A VOZ DE SUJEITOS-READAPTADOS EM DISCURSO: O LUGAR DO BIBLIOTECÁRIO

A realidade brasileira tem apresentado cada vez mais professores readaptados ocupando o lugar dos bibliotecários dentro das bibliotecas escolares brasileiras. Apesar da existência de diversos trabalhos na área da Ciência da Informação que enfoquem essa questão, chama a nossa atenção a ausência de pesquisas focadas na maneira que esses sujeitos-readaptados falam de sua atuação nesses espaços. Propomos, então, estudar através de uma comunidade virtual destinada a esses sujeitos, como eles discursivizam seu trabalho dentro das bibliotecas escolares e a forma que compreendem essa denominada readaptação profissional. Mobilizamos a Análise do Discurso de matriz francesa, especialmente as noções de sujeito, discurso e memória, para interpretar o dizer desses sujeitos e, no que se refere à Ciência da Informação, trabalhamos com a movimentação de sentidos acerca dessas unidades informacionais, discutindo a readaptação desses profissionais em um campo de trabalho que é diverso do seu. Nessa direção, construímos uma série de reflexões acerca das bibliotecas escolares

A influência da fisioterapia em instituições de longa permanência: uma revisão integrativa. | The influence of physiotherapy in long stay institutions: an integrative review.

Objetivo: analisar a influência da fisioterapia praticada dentro de ILPI’s na vida da pessoa idosa institucionalizada.  Fonte de dados: trata-se de uma revisão integrativa da literatura conduzida por meio das bases de dados Biblioteca Virtual em Saúde (BVS) e PubMed, no período de setembro a novembro de 2019. Os descritores utilizados foram: “fisioterapia”, “idoso” e “institucionalização”. Os critérios de inclusão foram: artigos que abordaram a fisioterapia em ILPIs; artigos publicados em português, inglês e espanhol; artigos publicados entre 2012 a 2019 e que tenham feito a pesquisa no Brasil. Os critérios de exclusão foram: artigos repetidos na busca; artigos que não abordaram a fisioterapia em ILPIs como tema principal; artigos de revisão de literatura, dissertações e teses. A amostra final foi composta por cinco artigos que avaliaram a fisioterapia nas instituições de longa permanência. Conclusão: os estudos abordaram, em sua maioria, a melhora dos pacientes submetidos à realização de fisioterapia. Foi possível evidenciar que, ao propor medidas para fortalecimento e exercícios em dupla tarefa, os pacientes apresentaram melhora nos escores, porém, a maioria dos idosos estudados faziam fisioterapia devido alguma disfunção, não sendo aplicada a fisioterapia desde a prevenção até a promoção de saúde.Palavras-chave: fisioterapia; idoso; institucionalização. -----------------------------------------------------------------------------------------AbstractObjective: to analyze the influence of physical therapy practiced within LTCFs in the life of the institutionalized elderly person Data sources: This is an integrative literature review conducted through the Virtual Health Library and PubMed databases, from September to November 2019. The descriptors used were: “physiotherapy”, “elderly” and "Institutionalization". Inclusion criteria were: articles that addressed physical therapy in LTCFs; articles published in Portuguese, English and Spanish; articles published between 2012 and 2019 that have done research in Brazil. Exclusion criteria were: repeated articles in the search; articles that did not address physical therapy in LTCF as the main theme; literature review articles, dissertations and theses. The final sample consisted of five articles that evaluated physical therapy in long-term care facilities. Conclusion: most studies addressed the improvement of patients undergoing physical therapy. It was possible to show that, when proposing measures for strengthening and double-task exercises, patients showed improvement in scores, but most of the elderly studied had physiotherapy due to some dysfunction, not being applied to physiotherapy from prevention to health promotion.Keywords: physiotherapy; elderly; institutionalization

