1,976 research outputs found
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How Stigma Impacts the Utilization of Mental Health Services Among Young Adults\u27 Within Three Different Ethnic Minority Communities
Mental health is an important aspect of every individual’s life. However, regardless of its importance, mental health is a topic that does not get much recognition. It is often simply brushed under the rug and ignored. Consequently, individuals who have mental health diagnoses may or may not choose to seek the necessary assistance. This specifically seems to be the case among adolescents and young adults within various ethnic communities, which may be due to the stigma surrounding mental health in their communities. To illustrate, regardless of the high prevalence rate of mental health issues among the minority youth, many of them still do not utilize the appropriate mental health services. With all that being said, this study questions how stigma influences the utilization of mental health services among young adults’ within the Latino/Latinx, African American, and Asian American communities through the descriptive, secondary data analysis of the UCLA Center for Health Policy Research 2021 California Health Interview Survey (CHIS) data. The key hypothesis for this study was that a major factor on whether or not these young adults’ speak out and seek help in regards to their mental health is the stigma that their race and ethnicity face. Descriptive analysis was utilized to identify frequencies of variables, quantitative analysis techniques were used to analyze the additional CHIS data, and a multiple logistic regression was conducted in order to identify any significant relationships between the variables. The findings of this research study indicate that stigma associated with mental health may not be the only factor in determining young adults’ utilization of mental health services
Monosexual and Nonmonosexual Women in Same-Sex Couples’ Relationship Quality During the First Five Years of Parenthood
Research on relationship quality in same-sex couples has rarely focused on (1) couples who are parents, or (2) couples in which partners differ in sexual identity. Insomuch as nonmonosexual women (i.e., women with non-exclusive sexual orientations) experience unique challenges due to monosexism, relationship quality may be influenced by whether partners share a monosexual or nonmonosexual identity. The current study is a longitudinal, dyadic analysis of 118 female parents within 63 same-sex couples whose relationship quality (relationship maintenance, conflict, love, ambivalence) was assessed at five time points across the first 5 years of adoptive parenthood. Monosexual women were those who identified as exclusively lesbian/gay (n = 68); nonmonosexual women were those who identified as mostly lesbian/gay, bisexual, queer, pansexual, or mostly heterosexual (n = 50). Analyses revealed both actor and partner effects on maintenance and conflict, such that nonmonosexual women reported more maintenance and conflict than monosexual women, and women with nonmonosexual partners reported more maintenance and conflict than women with monosexual partners. Depression was related to greater conflict and ambivalence and less love; internalized sexual stigma was related to greater conflict and ambivalence. Maintenance and love declined over time whereas ambivalence increased during early parenthood
Environmental Analysis of Toxic Metals Produced by Cigarette Smoking
Trace metal elements introduced into our environment from anthropogenic sources can become toxic at high levels contributing to a host of human and animal health problems. The purpose of this work is to initially characterize toxic metals present in cigarette tobacco and ash using Electrothermal Atomic Absorption Spectroscopy (ETAAS). The broader impact of this study is to assess the environmental effects of cigarette smoking around designated smoking areas on the Longwood University campus. Smokers may not be informed about the potential harm to the environment from ashing directly on the ground. If the toxic metals present in cigarette ash are not completely volatilized during smoking, they could accumulate over time in the soil adjacent to campus-designated smoking areas. The area surrounding the smoking facilities could, therefore, serve as a starting point for the introduction of toxic metals into the food chain, ground water, or nearby storm water system
Internet e Jurisdição, Acesso TransfronteirÃço a Dados e o Caso Irlanda Microsoft
A Internet trouxe uma revolução na forma como a sociedade pensa, age e interage. Ela também trouxe uma revolução na forma como documentos eletrônicos são acessados e guardados. Num mundo de computação nas nuvens, o uso do princÃpio territorial para definição de jurisdição tornou-se obsoleto e inadequado. PaÃses europeus, signatários ou não da Convenção de Budapeste, estão modificando o critério para definição de jurisdição e a forma como prova eletrônica é coletada e acessada. O novo critério é controle e não território – aqueles que têm controle sobre os dados precisam fornecê-los, independentemente do local em que estão fisicamente armazenados. A legislação brasileira também adotou o critério controle e a discussão sobre seus reflexos finalmente chegou à s Corte Norte-americanas com o Caso Microsoft Irlanda. O novo critério, controle, é hoje o único caminho possÃvel. O único caminho que respeita soberania e as peculiaridades da prova eletrônica
A unique biofilm in human deep mycoses: fungal amyloid is bound by host serum amyloid P component
Background/Objectives We have demonstrated the presence of Candida cell surface amyloids that are important in aggregation of fungi and adherence to tissue. Fungal amyloid was present in invasive human candidal infections and host serum amyloid P component (SAP) bound to the fungal amyloid. SAP is a protease-resistant glycoprotein that binds avidly to amyloid and interferes with host defence, especially against bacterial pathogens for which neutrophils are important. In this study, we investigated whether biofilm of fungal amyloid and SAP was a feature of other disseminated fungal infections. Methods Tissue specimens from 15 autopsies were systematically evaluated with multiple histochemical stains including thioflavin T and Congo red (dyes that stain amyloid), as well as antibody to SAP. We studied specimens with disseminated aspergillosis, mucormycosis and coccidioidomycosis. The structure of the lesions, host inflammatory cells and the presence of fungal amyloid and SAP were determined. Results The structure of the lesions was characteristic in aspergillosis (‘starburst’) and mucormycosis (closely apposed bundles of hyphae). Host inflammatory cells were absent or few in number within these lesions. In Coccidioides lesions, host inflammation was sparse as well. Fungal amyloid was a prominent feature of all lesions along with abundant SAP bound to hyphae and spherules. Fungal amyloid and SAP perhaps contributed to persistence in caseous necrosis lesions. SAP also bound to Aspergillus and Mucorales amyloid in vitro. Conclusions A biofilm including amyloid and SAP is present in invasive fungal infections. This biofilm may dampen host defence leading to the characteristic sparse inflammatory reaction found in these infections
