Synthesis and Characterization of Coated Gold Nanoparticles with Embedded SERS Tags

Gold nanoparticles were prepared with the potential to operate as drug delivery vehicles. Surface-enhanced Raman spectroscopy (SERS) is of particular importance as an optical bioimaging technique due to its ability to allow deep and high-resolution volumetric imaging of biological tissues. Characterization of the gold nanoparticles with para-mercaptobenzoic acid (pMBA), a SERS active molecule, silver, and a phospholipid bilayer was done using Raman and UV-vis spectroscopy and particle size analysis. Our results indicate successful coating of the gold nanoparticles and show consistent pMBA Raman spectroscopy peaks that will allow for the nanoparticle use in-vivo to be monitored

Computer program for predicting symmetric jet mixing of compressible flow in jets

Finite-difference computer program has been developed for treating mixing of two parallel and compressible air streams; one of them may be supersonic. This development is restricted to symmetric jet mixing in which high-speed jet is located on axis of channel and no provision is made for blowing or suction along channel walls

Design of wideband vibration-based electromagnetic generator by means of dual-resonator

This paper describes the design of a wideband electromagnetic energy harvester that utilizes a novel dual-resonator method to improve the operational frequency range of the vibration-based generator. The device consists of two separate resonator systems (coil and magnet), which each comply with their respective resonance frequencies. This is because both resonators are designed in such a way that both magnet and coil components will oscillate at an additive phase angle, and hence create greater relative motion between the two dominating resonance frequencies, which realizes the wideband generator. Each resonator system consists of a distinctive cantilever beam, one attached with four magnets and steel keepers, the other attached with a copper coil and stainless steel holder as the free end mass. Both cantilevers are clamped and fitted to a common base that is subjected to a vibration source. Basic analytical models are derived and a numerical model is implemented in MATLAB-Simulink. Electromagnetic, structural modal and static mechanical analysis for the design of the prototype are completed using ANSYS finite element tools. For a 0.8 m s−2 acceleration, the open-loop voltage obtained from the experiment shows a good correlation with those from the simulation. Peak induced voltage is measured to be 259.5Vrms as compared to 240.9Vrms from the simulator at 21.3 Hz, which implies an error range of 7.7%. The results also indicate that there is a maximum of 58.22% improvement in the induced voltage within the intermediate region which occurs at the intersection point between the output response plots of two single resonator generators

Tri-Dirac Surface Modes in Topological Superconductors

We propose a new type of topological surface modes having cubic dispersion in three-dimensional topological superconductors. Lower order dispersions are prohibited by the threefold rotational symmetry and time-reversal symmetry. Cooper pairing in the bulk changes sign under improper rotations, akin to$^{3}$He-B. The surface manifestations are a divergent surface density of states at the Fermi level and isospins that rotate three times as they circle the origin in momentum space. We propose that Heusler alloys with band inversion are candidate materials to harbor the novel topological superconductivity.Comment: Five-page main text plus five-page supplementary materials; three figure

Development of the selection and manipulation of self-generated thoughts in adolescence

The ability to select and manipulate self-generated (stimulus-independent, SI), as opposed to stimulus-oriented (SO), information, in a controlled and flexible way has previously only been studied in adults. This ability is thought to rely in part on the rostrolateral prefrontal cortex (RLPFC), which continues to mature anatomically during adolescence. We investigated (1) the development of this ability behaviorally, (2) the associated functional brain development, and (3) the link between functional and structural maturation. Participants classified according to their shape letters either presented visually (SO phases) or that they generated in their head by continuing the alphabet sequence (SI phases). SI phases were performed in the presence or absence of distracting letters. A total of 179 participants (7–27 years old) took part in a behavioral study. Resistance to visual distractors exhibited small improvements with age. SI thoughts manipulation and switching between SI and SO thoughts showed steeper performance improvements extending into late adolescence. Thirty-seven participants (11–30 years old) took part in a functional MRI (fMRI) study. SI thought manipulation and switching between SO and SI thought were each associated with brain regions consistently recruited across age. A single frontal brain region in each contrast exhibited decreased activity with age: left inferior frontal gyrus/anterior insula for SI thought manipulation, and right superior RLPFC for switching between SO and SI thoughts. By integrating structural and functional data, we demonstrated that the observed functional changes with age were not purely consequences of structural maturation and thus may reflect the maturation of neurocognitive strategies