yap MJ
- Yeeles DW
- Yelikar AB
- Ying M
- Yokogawa K
- Yokoyama J
- Yokozawa T
- Yoo J
- Yoshioka T
- Yu H
- Yu H
- Yuzurihara H
- Zadrozny A
- Zanolin M
- Zeidler S
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- Zevin M
- Zhan M
- Zhang H
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- Zhang T
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- Zhao G
- Zhao Y
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- Zhou R
- Zhou Z
- Zhu XJ
- Zhu Z-H
- Zimmerman AB
- Zucker ME
- Zweizig J
- Publication venue
- 'American Astronomical Society'
- Publication date
- 01/01/2022
- Field of study
We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC–2020 March 27 17:00 UTC). We conduct two independent searches: a generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate
Responsiveness of human male volunteers to immunization with ovine follicle stimulating hormone vaccine: Results of a pilot study
- Publication venue
- Oxford University Press
- Publication date
- Field of study
A study of 140 days duration was performed to examine if human male volunteers (n = 5) respond to ovine follicle stimulating hormone (oFSH) immunization (administered adsorbed on Alugel on days 1, 20, 40 and 70) by producing antibodies capable of both binding and neutralizing bioactivity of human FSH. The kinetics of antibody production for both the immunogen (oFSH) and the cross-reactive antigen (hFSH) were essentially similar, The volunteers responded only to the first two immunizations, The boosters given on days 40 and 70 were ineffective, probably because of the presence of substantial amounts of circulating antibody to oFSH. Of the antibodies generated to oFSH, 25-45% bound hFSH with a mean binding affinity of 0.65 x 10(9) +/- 0.53 M(-1). The binding capacities at the time of high (30-80 days of immunization) and low (>110 days) titres were 346 +/- 185 and 10.5 +/- 5.8 ng hFSH/ml respectively, During the period of high titre, free serum FSH (value in normal males 1-5 ng/ml) was not monitorable, A 50 mu l aliquot of the antiserum obtained from different volunteers between days 30 and 80 and on day 140 blocked binding of I-125-labelled hFSH to its receptor by 82 +/- 9.7 and 53 +/- 12.2% respectively, The antibody produced was specific for FSH, and no significant change in the values of related glycoprotein hormones (luteinizing hormone/testosterone and thyroid stimulating hormone/thyroxine) were recorded, Seminal plasma transferrin, a marker of Sertoli cell as well as of seminiferous tubular function, showed marked reduction (30-90%) following immunization with oFSH. Considering that endogenous FSH remained neutralized for approximately one sperm cycle only (65 days), the reduction in sperm counts (30-74%) exhibited by some volunteers is encouraging, Immunization with oFSH did not result in any significant changes in haematology, serum biochemistry or hormonal profiles, There was no production of antibodies capable of interacting with non-specific tissues, It is concluded that it should be possible to obtain a sustained long-term blockade of endogenous FSH action in men by using oFSH as an immunogen, This is a prerequisite for obtaining significant reduction in the quality and quantity of spermatozoa produced, thus leading to infertility
Pre-clinical toxicity & immunobiological evaluation of DNA rabies vaccine & combination rabies vaccine in rhesus monkeys (Macaca mulatta)
- Author
- Publication venue
- INDIAN COUNCIL MEDICAL RES
- Publication date
- Field of study
Background & objectives: Pre-clinical toxicology evaluation of biotechnology products is a challenge to the toxicologist. The present investigation is an attempt to evaluate the safety profile of the first indigenously developed recombinant DNA anti-rabies vaccine DRV (100 mu g)] and combination rabies vaccine CRV (100 mu g DRV and 1.25 IU of cell culture-derived inactivated rabies virus vaccine)], which are intended for clinical use by intramuscular route in Rhesus monkeys. Methods: As per the regulatory requirements, the study was designed for acute (single dose - 14 days), sub-chronic (repeat dose - 28 days) and chronic (intended clinical dose - 120 days) toxicity tests using three dose levels, viz. therapeutic, average (2x therapeutic dose) and highest dose (10 x therapeutic dose) exposure in monkeys. The selection of the model i.e. monkey was based on affinity and rapid higher antibody response during the efficacy studies. An attempt was made to evaluate all parameters which included physical, physiological, clinical, haematological and histopathological profiles of all target organs, as well as Tiers I, II, III immunotoxicity parameters. Results: In acute toxicity there was no mortality in spite of exposing the monkeys to 10XDRV. In sub chronic and chronic toxicity studies there were no abnormalities in physical, physiological, neurological, clinical parameters, after administration of test compound in intended and 10 times of clinical dosage schedule of DRV and CRV under the experimental conditions. Clinical chemistry, haematology, organ weights and histopathology studies were essentially unremarkable except the presence of residual DNA in femtogram level at site of injection in animal which received 10X DRV in chronic toxicity study. No Observational Adverse Effects Level (NOAEL) of DRV is 1000 ug/dose (10 times of therapeutic dose) if administered on 0, 4, 7, 14, 28th day. Interpretation & conclusions: The information generated by this study not only draws attention to the need for national and international regulatory agencies in formulating guidelines for pre-clinical safety evaluation of biotech products but also facilitates the development of biopharmaceuticals as safe potential therapeutic agents
Mechanical and ultrasonic characterisation of copper-nickel diffusion bonded joints
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Forest inventory, assessment, and monitoring, and long-term forest observational studies, with special reference to India
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
- …