Control of Haematobia irritans in the Minas Gerais Semiarid

Background: Beef cattle is considered to be one of the most important economic activities, however, it presents problems in the production chain such as the occurrence of parasites that reduce the growth, performance, productivity and may cause mortalities occasionally. The chemical control is the most used alternative to reduce ectoparasites. Nevertheless, inappropriate management of insecticides has contributed to the selection of population resistant to the products available on the market. This paper aimed to evaluate the practices of management and the application of insecticides used to control horn flies in farms of dairy cattle in the North of the state of Minas Gerais.Materials, Methods & Results: It was visited 62 rural properties, which produce milk. Semi-structured questionnaires were applied in order to obtain information on the characteristics of the properties (location, size and type of the cattle), on the knowledge about the epidemiology of the horn flies, and on the practices adopted to the control of those parasites. The practices adopted include the moment of application of the insecticides, frequency of the cattle treatment, used products, method of application, number of animals treated, and choice and substitution criteria of insecticides. The data collected were tabulated in contingency tables, and they were analyzed using the chi-square test, considering a significance of 5%. The racial composition of the cattle in the farms was mainly mixed-race of unknown origin, representing 77% of the animals evaluated. In this research, it was reported a greater incidence of horn flies infestation on adult beef herd, and 23.6% of the producers reported occurrences of infestation in the whole herd, not differing by categories. The infestation peaks of the fly occurred from November to March. It was also found a greater frequency of pyrethroid use in the region (P < 0.001), where 43.1% of the producers used associations of pyrethroid or organophosphate to control the flies, high efficiency being reported. From the properties assessed, 92% presented inadequacy in the practices of control of horn flies, for instance, the lack of using cattle manure tank, the accumulation of open waste, the lack of rotation of insecticides, which can favor the selection of resistant flies.Discussion: In this paper, it was reported 77.19% of predominance of Haematobia irritans infestation from November to March mainly in animals with a higher percentage of European or mixed-race genetics. Such results corroborate with the literature, because it was verified the influence of race and hair color in the level of infestation in the animals, although, in the same race, each individual presents different susceptibilities. Taurine beef cattle are more susceptible to infestation by horn flies than zebu cattle. Thus, the lower the proportion of zebu cattle genetics in the herd, the greater the infestation. Taurine beef cattle are more infested because shows a greater number of sebaceous glands and greater concentration of testosterone being attractive before the calves castrated, cows, and after, young animals. Cypermethrin was predominant in most part of the commercial insecticides used in the properties to control this ectoparasite, which could be justified by the large number of products available on the market with such compound in the formulations. The high efficiency of the associations of the insecticides reported by the producers could justify itself by the presence of active ingredients with different mechanisms of action. However, the limitation on the use of these associations is that not always the chemical compounds contained in the drug act simultaneously, being able to favor the selection of parasites resistant to different insecticides present in these formulations

Resistance profile of osimertinib in pre-treated patients with EGFR T790M-mutated non-small cell lung cancer

Background: Osimertinib efficacy in pre-treated patients with epidermal growth factor receptor (EGFR) T790M-mutated non-small cell lung cancer (NSCLC) has been demonstrated in clinical trials, but real-world data, particularly regarding resistance profile, remains limited. This study aims to analyze the resistance mechanisms acquired after treatment with Osimertinib. Methods: Clinical outcomes and molecular results from re-biopsies at the time of osimertinib progression of EGFR T790M-mutated NSCLC patient were analyzed. Results: Twenty-one patients with stage IV adenocarcinoma were included [median 69 years; 57.1% female; 85.7% never-smokers; 23.8% ECOG performance status (PS) >= 2]. Median PFS and OS were 13.4 (95% CI: 8.0-18.9) and 26.4 (95% IC: 8.9-43.8) months, respectively. At the time of analysis, 10 patients had tumor progression (47.6%). T790M loss occurred in 50%, being associated with earlier progression (median PFS 8.1 vs. 21.4 months, p = 0.011). Diverse molecular alterations were identified, including C797S mutation (n = 1), PIK3CA mutation (n = 2), MET amplification (n = 1), CTNNB1 mutation (n = 1), and DCTN1-ALK fusion (n = 1). Histological transformation into small cell carcinoma occurred in one patient. Conclusions: This real-world life study highlights the relevance of re-biopsy at the time of disease progression, contributing to understand resistance mechanisms and to guide treatment strategies

