Collapse of the Gd3+Gd^{3+} ESR fine structure throughout the coherent temperature of the Gd-doped Kondo Semiconductor CeFe4P12CeFe_{4}P_{12}

Experiments on the $Gd^{3+}$ Electron Spin Resonance (ESR) in the filled skutterudite $Ce_{1-x}Gd_{x}Fe_{4}P_{12}$ ($x \approx 0.001$), at temperatures where the host resistivity manifests a smooth insulator-metal crossover, provides evidence of the underlying Kondo physics associated with this system. At low temperatures (below $T \approx K$), $Ce_{1-x}Gd_{x}Fe_{4}P_{12}$ behaves as a Kondo-insulator with a relatively large hybridization gap, and the $Gd^{3+}$ ESR spectra displays a fine structure with lorentzian line shape, typical of insulating media. The electronic gap is attributed to the large hybridization present in the coherent regime of a Kondo lattice, when Ce 4f-electrons cooperate with band properties at half-filling. Mean-field calculations suggest that the electron-phonon interaction is fundamental at explaining the strong 4f-electron hybridization in this filled skutterudite. The resulting electronic structure is strongly temperature dependent, and at about $T^{*} \approx 160 K$ the system undergoes an insulator-to-metal transition induced by the withdrawal of 4f-electrons from the Fermi volume, the system becoming metallic and non-magnetic. The $Gd^{3+}$ ESR fine structure coalesces into a single dysonian resonance, as in metals. Still, our simulations suggest that exchange-narrowing via the usual Korringa mechanism, alone, is not capable of describing the thermal behavior of the ESR spectra in the entire temperature region ($4.2$ - $300$ K). We propose that temperature activated fluctuating-valence of the Ce ions is the missing ingredient that, added to the usual exchange-narrowing mechanism, fully describes this unique temperature dependence of the $Gd^{3+}$ ESR fine structure observed in $Ce_{1-x}Gd_{x}Fe_{4}P_{12}$.Comment: 19 pages, 6 figure

MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells

A number of microRNAs have been shown to regulate skeletal muscle development and differentiation. MicroRNA-222 is downregulated during myogenic differentiation and its overexpression leads to alteration of muscle differentiation process and specialized structures. By using RNA-induced silencing complex (RISC) pulldown followed by RNA sequencing, combined with in silico microRNA target prediction, we have identified two new targets of microRNA-222 involved in the regulation of myogenic differentiation, Ahnak and Rbm24. Specifically, the RNA-binding protein Rbm24 is a major regulator of muscle-specific alternative splicing and its downregulation by microRNA-222 results in defective exon inclusion impairing the production of muscle-specific isoforms of Coro6, Fxr1 and NACA transcripts. Reconstitution of normal levels of Rbm24 in cells overexpressing microRNA-222 rescues muscle-specific splicing. In conclusion, we have identified a new function of microRNA-222 leading to alteration of myogenic differentiation at the level of alternative splicing, and we provide evidence that this effect is mediated by Rbm24 protei

Non-linear response of single-molecule magnets: field-tuned quantum-to-classical crossovers

Quantum nanomagnets can show a field dependence of the relaxation time very different from their classical counterparts, due to resonant tunneling via excited states (near the anisotropy barrier top). The relaxation time then shows minima at the resonant fields H_{n}=n D at which the levels at both sides of the barrier become degenerate (D is the anisotropy constant). We showed that in Mn12, near zero field, this yields a contribution to the nonlinear susceptibility that makes it qualitatively different from the classical curves [Phys. Rev. B 72, 224433 (2005)]. Here we extend the experimental study to finite dc fields showing how the bias can trigger the system to display those quantum nonlinear responses, near the resonant fields, while recovering an classical-like behaviour for fields between them. The analysis of the experiments is done with heuristic expressions derived from simple balance equations and calculations with a Pauli-type quantum master equation.Comment: 4 pages, 3 figures. Submitted to Phys. Rev. B, brief report

The State of the Circumstellar Medium Surrounding Gamma-Ray Burst Sources and its Effect on the Afterglow Appearance

We present a numerical investigation of the contribution of the presupernova ejecta of Wolf-Rayet stars to the environment surrounding gamma-ray bursts (GRBs), and describe how this external matter can affect the observable afterglow characteristics. An implicit hydrodynamic calculation for massive stellar evolution is used here to provide the inner boundary conditions for an explicit hydrodynamical code to model the circumstellar gas dynamics. The resulting properties of the circumstellar medium are then used to calculate the deceleration of a relativistic, gas-dynamic jet and the corresponding afterglow light curve produced as the shock wave propagates through the shocked-wind medium. We find that variations in the stellar wind drive instabilities that may produce radial filaments in the shocked-wind region. These comet-like tails of clumps could give rise to strong temporal variations in the early afterglow lightcurve. Afterglows may be expected to differ widely among themselves, depending on the angular anisotropy of the jet and the properties of the stellar progenitor; a wide diversity of behaviors may be the rule, rather than the exception.Comment: 17 pages, 7 figures, ApJ in pres