SMEFiT: a flexible toolbox for global interpretations of particle physics data with effective field theories

The Standard Model Effective Field Theory (SMEFT) provides a robust framework to interpret experimental measurements in the context of new physics scenarios while minimising assumptions on the nature of the underlying UV-complete theory. We present the Python open source SMEFiT framework, designed to carry out parameter inference in the SMEFT within a global analysis of particle physics data. SMEFiT is suitable for inference problems involving a large number of EFT degrees of freedom, without restrictions on their functional dependence in the fitted observables, can include UV-inspired restrictions in the parameter space, and implements arbitrary rotations between operator bases. Posterior distributions are determined from two complementary approaches, Nested Sampling and Monte Carlo optimisation. SMEFiT is released together with documentation, tutorials, and post-analysis reporting tools, and can be used to carry out state-of-the-art EFT fits of Higgs, top quark, and electroweak production data. To illustrate its functionalities, we reproduce the results of the recent ATLAS EFT interpretation of Higgs and electroweak data from Run II and demonstrate how equivalent results are obtained in two different operator bases.Comment: 19 pages, 5 figures. The smefit framework is available from https://github.com/LHCfitNikhef/smefit_releas

Bayesian Approach to Inverse Problems: an Application to NNPDF Closure Testing

We discuss the Bayesian approach to the solution of inverse problems and apply the formalism to analyse the closure tests performed by the NNPDF collaboration. Starting from a comparison with the approach that is currently used for the determination of parton distributions (PDFs) by the NNPDF collaboration, we discuss some analytical results that can be obtained for linear problems and use these results as a guidance for the more complicated non-linear problems. We show that, in the case of Gaussian distributions, the posterior probability density of the parametrized PDFs is fully determined by the results of the NNPDF fitting procedure. In the particular case that we consider, the fitting procedure and the Bayesian analysis yield exactly the same result. Building on the insight that we obtain from the analytical results, we introduce new estimators to assess the statistical faithfulness of the fit results in closure tests. These estimators are defined in data space, and can be studied analytically using the Bayesian formalism in a linear model in order to clarify their meaning. Finally we present numerical results from a number of closure tests performed with current NNPDF methodologies. These further tests allow us to validate the NNPDF4.0 methodology and provide a quantitative comparison of the NNPDF4.0 and NNPDF3.1 methodologies. As PDFs determinations move into precision territory, the need for a careful validation of the methodology becomes increasingly important: the error bar has become the focal point of contemporary PDFs determinations. In this perspective, theoretical assumptions and other sources of error are best formulated and analysed in the Bayesian framework, which provides an ideal language to address the precision and the accuracy of current fits

Notes on lattice observables for parton distributions:nongauge theories

We review recent theoretical developments concerning the definition and the renormalization of equal-time correlators that can be computed on the lattice and related to Parton Distribution Functions (PDFs) through a factorization formula. We show how these objects can be studied and analyzed within the framework of a nongauge theory, gaining insight through a one-loop computation. We use scalar field theory as a playground to revise, analyze and present the main features of these ideas, to explore their potential, and to understand their limitations for extracting PDFs. We then propose a framework that would allow to include the available lattice QCD data in a global analysis to extract PDFs.Comment: 20 pages, 2 figure

On the positivity of MSbar parton distributions

We revisit our argument that shows that parton distribution Functions (PDFs) in the MSbar{ scheme are non-negative in the perturbative region, with the main goals of elucidating its domain of validity and clarifying its theoretical underpinnings. We specifically discuss recent results proving that PDFs can turn negative at sufficiently low scale, we clarify quantitatively various aspects of our derivation of positivity in the perturbative region, and we provide an estimate for the scale above which PDF positivity holds

Parton distributions from lattice data:the nonsinglet case

We revise the relation between Parton Distribution Functions (PDFs) and matrix elements computable from lattice QCD, focusing on the quasi-Parton Distribution Functions (qPDFs) approach. We exploit the relation between PDFs and qPDFs in the case of the unpolarized isovector parton distribution to obtain a factorization formula relating the real and imaginary part of qPDFs matrix elements to specific nonsinglet distributions, and we propose a general framework to extract PDFs from the available lattice data, treating them on the same footing as experimental data. We implement the proposed approach within the NNPDF framework, and we study the potentiality of such lattice data in constraining PDFs, assuming some plausible scenarios to assess the unknown systematic uncertainties. We finally extract the two nonsinglet distributions involved in our analysis from a selection of the available lattice data.Comment: 26 pages, 7 figures; added references, corrected typo

In vivo emergence of colistin resistance in Klebsiella pneumoniae producing KPC-type carbapenemases mediated by insertional inactivation of the PhoQ/PhoP mgrB regulator

Colistin is one of the few agents that retain activity against extensively drug-resistant strains of Klebsiella pneumoniae producing KPC-type carbapenemases (KPC-KP). However, resistance to colistin is increasingly reported among KPC-KP. Comparative genomic analysis of a pair of sequential KPC-KP isolates from the same patient including a colistin-susceptible isolate (KKBO-1) and a colistin-resistant isolate (KKBO-4) selected after colistin exposure revealed that insertional inactivation of the mgrB gene, encoding a negative regulator of the PhoQ/PhoP signaling system, is a genetic mechanism for acquired colistin resistance. The role of mgrB inactivation in acquired colistin resistance was confirmed by complementation experiments with wild-type mgrB, which restored colistin susceptibility in KKBO-4, and by construction of an mgrB deletion mutant from KKBO-1, which exhibited a colistin-resistant phenotype. Insertional mgrB inactivation was also detected in 60% of colistin-resistant mutants selected from KKBO-1 in vitro, following plating on colistin-containing medium, confirming the role (although not unique) of this mechanism in the emergence of acquired colistin resistance. In colistin-resistant mutants carrying insertional inactivation or deletion of the mgrB gene, upregulated transcription of phoP, phoQ, and pmrK (which is part of the pmrHFIJKLM operon) was detected. These findings confirmed the MgrB regulatory role in K. pneumoniae and were in agreement with the known association between upregulation of the PhoQ/PhoP system and activation of the pmrHFIJKLM operon, which eventually leads to resistance to polymyxins by modification of the lipopolysaccharide target

Draft genome sequence of Proteus mirabilis NO-051/ 03, representative of a multidrug-resistant clone spreading in Europe and expressing the CMY-16 AmpC-type β-lactamase

Proteus mirabilis NO-051/03, representative of a multidrug-resistant clone expressing the CMY-16 AmpC-type β-lactamase and circulating in Europe since 2003, was sequenced by a MiSeq platform using a paired-end approach. The genome was assembled in 100 scaffolds with a total length of 4,197,318 bp. Analysis of the draft genome sequence revealed the presence of several acquired resistance determinants to β-lactams, aminoglycosides, phenicols, tetracyclines, trimethoprim, and sulfonamides, of one plasmid replicon, and of a type I-E clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein (Cas) adaptive immune system