PROLAPSO URETRAL EM UM CÃO DA RAÇA AMERICAN BULLY

Urethral prolapse, which is uncommon in dogs, is characterized by protrusion of the urethral mucosa beyond the tip of the penis and the external orifice of the urethra. It can occur due to congenital or acquired causes, with a higher incidence in young animals not castrated. The present study aims to report a case of urethral prolapse in a non-castrated dog of 2 years old (American Bully Terrier), which was treated at the Estácio de Sá University located in Rio de Janeiro city, with a history of excessive penis licking, dysuria, prepucial bleeding, and protrusion of the urethral mucosa after an attempt of copulation. During the physical evaluation, the animal presented all clinical parameters within the normal range; however, it showed excessive agitation and pain in the affected region. Then, the diagnosis was defined through direct inspection of the visualization of the protruding urethral mucosa. Given the animal's clinical and physical condition, the surgical procedure of resection and anastomosis of the prolapsed urethral portion was adopted. Therefore, it is concluded that this surgical technique proved to be effective since the patient presented excellent recovery and urethral healing, without any signs of post-surgical complications.O prolapso uretral, o qual é incomum em cães, se caracteriza pela protusão da mucosa uretral além da extremidade do pênis e do orifício externo da uretra. Pode ocorrer por causas congênitas ou adquiridas, tendo maior incidência em animais jovens não castrados. O objetivo do presente trabalho é relatar um caso de prolapso uretral em um cão não castrado da raça American Bully Terrier, de dois anos, o qual foi atendido na Universidade Estácio de Sá localizada no Rio de Janeiro com histórico de lambedura excessiva do pênis, disúria, sangramento prepucial e protrusão da mucosa uretral após tentativa de cópula. Durante a avaliação física o animal apresentou todos os parâmetros clínicos dentro da normalidade, entretanto demonstrava agitação excessiva e dor na região afetada. Então, o diagnóstico foi definido por meio da inspeção direta da visualização da mucosa uretral protusa. Frente ao quadro clínico e físico do animal, foi adotado o procedimento cirúrgico de ressecção e anastomose da porção uretral prolapsada. Desta forma, conclui-se que esta técnica cirúrgica se mostrou eficaz, visto que o referido paciente apresentou ótima recuperação e cicatrização uretral, sem quaisquer sinais de complicações pós-cirúrgicas

Precisión diagnóstica del test rápido SARS-CoV-2 y período óptimo para la seropositividad según la aparición de síntomas

