Aspects of the unitarized soft multipomeron approach in DIS and diffraction

We studyin detail the main features of the unitarized Regge model (CFKS), recentlyprop osed to describe the small-Q2 domain. It takes into account a two-component description with two types of unitarized contributions: one is the multiple pomeron exchange contribution, interacting with the large dipole size configurations, and the other one consists of a unitarized dipole cross section, describing the interaction with the small size dipoles. We analyze the ratio between soft and hard pieces as a function of the virtuality, and also compare the resulting dipole cross section to that from the saturation model. Diffraction dissociation is also considered, showing the scaling violations in diffractive DIS and estimating the corresponding logarithmic slope

Quarkonium+γ\gamma production in coherent hadron - hadron interactions at LHC energies

In this paper we study the $H + \gamma$ ($H = J/\Psi$ and $\Upsilon$) production in coherent hadron - hadron interactions at LHC energies. Considering the ultrarelativistic protons as a source of photons, we estimate the $\gamma + p \rightarrow H + \gamma + X$ cross section using the non-relativistic QCD (NRQCD) factorization formalism and considering different sets of values for the matrix elements. Our results for the total $p + p \rightarrow p + H + \gamma + X$ cross sections and rapidity distributions at $\sqrt{s} = 7$ and 14 TeV demonstrate that the experimental analysis of the $J/\Psi + \gamma$ production at LHC is feasible.Comment: 6 pages, 3 figures, 1 table. Improved version with a new figure. Version to be published in European Physical Journal

A geometrical estimation of saturation of partonic densities

We propose a new criterium for saturation of the density of partons both in nucleons and nuclei. It is applicable to any multiple scattering model which would be used to compute the number of strings exchanged in $ep$ and $eA$ collisions. The criterium is based on percolation of strings, and the onset of percolation is estimated from expectations coming from the study of heavy ion collisions at high energies. We interpret this onset as an indication of saturation of the density of partons in the wave function of the hadron. In order to produce quantitative results, a particular model fitted to describe present HERA data and generalized to the nuclear case is used. Nevertheless, with the number of scatterings controlled by the relation between inclusive and diffractive processes, conclusions are weakly model-dependent as long as different models are tuned to describe the experimental data. This constitutes a new approach, based on the eikonal description of soft hadronic collisions, and different from others which employ either perturbative QCD ideas or semiclassical methods. It offers an alternative picture for saturation in the small $Q^2$ region.Comment: LaTeX, 15 pages, 2 eps figures included using epsfig; final version, abstract and discussions enlarged, references added and updated, results unchanged; more references adde

Modeling DNA Structure, Elasticity and Deformations at the Base-pair Level

We present a generic model for DNA at the base-pair level. We use a variant of the Gay-Berne potential to represent the stacking energy between neighboring base-pairs. The sugar-phosphate backbones are taken into account by semi-rigid harmonic springs with a non-zero spring length. The competition of these two interactions and the introduction of a simple geometrical constraint leads to a stacked right-handed B-DNA-like conformation. The mapping of the presented model to the Marko-Siggia and the Stack-of-Plates model enables us to optimize the free model parameters so as to reproduce the experimentally known observables such as persistence lengths, mean and mean squared base-pair step parameters. For the optimized model parameters we measured the critical force where the transition from B- to S-DNA occurs to be approximately $140{pN}$. We observe an overstretched S-DNA conformation with highly inclined bases that partially preserves the stacking of successive base-pairs.Comment: 15 pages, 25 figures. submitted to PR

Quantificação de neurofilamentos de hipocampo de ratos submetidos à isquemia cerebral transitória

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Immunogenicity of AGS-004 Dendritic Cell Therapy in Patients Treated during Acute HIV Infection

