Evidence-based psychotherapeutic interventions for young people with mood disorders: a systematic review

INTRODUCTION: Mood disorders are amongst the most common groups of mental disorders in young people (YP). Depression may affect 8-20% of all YP and may result in a cascade of negative developmental outcomes predicting long-term morbidity and poor functioning. In view of this, the COST action ‘European Network of Individualized Psychotherapy Treatment of Young People with Mental Disorders’ (TREATme) was set up to help improve mental health services in YP.OBJECTIVES: One of the overarching aims of TREATme is to carry out a systematic review to assess for the effectiveness of psychotherapeutic interventions in YP. In this study, we present results from the systematic review of treatment effectiveness of youth interventions for mood disorders.[excerpt]peer-reviewe

Advances in structure elucidation of small molecules using mass spectrometry

The structural elucidation of small molecules using mass spectrometry plays an important role in modern life sciences and bioanalytical approaches. This review covers different soft and hard ionization techniques and figures of merit for modern mass spectrometers, such as mass resolving power, mass accuracy, isotopic abundance accuracy, accurate mass multiple-stage MS(n) capability, as well as hybrid mass spectrometric and orthogonal chromatographic approaches. The latter part discusses mass spectral data handling strategies, which includes background and noise subtraction, adduct formation and detection, charge state determination, accurate mass measurements, elemental composition determinations, and complex data-dependent setups with ion maps and ion trees. The importance of mass spectral library search algorithms for tandem mass spectra and multiple-stage MS(n) mass spectra as well as mass spectral tree libraries that combine multiple-stage mass spectra are outlined. The successive chapter discusses mass spectral fragmentation pathways, biotransformation reactions and drug metabolism studies, the mass spectral simulation and generation of in silico mass spectra, expert systems for mass spectral interpretation, and the use of computational chemistry to explain gas-phase phenomena. A single chapter discusses data handling for hyphenated approaches including mass spectral deconvolution for clean mass spectra, cheminformatics approaches and structure retention relationships, and retention index predictions for gas and liquid chromatography. The last section reviews the current state of electronic data sharing of mass spectra and discusses the importance of software development for the advancement of structure elucidation of small molecules

Net analyte signal-based methods for the simultaneous determination of paracetamol, propyphenazone and caffeine by UV spectrophotometry

© 2018 Bulgarian Academy of Sciences, Union of Chemists in Bulgaria.Three different net analyte signal-based (NAS) methods - NAP CLS, HLA/GO and HLA XS were successfully applied for the determination of ternary mixtures of paracetamol (PAR), propyphenazone (PRO) and caffeine (CAF). The methods used absorbance UV-spectral data for resolving this complex system with overlapping drug spectra. A reduced five-level orthogonal design was used for the formation of a calibration set including the three compounds. The chemometric models were tested on an external validation dataset with concentrations within the calibration range. All proposed chemometric algorithms could be successfully applied for the determination of the above compounds in the pharmaceutical tablet formulation Saridon®. The obtained results showed that the NAS performance was similar compared to partial least-squares method (PLS-1). In addition, the use of the net analyte signal concept allowed the calculations of the analytical figures of merit. A moving window wavelength selection strategy was used, which significantly reduced the number of factors and improved the analytical recoveries

Assessment of different PLS algorithms for quantification of three spectrally overlapping drugs

The primary aim of the present study was to compare the prediction power of different PLS algorithms as applied to the quantification of three spectrally overlapping drugs. Four variants of PLS were chosen for multivariate calibration and prediction of the three components of the drug formulation (paracetamol, propyphenazone and caffeine). NIPALS and SIMPLS algorithms were the most commonly used algorithms. The other tested algorithms were Kernel and Bidiagonalization which have been rarely applied in pharmaceutical analysis

Evidence-based psychotherapeutic interventions for young people with substance use disorder : a systematic literature review.

INTRODUCTION: Substance use disorders (SUD) are a global problem with many health and economic consequences, impacting the user, the mental health system and society at large. Over half of SUD problems begin during adolescence. Treatment approaches and effective management frequently involve psychotherapeutic interventions, which prevents long term morbidity and mortality. Recognizing this public health concern and the need for more empirical based knowledge, the European Cooperation in Science and Technology (COST) funded the ‘European Network of Individualized Psychotherapy Treatment of Young People with Mental Disorders’ (TREATme).OBJECTIVES: As part of the aims of TREATme, in this particular study a systematic review of the published literature was conducted to determine the effectiveness of specific psychotherapeutic interventions (PI) in young people (YP) with SUDs.[excerpt]peer-reviewe

Evidence-based psychotherapeutic interventions for young people with mood disorders : a systematic review

INTRODUCTION: Mood disorders are amongst the most common groups of mental disorders in young people (YP). Depression may affect 8-20% of all YP and may result in a cascade of negative developmental outcomes predicting long-term morbidity and poor functioning. In view of this, the COST action ‘European Network of Individualized Psychotherapy Treatment of Young People with Mental Disorders’ (TREATme) was set up to help improve mental health services in YP.OBJECTIVES: One of the overarching aims of TREATme is to carry out a systematic review to assess for the effectiveness of psychotherapeutic interventions in YP. In this study, we present results from the systematic review of treatment effectiveness of youth interventions for mood disorders.[excerpt]peer-reviewe