Point-of-care serological tests for SARS-CoV-2 have been used for COVID-19 diagnosis. However, their accuracy over time regarding the onset of symptoms is not fully understood. We aimed to assess the accuracy of a point-of-care lateral flow immunoassay (LFI). Subjects, aged over 18 years, presenting clinical symptoms suggestive of acute SARS-CoV-2 infection were tested once by both nasopharyngeal and oropharyngeal RT-PCR and LFI. The accuracy of LFI was assessed in periodic intervals of three days in relation to the onset of symptoms. The optimal cut-off point was defined as the number of days required to achieve the best sensitivity and specificity. This cut-off point was also used to compare LFI accuracy according to participants’ status: outpatient or hospitalized. In total, 959 patients were included, 379 (39.52%) tested positive for SARS-CoV-2 with RT-PCR, and 272 (28.36%) tested positive with LFI. LFI best performance was achieved after 10 days of the onset of symptoms, with sensitivity and specificity of 84.9% (95%CI: 79.8-89.1) and 94.4% (95%CI: 91.0-96.8), respectively. Although the specificity was similar (94.6% vs. 88.9%, p = 0.051), the sensitivity was higher in hospitalized patients than in outpatients (91.7% vs. 82.1%, p = 0.032) after 10 days of the onset of symptoms. Best sensitivity of point-of-care LFI was found 10 days after the onset of symptoms which may limit its use in acute care. Specificity remained high regardless of the number of days since the onset of symptoms.Os testes sorológicos no local de atendimento (point -of-care) para a infecção pelo SARS-CoV-2 têm sidos utilizados para o diagnóstico da COVID-19. Entretanto, não está plenamente elucidada a acurácia dos testes ao longo do tempo em relação ao início dos sintomas. Nosso objetivo foi de avaliar a acurácia, no local de atendimento, do imunoensaio de fluxo lateral (LFI). Pacientes com ≥ 18 anos de idade que apresentavam sintomas clínicos sugestivos de infecção aguda pelo SARS-CoV-2 foram testados uma vez com RT-PCR da nasofaringe e orofaringe, além do LFI. A acurácia do LFI foi avaliada com intervalos periódicos de 3 dias a partir do início dos sintomas. O ponto de corte ótimo foi definido como o número necessário de dias para atingir a melhor sensibilidade e especificidade. Esse ponto foi utilizado também para comparar a acurácia do LFI de acordo com a situação do paciente (ambulatorial ou hospitalizado). Foram incluídos 959 pacientes, dos quais 379 (39,52%) testaram positivos para SARS-CoV-2 pelo RT-PCR e 272 (28,36%) pelo LFI. Foi atingido o melhor desempenho para o LFI com 10 dias a partir do início dos sintomas, com sensibilidade e especificidade de 84,9% (IC95%: 79,8-89,1) e 94,4% (IC95%: 91,0-96,8), respectivamente. Embora a especificidade não tenha sido diferente entre os grupos de pacientes (94,6% vs. 88,9%, p = 0,051), a sensibilidade foi mais alta nos pacientes hospitalizados que nos ambulatoriais (91,7% vs. 82,1%, p = 0,032) no dia 10 depois do início dos sintomas. A melhor sensibilidade do LFI no local de atendimento ocorre 10 dias depois do início dos sintomas, o que pode limitar seu uso no atendimento agudo. A especificidade permanece alta, independentemente do número de dias desde o início dos sintomas.Los puestos de atención para pruebas serológicas del SARS-CoV-2 han sido usado para la diagnosis de la COVID-19. No obstante, su precisión a lo largo del tiempo, en lo que respecta a la aparición de los síntomas, no se ha comprendido completamente. Nuestro objetivo fue evaluar la precisión de un puesto de atención de inmunoanálisis de flujo lateral (LFI). Se hizo pruebas a individuos ≥ 18 años, presentando síntomas clínicos compatibles con una infección aguda de SARS-CoV-2, tanto vía nasofaríngea y orofaríngea RT-PCR, como LFI. La precisión de LFI fue evaluada en intervalos periódicos de 3 días con respecto a la aparición de los síntomas. El punto óptimo de corte se definió como el número de días requerido para alcanzar la mejor sensibilidad y especificidad. Este punto también se usó para comparar la precisión del LFI, según el estatus de los participantes: ambulatorios u hospitalizados. Se incluyeron a 959 pacientes, 379 (39,52%) dieron positivo en las pruebas de SARS-CoV-2 RT-PCR, y 272 (28,36%) fueron positivos en los LFI. Se alcanzó el mejor rendimiento de los LFI tras 10 días de la aparición de los síntomas, con una sensibilidad y especificidad de un 84,9% (IC95%: 79,8-89,1) y 94,4% (IC95%: 91,0- 96,8), respectivamente. A pesar de que la especificidad no fue diferente (94,6% vs. 88,9%, p = 0,051), la sensibilidad fue mayor en pacientes hospitalizados que en los ambulatorios (91,7% vs. 82,1%, p = 0,032) tras 10 días desde la aparición de los síntomas. La mejor sensibilidad LFI del puesto de cuidado se produce tras 10 días de la aparición de los síntomas, lo que quizás limite su uso en el cuidado de urgencias. La especificidad permanece alta independientemente del número de días desde la aparición de los síntomas

Aspects related to the plasticity of a psychosocial care center in southern Brazil

