Ever changing sand patterns on the Lake Pedder beach, ripple in the light of early morning, Tasmania, ca. 1969 [picture] /

Title devised by cataloguer based on information supplied by the vendor.; In: Olegas Truchanas Lake Pedder audiovisual collection.; This is a digital image made by the National Library of Australia from an original in private ownership.; AV Reference number: 067.; Reproduced from: 1 slide : col. ; 3.5 x 2.4 cm.; Mode of access: Internet via World Wide Web at: http://nla.gov.au/nla.pic-vn3885846-s67; Copied by permission of Mrs. Melva Truchanas, 2006

A national epidemiologial study investigating risk factors for police interrogation and false confession among juveniles and young persons

Purpose The principal aims of this study are to identify risk factors associated with police arrest and false confessions and to investigate whether the severity of the ADHD condition/symptoms increases the risk. Methods 22,226 young persons in Iceland anonymously completed self-report questionnaires screening for conduct disorder and ADHD. In addition, they stated whether they had a diagnosis of ADHD and had received ADHD medication, and their history of offending, police interrogation and false confession. Participants were stratified into two age groups, 14–16 and 17–24 years. Results The older group was significantly more likely to have been interrogated by the police but the younger group were much more vulnerable to false confession during interrogation. Males were more likely to be at risk for both than females. The severity of the ADHD condition increased the risk of both interrogation and false confession. Negative binomial regressions showed that age, gender, conduct disorder, offending, and ADHD symptoms were all significant predictors of both interrogations and number of false confessions. Conduct disorder was the single best predictor of police interrogation, but the findings were more mixed regarding false confessions. Young people presenting with a combination of severe ADHD and comorbid conduct disorder had the worst outcome for both interrogation and false confessions. Conclusions The findings endorse the need for support of persons with ADHD to be put in place to ensure fair due process and to prevent miscarriages of justice

An epidemiological study of ADHD and conduct disorder: does family conflict moderate the association?

Attention deficit hyperactivity disorder ( ADHD ) is a developmental disorder, worldwide affecting about 5% of people under 18 years of age [1] . Often, t he disorde r negatively affects peoples’ daily lives, due to their symptoms of inattentive ness , hyperactiv ity and impulsiv ity . These symptoms often persist into adulthood [2] . Numerous studies have found that adolescents with ADHD are more likely than adolescents without ADHD to have behavioral problems. Conduct disorder (CD) is one such behavioral problem, occurring in about 30% to 50% of adolescents with ADHD [3 - 5] and they seem to share a common genetic influence [6]

Use of a bereavement risk assessment checklist in an Icelandic hospital

To access publisher's site click on the hyperlink at the bottom of the pageThere are many factors influencing people’s response to the loss of a loved one, including previous experience of death and bereavement, social circumstances, age, relationship to the deceased and personality. Each death – and each bereaved person – is unique and the need for support therefore varies

Use of a bereavement risk assessment checklist in an Icelandic hospital

To access publisher's site click on the hyperlink at the bottom of the pageThere are many factors influencing people’s response to the loss of a loved one, including previous experience of death and bereavement, social circumstances, age, relationship to the deceased and personality. Each death – and each bereaved person – is unique and the need for support therefore varies

Translational implications of endothelial cell dysfunction in association with chronic allograft rejection

International audienceAdvances in therapeutics have dramatically improved short-term graft survival, while the incidence of chronic rejection has not changed in the past 20 years. New insights into mechanism are sorely needed at this time and it is hoped that the development of predictive biomarkers will pave the way for the emergence of preventative therapeutics. In this review, we discuss a paradigm suggesting that sequential changes within graft endothelial cells (EC) lead to an intragraft microenvironment that favors the development of chronic rejection. Key changes include EC injury, activation and uncontrolled leukocyte-induced angiogenesis. We propose that all of these changes may lead to abnormal blood flow patterns, local tissue hypoxia and an associated overexpression of HIF-1α-inducible genes including Vascular Endothelial Growth Factor. We also discuss how regulators of mTOR-mediated signaling within EC are of critical importance in microvascular stability and the inhibition of chronic rejection. Finally, we discuss recent findings indicating that miRNAs regulate EC stability, and their potential as novel noninvasive biomarkers of allograft rejection. Altogether, this review provides insights into molecular events, genes and signals that promote chronic rejection and their potential as biomarkers for the future development of interruption therapeutics