AGS-004 consists of matured autologous dendritic cells co-electroporated with in vitro transcribed RNA encoding autologous HIV antigens. In an open-label, single arm sub-study of AGS-004-003, AGS-004 was administered monthly to suppressed participants who started antiretroviral therapy (ART) during acute HIV infection. HIV-1 specific T cell responses were measured by multicolor flow cytometry after 3-4 doses. The frequency of resting CD4+ T-cell infection (RCI) was measured by quantitative viral outgrowth assay. Participants demonstrating increased immune response postvaccination were eligible for analytic treatment interruption (ATI). AGS-004 induced a positive immune response defined as ≥2-fold increase from baseline in the number of multifunctional HIV-1 specific CD28+/CD45RA- CD8+ effector/memory cytoxic T-lymphocytes (CTLs) in all six participants. All participants underwent ATI with rebound viremia at a median of 29 days. Immune correlates between time to viral rebound and the induction of effector CTLs were determined. Baseline RCI was low in most participants (0.043-0.767 IUPM). One participant had a >2-fold decrease (0.179-0.067 infectious units per million [IUPM]) in RCI at week 10. One participant with the lowest RCI had the longest ATI. AGS-004 dendritic cell administration increased multifunctional HIV-specific CD28+/CD45RA- CD8+ memory T cell responses in all participants, but did not permit sustained ART interruption. However, greater expansion of CD28-/CCR7-/CD45RA- CD8+ effector T cell responses correlated with a longer time to viral rebound. AGS-004 may be a useful tool to augment immune responses in the setting of latency reversal and eradication strategies

Rapid analysis of local data to inform off-label tocilizumab use early in the COVID-19 pandemic

The interleukin-6 receptor antagonist tocilizumab became widely used early in the coronavirus disease 2019 (COVID-19) pandemic based on small observational studies that suggested clinical benefit in COVID-19 patients with a hyperinflammatory state. To inform our local treatment algorithms in the absence of randomized clinical trial results, we performed a rapid analysis of the first 11 hospitalized COVID-19 patients treated with tocilizumab at our academic medical center. We report their early clinical outcomes and describe the process by which we assembled a team of diverse trainees and stakeholders to extract, analyze, and disseminate data during a time of clinical uncertainty

Second-generation colon capsule endoscopy compared with colonoscopy

Colon capsule endoscopy (CCE) represents a noninvasive technology that allows visualization of the colon without requiring sedation and air insufflation. A second-generation colon capsule endoscopy system (PillCam Colon 2) (CCE-2) was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. OBJECTIVE: To assess the feasibility, accuracy, and safety of CCE-2 in a head-to-head comparison with colonoscopy. DESIGN AND SETTING: Prospective, multicenter trial including 8 European sites. PATIENTS: This study involved 117 patients (mean age 60 years). Data from 109 patients were analyzed. INTERVENTION: CCE-2 was prospectively compared with conventional colonoscopy as the criterion standard for the detection of colorectal polyps that are >/=6 mm or masses in a cohort of patients at average or increased risk of colorectal neoplasia. Colonoscopy was independently performed within 10 hours after capsule ingestion or on the next day. MAIN OUTCOME MEASUREMENTS: CCE-2 sensitivity and specificity for detecting patients with polyps >/=6 mm and >/=10 mm were assessed. Capsule-positive but colonoscopy-negative cases were counted as false positive. Capsule excretion rate, level of bowel preparation, and rate of adverse events also were assessed. RESULTS: Per-patient CCE-2 sensitivity for polyps >/=6 mm and >/=10 mm was 84% and 88%, with specificities of 64% and 95%, respectively. All 3 invasive carcinomas were detected by CCE-2. The capsule excretion rate was 88% within 10 hours. Overall colon cleanliness for CCE-2 was adequate in 81% of patients. LIMITATIONS: Not unblinding the CCE-2 results at colonoscopy; heterogenous patient population; nonconsecutive patients. CONCLUSION: In this European, multicenter study, CCE-2 appeared to have a high sensitivity for the detection of clinically relevant polypoid lesions, and it might be considered an adequate tool for colorectal imaging

Search for direct production of charginos and neutralinos in events with three leptons and missing transverse momentum in √s = 7 TeV pp collisions with the ATLAS detector

A search for the direct production of charginos and neutralinos in final states with three electrons or muons and missing transverse momentum is presented. The analysis is based on 4.7 fb−1 of proton–proton collision data delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in three signal regions that are either depleted or enriched in Z-boson decays. Upper limits at 95% confidence level are set in R-parity conserving phenomenological minimal supersymmetric models and in simplified models, significantly extending previous results