Identificar os aspectos relacionados à plasticidade de um Centro de Atenção Psicossocial (CAPS) da região sul do Brasil. Trata-se de um recorte da pesquisa de avaliação dos CAPS da região sul do Brasil - CAPSUL . Sendo um estudo de abordagem qualitativa, utilizando o referencial de quarta geração, construtivista, responsiva e com abordagem hermenêutico-dialética. Neste recorte foi avaliado o CAPS de Alegrete/RS, a partir de entrevistas com 11 usuários, 14 familiares e 26 trabalhadores. A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa da Faculdade de Medicina da Universidade Federal de Pelotas, conforme ofício nº. 014/07. Nota-se que a equipe é comprometida com as transformações sociais da vida dos usuários do serviço estudado, demonstrando a plasticidade deste CAPS. Entretanto existem alguns dificultadores neste processo de reabilitação como por exemplo a falta de medicação. Outro facilitador seria o fato dos usuários usarem talheres de alumínio e prato de porcelana, assim estimulando a auto-estima. O CAPS de Alegrete, apesar das dificuldades presentes no serviço, mostra-se capaz no que diz respeito ao cuidado dos indivíduos portadores de sofrimento psíquico, comprometendo-se com questões biopsicossociais e buscando maneiras de cuidar em liberdade

Effects of Aqueous Extracts of Caryocar brasiliense in Mice

Background: Caryocar brasiliense Cambess (Caryocaraceae) is an arboreal plant native of Brasilian Cerrado and its fruit is an important source of food and income for the human population of this region. In addition to using as food, different parts of this tree have great medicinal potential as antimicrobial, anti-inflammatory, antioxidant and antihelmintic. However, the active metabolites those are likely to confer these pharmacological properties healing may also be toxic dependent upon the dose and route of administration. In this quest, the aim of this study was to assess the acute toxicity of aqueous extracts of fruit peels and leaves of C. brasiliense in mice of both genders.Materials, Methods & Results: The aqueous extracts were obtained by decoction, diluted in water and filtered through membrane. The toxicity of extract of fruit peels (62.5 at 500 mg/kg of body weight (BW) and leaf extract (18.75 mg/kg bw) were evaluated in males and  females mice (Mus musculus) Swiss by intraperitoneal route. For 2 control groups were administered injection water. The clinical signs and deaths were recorded up to 14 days after administration. The lethal doses for 10 (LD10) or 50 (LD50) % of population were estimated with Probit regression analysis. The Chi-square test was used to analyze differences of mortality frequencies between males and females. The groups treated with the two lower doses of both extracts completely abolished the clinical alteration between two and four hours after inoculation. The comportment of control group’s animals was normalized immediately after administration of injection water. The higher dose administered in both experiments were lethal for all animals, but the doses 250 mg/kg BW of fruit peels extract and 150 mg/kg  of BW of leaves extract caused mortality of 100% just in males.  However, in both experiments there were no significant differences between the mortality frequency for groups of male and female, as well the comportment of these animals when these doses were administered. Dose-dependent response was observed to mortality. The LD10 corresponded to 89.6 mg/kg BW and LD50 was 149.8 mg/kg BW for fruit peel extract. For the leaf extract , LD10 and LD50 were 33.35 and 67.01 mg/kg BW, respectively.Discussion: Aqueous extracts of the fruit peels and leaves of C. brasiliense were classified as very toxic since the LD50 ranged from 50 to 500 mg / kg BW. For both extracts, similar behavioral changes were observed. Among the secondary metabolites present in fruit peel and leaves, saponins and tannins can promote nervous symptoms. Although there are no records in the literature about animals and human orally intoxicated with any part of C. brasiliense, the development of specific studies to determine its toxicity is relevant, considering the social and ecological importance of this plant

Fruits of the Brazilian Cerrado are a potential alternative for food tourism and regional development

Abstract The Cerrado biome has tremendous social, heritage, and income-generating importance for traditional communities from this Brazilian region. Although the exotic fruits of Brazilian Cerrado are a subsistence source for communities that cultivate them and contribute to regional tourism promotion, they are not systematically studied. This study explores the potential of the biodiversity of exotic fruits from the Brazilian Cerrado biome as a promoter of food tourism. Exploring tourism and local production chains can enhance the development of Cerrado. Articulating this ‘new’ type of interaction between national public policies, local productive arrangements (LPA), traditional communities, and tourist activity actors can also help promote the exotic fruits from Cerrado. Thus, this is the first time the tourism experience emphasizing fruits has been explored as a promising alternative to regional development