(microcystic) form

https://stars.library.ucf.edu/cfm-ch-register-vol13/1302/thumbnail.jp

calcium-phosphate cement reduces the side effects on soft tissue healing

Objectives: This study aims to evaluate whether the collagen membrane (membrane) wrapping around the methotrexate (MTX)-containing calcium-phosphate cement (CPC) reduces the side effects on soft tissue healing.Material and methods: In 36 rats, femoral bone defects were created and treated in six groups which were CPC only, CPC and membrane wrapping around, CPC containing 2% MTX, CPC containing 2% MTX and membrane wrapping around, CPC containing 5% MTX, CPC containing 5% MTX and membrane wrapping around.Results: Histological examinations revealed a statistically significantly improved healing in the connective tissue samples of the CPC containing 5% MTX group wrapped around by membrane compared to those without membrane (p=0.04). However, this was not seen in other groups.Conclusion: Membrane wrapping around the CPC containing MTX reduces the side effect of MTX on cellular proliferation at its highest concentration, particularly. Membrane wrapping may allow administration of higher doses of an anti-neoplastic drug which can be more effective. Keywords: Animal model; calcium-phosphate cement; collagen membrane; methotrexate; soft tissue healing

factors

Introduction: F-1(8)-FDG PET/CT provides very effective results in detecting metastases of breast cancer. In our study, we investigated the relationship between maximum standard uptake value (SUVmax) and prognostic pathologic factors in breast cancer cases with isolated bone metastasis and whether there was any difference in terms of prognostic pathologic factors between the group with and without bone metastasis.Methods. Between 2013 and 2016, isolated bone metastases (55 female; 56 +/- 12 years; 32-87), and non-metastatic (46 female; 55 +/- 13 years; 30-81) patients who were referred to department of nuclear medicine and underwent F-18-FDG PET/CT for staging were included in the study. PET/CT images of patients and pathologic prognostic factors were evaluated retrospectively. SUVmax value of the most intense activity from metastatic bone lesions was calculated. p <0.05 was considered statistically significant.Results: In the metastatic group, there was no statistically significant relationship between measured SUVmax value of bone metastasis and pathologic prognostic factors. A statistically significant difference was found between the metastatic group and the non-metastatic group in terms of lymph node stage, lymphovascular/perineural invasion. The lymph node stage in the metastatic group was higher than the non-metastatic group. The presence of lymphovascular/perineural invasion in bone metastasis cases was more than in the non-metastatic group.Conclusion: In our study, it was determined that there was a relationship between the lymph node stage, lymphovascular/perineural invasion and formation of bone metastasis in breast cancer. Between SUVmax values and other factors in the metastatic group, no significant relationship was detected.C1 [Sengoz, Tarik; Yaylali, Olga; Yuksel, Dogangun] Pamukkale Univ, Fac Med, Dept Nucl Med, Denizli, Turkey.[Dogu, Gamze Gokoz] Pamukkale Univ, Fac Med, Dept Oncol, Denizli, Turkey.[Bir, Ferda] Pamukkale Univ, Fac Med, Dept Pathol, Denizli, Turkey

non-metastatic breast cancer

We aimed to assess the association between IGF-I gene (CA repeats) polymorphism in breast cancer patients and their clinicopathological features, as well as disease recurrence and survival. Seventy-six non-metastatic breast cancer patients were enrolled in the present study. The IGF-I (CA) repeats were studied with polymerase chain reaction by using proper primers belonging to these gene areas from DNA samples. Results show that the non 19- non 19 homozygote were more common in patients without lymph node involvement (p = 0.04), with low histological grade (p = 0.04), with positive hormone receptor status (p = 0.01), and in patients without recurrence (p = 0.06). These results suggest that the non 19-non 19 carriers have some favorable prognostic factors, and IGF-I gene polymorphism (CA repeats) may affect disease recurrence and overall survival. (C) 2012 Elsevier B.V. All rights reserved