Potencial de Cleruchoides noackae para o controle biológico de Thaumastocoris peregrinus.

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Avaliação de Cleruchoides noackae em Laboratório e Campo em Minas Gerais, Brasil.

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Efeito do armazenamento a baixa temperatura na viabilidade do ovo de Thaumastocoris peregrinus (Hemiptera, Thaumastocoridae).

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Influência da densidade de fêmeas no parasitismo de Cleruchoides noackae (Hymenoptera, Mymaridae) sobre ovos de Thaumastocoris peregrinus (Hemiptera, Thaumastocoridae).

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Stimulation of lymphocyte anti-melanoma activity by co-cultured macrophages activated by complex homeopathic medication

<p>Abstract</p> <p>Background</p> <p>Melanoma is the most aggressive form of skin cancer, and the most rapidly expanding cancer in terms of worldwide incidence. Chemotherapeutic approaches to treat melanoma have been uniformly disappointing. A Brazilian complex homeopathic medication (CHM), used as an immune modulator, has been recommended for patients with depressed immune systems. Previous studies in mice have demonstrated that the CHM activates macrophages, induces an increase in the number of leukocytes and improves the murine response against Sarcoma-180.</p> <p>Methods</p> <p>Here we studied the interaction of mouse lymph node lymphocytes, co-cultured <it>in vitro </it>with macrophages in the presence or absence of the CHM, with B16F10 melanoma cells.</p> <p>Results</p> <p>Lymphocytes co-cultured with macrophages in the presence of the CHM had greater anti-melanoma activity, reducing melanoma cell density and increasing the number of lysed tumor cells. There was also a higher proportion of activated (CD25⁺) lymphocytes with increased viability. Overall, lymphocytes activated by treatment destroyed growing cancer cells more effectively than control lymphocytes.</p> <p>Conclusion</p> <p>Co-culture of macrophages with lymphocytes in the presence of the CHM enhanced the anti-cancer performance of lymphocytes against a very aggressive lineage of melanoma cells. These results suggest that non-toxic therapies using CHMs are a promising alternative approach to the treatment of melanomas. In addition, they are attractive combination-therapy candidates, which may enhance the efficacy of conventional medicines by improving the immune response against tumor cells.</p

Formação de Professores que Ensinam Matemática: um olhar sobre as redes sociais e intelectuais do BOLEMA

Nosso trabalho se insere no campo da formação de professores que ensinam Matemática, tendo como proposta analisar a rede social e intelectual dos artigos que tratam sobre o tema, publicados no periódico BOLEMA (1985-2015). Tem aporte teórico na epistemologia fleckiana, considerando que o conhecimento é produzido coletivamente, de forma que os pesquisadores ao compartilharem um problema, referencial teórico e práticas comuns formam um coletivo de pensamento. A pesquisa que dá origem ao texto é quali e quantitativa, desenvolvida a partir da metodologia de Análise de Redes Sociais (ARS) e com o auxílio do software Gephi que forneceu estatísticas para a análise. Apoiada nas categorias fleckianas, a análise nos permite inferir que: a produção do conhecimento disponibilizada no periódico está fortemente vinculada à pós-graduação; a maioria dos artigos é oriunda de instituições da região Sudeste; a rede de coautoria que emerge tem baixa densidade, o que implica em pouca representatividade perante as relações compartilhadas; a rede intelectual concentra-se em três clusters: a formação inicial; a formação continuada e a formação contínua e desenvolvimento profissional, as quais apresentam circulação intra e intercoletiva de ideias que possibilitam emergir novas categorias, tratando de questões mais específicas

Preliminary evidence of age-dependent clinical signs associated with porcine circovirus 2b in experimentally infected CH3/Rockefeller mice

Mice and rats are susceptible to porcine circovirus 2b (PCV2) infection under field and experimental conditions. However, whether PCV2 induces disease in rodents remains a matter of debate. The objectives of the present study were to determine whether PCV2-induced disease in mice is age-dependent and whether intranasally inoculated animals are able to infect animals they come into contact with. Twenty-five CH3/Rockefeller mice were divided into six groups and intranasally inoculated with 25 µL of either PCV2b or PBS on days 0, 3 and 6. One group remained untreated. Two age groups were tested: 3-week-old mice and 6-week-old mice. The administration of three PCV2 intranasal inoculations at intervals of three days was able to induce infection and support virus transmission in susceptible mice, regardless of the age at inoculation. The clinical signs associated with PCV2 infection were more severe in younger mice, and PCV2-DNA load was higher in their faeces. In conclusion, PCV2 induced disease in mice