Retinal and cerebral microvascular signs and diabetes: the age, gene/environment susceptibility-Reykjavik study
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldOBJECTIVE: Diabetes increases the risk for microvascular disease. The retina and the brain both have intricate microvascular systems that are developmentally similar. We sought to examine whether microvascular lesions in the retina and in the brain are associated and whether this association differs among people with and without diabetes. RESEARCH DESIGN AND METHODS: The analysis included 4,218 participants of the Icelandic population-based Age, Gene/Environment Susceptibility-Reykjavik Study who were born in 1907-1935 and who were previously followed as a part of the Reykjavik Study. Retinal focal arteriolar narrowing, arteriovenous (AV) nicking, and microaneurysms/hemorrhages were evaluated on digital retinal images of both eyes. Cerebral microbleeds (CMBs) were evaluated from magnetic resonance images. Data were analyzed with logistic and multinomial logistic regression models controlling for demographics, major cardiovascular risk factors, cerebral infarcts, and white matter lesions. RESULTS: Evidence of brain microbleeds was found in 485 (11.5%) people, including 192 with multiple (>or=2) microbleeds. Subjects with signs of retinal microvascular lesions were at a significantly increased likelihood for having multiple CMBs. People with diabetes in combination with the presence of either retinal AV nicking (odds ratio [OR] 2.47 [95% CI 1.42-4.31]) or retinal microaneurysms/hemorrhages (2.28 [1.24-4.18]) were significantly more likely to have multiple CMBs. CONCLUSIONS: Retinal microvascular abnormalities and brain microbleeds may occur together in older adults. People with both diabetes and signs of retinal microvascular lesions (AV nicking and microaneurysms/hemorrhages) are more likely to have multiple microbleeds in the brain. Microvascular disease in diabetes extends to the brain
PRIMARY RENAL LYMPHOMA IN TWO CATS: CASE REPORT
Lymphoma is a hematopoietic neoplasia which occurs due to the proliferation of malignant lymphocytes. It can be present in different forms, including alimentary, mediastinal, multicentric and extranodal. Â Â In both cases described in this report, signs consistent with chronic kidney disease were present. An ultrasound-guided fine-needle aspiration was performed and suggested a lymphocyte neoplastic process. Both cats received prednisolone and life support treatment, with mild improvement. One cat was euthanatized and the other died spontaneously, five and seven days after onset of treatment, respectively. The kidneys were enlarged, whitish, irregular, with a firm mass in the cortex. Histopathology confirmed that the lymphoma was restricted to the kidneys
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Francisella tularensis Transmission by Solid Organ Transplantation, 20171.
In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected only after blood cultures from the surviving kidney recipient grew Francisella species. The organ donor, a middle-aged man from the southwestern United States, had been hospitalized for acute alcohol withdrawal syndrome, pneumonia, and multiorgan failure. F. tularensis subsp. tularensis (clade A2) was cultured from archived spleen tissue from the donor and blood from both kidney recipients. Whole-genome multilocus sequence typing indicated that the isolated strains were indistinguishable. The heart recipient remained seronegative with negative blood cultures but had been receiving antimicrobial drugs for a medical device infection before transplant. Two lagomorph carcasses collected near the donor's residence were positive by PCR for F. tularensis subsp. tularensis (clade A2). This investigation documents F. tularensis transmission by solid organ transplantation
Parity-related molecular signatures and breast cancer subtypes by estrogen receptor status
Abstract Introduction Relationships of parity with breast cancer risk are complex. Parity is associated with decreased risk of postmenopausal hormone receptor–positive breast tumors, but may increase risk for basal-like breast cancers and early-onset tumors. Characterizing parity-related gene expression patterns in normal breast and breast tumor tissues may improve understanding of the biological mechanisms underlying this complex pattern of risk. Methods We developed a parity signature by analyzing microRNA microarray data from 130 reduction mammoplasty (RM) patients (54 nulliparous and 76 parous). This parity signature, together with published parity signatures, was evaluated in gene expression data from 150 paired tumors and adjacent benign breast tissues from the Polish Breast Cancer Study, both overall and by tumor estrogen receptor (ER) status. Results We identified 251 genes significantly upregulated by parity status in RM patients (parous versus nulliparous; false discovery rate = 0.008), including genes in immune, inflammation and wound response pathways. This parity signature was significantly enriched in normal and tumor tissues of parous breast cancer patients, specifically in ER-positive tumors. Conclusions Our data corroborate epidemiologic data, suggesting that the etiology and pathogenesis of breast cancers vary by ER status, which may have implications for developing prevention strategies for these tumors
Complete Genome Sequences of Genamy16 and NovaSharks, Two Gordonia rubripertincta Bacteriophages Isolated from Soil in Southeastern Florida
We report on two actinobacteriophages, Genamy16 and NovaSharks, that were isolated from soil in Florida using Gordonia rubripertincta NRRL B-16540. The genomes of both phages are ~65,000 bp, with similar GC contents, and, based on gene content similarity to phages in the Actinobacteriophage Database, were assigned to phage cluster DV
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